Abstract:
BACKGROUND:The optimal timing of angiography and percutaneous coronary intervention (PCI) in patients with non-ST elevation acute coronary syndromes (NSTEACS) remains uncertain. We sought to assess clinical characteristics and outcomes of patients in real-world contemporary practice who have early versus delayed PCI for NSTEACS. METHODS:We analyzed baseline clinical and procedural characteristics of 4307 patients with NSTEACS who underwent PCI from the Melbourne Interventional Group registry. Patients were assigned to the early PCI group if intervention was performed within a calendar day of presentation. The delayed PCI group received an intervention after one calendar day, but within the index admission. We assessed 30 days and 12-month mortality, myocardial infarction, target vessel revascularization, and major adverse cardiovascular events. The safety endpoint was in-hospital bleeding. RESULTS:Of the 4307 patients, 2210 (51%) received early PCI. The delayed PCI group were older (67±12 vs. 64±12, P<0.01), more likely to have biomarker elevation (70 vs. 66%, P<0.01), and had more comorbidities. There was no difference in efficacy at 30 days between the groups. At 12 months, delayed PCI was associated with higher mortality (4.6 vs. 3.3%, P=0.02), myocardial infarction (7.9 vs. 5.2%, P<0.01), and MACE (15.5 vs. 12.4%, P<0.01). On multivariate analysis, delayed PCI was not associated with increased mortality at 12 months (odds ratio 0.95, 95% confidence interval 0.7-1.3). CONCLUSION:In patients with stable NSTEACS treated with PCI, delayed intervention was performed in those who were older and had higher risk features. However, there appears to be no mortality hazard for these high-risk patients where PCI is delayed beyond the first 24 h after presentation and performed within the index admission.
journal_name
Coron Artery Disjournal_title
Coronary artery diseaseauthors
Yudi MB,Ajani AE,Andrianopoulos N,Duffy SJ,Farouque O,Ramchand J,Gurvitch R,Lefkovits J,Freeman M,Brennan A,Clark DJ,Reid C,Eccleston D,Melbourne Interventional Group.doi
10.1097/MCA.0000000000000374subject
Has Abstractpub_date
2016-08-01 00:00:00pages
344-9issue
5eissn
0954-6928issn
1473-5830journal_volume
27pub_type
杂志文章,多中心研究abstract:BACKGROUND:The 2015 American College of Cardiology/American Heart Association update on primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) recommended PCI of the non-infarct-related artery at the time of primary PCI (class IIb recommendation). Despite ev...
journal_title:Coronary artery disease
pub_type: 杂志文章,meta分析
doi:10.1097/MCA.0000000000000578
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The failure of reperfusion therapy in patients with ST-segment elevation myocardial infarction (STEMI) is more frequent than considered previously. AIM:To evaluate sex-related differences in long-term outcomes in patients with STEMI and incomplete infarct-related artery reperfusion after a primary percutane...
journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0000000000000703
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:A more sensitive transthoracic color Doppler technology (convergent color Doppler), along with a heart rate (HR) reduction and new tomographic planes, can greatly improve coronary blood flow velocity (BFV) recordings in the left main (LMCA) and left anterior descending (LAD) coronary arteries, allowing the d...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000873
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:The association of adipocyte-derived proteins, adiponectin and leptin, with the degree of coronary atherosclerosis has not been not been well elucidated. This study aimed to determine the relationship between serum adiponectin and leptin with the presence and degree of coronary atherosclerosis. METHODS:Seve...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3283452431
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:The ability of 64-slice computed tomography (CT) angiography to differentiate plaque types remains unclear. We evaluated whether the density of noncalcified coronary plaques by 64-slice CT angiography correlates with plaque components assessed by integrated backscatter intravascular ultrasound (IB-IVUS). ME...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32833578f4
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Different cardiovascular risk calculators and risk-based thresholds for initiating statin therapy are currently in use. Using coronary computed tomography angiography, we sought to compare the Pooled-Cohort Equation [atherosclerotic cardiovascular disease (ASCVD) score] with the Systematic COronary Risk Eval...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000398
更新日期:2016-11-01 00:00:00
abstract:AIM:The purpose of this study was a head-to-head comparison of tomographic imaging (SPECT) with technetium-99m (Tc-99m)-sestamibi and thallium-201 (Tl-201) using dipyridamole-low-level bicycle exercise stress for the assessment of coronary artery disease. METHODS:We studied 38 consecutive patients referred for the eva...
journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-09-01 00:00:00
abstract::The coronary microvasculature plays a key role in determining and modulating coronary blood flow across the spectrum of myocardial demand. Our understanding of this complex system has been limited partly due to our inability to visualize the anatomy of an extensive microvascular bed and its complicated functional path...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/MCA.0000000000000119
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:17 beta-Estradiol and phytoestrogens are known to have beneficial effects on the cardiovascular systems of women. The exact mechanisms for how estrogens and phytoestrogens influence the cardiovascular system are not yet understood in detail. OBJECTIVE:The objective of this study was to investigate whether 1...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199912000-00010
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:To report the final, cumulative, 5-year outcomes from the TAXUS ATLAS program, which studied the use of the TAXUS Liberté paclitaxel-eluting stent in de-novo coronary artery lesions. METHODS:TAXUS ATLAS Workhorse, Small Vessel, and Long Lesion are nonrandomized studies comparing TAXUS Liberté (N=871), TAXUS ...
journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0b013e32835b3932
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:The serum level of parathyroid hormone (PTH) has been shown to be a predictor of cardiovascular mortality. Data on the association between PTH level and degree of atherosclerosis severity are lacking. The objective of this study was to determine the relationship of serum PTH level and number of stenotic co...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000089
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:This study was designed to evaluate whether differences between sexes exist in serum-lipoprotein (a) [Lp(a)] and arterial-wall-apolipoprotein (a) [Apo(a)] levels in patients with advanced coronary artery disease. METHODS:The concentrations of Lp(a) in serum and Apo(a) in aortic biopsies were studied in 76 m...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199504000-00013
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:Levels of galectin-3, a member of a family of soluble β-galactoside-binding lectins, are reported to be higher in patients with type 2 diabetes mellitus (DM) and metabolic syndrome. Conflicting results exist on the effects of galectin-3 in diabetic patients. The aim of this study was to investigate the relat...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000252
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Measurement of antibodies to oxidized low-density lipoprotein (AB-oxLDL) has been proposed as a way of identifying individuals at risk for cardiovascular disease beyond the determination of LDL cholesterol (LDL-c) alone. While this hypothesis is appealing, evidence that AB-oxLDL is a risk factor independent ...
journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00019501-200304000-00009
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:The efficacy of thrombolytic therapy might be influenced by changes in the hemodynamic status. The aim of the study was to examine whether changes in perfusion pressure could affect the time to reflow in an in-vitro model. METHODS:The in-vitro flow system comprised flexible plastic tubes that enclosed a blo...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199809010-00007
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Platelet-derived growth factor (PDGF) is a potent mitogen for vascular smooth muscle cells and is implicated in the vascular response to injury and the pathogenesis of atherosclerosis. It is also a potent vasoconstrictor. METHODS:To examine whether acute myocardial ischemia increases the level of PDGF in th...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199305000-00007
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Low-molecular-weight heparins may have a higher benefit to risk ratio than unfractionated heparin in preventing perioperative thrombosis. The antithrombotic effects of low-molecular-weight heparins, given as adjunctive therapy to alteplase and aspirin, have not previously been compared with those of unfracti...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Both intravascular ultrasound and optical coherence tomography have been purported to accurately detect and characterize coronary atherosclerotic plaque composition. The aim of our study was to directly compare the reproducibility and diagnostic accuracy of optical coherence tomography and intravascular ultr...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200608000-00005
更新日期:2006-08-01 00:00:00
abstract::During myocardial ischemia, cardiomyocytes can undergo apoptosis or compensatory hypertrophy. Fas expression is upregulated in the myocardial ischemia and is coupled to both apoptosis and hypertrophy of cardiomyocytes. The role of Fas in apoptosis induction or cardiomyocyte hypertrophy during ischemic conditions is, h...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/MCA.0b013e3283093707
