Variation in plasma platelet-activating factor degradation and serum lipids after acute myocardial infarction.

Abstract:

BACKGROUND:Platelet-activating factor is a biologically potent phospholipid that may mediate cell damage in patients with myocardial ischemia. In plasma, its inactivation to lyso-platelet-activating factor is catalyzed by a specific, lipoprotein-associated acetylhydrolase. Because lipoprotein levels decrease after myocardial infarction, a possible reduction was suspected to occur in plasma degradation of platelet-activating factor. METHODS:Degradation of platelet-activating factor was examined in an optimized assay of acetylhydrolase activity and in relation to the in vitro plasma half-life of platelet-activating factor. These, plasma lyso-platelet-activating factor and serum lipids, were measured in 12 men with acute myocardial infarction at presentation and at 2 and 7 days later. RESULTS:Acetylhydrolase activity was depressed at day 2 and at day 7. The corresponding increase in plasma half-life of platelet-activating factor was minimal and insignificant. A significant linear relation existed between the half-life of platelet-activating factor and the reciprocal of acetylhydrolase activity at each time of study, indicating a hyperbolic relation between the two. By day 2, total and low-density lipoprotein cholesterol had decreased but showed no further change by day 7; high-density lipoprotein cholesterol had not decreased at day 2 but was depressed by day 7. Plasma lyso-platelet-activating factor had decreased by day 2 and had returned to its initial level by day 7. CONCLUSIONS:Acute myocardial infarction is associated with depression of plasma acetylhydrolase activity, and because of the hyperbolic relation between the plasma enzyme activity and the half-life of platelet-activating factor, the latter shows negligible change. Hence, the mechanism for the inactivation of any platelet-activating factor that might be released as a consequence of tissue damage is preserved.

journal_name

Coron Artery Dis

journal_title

Coronary artery disease

authors

Stephens CJ,Graham RM,Sturm MJ,Richardson M,Taylor RR

doi

10.1097/00019501-199302000-00009

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

187-93

issue

2

eissn

0954-6928

issn

1473-5830

journal_volume

4

pub_type

杂志文章
  • Patterns of coronary plaque progression: phasic versus gradual. A combined optical coherence tomography and intravascular ultrasound study.

    abstract:OBJECTIVE:Some plaques grow slowly in a linear manner, whereas others undergo a rapid phasic progression. However, the detailed in-vivo relationship between plaque characteristics and plaque progression pattern has not been reported. The current study aimed to investigate the plaque progression patterns with serial int...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000420

    authors: Xie Z,Hou J,Yu H,Jia H,Du H,Lee H,Yu B,Tian J,Jang IK

    更新日期:2016-12-01 00:00:00

  • Clinical outcomes of SeQuent Please paclitaxel-coated balloons for de novo small coronary artery lesion in a Japanese multicenter post-approval registry.

    abstract:OBJECTIVE:Drug-coated balloon (DCB) angioplasty has emerged as an effective management strategy worldwide. In June 2016, DCB became available for the treatment of de novo small coronary lesions in Japan; however, there has been no multicenter analysis in a post-approval real-world clinical setting to date. The aim of t...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000782

    authors: Funayama N,Muratsubaki S,Kawahatsu K,Miyata M,Katou Y,Oikawa T

    更新日期:2020-01-01 00:00:00

  • The relation between ABO blood types and clinical and platelet function parameters in patients who underwent percutaneous coronary intervention.

    abstract:BACKGROUND:ABO blood groups have been associated with venous thromboembolism and arterial thrombosis. Although platelets play key roles in thrombogenesis, the relation between ABO groups and platelets is not well known and was investigated in this study. PATIENTS AND METHODS:ABO blood type information was retrospectiv...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000676

    authors: Timur AA,Barnard J,Murugesan G,Gandhi S,Bhatt DL,Kottke-Marchant K

    更新日期:2019-01-01 00:00:00

  • Plaque composition and morphologic characteristics in significant left main bifurcation disease; virtual histology intravascular ultrasound study.

