Effects of electrode size and spacing on the resolution of intracardiac electrograms.


BACKGROUND:Electrogram fractionation can result when multiple groups of cardiac cells are excited asynchronously within the recording region of a mapping electrode. The spatial resolution of an electrode thus plays an important role in mapping complex rhythms. METHODS:We used a computational model, validated against experimental measurements in vitro, to determine how spatial resolution is affected by electrode diameter, electrode length, interelectrode distance (in the case of bipolar recordings), and height of the electrode above a dipole current source. RESULTS:We found that increases in all these quantities caused progressive degradation in two independent measures of spatial resolution, with the strongest effect being due to changes in height above the tissue. CONCLUSION:Our calculations suggest that if electrodes could be constructed to have negligible dimensions compared with those in use today, we would increase resolution by about one order of magnitude at most.


Coron Artery Dis


Coronary artery disease


Stinnett-Donnelly JM,Thompson N,Habel N,Petrov-Kondratov V,Correa de Sa DD,Bates JH,Spector PS




Has Abstract


2012-03-01 00:00:00












  • Serum adiponectin and leptin as predictors of the presence and degree of coronary atherosclerosis.

    abstract:BACKGROUND:The association of adipocyte-derived proteins, adiponectin and leptin, with the degree of coronary atherosclerosis has not been not been well elucidated. This study aimed to determine the relationship between serum adiponectin and leptin with the presence and degree of coronary atherosclerosis. METHODS:Seve...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Hasan-Ali H,Abd El-Mottaleb NA,Hamed HB,Abd-Elsayed A

    更新日期:2011-06-01 00:00:00

  • Psychosocial factors predict medical outcome following a first myocardial infarction. Working Group on Cardiac Rehabilitation of the Swiss Society of Cardiology.

    abstract:BACKGROUND:The aim of this study was to identify psychosocial variables that, in addition to known medical factors, predict the long-term outcome after a first myocardial infarction. PATIENTS AND METHODS:The study population consisted of 222 men aged 30-60 years who entered an inpatient rehabilitation program a mean o...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Hoffmann A,Pfiffner D,Hornung R,Niederhauser H

    更新日期:1995-02-01 00:00:00

  • Thrombocytopenia: a risk factor for acute myocardial infarction during the acute phase of Kawasaki disease.

    abstract:BACKGROUND:We report on 10 patients with Kawasaki disease and thrombocytopenia who were found to have a high incidence of coronary artery aneurysm and acute myocardial infarction. The clinical features of these patients, the cause of their thrombocytopenia and the relationship between cardiovascular pathology and throm...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Niwa K,Aotsuka H,Hamada H,Uchishiba M,Terai M,Niimi H

    更新日期:1995-11-01 00:00:00

  • High-dose diltiazem prevents migration and proliferation of vascular smooth muscle cells in various in-vitro models of human coronary restenosis.

    abstract:BACKGROUND:Restenosis after coronary angioplasty is considered to be caused mainly by increased migration and proliferation of smooth muscle cells (SMC). The concept of local, site-specific delivery of pharmacologic therapies has opened the door for new, high-dose drug regimes. METHODS AND RESULTS:SMC were isolated by...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Voisard R,Koschnick S,Baur R,Vogel U,Mattfeldt T,Hemmer W,Hannekum A,Höher M,Hombach V

    更新日期:1997-03-01 00:00:00

  • The antiarrhythmic effect and clinical consequences of ischemic preconditioning.

    abstract::Potentially hazardous short ischemic episodes increase the tolerance of myocardium to ischemia paradoxically. This condition decreases the infarct area markedly caused by a longer duration of coronary occlusion. This phenomenon is known as 'ischemic preconditioning' and its powerful cardioprotective effect has been sh...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Evrengul H,Seleci D,Tanriverdi H,Kaftan A

    更新日期:2006-05-01 00:00:00

  • Early versus delayed percutaneous coronary intervention in patients with non-ST elevation acute coronary syndromes.

    abstract:BACKGROUND:The optimal timing of angiography and percutaneous coronary intervention (PCI) in patients with non-ST elevation acute coronary syndromes (NSTEACS) remains uncertain. We sought to assess clinical characteristics and outcomes of patients in real-world contemporary practice who have early versus delayed PCI fo...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,多中心研究


    authors: Yudi MB,Ajani AE,Andrianopoulos N,Duffy SJ,Farouque O,Ramchand J,Gurvitch R,Lefkovits J,Freeman M,Brennan A,Clark DJ,Reid C,Eccleston D,Melbourne Interventional Group.

