Circulating T-lymphocyte activation in patients with variant angina.

Abstract:

BACKGROUND:Both experimental and pathological studies suggest that immune response and inflammation may play an important role in the pathogenesis of coronary spasm. DESIGN:To elucidate the role of systemic immune and inflammatory responses in the pathogenesis of coronary spasm, we studied circulating T-lymphocyte activation in variant angina patients (VAPs), stable effort angina patients (EAPs) and in control participants. METHODS:Twenty documented VAPs, 13 EAPs and 20 control participants were studied. To evaluate T-lymphocyte activation, T-lymphocyte surface antigen expression, including CD3, CD4, CD8 and HLA-DR, was measured by two-colour flow cytometric analysis. Serum-soluble interleukin-2 receptor (sIL-2R) and C-reactive protein (CRP) were also measured by enzyme-linked immunosorbent assay. We restudied 10 of the VAPs to investigate the relationship between the disease activity of variant angina and T-lymphocyte activation. RESULTS:The percentage of CD3+/DR+ T-lymphocytes in VAPs (14.8%) was significantly higher than in EAPs (10.7%, P < 0.05) and control participants (9.7%, P < 0.005); however, levels of sIL-2R were the same among the three groups. Levels of CRP were within normal range in all VAPs. The percentage of CD8+/DR+ T-lymphocytes was significantly higher in VAPs (9.5%, P < 0.005) than in EAPs (5.5%) and control participants (5.9%), whereas the percentage of CD4+/DR+ T-lymphocytes was similar among the three groups. The percentage of activated T-lymphocytes in VAPs was unchanged during the follow-up period (mean intervals, 10 months). CONCLUSIONS:These results indicate that the chronic activation of T-lymphocytes, especially CD8+ T-lymphocytes, may be involved in the pathogenesis of coronary spasm.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Terashima M,Akita H,Kanazawa K,Shiga N,Matsuda Y,Hirata K,Kawashima S,Yokoyama M

doi

10.1097/00019501-200205000-00005

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

161-8

issue

3

eissn

0954-6928

issn

1473-5830

journal_volume

13

pub_type

杂志文章
  • Association between serum galectin-3 levels and coronary atherosclerosis and plaque burden/structure in patients with type 2 diabetes mellitus.

    abstract:BACKGROUND:Levels of galectin-3, a member of a family of soluble β-galactoside-binding lectins, are reported to be higher in patients with type 2 diabetes mellitus (DM) and metabolic syndrome. Conflicting results exist on the effects of galectin-3 in diabetic patients. The aim of this study was to investigate the relat...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000252

    authors: Ozturk D,Celik O,Satilmis S,Aslan S,Erturk M,Cakmak HA,Kalkan AK,Ozyilmaz S,Diker V,Gul M

    更新日期:2015-08-01 00:00:00

  • Clinical implications of circulating soluble Fas and Fas ligand in patients with acute myocardial infarction.

    abstract:BACKGROUND:Apoptotic cell death is the major form of myocardial damage produced by coronary ischemic events. OBJECTIVE:To assess whether circulating levels of soluble Fas (sFas), an inhibitor of apoptosis, and sFas ligand, an inducer of apoptosis, in patients with coronary artery disease are greater than normal. METH...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199906000-00003

    authors: Ohtsuka T,Hamada M,Sasaki O,Suzuki M,Hara Y,Shigematsu Y,Ohtani T,Honda T,Hiwada K

    更新日期:1999-06-01 00:00:00

  • Single nucleotide polymorphisms associated with abnormal coronary microvascular function.

    abstract:BACKGROUND:Single nucleotide polymorphisms (SNPs) are the most common source of genetic variation. Although microvascular pathology is associated with cardiovascular events, genetic phenotypes causing microvascular disease remain largely unknown. This study identifies sex-specific SNPs associated with coronary microvas...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000104

    authors: Yoshino S,Cilluffo R,Best PJ,Atkinson EJ,Aoki T,Cunningham JM,de Andrade M,Choi BJ,Lerman LO,Lerman A

    更新日期:2014-06-01 00:00:00

  • Implantation of sirolimus-eluting stents in saphenous vein grafts is associated with high clinical follow-up event rates compared with treatment of native vessels.

