Abstract:
INTRODUCTION:We investigated the relationship between heart rate variability and preclinical carotid intima-media thickening, a putative index of atherosclerosis. METHODS:A sample of 350 men and women (mean age 56.8 years) selected for the presence or absence of untreated hypertension was assessed for heart rate variability at rest and separately for carotid intima-media thickness using duplex ultrasonography (Pittsburgh study). Findings from this sample were cross-validated in a subsample of 68 men drawn from the Kuopio Ischemic Heart Disease Risk Factor trial and selected for the presence or absence of angina. RESULTS:In both samples, regression analyses, controlling for known risk factors, showed a significant negative relationship between mean carotid intima-media thickness and low-frequency (0.05-0.15 Hz) heart rate variability, but not high-frequency variability. DISCUSSION:The mechanism underlying this relationship remains unclear. The absence of difference in high-frequency variation questions any interpretation in terms of vagal function; the difference in low-frequency variation may implicate vessel wall characteristics or decreased sympathetic nervous system influence. CONCLUSION:Decreased amplitude of low-frequency heart rate variability seems associated with a preclinical atherosclerotic index.
journal_name
Coron Artery Disjournal_title
Coronary artery diseaseauthors
Gautier C,Stine L,Jennings JR,Sutton-Tyrrell K,Muldoon MB,Kamarck TW,Kaplan GA,Salonen J,Manuck SBdoi
10.1097/MCA.0b013e328011ac01subject
Has Abstractpub_date
2007-03-01 00:00:00pages
97-104issue
2eissn
0954-6928issn
1473-5830pii
00019501-200703000-00004journal_volume
18pub_type
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journal_title:Coronary artery disease
pub_type: 杂志文章
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journal_title:Coronary artery disease
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journal_title:Coronary artery disease
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journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/00019501-200509000-00004
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199705000-00004
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200412000-00006
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journal_title:Coronary artery disease
pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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journal_title:Coronary artery disease
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更新日期:2016-11-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200502000-00009
更新日期:2005-02-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-09-01 00:00:00
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journal_title:Coronary artery disease
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doi:10.1097/MCA.0b013e328330d5ab
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pub_type: 杂志文章,多中心研究
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更新日期:2013-09-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
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journal_title:Coronary artery disease
pub_type: 杂志文章
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更新日期:2003-05-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
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更新日期:1993-10-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
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更新日期:2011-12-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
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更新日期:2019-05-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
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更新日期:2009-05-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199912000-00010
更新日期:1999-12-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3283452431
更新日期:2011-06-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199412000-00006
更新日期:1994-12-01 00:00:00