    更新日期:2016-08-01 00:00:00

  • Circulating adhesion molecules and severity of coronary atherosclerosis.

    abstract:BACKGROUND:Circulating leukocytes are recruited at atherosclerotic sites through a family of adhesion molecules. Circulating forms of adhesion molecules in peripheral blood can be quantified now. OBJECTIVE:To evaluate the relationship between circulating adhesion molecules and severity of coronary atherosclerosis. ME...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Oishi Y,Wakatsuki T,Nishikado A,Oki T,Ito S

    更新日期:2000-02-01 00:00:00

  • Early repolarization in the inferolateral leads predicts the presence of vasospastic angina: a novel predictor in patients with resting angina.

    abstract:BACKGROUND:An association between early repolarization and ventricular fibrillation has recently been reported in patients with vasospastic angina (VSA). However, no studies have clarified whether the presence of early repolarization can predict VSA. METHODS:Participants comprised 286 patients (136 males) with clinica...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ikeda H,Hasegawa K,Uzui H,Fukuoka Y,Shiomi Y,Tama N,Miyazaki S,Ishida K,Tada H

    更新日期:2020-11-13 00:00:00

  • Appropriate use of multimodality stress testing for chest pain in new patient referrals to cardiologists.

    abstract:OBJECTIVE:In response to the growing use of imaging-based cardiac stress tests in the evaluation of stable ischemic heart disease, professional societies have developed appropriate use criteria (AUC). AUC will soon be linked to reimbursement of advanced diagnostic imaging for Medicare beneficiaries via Clinical Decisio...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Lam DH,Tiwana J,Li S,Kirkpatrick JN,Cheng RK

    更新日期:2020-08-13 00:00:00

  • Hemodynamic changes determine the efficacy of thrombolysis: results from an in-vitro flow model.

    abstract:BACKGROUND:The efficacy of thrombolytic therapy might be influenced by changes in the hemodynamic status. The aim of the study was to examine whether changes in perfusion pressure could affect the time to reflow in an in-vitro model. METHODS:The in-vitro flow system comprised flexible plastic tubes that enclosed a blo...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Kornowski R,Mendelevich L,Zaretsky U,Einav S,Laniado S,Keren G

    更新日期:1998-01-01 00:00:00

  • Reactive coagulation induced by plasmin in patients treated with recombinant tissue-type plasminogen activator.

    abstract:BACKGROUND:We and others have demonstrated that administration of thrombolytic agents causes the generation of thrombosis-promoting agents. At present, we have studied whether formation in vivo of excessive amounts of plasmin is responsible for the activation of coagulation in patients treated with recombinant tissue-t...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Gram J,Munkvad S,Leebeek FW,Kluft C,Jespersen J

    更新日期:1993-04-01 00:00:00

  • Frequency-domain optical coherence tomography plaque morphology in stable coronary artery disease: sex differences.

    abstract:BACKGROUND:The cause for discrepancy in the clinical presentation and outcome of coronary artery disease (CAD) between men and women is not established. Different prevalences of risk factors or specific sex-related atherosclerotic aspects have been advocated as possible explanations. We investigated coronary plaque mor...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Mariani L,Burzotta F,Aurigemma C,Romano A,Niccoli G,Leone AM,Porto I,Trani C,Crea F

    更新日期:2017-09-01 00:00:00

  • Coronary intervention for chronic total occlusion: current indications and future directions.

    abstract::Chronic total occlusions (CTOs) are routinely encountered during coronary angiography, but subsequent revascularization rates are low. This has likely been driven by a historical belief that there is minimal clinical benefit and poor success rates with a percutaneous coronary intervention (PCI). However, in the curren...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Sathananthan J,Džavík V

    更新日期:2017-08-01 00:00:00

  • The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age.

    abstract:OBJECTIVE:To examine the contribution of six cardiovascular polymorphisms to the occurrence of a first event of ischemic heart disease (IHD) in a primary care population with a high prevalence of hypertension. Furthermore, we specified the data for sex and age. METHODS:In this cross sectional case-control study, patie...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Plat AW,Stoffers HE,de Leeuw PW,van Schayck CP,Soomers FL,Kester AD,Aretz K,Kroon AA

    更新日期:2009-12-01 00:00:00

  • A brief review of the past and future of platelet P2Y12 antagonist.

    abstract::ADP plays a pivotal role in localized platelet activation and recruitment, and, with that, in the maintenance of thrombus integrity, making it a suitable target for the control of intravascular thrombosis. The limited distribution of one of its receptors, the P2Y12 receptor, primarily to platelets makes it an especial...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Barn K,Steinhubl SR

