Abstract:
BACKGROUND:Platelet-activating factor is a biologically potent phospholipid that may mediate cell damage in patients with myocardial ischemia. In plasma, its inactivation to lyso-platelet-activating factor is catalyzed by a specific, lipoprotein-associated acetylhydrolase. Because lipoprotein levels decrease after myocardial infarction, a possible reduction was suspected to occur in plasma degradation of platelet-activating factor. METHODS:Degradation of platelet-activating factor was examined in an optimized assay of acetylhydrolase activity and in relation to the in vitro plasma half-life of platelet-activating factor. These, plasma lyso-platelet-activating factor and serum lipids, were measured in 12 men with acute myocardial infarction at presentation and at 2 and 7 days later. RESULTS:Acetylhydrolase activity was depressed at day 2 and at day 7. The corresponding increase in plasma half-life of platelet-activating factor was minimal and insignificant. A significant linear relation existed between the half-life of platelet-activating factor and the reciprocal of acetylhydrolase activity at each time of study, indicating a hyperbolic relation between the two. By day 2, total and low-density lipoprotein cholesterol had decreased but showed no further change by day 7; high-density lipoprotein cholesterol had not decreased at day 2 but was depressed by day 7. Plasma lyso-platelet-activating factor had decreased by day 2 and had returned to its initial level by day 7. CONCLUSIONS:Acute myocardial infarction is associated with depression of plasma acetylhydrolase activity, and because of the hyperbolic relation between the plasma enzyme activity and the half-life of platelet-activating factor, the latter shows negligible change. Hence, the mechanism for the inactivation of any platelet-activating factor that might be released as a consequence of tissue damage is preserved.
journal_name
Coron Artery Disjournal_title
Coronary artery diseaseauthors
Stephens CJ,Graham RM,Sturm MJ,Richardson M,Taylor RRdoi
10.1097/00019501-199302000-00009subject
Has Abstractpub_date
1993-02-01 00:00:00pages
187-93issue
2eissn
0954-6928issn
1473-5830journal_volume
4pub_type
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journal_title:Coronary artery disease
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journal_title:Coronary artery disease
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journal_title:Coronary artery disease
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journal_title:Coronary artery disease
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更新日期:1998-01-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
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更新日期:1993-12-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-04-01 00:00:00
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更新日期:2020-03-01 00:00:00
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journal_title:Coronary artery disease
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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更新日期:2019-06-01 00:00:00