    abstract:AIMS:The clinical effectiveness of sirolimus-eluting stents (SES) for treatment of patients with saphenous vein graft disease is not well defined. This analysis sought to evaluate the clinical follow-up after treatment of stenotic saphenous vein grafts using SES in a large patient registry. Patients treated with SES fo...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCA.0b013e3282ef5b40

    authors: Hoffmann R,Hamm C,Nienaber CA,Levenson B,Bonzel T,Sabin G,Senges J,Zahn R,Tebbe U,Pfannebecker T,Richardt HG,Schneider S,Kelm M,German Cypher Registry.

    更新日期:2007-11-01 00:00:00

  • Cardiovascular magnetic resonance of anomalous coronary arteries.

    abstract::Cardiovascular magnetic resonance of anomalous coronary arteries is a class I indication. The term anomalous coronary artery encompasses those with an abnormal origin (from the incorrect sinus, too-high or too-low from the correct sinus, or from the pulmonary artery) and/or number of ostia. Their clinical significance...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/00019501-200509000-00004

    authors: Varghese A,Keegan J,Pennell DJ

    更新日期:2005-09-01 00:00:00

  • Clinical manifestations of myocardial stunning.

    abstract::The phenomenon of myocardial stunning has been observed in all animal species studied. The possible occurrence of myocardial stunning in man has been demonstrated after either regional ischemia (such as exercise-induced angina, vasospastic or unstable angina) or after global ischemia (i.e., after cardioplegic arrest d...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/00019501-200108000-00004

    authors: Ambrosio G,Tritto I

    更新日期:2001-08-01 00:00:00

  • Hemodynamic changes determine the efficacy of thrombolysis: results from an in-vitro flow model.

    abstract:BACKGROUND:The efficacy of thrombolytic therapy might be influenced by changes in the hemodynamic status. The aim of the study was to examine whether changes in perfusion pressure could affect the time to reflow in an in-vitro model. METHODS:The in-vitro flow system comprised flexible plastic tubes that enclosed a blo...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199809010-00007

    authors: Kornowski R,Mendelevich L,Zaretsky U,Einav S,Laniado S,Keren G

    更新日期:1998-01-01 00:00:00

  • Visual scoring of coronary artery calcification in lung cancer screening computed tomography: association with all-cause and cardiovascular mortality risk.

    abstract:OBJECTIVE:Current and former smokers are at an increased risk for lung cancer and cardiovascular disease (CVD). We investigated two methods of visual scoring of coronary artery calcium on lung cancer screening computed tomography (CT) to predict cardiovascular and all-cause mortality. PARTICIPANTS AND METHODS:Cases we...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000189

    authors: Watts JR Jr,Sonavane SK,Snell-Bergeon J,Nath H

    更新日期:2015-03-01 00:00:00

  • Incidence, predictors, and 30-day outcomes of new-onset atrial fibrillation after primary percutaneous coronary intervention: insight into the RISK-PCI trial.

    abstract:OBJECTIVES:Limited data exist about the prognostic significance of new-onset atrial fibrillation (AF) after contemporary primary percutaneous coronary intervention (pPCI). The objective of this study was to identify the incidence and predictors of new-onset AF and associated adverse 30-day outcomes in AF patients who u...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章

    doi:10.1097/MCA.0b013e32834df552

    authors: Mrdovic I,Savic L,Krljanac G,Perunicic J,Asanin M,Lasica R,Antonijevic N,Kocev N,Marinkovic J,Vasiljevic Z,Ostojic M

    更新日期:2012-01-01 00:00:00

  • Is reoperative coronary artery bypass grafting in patients with poor left ventricular ejection fractions < or = 25% worthwhile?

    abstract:AIM:This study aimed to investigate whether patients with very low left ventricular ejection fractions (LVEF) should be accepted for reoperative coronary artery bypass grafting (CABG). STUDY POPULATION:Between January 1990 and December 1993, 1681 patients underwent primary CABG and 308 (15.5%) reoperative CABG. One hu...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199505000-00010

    authors: Christenson JT,Bloch A,Maurice J,Simonet F,Velebit V,Schmuziger M

    更新日期:1995-05-01 00:00:00

  • Elderly patients with hypercholesterolaemia: a double-blind study of the efficacy, safety and tolerability of fluvastatin.