    abstract:OBJECTIVES:Although the left main coronary artery (LMCA) is clinically the most important site, little is known about the longitudinal plaque distribution and composition in the significant LMCA disease. METHODS:Preprocedure virtual histology intravascular ultrasound data were analyzed in 120 patients with significant...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000417

    authors: Chang M,Kang SJ,Yoon SH,Ahn JM,Park DW,Lee SW,Kim YH,Lee CW,Park SW,Nakazawa G,Mintz GS,Park SJ

    更新日期:2016-12-01 00:00:00

  • The role of Fas in the progression of ischemic heart failure: prohypertrophy or proapoptosis.

    abstract::During myocardial ischemia, cardiomyocytes can undergo apoptosis or compensatory hypertrophy. Fas expression is upregulated in the myocardial ischemia and is coupled to both apoptosis and hypertrophy of cardiomyocytes. The role of Fas in apoptosis induction or cardiomyocyte hypertrophy during ischemic conditions is, h...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/MCA.0b013e3283093707

    authors: Feng QZ,Zhao YS,Abdelwahid E

    更新日期:2008-11-01 00:00:00

  • Atrial fibrillation, bleeding, and coronary intervention: current recommendations.

    abstract::The patient population with the need for oral anticoagulation to reduce stroke risk associated with atrial fibrillation (AF) and dual antiplatelet therapy to prevent stent thrombosis and myocardial infarction after percutaneous coronary intervention is increasing. However, patients treated with a triple therapy consis...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,评审

    doi:10.1097/MCA.0000000000000549

    authors: Farhan S,Mehran R

    更新日期:2017-12-01 00:00:00

  • Thrombocytopenia: a risk factor for acute myocardial infarction during the acute phase of Kawasaki disease.

    abstract:BACKGROUND:We report on 10 patients with Kawasaki disease and thrombocytopenia who were found to have a high incidence of coronary artery aneurysm and acute myocardial infarction. The clinical features of these patients, the cause of their thrombocytopenia and the relationship between cardiovascular pathology and throm...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:

    authors: Niwa K,Aotsuka H,Hamada H,Uchishiba M,Terai M,Niimi H

    更新日期:1995-11-01 00:00:00

  • Metabolic syndrome negatively impacts early patency of saphenous vein grafts.

    abstract:BACKGROUND:Coronary artery bypass grafting has been performed for a long period utilizing saphenous vein grafts, the fate of which might be crucial to prognosis following the operation. Metabolic syndrome, on the other hand, has become an increasingly important part of cardiovascular practice. We examined whether there...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200602000-00007

    authors: Yilmaz MB,Guray U,Guray Y,Biyikoglu SF,Tandogan I,Sasmaz H,Korkmaz S

    更新日期:2006-02-01 00:00:00

  • Predictors of atrial fibrillation after coronary artery bypass surgery.

    abstract:OBJECTIVE:Atrial fibrillation is one of the most common arrhythmias associated with not only increased morbidity after coronary artery bypass grafting but also increased healthcare costs. Many factors are associated with atrial fibrillation onset after coronary artery bypass grafting. We prospectively examined which fa...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e3281689a2c

    authors: Dogan SM,Buyukates M,Kandemir O,Aydin M,Gursurer M,Acikgoz S,Yavuzer R,Cam F,Dursun A

    更新日期:2007-08-01 00:00:00

  • Plasma homocysteine level and development of coronary artery disease.

    abstract:BACKGROUND:The plasma level of homocysteine is an independent risk factor for atherosclerotic vascular disease. The relationship between plasma homocysteine level and the onset of coronary artery disease (CAD) has not been established. OBJECTIVE:To investigate the relationship between plasma homocysteine level and the...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199910000-00002

    authors: Kawashiri M,Kajinami K,Nohara A,Yagi K,Inazu A,Koizumi J,Haraki T,Takegoshi T,Mabuchi H

    更新日期:1999-10-01 00:00:00

  • Changes in coronary plaque morphology in patients with acute coronary syndrome versus stable angina pectoris after initiation of statin therapy.

    abstract:OBJECTIVES:The aim of this study was to examine coronary plaque morphology after initiation of statins and compare changes in plaque morphology in patients presenting with acute coronary syndrome (ACS) versus stable angina pectoris (SAP). BACKGROUND:ACS is associated with a pan-inflammatory state, and intraplaque feat...

