The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age.

Abstract:

OBJECTIVE:To examine the contribution of six cardiovascular polymorphisms to the occurrence of a first event of ischemic heart disease (IHD) in a primary care population with a high prevalence of hypertension. Furthermore, we specified the data for sex and age. METHODS:In this cross sectional case-control study, patients with a first event of IHD (157) and event-free controls (571) were studied. Both the groups were genotyped for the angiotensin II type 1 receptor (A1166C), angiotensinogen (M235 T), angiotensin converting enzyme (4656rpt), endothelial nitric oxide synthase (E298D), G-protein beta3 subunit (C825 T), and alpha-adducin (G460W) polymorphisms. Univariate and multivariate odds ratios (ORs) were calculated to assess the association between a first ischemic event and these polymorphisms. Sliding mean analyses were performed to show age-specific associations. RESULTS:Multivariate ORs indicated a protective association for the carrier status of the T-allele of AGT, overall [OR = 0.69 (0.34-0.90)] and for males [OR = 0.58 (0.27-0.89)]. Sliding mean analyses showed a continuous protective association with IHD of the T-allele of AGT with increasing age in males, whereas in females an increased risk for IHD was observed with a maximum OR of 1.6 at the age of 56 years. CONCLUSION:In this population the T-allele of the AGT polymorphism is protective for a first event of IHD in males.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Plat AW,Stoffers HE,de Leeuw PW,van Schayck CP,Soomers FL,Kester AD,Aretz K,Kroon AA

doi

10.1097/MCA.0b013e328330d541

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

499-505

issue

8

eissn

0954-6928

issn

1473-5830

journal_volume

20

pub_type

杂志文章
  • Circulating adhesion molecules and severity of coronary atherosclerosis.

    abstract:BACKGROUND:Circulating leukocytes are recruited at atherosclerotic sites through a family of adhesion molecules. Circulating forms of adhesion molecules in peripheral blood can be quantified now. OBJECTIVE:To evaluate the relationship between circulating adhesion molecules and severity of coronary atherosclerosis. ME...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200002000-00013

    authors: Oishi Y,Wakatsuki T,Nishikado A,Oki T,Ito S

    更新日期:2000-02-01 00:00:00

  • Angina-linked syncope and lack of calcium antagonist therapy predict cardiac arrest before definitive diagnosis of vasospastic angina.

    abstract:BACKGROUND:Several prognostic factors have been identified in patients with vasospastic angina; however, factors that would predict potentially fatal cardiac arrest during the period between the onset of angina and its definitive diagnosis remain unknown. We investigated the predictive value of the clinical findings th...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章

    doi:

    authors: Igarashi Y,Tamura Y,Tanabe Y,Fujita T,Yamazoe M,Shibata A

    更新日期:1994-11-01 00:00:00

  • Early versus delayed percutaneous coronary intervention in patients with non-ST elevation acute coronary syndromes.

    abstract:BACKGROUND:The optimal timing of angiography and percutaneous coronary intervention (PCI) in patients with non-ST elevation acute coronary syndromes (NSTEACS) remains uncertain. We sought to assess clinical characteristics and outcomes of patients in real-world contemporary practice who have early versus delayed PCI fo...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCA.0000000000000374

    authors: Yudi MB,Ajani AE,Andrianopoulos N,Duffy SJ,Farouque O,Ramchand J,Gurvitch R,Lefkovits J,Freeman M,Brennan A,Clark DJ,Reid C,Eccleston D,Melbourne Interventional Group.

