Abstract:
OBJECTIVES:We analyzed a large patient group to develop a clinical risk score that could be applied to patients after primary percutaneous coronary intervention (PCI). METHODS:We reviewed 2529 consecutive patients treated with primary PCI for ST-elevation myocardial infarction between 2003 and 2008. All clinical, angiographic and follow-up data were retrospectively collected. Independent predictors of in-hospital cardiovascular mortality were determined by multivariate Cox regression analysis in all study patients. RESULTS:Five variables (Killip class 2/3, unsuccessful procedure, contrast-induced nephropathy, diabetes mellitus, and age >70 years) were selected from the initial multivariate model. Each of them was weighted with 1 point according to their respective odds ratio for in-hospital mortality and then total risk score was calculated for each patient with a range of 0-5 points. For simplicity, four strata of risk were defined (low risk, score 0; intermediate risk, score 1; high risk, score 2 and very high risk, score > or =3). Each risk strata had a strong association with in-hospital cardiovascular mortality (P<0.001 for trend). Moreover, among survivors after an in-hospital period, our risk score continued to be a powerful predictor of long-term mortality (P<0.001 for trend). CONCLUSION:In patients treated with primary PCI, a risk score, which was developed from five risk factors readily available after intervention, may be useful to predict in-hospital and long-term cardiovascular mortality.
journal_name
Coron Artery Disjournal_title
Coronary artery diseaseauthors
Ergelen M,Gorgulu S,Uyarel H,Norgaz T,Ayhan E,Akkaya E,Soylu O,Ugur M,Tezel Tdoi
10.1097/MCA.0b013e328333f528subject
Has Abstractpub_date
2010-06-01 00:00:00pages
207-11issue
4eissn
0954-6928issn
1473-5830journal_volume
21pub_type
杂志文章abstract::Ischemic heart disease is a major cause of morbidity and mortality throughout the world. Percutaneous coronary intervention (PCI) has rapidly evolved from balloon angioplasty to drug-eluting stents over the past 25 years and has become an important treatment option for coronary heart disease. During PCI, atherosclerot...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/MCA.0b013e32833729e3
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:We investigated whether diffuse coronary vasoconstriction induced by acetylcholine caused myocardial ischemia. METHODS:We studied 30 patients (40 coronary arteries) with spontaneous chest pain or equivocal studies on treadmill exercise testing and no significant coronary stenosis or previous myocardial infa...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Adiponectin and resistin, which have counteracting effects, are suggested to be associated with inflammation and atherosclerosis. The relationship between their levels and prognosis in high risk patients is, however, still unclear. The aim of this study was to evaluate the prognostic values of these adipokin...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e328318ecb0
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Several investigators have indirectly implicated oxygen free radicals in reperfusion injury following ischemia in the isolated rabbit heart. METHODS:A quantitative assessment of free-radical production during ischemia and reperfusion was made using electron paramagnetic resonance (EPR) spectroscopy. Serial ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199312000-00009
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:K1K2Pu is a recombinant chimeric tissue-type and urokinase-type plasminogen activator consisting of the two kringle domains (K1 and K2) of human tissue-type plasminogen activator (t-PA) and the serine proteinase domain (Pu) of single-chain urokinase-type plasminogen activator (scu-PA). In experimental animal...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199310000-00013
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:The Cardiac Health Profile (CHP) is a new questionnaire for assessing health-related quality of life of patients with cardiovascular diseases. It consists of three parts assessed as follows: the degree of angina pectoris (the CCS scale), the quality of life and subjective scoring of psychosocial 'cost-benefi...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract:AIM:This study aimed to investigate whether patients with very low left ventricular ejection fractions (LVEF) should be accepted for reoperative coronary artery bypass grafting (CABG). STUDY POPULATION:Between January 1990 and December 1993, 1681 patients underwent primary CABG and 308 (15.5%) reoperative CABG. One hu...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199505000-00010
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Coronary heart disease is mainly caused by the effects of obstruction to blood flow in the coronary arteries from discrete mural lesions that encroach into the lumen and usually occur in arteries that are involved by atherosclerosis. Even though the level of certain lipoproteins is indisputably related to th...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199303000-00006
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:A more sensitive transthoracic color Doppler technology (convergent color Doppler), along with a heart rate (HR) reduction and new tomographic planes, can greatly improve coronary blood flow velocity (BFV) recordings in the left main (LMCA) and left anterior descending (LAD) coronary arteries, allowing the d...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000873
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Single nucleotide polymorphisms (SNPs) are the most common source of genetic variation. Although microvascular pathology is associated with cardiovascular events, genetic phenotypes causing microvascular disease remain largely unknown. This study identifies sex-specific SNPs associated with coronary microvas...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000104
更新日期:2014-06-01 00:00:00
abstract:OBJECTIVES:Slow coronary flow (SCF) has long since been identified and endothelial dysfunction and atherosclerosis of the epicardial coronary arteries and microvasculature are reported to be associated with SCF. Serum uric acid is an independent biochemical marker of atherosclerosis, oxidative stress and endothelial dy...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3282f0a2a7
更新日期:2007-12-01 00:00:00
abstract::Chronic total occlusions (CTOs) are routinely encountered during coronary angiography, but subsequent revascularization rates are low. This has likely been driven by a historical belief that there is minimal clinical benefit and poor success rates with a percutaneous coronary intervention (PCI). However, in the curren...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/MCA.0000000000000490
更新日期:2017-08-01 00:00:00
abstract::Detection of viable myocardium in patients with left ventricular dysfunction has become an increasingly important guide to prognosis and treatment. This article reviews the current status and future potential for the application of modalities to assess myocardial viability. Imaging and other techniques that are review...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/00019501-200609000-00011
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:Although drug-coated balloons (DCBs) are established for de-novo lesions in small coronary arteries, the impact of DCB treatment according to the reference vessel diameter (RVD) remains poorly defined. This study aimed to evaluate the angiographic and long-term clinical outcomes of DCB treatment for de-novo ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000001006
更新日期:2021-01-18 00:00:00
abstract:BACKGROUND:The high-frequency contribution (i.e. 60-120 Hz) within the QRS complex of the surface ECG is supposed to be related to the arrhythmogenic substrate underlying sustained ventricular tachycardia in patients with coronary artery disease. One of the factors that prevents a wider clinical application of spectral...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199403000-00011
更新日期:1994-03-01 00:00:00
abstract:INTRODUCTION:We investigated the relationship between heart rate variability and preclinical carotid intima-media thickening, a putative index of atherosclerosis. METHODS:A sample of 350 men and women (mean age 56.8 years) selected for the presence or absence of untreated hypertension was assessed for heart rate varia...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e328011ac01
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Heart rate variability (HRV) time and frequency domain indices are strong predictors of malignant arrhythmias and sudden cardiac death. The effect of various angiotensin-converting enzyme (ACE) inhibitors on HRV in patients with acute myocardial infarction (AMI) has not been studied. METHODS:Ninety patients...
journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Although lipid-lowering therapy affects the luminal size of atherosclerotic coronary arteries the role of vascular remodeling has not been systematically studied. DESIGN/METHODS:Serial three-dimensional volumetric intravascular ultrasound (IVUS) was used to study remodeling, which was defined as changes in ...
journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/00019501-200402000-00007
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study is to determine the prevalence of coronary artery ectasia and its relationship to atheromatous changes in participants undergoing coronary computed tomography angiography. BACKGROUND:Coronary artery ectasia occasionally encountered on conventional coronary angiography is considered a m...
journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章
doi:10.1097/MCA.0b013e3280144be1
更新日期:2007-05-01 00:00:00
abstract::The risk of cardiovascular events in patients with diabetes is similar to that of patients with previous history of ischaemic heart disease and the prevalence of ischaemic heart disease complicating diabetic syndromes is growing rapidly. Management of ischaemic heart disease in diabetic patients remains a challenge. T...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/00019501-200511001-00005
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:This study was designed to evaluate whether differences between sexes exist in serum-lipoprotein (a) [Lp(a)] and arterial-wall-apolipoprotein (a) [Apo(a)] levels in patients with advanced coronary artery disease. METHODS:The concentrations of Lp(a) in serum and Apo(a) in aortic biopsies were studied in 76 m...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199504000-00013
更新日期:1995-04-01 00:00:00
abstract:OBJECTIVE:In response to the growing use of imaging-based cardiac stress tests in the evaluation of stable ischemic heart disease, professional societies have developed appropriate use criteria (AUC). AUC will soon be linked to reimbursement of advanced diagnostic imaging for Medicare beneficiaries via Clinical Decisio...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000928
更新日期:2020-08-13 00:00:00
abstract:OBJECTIVE:Ga-NOTA-RGD PET is a newly developed molecular imaging for angiogenesis. In this study, Ga-NOTA-RGD PET was used to investigate imaging characteristics in a rat myocardial infarction (MI) model and to monitor the efficacy of an angiogenesis induction therapy. MATERIALS AND METHODS:Ga-NOTA-RGD PET was perform...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3283608c32
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:Although the left main coronary artery (LMCA) is clinically the most important site, little is known about the longitudinal plaque distribution and composition in the significant LMCA disease. METHODS:Preprocedure virtual histology intravascular ultrasound data were analyzed in 120 patients with significant...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000417
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:To examine the contribution of six cardiovascular polymorphisms to the occurrence of a first event of ischemic heart disease (IHD) in a primary care population with a high prevalence of hypertension. Furthermore, we specified the data for sex and age. METHODS:In this cross sectional case-control study, patie...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e328330d541
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Elderly patients with ischaemic heart disease are often treated more conservatively and for longer than younger patients, but this strategy may result in subsequent invasive intervention of more advanced and higher risk coronary disease. METHODS:We performed a retrospective analysis of 109 patients aged > o...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199711000-00006
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:ABO blood groups have been associated with venous thromboembolism and arterial thrombosis. Although platelets play key roles in thrombogenesis, the relation between ABO groups and platelets is not well known and was investigated in this study. PATIENTS AND METHODS:ABO blood type information was retrospectiv...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000676
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Recent studies have reported a strong independent association between increased red cell distribution width (RDW) and the risk of adverse outcomes in patients with heart failure, stable coronary disease, and acute coronary syndromes. However, in this study we aimed to determine the impact of an elevated RDW ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3283587897
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the association of widowhood with the severity and extent of coronary artery disease (CAD), and whether it is modified by sex or socioeconomic status. PATIENTS AND METHODS:A total of 1068 patients undergoing coronary angiography at five centers in Saudi Arabia and the Uni...
journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0000000000000436
更新日期:2017-03-01 00:00:00
abstract:UNLABELLED:Plasma soluble adhesion molecules, intercellular adhesion molecule-1 (ICAM)-1, vascular cell adhesion molecule-1 (VCAM-1) and E-selectin leves of patients with isolated coronary artery ectasia (CAE), patients with obstructive coronary artery disease without CAE and subjects with angiographically normal coron...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200502000-00009
更新日期:2005-02-01 00:00:00