    journal_title:Coronary artery disease

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MCA.0000000000000415

    authors: Gin AL,Vergallo R,Minami Y,Ong DS,Hou J,Jia H,Soeda T,Hu S,Zhang S,Lee H,Yu B,Jang IK

    更新日期:2016-12-01 00:00:00

  • Incidence, treatment, and in-hospital outcome of bifurcation lesions in patients undergoing percutaneous coronary interventions for chronic total occlusions.

    abstract:BACKGROUND:Bifurcation lesions represent a distinct lesion subset associated with an increased risk of procedural complications. Data on the incidence, treatment, and outcome of bifurcation lesions associated with chronic total occlusions are limited. METHODS:Among chronic total occlusion procedures performed by a sin...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000194

    authors: Galassi AR,Boukhris M,Tomasello SD,Marzà F,Azzarelli S,Giubilato S,Khamis H

    更新日期:2015-03-01 00:00:00

  • Prognostic impact of lipoprotein(a) levels during lipid management with statins after ST-elevation acute myocardial infarction.

    abstract::The causal relationship of lipoprotein(a) with cardiovascular disease has been established. However, clinical impacts of lipoprotein(a) levels on adverse vascular events in patients with established coronary artery disease who are undergoing statin treatment have not been fully elucidated. We measured lipoprotein(a) l...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000798

    authors: Mitsuda T,Uemura Y,Ishii H,Tanaka A,Takemoto K,Koyasu M,Ishikawa S,Shibata R,Watarai M,Murohara T

    更新日期:2019-12-01 00:00:00

  • Effect of niceritrol on fibrinolysis and lipoprotein (a) levels in patients with coronary artery disease.

    abstract:BACKGROUND:Lipoprotein (a) [Lp(a)] is an independent risk factor for coronary artery disease and niceritrol (a prodrug of nicotinic acid) is known to reduce Lp(a) levels. Patients with coronary artery disease often have impairment of the fibrinolytic system. METHODS:To elucidate the effect of niceritrol on fibrinolysi...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199602000-00012

    authors: Suefuji H,Ogawa H,Yasue H,Imoto N,Sakamoto T,Miyao Y,Kaikita K,Soejima H,Nishiyama K

    更新日期:1996-02-01 00:00:00

  • Association of coronary artery calcium with bone mineral density in postmenopausal women.

    abstract:OBJECTIVES:Atherosclerosis and osteoporosis (OP) are common diseases in elderly individuals and may share common pathogenetic mechanisms. The aim of this study was to investigate the association between bone mineral density (BMD) and coronary artery calcium (CAC) in postmenopausal women. METHODS:In this cross-sectiona...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000402

    authors: Xu R,Yang HN,Li YQ,Wang QF,Guo AH,Ayiti A,Chen XC,Gong R,Banu G,Jian LD,Gao Y,Sheng K,Maimti Y

    更新日期:2016-11-01 00:00:00

  • Immediate effect of Biosense guided percutaneous direct myocardial revascularization with holmium:yttrium aluminium garnet laser on myocardial contractility assessed by transesophageal echocardiography.

    abstract:OBJECTIVE:To evaluate immediate changes in left ventricular wall motion in patients treated using Biosense direct myocardial revascularization laser system. METHODS:Regional wall motion in 10 patients undergoing catheter-based direct myocardial revascularization using a holmium:yttrium aluminium garnet laser was asses...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200006000-00010

    authors: Shiran A,Goldstein SA,Ellahham S,Leon MB,Kornowski R

    更新日期:2000-06-01 00:00:00

  • Hemodynamic changes determine the efficacy of thrombolysis: results from an in-vitro flow model.

    abstract:BACKGROUND:The efficacy of thrombolytic therapy might be influenced by changes in the hemodynamic status. The aim of the study was to examine whether changes in perfusion pressure could affect the time to reflow in an in-vitro model. METHODS:The in-vitro flow system comprised flexible plastic tubes that enclosed a blo...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199809010-00007

    authors: Kornowski R,Mendelevich L,Zaretsky U,Einav S,Laniado S,Keren G

    更新日期:1998-01-01 00:00:00

  • Quantitative assessment of free-radical generation during ischemia and reperfusion in the isolated rabbit heart.