    更新日期:2012-09-01 00:00:00

  • Clinical manifestations of myocardial stunning.

    abstract::The phenomenon of myocardial stunning has been observed in all animal species studied. The possible occurrence of myocardial stunning in man has been demonstrated after either regional ischemia (such as exercise-induced angina, vasospastic or unstable angina) or after global ischemia (i.e., after cardioplegic arrest d...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Ambrosio G,Tritto I

    更新日期:2001-08-01 00:00:00

  • Comprehensive overview of definitions for optical coherence tomography-based plaque and stent analyses.

    abstract::Optical coherence tomography (OCT) is the current state-of-the-art intracoronary imaging modality that allows visualization of detailed morphological characteristics of both atherosclerotic plaque and stent. So far, three expert review documents have been released for standardization of OCT image analysis. In the real...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Di Vito L,Yoon JH,Kato K,Yonetsu T,Vergallo R,Costa M,Bezerra HG,Arbustini E,Narula J,Crea F,Prati F,Jang IK,COICO group (Consortium of Investigators for Coronary OCT).

    更新日期:2014-03-01 00:00:00

  • Angiogenesis imaging in myocardial infarction using 68Ga-NOTA-RGD PET: characterization and application to therapeutic efficacy monitoring in rats.

    abstract:OBJECTIVE:Ga-NOTA-RGD PET is a newly developed molecular imaging for angiogenesis. In this study, Ga-NOTA-RGD PET was used to investigate imaging characteristics in a rat myocardial infarction (MI) model and to monitor the efficacy of an angiogenesis induction therapy. MATERIALS AND METHODS:Ga-NOTA-RGD PET was perform...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Eo JS,Paeng JC,Lee S,Lee YS,Jeong JM,Kang KW,Chung JK,Lee DS

    更新日期:2013-06-01 00:00:00

  • Prevalence and severity of abnormal glucose regulation and its relation to long-term prognosis after coronary artery bypass grafting.

    abstract:BACKGROUND:Diabetes is a strong predictor of a poor outcome after coronary artery bypass grafting (CABG). The prevalence of prediabetes and its impact on the prognosis after CABG is not well described. In this study, we evaluated the prevalence and prognostic impact of the different states of abnormal glucose regulatio...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Petursson P,Herlitz J,Lindqvist J,Sjöland H,Gudbjörnsdottir S

    更新日期:2013-11-01 00:00:00

  • Mechanism of lumen gain during coronary stent deployment in diabetic patients compared with non-diabetic patients.

    abstract:BACKGROUND:Diabetic patients show an increased incidence of restenosis after coronary angioplasty than non-diabetic patients. This may be because of differences in the mechanism of lumen gain during coronary revascularization in this population cohort. DESIGN:This study analyses the mechanism of lumen gain during coro...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Syeda B,Wexberg P,Gyongyosi M,Denk S,Beran G,Sperker W,Yahya N,Glogar D

    更新日期:2002-08-01 00:00:00

  • The cardiac health profile: content, reliability and validity of a new disease-specific quality of life questionnaire.

    abstract:BACKGROUND:The Cardiac Health Profile (CHP) is a new questionnaire for assessing health-related quality of life of patients with cardiovascular diseases. It consists of three parts assessed as follows: the degree of angina pectoris (the CCS scale), the quality of life and subjective scoring of psychosocial 'cost-benefi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Währborg P,Emanuelsson H

    更新日期:1996-11-01 00:00:00

  • Acute cardiorenal anemia syndrome among ST-elevation myocardial infarction patients treated by primary percutaneous intervention.

    abstract:BACKGROUND:Acute kidney injury (AKI) and anemia have been extensively studied in ST-elevation myocardial infarction (STEMI), yet the precise nature of their reciprocal relationship has not been elucidated in STEMI patients. METHODS:We performed a retrospective analysis of 2096 consecutive patients admitted for STEMI b...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Merdler I,Loewenstein I,Zahler D,Levit D,Hochstadt A,Banai S,Gal-Oz A,Shacham Y

    更新日期:2020-10-13 00:00:00

  • The predictive value of PRECISE-DAPT score for arrhythmic complications in patients with ST-elevation myocardial infarction.

    abstract:OBJECTIVE:To investigate the predictive value of the PRECISE-DAPT score for the development of arrhythmias in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. METHOD:A total of 706 patients with a diagnosis of ST-segment elevation myocardial infarction who...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yildirim E,Turkkan C,Ozcan KS,Ceylan US,Zengin A