    abstract:BACKGROUND:Coronary heart disease is a major cause of morbidity and mortality in the elderly, a rapidly growing section of the population. Elderly patients have been excluded from most preventative risk factor trials. METHODS:We evaluated fluvastatin, a fully synthetic hydroxymethyl glutaryl coenzyme A reductase inhib...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Lye M,Valacio R,Reckless JP,Ghosh AK,Findlay IN,Ghosh MK,Passmore AP,Fulcher RA

    更新日期:1998-01-01 00:00:00

  • Dual response to Fas ligation in human endothelial cells: apoptosis and induction of chemokines, interleukin-8 and monocyte chemoattractant protein-1.

    abstract:BACKGROUND:To maintain the integrity of tissues, endothelial cells play critical roles. Fas ligand (FasL) is well known to deliver a death signal through its receptor, Fas. The Fas/FasL system may concomitantly induce expressions of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) besides triggering ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200302000-00010

    authors: Yamaoka-Tojo M,Yamaguchi S,Nitobe J,Abe S,Inoue S,Nozaki N,Okuyama M,Sata M,Kubota I,Nakamura H,Tomoike H

    更新日期:2003-02-01 00:00:00

  • Role of activation-dependent platelet membrane glycoproteins in development of subacute occlusive coronary stent thrombosis.

    abstract:BACKGROUND:Platelets have an important role in coronary thrombosis. METHODS:We studied 151 consecutive patients undergoing implantation of Palmaz-Schatz stents because of suboptimal results after coronary balloon angioplasty treated by intense anticoagulation. Surface exposure of the constitutively expressed glycoprot...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199703000-00001

    authors: Gawaz M,Neumann FJ,Ott I,May A,Rüdiger S,Schömig A

    更新日期:1997-03-01 00:00:00

  • The effect of low FT3 levels on coronary artery calcification and MACE in outpatients with suspected coronary artery disease.

    abstract:OBJECTIVE:Considerable evidence suggests that thyroid dysfunction, especially hypothyroidism, may lead to coronary artery disease (CAD). The aim of this study is to investigate the effect of low serum levels of free triiodothyronine (FT3) on coronary artery calcification in outpatients with suspected CAD and the occurr...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000095

    authors: Zhu L,Gao C,Wang X,Qi D,Zhang Y,Li M,Liu W,Hao P

    更新日期:2014-08-01 00:00:00

  • One-year outcome following coronary angiography in elderly patients with non-ST elevation myocardial infarction: real-world data from the Acute Coronary Syndromes Israeli Survey (ACSIS).

    abstract:OBJECTIVES:We aimed to evaluate the management and outcomes of patients of the octogenarian age group with non-ST elevation myocardial infarction (NSTEMI) in a real-world setting. METHODS:The risk of 30-day and 1-year mortality by age and the time of coronary angiography [categorized as early (≤48 h of admission) and ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCA.0b013e32835c8f53

    authors: Buber J,Goldenberg I,Kimron L,Guetta V

    更新日期:2013-03-01 00:00:00

  • Fetuin-A is associated with calcified coronary artery disease.

    abstract:OBJECTIVE:Fetuin-A is a circulating glycoprotein that is involved in various stages of atherosclerosis. Despite the fact that emerging evidence suggests fetuin-A acts as a calcification inhibitor that protects against advanced calcified atherosclerosis in dialyzed patients, the role of fetuin-A in cardiovascular diseas...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e32832fe5d5

    authors: Mori K,Ikari Y,Jono S,Emoto M,Shioi A,Koyama H,Shoji T,Ishimura E,Inaba M,Hara K,Nishizawa Y

    更新日期:2010-08-01 00:00:00

  • Serum levels of YKL-40 increases in patients with acute myocardial infarction.