    abstract:BACKGROUND:Several investigators have indirectly implicated oxygen free radicals in reperfusion injury following ischemia in the isolated rabbit heart. METHODS:A quantitative assessment of free-radical production during ischemia and reperfusion was made using electron paramagnetic resonance (EPR) spectroscopy. Serial ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199312000-00009

    authors: Premaratne S,Limm W,Mugiishi MM,Piette LH,McNamara JJ

    更新日期:1993-12-01 00:00:00

  • Reduced low-frequency heart rate variability relates to greater intimal-medial thickness of the carotid wall in two samples.

    abstract:INTRODUCTION:We investigated the relationship between heart rate variability and preclinical carotid intima-media thickening, a putative index of atherosclerosis. METHODS:A sample of 350 men and women (mean age 56.8 years) selected for the presence or absence of untreated hypertension was assessed for heart rate varia...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e328011ac01

    authors: Gautier C,Stine L,Jennings JR,Sutton-Tyrrell K,Muldoon MB,Kamarck TW,Kaplan GA,Salonen J,Manuck SB

    更新日期:2007-03-01 00:00:00

  • Predictive value of coronary artery dilation response to nitrate for a positive intracoronary acetylcholine provocation test.

    abstract:BACKGROUND:Baseline coronary artery diameter and coronary artery dilation response to nitrate are associated with coronary vasoreactivity. OBJECTIVES:The present study investigated the predictive value of coronary artery tone for a positive intracoronary acetylcholine (ACh) provocation test. METHODS:A total of 197 pa...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000401

    authors: Saito Y,Kitahara H,Shoji T,Tokimasa S,Nakayama T,Sugimoto K,Fujimoto Y,Kobayashi Y

    更新日期:2016-11-01 00:00:00

  • Gliding-window fast Fourier transform analysis of the entire QRS complex and the distribution of area ratio peaks in healthy subjects and patients with myocardial infarction.

    abstract:BACKGROUND:The high-frequency contribution (i.e. 60-120 Hz) within the QRS complex of the surface ECG is supposed to be related to the arrhythmogenic substrate underlying sustained ventricular tachycardia in patients with coronary artery disease. One of the factors that prevents a wider clinical application of spectral...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199403000-00011

    authors: Slavkovský P,Hulín I

    更新日期:1994-03-01 00:00:00

  • Platelet-derived growth factor is released into the coronary circulation after coronary spasm.

    abstract:BACKGROUND:Platelet-derived growth factor (PDGF) is a potent mitogen for vascular smooth muscle cells and is implicated in the vascular response to injury and the pathogenesis of atherosclerosis. It is also a potent vasoconstrictor. METHODS:To examine whether acute myocardial ischemia increases the level of PDGF in th...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-199305000-00007

    authors: Ogawa H,Yasue H,Okumura K,Fujii H,Masuda T,Miyao Y,Bannai S,Takanashi N

    更新日期:1993-05-01 00:00:00

  • Comparison of a low-molecular-weight heparin (nadroparin calcium) and unfractionated heparin as adjunct to coronary thrombolysis with alteplase and aspirin in dogs.

    abstract:BACKGROUND:Low-molecular-weight heparins may have a higher benefit to risk ratio than unfractionated heparin in preventing perioperative thrombosis. The antithrombotic effects of low-molecular-weight heparins, given as adjunctive therapy to alteplase and aspirin, have not previously been compared with those of unfracti...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:

    authors: Jun L,Arnout J,Vanhove P,Dol F,Lormeau JC,Herbert JM,Collen D,Van de Werf F

    更新日期:1995-03-01 00:00:00

  • Antibodies to oxidized low-density lipoprotein in patients following coronary artery revascularization.

    abstract:BACKGROUND:Measurement of antibodies to oxidized low-density lipoprotein (AB-oxLDL) has been proposed as a way of identifying individuals at risk for cardiovascular disease beyond the determination of LDL cholesterol (LDL-c) alone. While this hypothesis is appealing, evidence that AB-oxLDL is a risk factor independent ...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00019501-200304000-00009

    authors: Miller ER 3rd,Erlinger TP,Blumenthal RS,Margolis S,Allen JK

    更新日期:2003-04-01 00:00:00

  • Plasma soluble adhesion molecules; intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin levels in patients with isolated coronary artery ectasia.