    更新日期:2019-11-01 00:00:00

  • Diagnostic accuracy of optical coherence tomography and intravascular ultrasound for the detection and characterization of atherosclerotic plaque composition in ex-vivo coronary specimens: a comparison with histology.

    abstract:BACKGROUND:Both intravascular ultrasound and optical coherence tomography have been purported to accurately detect and characterize coronary atherosclerotic plaque composition. The aim of our study was to directly compare the reproducibility and diagnostic accuracy of optical coherence tomography and intravascular ultr...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Rieber J,Meissner O,Babaryka G,Reim S,Oswald M,Koenig A,Schiele TM,Shapiro M,Theisen K,Reiser MF,Klauss V,Hoffmann U

    更新日期:2006-08-01 00:00:00

  • Comparison of serum levels of inflammatory markers and allelic variant of interleukin-6 in patients with acute coronary syndrome and stable angina pectoris.

    abstract:OBJECTIVES:Although the relationship between atherosclerosis and inflammatory cells has been recognized in recent years, the effect of interleukin-6 (IL-6) genetic variants associated with atherosclerosis is still controversial. Therefore, we investigated the association between IL-6 polymorphism and levels of IL-6 in ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Ozdemir O,Gundogdu F,Karakelleoglu S,Sevimli S,Pirim I,Acikel M,Arslan S,Serdar S

    更新日期:2008-02-01 00:00:00

  • Association of plasminogen activator inhibitor-1 and low-density lipoprotein heterogeneity as a risk factor of atherosclerotic cardiovascular disease with triglyceride metabolic disorder: a pilot cross-sectional study.

    abstract:BACKGROUND:We hypothesized that an increase in plasminogen activator inhibitor 1 (PAI-1) might reduce low-density lipoprotein (LDL) particle size in conjunction with triglyceride (TG) metabolism disorder, resulting in an increased risk of atherosclerotic cardiovascular disease (ASCVD). METHODS:This study was carried o...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Iida K,Tani S,Atsumi W,Yagi T,Kawauchi K,Matsumoto N,Hirayama A

    更新日期:2017-11-01 00:00:00

  • Incidence, predictors, and 30-day outcomes of new-onset atrial fibrillation after primary percutaneous coronary intervention: insight into the RISK-PCI trial.

    abstract:OBJECTIVES:Limited data exist about the prognostic significance of new-onset atrial fibrillation (AF) after contemporary primary percutaneous coronary intervention (pPCI). The objective of this study was to identify the incidence and predictors of new-onset AF and associated adverse 30-day outcomes in AF patients who u...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章


    authors: Mrdovic I,Savic L,Krljanac G,Perunicic J,Asanin M,Lasica R,Antonijevic N,Kocev N,Marinkovic J,Vasiljevic Z,Ostojic M

    更新日期:2012-01-01 00:00:00

  • Expression of monocyte and lymphocyte adhesion molecules is increased in isolated coronary artery ectasia.

    abstract:BACKGROUND:Coronary artery ectasia is defined as localized or diffuse dilation of the coronary arteries exceeding the 1.5-fold of normal adjacent segment. Scarce data are available about the role of inflammation in coronary artery ectasia. In the present study, we aimed to evaluate the expression of CD11b and CD45 adhe...

    journal_title:Coronary artery disease

    pub_type: 杂志文章


    authors: Yildirim N,Tekin IO,Dogan SM,Aydin M,Gursurer M,Cam F,Gungorduk A,Akoz A

    更新日期:2007-02-01 00:00:00

  • Coronary revascularization in patients with type 2 diabetes and results of the BARI 2D trial.

    abstract:OBJECTIVES:This Perspective reviews the results of early and contemporary studies evaluating the safety and efficacy of coronary revascularization in patients with diabetes. It also addresses the implications of some of the data in the Bypass Angioplasty Revascularization Investigation in type 2 diabetes (BARI 2D) tria...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审


    authors: Sobel BE

    更新日期:2010-05-01 00:00:00

  • Safety and efficacy of transradial versus transfemoral percutaneous coronary intervention in acute myocardial infarction: a meta-analysis of randomized trials.

    abstract:BACKGROUND:The transradial approach has gained increasing popularity for elective percutaneous coronary intervention. However, the safety and feasibility of transradial coronary intervention (TRI) in acute myocardial infarction (AMI) remains uncertain. Hence, a meta-analysis of randomized trials was performed to compar...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,meta分析


    authors: Singh PP,Singh M,Khosla N,Shah T,Molnar J,Arora R,Khosla S

    更新日期:2012-06-01 00:00:00