    更新日期:2016-08-01 00:00:00

  • Low-pressure deployment of stents: short- and long-term outcome.

    abstract::This study investigates a strategy of low-pressure stenting with concomitant anti-platelet treatment designed to prevent short- and long-term events after stenting. Ninety consecutive patients who underwent percutaneous transluminal coronary angioplasty with stenting using low-pressure stent deployment (mean 8.1 atmos...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200106000-00007

    authors: Cafri C,Weinstein JM,Gilutz H,Kobal S,Ilia R

    更新日期:2001-06-01 00:00:00

  • Relation between N-terminal pro-B-type natriuretic peptide and coronary plaque components in patients with acute coronary syndrome: virtual histology-intravascular ultrasound analysis.

    abstract:BACKGROUND:The N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is a sensitive indicator of hemodynamic stress and its increased level is associated with higher mortality in acute coronary syndrome (ACS) patients. Virtual histology-intravascular ultrasound (VH-IVUS) can provide quantitative information on plaque ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e32832a196e

    authors: Hong YJ,Ahn Y,Sim DS,Yoon NS,Yoon HJ,Kim KH,Park HW,Kim JH,Jeong MH,Cho JG,Park JC,Kang JC

    更新日期:2009-12-01 00:00:00

  • Relationship of blood cholesterol and apoprotein B levels to angiographically defined coronary artery disease in young males.

    abstract:BACKGROUND:Coronary heart disease is mainly caused by the effects of obstruction to blood flow in the coronary arteries from discrete mural lesions that encroach into the lumen and usually occur in arteries that are involved by atherosclerosis. Even though the level of certain lipoproteins is indisputably related to th...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199303000-00006

    authors: McGill DA,Talsma P,Ardlie NG

    更新日期:1993-03-01 00:00:00

  • The cardiac health profile: content, reliability and validity of a new disease-specific quality of life questionnaire.

    abstract:BACKGROUND:The Cardiac Health Profile (CHP) is a new questionnaire for assessing health-related quality of life of patients with cardiovascular diseases. It consists of three parts assessed as follows: the degree of angina pectoris (the CCS scale), the quality of life and subjective scoring of psychosocial 'cost-benefi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:

    authors: Währborg P,Emanuelsson H

    更新日期:1996-11-01 00:00:00

  • Adjunctive pharmacologic therapy in percutaneous coronary intervention: part I antiplatelet therapy.

    abstract::Ischemic heart disease is a major cause of morbidity and mortality throughout the world. Percutaneous coronary intervention (PCI) has rapidly evolved from balloon angioplasty to drug-eluting stents over the past 25 years and has become an important treatment option for coronary heart disease. During PCI, atherosclerot...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/MCA.0b013e32833729e3

    authors: Kim SJ,Giugliano RP,Jang IK

    更新日期:2011-03-01 00:00:00

  • Clinical outcomes of SeQuent Please paclitaxel-coated balloons for de novo small coronary artery lesion in a Japanese multicenter post-approval registry.

    abstract:OBJECTIVE:Drug-coated balloon (DCB) angioplasty has emerged as an effective management strategy worldwide. In June 2016, DCB became available for the treatment of de novo small coronary lesions in Japan; however, there has been no multicenter analysis in a post-approval real-world clinical setting to date. The aim of t...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000782

    authors: Funayama N,Muratsubaki S,Kawahatsu K,Miyata M,Katou Y,Oikawa T

    更新日期:2020-01-01 00:00:00

  • A new noninvasive method for assessing mild coronary atherosclerosis: transthoracic convergent color Doppler after heart rate reduction. Validation vs. intracoronary ultrasound.

    abstract:BACKGROUND:A more sensitive transthoracic color Doppler technology (convergent color Doppler), along with a heart rate (HR) reduction and new tomographic planes, can greatly improve coronary blood flow velocity (BFV) recordings in the left main (LMCA) and left anterior descending (LAD) coronary arteries, allowing the d...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000873

    authors: Caiati C,Lepera ME,Pollice P,Iacovelli F,Favale S

    更新日期:2020-09-01 00:00:00

  • Quantitative assessment of free-radical generation during ischemia and reperfusion in the isolated rabbit heart.

    abstract:BACKGROUND:Several investigators have indirectly implicated oxygen free radicals in reperfusion injury following ischemia in the isolated rabbit heart. METHODS:A quantitative assessment of free-radical production during ischemia and reperfusion was made using electron paramagnetic resonance (EPR) spectroscopy. Serial ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199312000-00009

    authors: Premaratne S,Limm W,Mugiishi MM,Piette LH,McNamara JJ

    更新日期:1993-12-01 00:00:00

  • High-dose diltiazem prevents migration and proliferation of vascular smooth muscle cells in various in-vitro models of human coronary restenosis.

