Abstract:
BACKGROUND:Both intravascular ultrasound and optical coherence tomography have been purported to accurately detect and characterize coronary atherosclerotic plaque composition. The aim of our study was to directly compare the reproducibility and diagnostic accuracy of optical coherence tomography and intravascular ultrasound for the detection and characterization of coronary plaque composition ex vivo as compared with histology. METHODS AND RESULTS:Intravascular ultrasound (20 MHz) and optical coherence tomography imaging was performed in eight heart specimens using motorized pullback. Standard histology using hematoxylin-eosin and van Gieson staining was performed on 4 mum thick slices. Each slice was divided into quadrants and accurately matched cross-sections were analyzed for the presence of fibrous, lipid-rich, and calcified coronary plaque using standard definitions for both intravascular ultrasound and optical coherence tomography and correlated with histology. After exclusion of 145/468 quadrants, we analyzed the remaining 323 quadrants with excellent image quality in each procedure. Optical coherence tomography demonstrated a sensitivity and specificity of 91/88% for normal wall, 64/88% for fibrous plaque, 77/94% for lipid-rich plaque, and 67/97% for calcified plaque as compared with histology. Intravascular ultrasound demonstrated a sensitivity and specificity of 55/79% for normal wall, 63/59% for fibrous plaque, 10/96% for lipid-rich plaque, and 76/98% for calcified plaque. Both intravascular ultrasound and optical coherence tomography demonstrated excellent intraobserver and interobserver agreement (optical coherence tomography: kappa=0.90, kappa=0.82; intravascular ultrasound: kappa=0.87, kappa=0.86). CONCLUSION:Optical coherence tomography is superior to intravascular ultrasound for the detection and characterization of coronary atherosclerotic plaque composition, specifically for the differentiation of noncalcified, lipid-rich, or fibrous plaque.
journal_name
Coron Artery Disjournal_title
Coronary artery diseaseauthors
Rieber J,Meissner O,Babaryka G,Reim S,Oswald M,Koenig A,Schiele TM,Shapiro M,Theisen K,Reiser MF,Klauss V,Hoffmann Udoi
10.1097/00019501-200608000-00005subject
Has Abstractpub_date
2006-08-01 00:00:00pages
425-30issue
5eissn
0954-6928issn
1473-5830pii
00019501-200608000-00005journal_volume
17pub_type
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e328341baa9
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVES:Our aim was to investigate the safety and efficacy of transradial approach, predictors of bleeding complications, and choice of radial access site in a real-life setting using a contemporary European registry of percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI). BACKGROU...
journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0b013e32833aa6d1
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:Serum gamma-glutamyl transferase (GGT) activity, an enzyme responsible for the extracellular catabolism of antioxidant glutathione, may directly take part in atherogenesis and evolve as a potential biochemical risk indicator of cardiovascular morbidity and mortality. An important characteristic of coronary a...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32830eaba1
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to clarify clinical and angiographical characteristics of acetylcholine (ACh)-induced spasm in the right and left coronary artery. METHODS AND RESULTS:We performed 557 consecutive procedures of spasm provocation tests of ACh from January 1991 to December 2000 in patients withou...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200206000-00005
更新日期:2002-06-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000676
更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1097/00019501-200609000-00001
更新日期:2006-09-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
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journal_title:Coronary artery disease
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doi:10.1097/MCA.0b013e3281689a2c
更新日期:2007-08-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-08-01 00:00:00
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journal_title:Coronary artery disease
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journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0b013e3282ef5b40
更新日期:2007-11-01 00:00:00
abstract::The Editor and Associate Editors are pleased that our readership will have the opportunity to benefit from a series of contributions by Dr John Rutherford addressing current issues in pharmacology and therapeutics pertinent to coronary artery disease. We are pleased also that Dr Rutherford will provide authoritative p...
journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200012000-00008
更新日期:2000-12-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199703000-00001
更新日期:1997-03-01 00:00:00
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journal_title:Coronary artery disease
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doi:10.1097/MCA.0b013e328089f19b
更新日期:2007-08-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199912000-00010
更新日期:1999-12-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 临床试验,杂志文章
doi:10.1097/MCA.0b013e32834df552
更新日期:2012-01-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e3282f0a2a7
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:We sought to compare the long-term effectiveness and safety of triple antiplatelet therapy (TAPT) versus dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) for unprotected left main coronary artery disease (uLMCAD). BACKGROUND:An additional strategy to reduce recurrent ischemia ...
journal_title:Coronary artery disease
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doi:10.1097/MCA.0b013e328363abbd
更新日期:2013-11-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
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journal_title:Coronary artery disease
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0b013e32801104d4
更新日期:2007-02-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-199307000-00010
更新日期:1993-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00019501-200002000-00013
更新日期:2000-02-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章,多中心研究
doi:10.1097/MCA.0b013e3283645c4e
更新日期:2013-09-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000001001
更新日期:2021-01-06 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/MCA.0000000000000593
更新日期:2018-05-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
doi:10.1097/00019501-200006000-00010
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate microvascular function in patients with valvular heart disease (VHD), which causes chronic left ventricular volume and/or pressure overload, therefore change in coronary microvascular hemodynamics. PATIENTS AND METHODS:We prospectively enrolled 30 patients with VHD c...
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pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00