    abstract:UNLABELLED:Plasma soluble adhesion molecules, intercellular adhesion molecule-1 (ICAM)-1, vascular cell adhesion molecule-1 (VCAM-1) and E-selectin leves of patients with isolated coronary artery ectasia (CAE), patients with obstructive coronary artery disease without CAE and subjects with angiographically normal coron...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200502000-00009

    authors: Turhan H,Erbay AR,Yasar AS,Aksoy Y,Bicer A,Yetkin G,Yetkin E

    更新日期:2005-02-01 00:00:00

  • Noninvasive assessment of coronary artery ectasia using multidetector computed tomography.

    abstract:OBJECTIVES:The aim of this study is to determine the prevalence of coronary artery ectasia and its relationship to atheromatous changes in participants undergoing coronary computed tomography angiography. BACKGROUND:Coronary artery ectasia occasionally encountered on conventional coronary angiography is considered a m...

    journal_title:Coronary artery disease

    pub_type: 临床试验,杂志文章

    doi:10.1097/MCA.0b013e3280144be1

    authors: Zeina AR,Sharif D,Blinder J,Rosenschein U,Barmeir E

    更新日期:2007-05-01 00:00:00

  • Predictive value of the combination of age, creatinine, and ejection fraction score and diabetes in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention.

    abstract:BACKGROUND:This study investigated whether the age, creatinine, and ejection fraction (ACEF) score [age (years) /ejection fraction (%) +1 (if creatinine>176μmol/L)] could predict 1-year outcomes following ST-segment elevation myocardial infarction after percutaneous coronary intervention, and whether accuracy could be ...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000791

    authors: Gao S,Liu Q,Ding X,Chen H,Zhao X,Li H

    更新日期:2020-03-01 00:00:00

  • Infectious agents in coronary lesions obtained by endatherectomy: pattern of distribution, coinfection, and clinical findings.

    abstract:BACKGROUND:Cytomegalovirus (CMV), Chlamydia pneumoniae (C. pneumoniae), and Helicobacter pylori (H. pylori) have been implicated in atherosclerosis and restenosis after angioplasty. The patterns of distribution within coronary lesions and possible coinfections of these pathogens in the coronary vasculature had not prev...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/00019501-200102000-00001

    authors: Radke PW,Merkelbach-Bruse S,Messmer BJ,vom Dahl J,Dörge H,Naami A,Vogel G,Handt S,Hanrath P

    更新日期:2001-02-01 00:00:00

  • Treatment of mild-moderate calcified coronary lesions with sirolimus-eluting stent: real world data from a single center.

    abstract:BACKGROUND:Calcified coronary lesions have commonly been considered as a challenge for interventional cardiologists, and few previous studies of sirolimus-eluting stent (SES) for calcified lesion have been limited by small sample size. Therefore, we evaluated the effectiveness of SES implantation for the treatment of c...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0b013e328330d5ab

    authors: Yuan JQ,Li JJ,Qin XW,Xu B,Yang YJ,Chen JL,Qiao SB,Ma WH,Yao M,Liu HB,Wu YJ,Chen J,You SJ,Dai J,Xia R,Gao RL

    更新日期:2010-01-01 00:00:00

  • Primary percutaneous coronary intervention in ST-elevation myocardial infarction with an ectatic infarct-related artery.

    abstract:OBJECTIVE:The aim of this study was to describe the procedural characteristics, myocardial perfusion, and long-term outcomes in ST-elevation myocardial infarction patients with an ectatic infarct-related artery (IRA). PATIENTS AND METHODS:The retrospective analysis included 1270 consecutive ST-elevation myocardial inf...

    journal_title:Coronary artery disease

    pub_type: 杂志文章

    doi:10.1097/MCA.0000000000000720

    authors: Popovic B,Agrinier N,Metzdorf PA,Camenzind E

    更新日期:2019-06-01 00:00:00