    abstract:BACKGROUND:Restenosis after coronary angioplasty is considered to be caused mainly by increased migration and proliferation of smooth muscle cells (SMC). The concept of local, site-specific delivery of pharmacologic therapies has opened the door for new, high-dose drug regimes. METHODS AND RESULTS:SMC were isolated by...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199703000-00011

    authors: Voisard R,Koschnick S,Baur R,Vogel U,Mattfeldt T,Hemmer W,Hannekum A,Höher M,Hombach V

    更新日期:1997-03-01 00:00:00

  • Predictors of 30-day and 1-year mortality after primary percutaneous coronary intervention for ST-elevation myocardial infarction.

    abstract:OBJECTIVE:Predictors of 30-day mortality may differ from predictors of mortality at 1 year among 30-day survivors of ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). We aimed to evaluate the predictors of 30-day and 1-year mortality in unselected patients with ST...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e32832e5c4c

    authors: Rasoul S,Ottervanger JP,de Boer MJ,Dambrink JH,Hoorntje JC,Marcel Gosselink AT,Zijlstra F,Suryapranata H,van 't Hof AW,Zwolle Myocardial Infarction Study Group.

    更新日期:2009-09-01 00:00:00

  • Acute right ventricular infarction: clinical spectrum, results of reperfusion therapy and short-term prognosis.

    abstract:BACKGROUND:The role of thrombolytic therapy (TT) and percutaneous coronary interventions (PCIs) in subgroups of patients with right ventricular infarction (RVI) has not been evaluated. METHODS AND RESULTS:We risk-stratified 302 patients with RVI into three subsets upon admission. Class A (n=197) comprised patients wit...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200202000-00008

    authors: Lupi-Herrera E,Lasses LA,Cosio-Aranda J,Chuquiure-Valenzuela E,Martínez-Sánchez C,Ortiz P,González-Pacheco H,Juárez-Herrera U,Rodriguez Mdel C,Vargas-Barrón J,Martínez-Rios MA

    更新日期:2002-02-01 00:00:00

  • Association of the serum apolipoprotein levels with the occurrence of coronary vasospasm.

    abstract:BACKGROUND:The relationship between the serum levels of atherosclerosis-related apolipoprotein (apo) and the risk of coronary spastic angina remains unknown. METHODS AND RESULTS:This study consists of 111 patients who were admitted to our facility with the chief complaint of chest pain, in whom coronary angiography sh...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e328341baa9

    authors: Tani S,Nagao K,Kawamorita T,Hirayama A

    更新日期:2011-05-01 00:00:00

  • Women react with more myocardial ischemia and angina pectoris during elective percutaneous transluminal coronary angioplasty.

    abstract:BACKGROUND:Women have been considered to be at higher risk of complications relating to percutaneous transluminal coronary angioplasty (PTCA) than are men. One reason for this sex-related difference could be the ischemic response of myocardium during the procedure. OBJECTIVE:To investigate whether there are sex-relate...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200010000-00003

    authors: Jensen J,Eriksson SV,Lindvall B,Lundin P,Sylven C

    更新日期:2000-10-01 00:00:00

  • A brief review of the past and future of platelet P2Y12 antagonist.

    abstract::ADP plays a pivotal role in localized platelet activation and recruitment, and, with that, in the maintenance of thrombus integrity, making it a suitable target for the control of intravascular thrombosis. The limited distribution of one of its receptors, the P2Y12 receptor, primarily to platelets makes it an especial...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/MCA.0b013e3283564930

    authors: Barn K,Steinhubl SR

    更新日期:2012-09-01 00:00:00

  • Implantation of sirolimus-eluting stents in saphenous vein grafts is associated with high clinical follow-up event rates compared with treatment of native vessels.

    abstract:AIMS:The clinical effectiveness of sirolimus-eluting stents (SES) for treatment of patients with saphenous vein graft disease is not well defined. This analysis sought to evaluate the clinical follow-up after treatment of stenotic saphenous vein grafts using SES in a large patient registry. Patients treated with SES fo...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究

    doi:10.1097/MCA.0b013e3282ef5b40

    authors: Hoffmann R,Hamm C,Nienaber CA,Levenson B,Bonzel T,Sabin G,Senges J,Zahn R,Tebbe U,Pfannebecker T,Richardt HG,Schneider S,Kelm M,German Cypher Registry.