更新日期:2008-11-01 00:00:00
abstract::This study investigates a strategy of low-pressure stenting with concomitant anti-platelet treatment designed to prevent short- and long-term events after stenting. Ninety consecutive patients who underwent percutaneous transluminal coronary angioplasty with stenting using low-pressure stent deployment (mean 8.1 atmos...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200106000-00007
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:This study investigated whether the age, creatinine, and ejection fraction (ACEF) score [age (years) /ejection fraction (%) +1 (if creatinine>176μmol/L)] could predict 1-year outcomes following ST-segment elevation myocardial infarction after percutaneous coronary intervention, and whether accuracy could be ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000791
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:Biomarker expression can predict subsequent cardiovascular events. The goal of this study was to determine the pattern of expression in blood of a broad array of cytokines and growth factors taken 24-72 h after an ST elevation myocardial infarction (STEMI) involving the left anterior descending (LAD) coronar...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e328346b88d
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Thrombomodulin (TM) -33G/A and Ala455Val polymorphisms have been indicated to be correlated with the risk of coronary artery disease (CAD), but study results are still inclusive. Thus, a meta-analysis was carried out. MATERIALS AND METHODS:Databases including PubMed, Embase, CNKI, and Web of Science (ISI) w...
journal_title:Coronary artery disease
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MCA.0000000000000161
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to identify psychosocial variables that, in addition to known medical factors, predict the long-term outcome after a first myocardial infarction. PATIENTS AND METHODS:The study population consisted of 222 men aged 30-60 years who entered an inpatient rehabilitation program a mean o...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199502000-00009
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVE:Electrocardiographic indices like maximum P-wave duration (P(max)) and P-wave dispersion (PD) can be used to detect patients with atrial conduction disorders, myocardial ischemia and those at risk for atrial fibrillation. Considering the diurnal variation of ischemia in patients with significant coronary lesi...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/01.mca.0000236284.64059.be
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVES:We treated patients experiencing drug-eluting stent (DES) restenosis with plain old balloon angioplasty (POBA), implantation of the same type of DES [homogeneous drug-eluting stent (HOMO-DES)], or implantation of a different type of DES [heterogeneous drug-eluting stent (HETERO-DES)], and compared the effica...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000159
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:The N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is a sensitive indicator of hemodynamic stress and its increased level is associated with higher mortality in acute coronary syndrome (ACS) patients. Virtual histology-intravascular ultrasound (VH-IVUS) can provide quantitative information on plaque ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32832a196e
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Circulating leukocytes are recruited at atherosclerotic sites through a family of adhesion molecules. Circulating forms of adhesion molecules in peripheral blood can be quantified now. OBJECTIVE:To evaluate the relationship between circulating adhesion molecules and severity of coronary atherosclerosis. ME...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200002000-00013
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Coronary stenosis of the left anterior descending artery (LAD) is respected by cardiologists because of its negative influence on morbidity and mortality. An important anatomical consideration is the length of the LAD. OBJECTIVE:To investigate the relationship between length of LAD and coronary dominance. ...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200102000-00011
更新日期:2001-02-01 00:00:00
abstract::Optical coherence tomography (OCT) is the current state-of-the-art intracoronary imaging modality that allows visualization of detailed morphological characteristics of both atherosclerotic plaque and stent. So far, three expert review documents have been released for standardization of OCT image analysis. In the real...
journal_title:Coronary artery disease
pub_type: 杂志文章,评审
doi:10.1097/MCA.0000000000000072
更新日期:2014-03-01 00:00:00