    abstract:OBJECTIVES:YKL-40 is secreted by macrophages, including those in atherosclerotic plaques, neutrophils, and vascular smooth muscle cells. Circulating YKL-40 is elevated in patients with inflammation and increased tissue remodeling. The aim was to examine the sequential changes in serum YKL-40 in patients with acute myoc...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e3282f40dd5

    authors: Nøjgaard C,Høst NB,Christensen IJ,Poulsen SH,Egstrup K,Price PA,Johansen JS

    更新日期:2008-06-01 00:00:00

  • Safety and efficacy of the NovaCross microcatheter in facilitating crossing of chronic total occlusion coronary lesions: a multicenter, single-arm clinical trial.

    abstract:BACKGROUND:The aim of this study was to evaluate the safety and efficacy of the novel NovaCross microcatheter system in patients with ischemic heart disease due to coronary chronic total occlusions (CTO). METHODS:A total of 191 subjects between the ages of 25-80 years were recruited in 10 investigational sites. Each s...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000947

    authors: Walsh SJ,Dudek D,Bryniarski L,Nicholson W,Karmpaliotis D,Uretsky B,McEntegart M,Assali A,Knaapen P,Kornowski R,Spratt JC,Goodwin M,Hanratty CG

    更新日期:2020-11-01 00:00:00

  • Association of coronary artery calcium with bone mineral density in postmenopausal women.

    abstract:OBJECTIVES:Atherosclerosis and osteoporosis (OP) are common diseases in elderly individuals and may share common pathogenetic mechanisms. The aim of this study was to investigate the association between bone mineral density (BMD) and coronary artery calcium (CAC) in postmenopausal women. METHODS:In this cross-sectiona...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000402

    authors: Xu R,Yang HN,Li YQ,Wang QF,Guo AH,Ayiti A,Chen XC,Gong R,Banu G,Jian LD,Gao Y,Sheng K,Maimti Y

    更新日期:2016-11-01 00:00:00

  • Treatment of mild-moderate calcified coronary lesions with sirolimus-eluting stent: real world data from a single center.

    abstract:BACKGROUND:Calcified coronary lesions have commonly been considered as a challenge for interventional cardiologists, and few previous studies of sirolimus-eluting stent (SES) for calcified lesion have been limited by small sample size. Therefore, we evaluated the effectiveness of SES implantation for the treatment of c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e328330d5ab

    authors: Yuan JQ,Li JJ,Qin XW,Xu B,Yang YJ,Chen JL,Qiao SB,Ma WH,Yao M,Liu HB,Wu YJ,Chen J,You SJ,Dai J,Xia R,Gao RL

    更新日期:2010-01-01 00:00:00

  • The protection by ischemic preconditioning against myocardial ischemia- and reperfusion-induced arrhythmias is not mediated by ATP-sensitive potassium channels in rats.

    abstract:BACKGROUND:Single or multiple brief periods of myocardial ischemic preconditioning (PC) limits ischemia- and reperfusion-induced arrhythmias. This study tested whether PC protects against ischemia/reperfusion-induced arrhythmias and, if so, whether the protective effect was mediated by the opening of ATP-sensitive (KAT...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199307000-00010

    authors: Lu H,Remeysen P,De Clerck F

    更新日期:1993-07-01 00:00:00

  • Red cell distribution width as a novel prognostic marker in patients undergoing primary angioplasty for acute myocardial infarction.

    abstract:OBJECTIVES:Red cell distribution width (RDW), a measure of red blood cell size heterogeneity, was evaluated in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). BACKGROUND:Higher RDW is associated with mortality in patients with symptomatic car...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e328342c77b

    authors: Uyarel H,Ergelen M,Cicek G,Kaya MG,Ayhan E,Turkkan C,Yıldırım E,Kırbas V,Onturk ET,Erer HB,Yesilcimen K,Gibson CM

    更新日期:2011-05-01 00:00:00

  • Invasive assessment of microvascular function in patients with valvular heart disease.

    abstract:BACKGROUND:The aim of this study was to investigate microvascular function in patients with valvular heart disease (VHD), which causes chronic left ventricular volume and/or pressure overload, therefore change in coronary microvascular hemodynamics. PATIENTS AND METHODS:We prospectively enrolled 30 patients with VHD c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000594

    authors: Nishi T,Kitahara H,Saito Y,Nishi T,Nakayama T,Fujimoto Y,Matsumiya G,Kobayashi Y