    更新日期:2007-11-01 00:00:00

  • Preconditioning effects of adenosine in patients with severe coronary artery disease but preserved coronary flow reserve.

    abstract:BACKGROUND:Adenosine plays a key role in different protective and adaptive responses to ischemia and has been suggested to induce ischemic preconditioning. AIM:To investigate whether a low-dose adenosine infusion reduces the ischemic burden induced by pharmacological stress without affecting the coronary flow reserve ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/mca.0b013e32832ac5c1

    authors: Sadigh B,Shahgaldi K,Sylvén C,Quintana M,Winter R

    更新日期:2009-08-01 00:00:00

  • Improved anemia is associated with favorable long-term clinical outcomes in patients undergoing PCI.

    abstract:BACKGROUND:Anemia is associated with an increased risk of mortality in patients who underwent percutaneous coronary intervention (PCI) in the bare-metal stent era. However, there have been no data concerning the clinical importance of anemia improvement during the follow-up period after discharge from the hospital duri...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e3283564869

    authors: Kim TH,Koh YS,Chang K,Seo SM,Kim CJ,Park HJ,Kim PJ,Her SH,Kim DB,Lee JM,Park CS,Kim HY,Yoo KD,Jeon DS,Park JH,Chung WS,Seung KB,CathOlic university of Korea – percutAneous Coronary inTervention registry investigators.

    更新日期:2012-09-01 00:00:00

  • Effects of intracoronary autologous bone marrow cells on left ventricular function in acute myocardial infarction: a systematic review and meta-analysis for randomized controlled trials.

    abstract:BACKGROUND:Experimental and clinical studies have suggested that intracoronary infusion of bone marrow-derived stem/progenitor cells (BMC) may improve left ventricular function after acute myocardial infarction (AMI). We conducted a systematic review and meta-analysis to investigate the efficacy and safety of BMC thera...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MCA.0b013e328300dbd3

    authors: Kang S,Yang YJ,Li CJ,Gao RL

    更新日期:2008-08-01 00:00:00

  • Accuracy of Pooled-Cohort Equation and SCORE cardiovascular risk calculators to identify individuals with high coronary atherosclerotic burden - implications for statin treatment.

    abstract:BACKGROUND:Different cardiovascular risk calculators and risk-based thresholds for initiating statin therapy are currently in use. Using coronary computed tomography angiography, we sought to compare the Pooled-Cohort Equation [atherosclerotic cardiovascular disease (ASCVD) score] with the Systematic COronary Risk Eval...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000398

    authors: Tralhão A,Ferreira AM,Gonçalves Pde A,Rodrigues R,Costa C,Guerreiro S,Cardim N,Marques H

    更新日期:2016-11-01 00:00:00

  • Risk stratification for malignant arrhythmic events in patients with an acute myocardial infarction: role of an open infarct-related artery and the signal-averaged ECG.

    abstract:BACKGROUND:There is increasing evidence that an open infarct-related artery results in increased electrical stability of the heart and that this effect is at least in part responsible for the favorable outcome of these patients. In the thrombolytic era the optimal strategy for risk stratification remains controversial....

