Meeting the challenge of chronic ischaemic heart disease with trimetazidine.

Abstract:

:The risk of cardiovascular events in patients with diabetes is similar to that of patients with previous history of ischaemic heart disease and the prevalence of ischaemic heart disease complicating diabetic syndromes is growing rapidly. Management of ischaemic heart disease in diabetic patients remains a challenge. Therapeutic options include several antianginal agents, and mechanical removal of coronary obstructions by percutaneous transluminal coronary angioplasty, and aorto-coronary by-pass surgery. Unfortunately, all treatments are less effective in diabetic patients than in nondiabetic patients. Direct modulation of cardiac metabolic alterations associated with the diabetic syndrome appears as a promising alternative for the management of ischaemic heart disease in diabetic patients. Results obtained in anginal patients with the metabolic agent trimetazidine are consistent with this hypothesis.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Marzilli M,Affinito S

doi

10.1097/00019501-200511001-00005

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

S23-7

eissn

0954-6928

issn

1473-5830

pii

00019501-200511001-00005

journal_volume

16 Suppl 1

pub_type

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