    更新日期:2018-05-01 00:00:00

  • Thrombomodulin -33G/A and Ala455Val polymorphisms are associated with the risk of coronary artery disease: a meta-analysis including 12 584 patients.

    abstract:BACKGROUND:Thrombomodulin (TM) -33G/A and Ala455Val polymorphisms have been indicated to be correlated with the risk of coronary artery disease (CAD), but study results are still inclusive. Thus, a meta-analysis was carried out. MATERIALS AND METHODS:Databases including PubMed, Embase, CNKI, and Web of Science (ISI) w...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MCA.0000000000000161

    authors: Wang H,Dong P

    更新日期:2015-01-01 00:00:00

  • Association of plasminogen activator inhibitor-1 and low-density lipoprotein heterogeneity as a risk factor of atherosclerotic cardiovascular disease with triglyceride metabolic disorder: a pilot cross-sectional study.

    abstract:BACKGROUND:We hypothesized that an increase in plasminogen activator inhibitor 1 (PAI-1) might reduce low-density lipoprotein (LDL) particle size in conjunction with triglyceride (TG) metabolism disorder, resulting in an increased risk of atherosclerotic cardiovascular disease (ASCVD). METHODS:This study was carried o...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000521

    authors: Iida K,Tani S,Atsumi W,Yagi T,Kawauchi K,Matsumoto N,Hirayama A

    更新日期:2017-11-01 00:00:00

  • The predictive value of PRECISE-DAPT score for arrhythmic complications in patients with ST-elevation myocardial infarction.

    abstract:OBJECTIVE:To investigate the predictive value of the PRECISE-DAPT score for the development of arrhythmias in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. METHOD:A total of 706 patients with a diagnosis of ST-segment elevation myocardial infarction who...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000788

    authors: Yildirim E,Turkkan C,Ozcan KS,Ceylan US,Zengin A

    更新日期:2019-11-01 00:00:00

  • Effects of exercise training on mortality in patients with coronary heart disease.

    abstract::Endothelial dysfunction not only precedes the development of significant coronary artery stenosis, it has also been identified as a general phenomenon predicting future cardiovascular events in patients who are at risk. As regular physical activity as a part of a multifactorial intervention has been shown to affect sy...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/00019501-200605000-00003

    authors: Erbs S,Linke A,Hambrecht R

    更新日期:2006-05-01 00:00:00

  • Effects of intracoronary autologous bone marrow cells on left ventricular function in acute myocardial infarction: a systematic review and meta-analysis for randomized controlled trials.

    abstract:BACKGROUND:Experimental and clinical studies have suggested that intracoronary infusion of bone marrow-derived stem/progenitor cells (BMC) may improve left ventricular function after acute myocardial infarction (AMI). We conducted a systematic review and meta-analysis to investigate the efficacy and safety of BMC thera...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MCA.0b013e328300dbd3

    authors: Kang S,Yang YJ,Li CJ,Gao RL

    更新日期:2008-08-01 00:00:00

  • Predictive value of the combination of age, creatinine, and ejection fraction score and diabetes in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention.

    abstract:BACKGROUND:This study investigated whether the age, creatinine, and ejection fraction (ACEF) score [age (years) /ejection fraction (%) +1 (if creatinine>176μmol/L)] could predict 1-year outcomes following ST-segment elevation myocardial infarction after percutaneous coronary intervention, and whether accuracy could be ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000791

    authors: Gao S,Liu Q,Ding X,Chen H,Zhao X,Li H

    更新日期:2020-03-01 00:00:00

  • Early versus delayed coronary artery bypass graft surgery for patients with non-ST elevation myocardial infarction.

    abstract:BACKGROUND:Although coronary artery bypass graft surgery (CABG) has been proven to have mortality and morbidity benefits in patients with non-ST elevation myocardial infarction and multivessel disease, the appropriate timing of this procedure remains unclear. Therefore, we proposed a propensity score-matched analysis c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000537

    authors: Ha LD,Ogunbayo G,Elbadawi A,Olorunfemi O,Messerli A

    更新日期:2017-12-01 00:00:00