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:

    authors: Hermosillo AG,Araya V,Casanova JM

    更新日期:1995-12-01 00:00:00

  • On-line computerized vectorcardiography monitoring of myocardial ischemia during coronary angioplasty: comparison with 12-lead electrocardiography.

    abstract:BACKGROUND:With new interventions minimizing ischemic myocardial injury, accurate and reliable techniques for the detection and continuous monitoring of myocardial ischemia are essential. We compared two techniques used for the detection of myocardial ischemia during coronary angioplasty: on-line computerized vectorcar...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:

    authors: Jensen SM,Johansson G,Osterman G,Reiz S,Näslund U

    更新日期:1994-06-01 00:00:00

  • Myocardial Doppler tissue velocity improves following myocardial gene therapy with VEGF-A165 plasmid in patients with inoperable angina pectoris.

    abstract:BACKGROUND:Myocardial tissue velocity and perfusion were studied in patients with severe angina pectoris following gene therapy by intramyocardial injection of phVEGF-A165 via thoracotomy. Plasma concentrations of VEGF-A increased postoperatively. Two months after treatment anginal status and myocardial tissue velocity...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200105000-00010

    authors: Sylvén C,Sarkar N,Rück A,Drvota V,Hassan SY,Lind B,Nygren A,Källner Q,Blomberg P,van der Linden J,Lindblom D,Brodin LA,Islam KB

    更新日期:2001-05-01 00:00:00

  • Assessment of left ventricular myocardial perfusion and diastolic function during acetylcholine-induced diffuse coronary vasoconstriction by Doppler echocardiography and thallium-201 scintigraphy.

    abstract:BACKGROUND:We investigated whether diffuse coronary vasoconstriction induced by acetylcholine caused myocardial ischemia. METHODS:We studied 30 patients (40 coronary arteries) with spontaneous chest pain or equivocal studies on treadmill exercise testing and no significant coronary stenosis or previous myocardial infa...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:

    authors: Uzui H,Kondo M,Murayama T,Nishiue T,Tsubokawa A,Tanio H,Shimono Y

    更新日期:1995-06-01 00:00:00

  • Can we use plasma hyperosmolality as a predictor of mortality for ST-segment elevation myocardial infarction?

    abstract:BACKGROUND:The aim of this study was to investigate the association of plasma osmolality with all-cause mortality in ST-segment elevation myocardial infarction (STEMI) patients treated with a primary percutaneous coronary intervention. METHODS:This study included 3748 patients (mean age 58.3±11.8 years, men 81%) with ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000426

    authors: Tatlisu MA,Kaya A,Keskin M,Uzman O,Borklu EB,Cinier G,Hayiroglu MI,Tatlisu K,Eren M

    更新日期:2017-01-01 00:00:00

  • Comprehensive overview of definitions for optical coherence tomography-based plaque and stent analyses.

    abstract::Optical coherence tomography (OCT) is the current state-of-the-art intracoronary imaging modality that allows visualization of detailed morphological characteristics of both atherosclerotic plaque and stent. So far, three expert review documents have been released for standardization of OCT image analysis. In the real...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/MCA.0000000000000072

    authors: Di Vito L,Yoon JH,Kato K,Yonetsu T,Vergallo R,Costa M,Bezerra HG,Arbustini E,Narula J,Crea F,Prati F,Jang IK,COICO group (Consortium of Investigators for Coronary OCT).

    更新日期:2014-03-01 00:00:00

  • Elderly patients with hypercholesterolaemia: a double-blind study of the efficacy, safety and tolerability of fluvastatin.

    abstract:BACKGROUND:Coronary heart disease is a major cause of morbidity and mortality in the elderly, a rapidly growing section of the population. Elderly patients have been excluded from most preventative risk factor trials. METHODS:We evaluated fluvastatin, a fully synthetic hydroxymethyl glutaryl coenzyme A reductase inhib...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Lye M,Valacio R,Reckless JP,Ghosh AK,Findlay IN,Ghosh MK,Passmore AP,Fulcher RA

    更新日期:1998-01-01 00:00:00

  • Metabolic syndrome negatively impacts early patency of saphenous vein grafts.

    abstract:BACKGROUND:Coronary artery bypass grafting has been performed for a long period utilizing saphenous vein grafts, the fate of which might be crucial to prognosis following the operation. Metabolic syndrome, on the other hand, has become an increasingly important part of cardiovascular practice. We examined whether there...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200602000-00007

    authors: Yilmaz MB,Guray U,Guray Y,Biyikoglu SF,Tandogan I,Sasmaz H,Korkmaz S

    更新日期:2006-02-01 00:00:00