Nimodipine inhibits the pressor activity of diaspirin-crosslinked hemoglobin (DCLHb) in the rat.

abstract：:Our studies are guided by the novel hypothesis that protein tyrosine phosphorylation is an important mechanism for regulating contraction of smooth muscle. Several lines of evidence are reviewed which suggest that enhanced tyrosine phosphorylation participates in mechanisms that regulate cytosolic Ca2+ and Ca2+ sensit...

journal_title：Canadian journal of physiology and pharmacology

authors： Di Salvo J,Pfitzer G,Semenchuk LA

更新日期：1994-11-01 00:00:00

abstract：:A variety of porphyrinogenic xenobiotics cause mechanism-based inactivation of a number of rat hepatic cytochrome P450 isozymes. As a result, a mixture of four N-alkylprotoporphyin IX (N-alkylPP) regioisomers, with ferrochelatase-inhibitory properties, are formed. This study was designed to determine whether all four ...

journal_title：Canadian journal of physiology and pharmacology

authors： McNamee JP,Kobus SM,Marks GS

更新日期：1996-08-01 00:00:00

abstract：:To assess the physiological and clinical implications of the C-type natriuretic peptide (CNP)/guanylyl cyclase B (GC-B) system in the human vasculature, we have examined gene expressions of CNP and its receptor, GC-B, in human vascular endothelial cells (ECs) and smooth muscle cells (SMCs) and have also compared the e...

journal_title：Canadian journal of physiology and pharmacology

authors： Taura D,Nakao K,Nakagawa Y,Kinoshita H,Sone M,Nakao K

更新日期：2020-09-01 00:00:00

abstract：:Techniques to dissociate different sites or stores important for Ca2+ entry or release in smooth muscle include washouts of 45Ca in cold La3+ -substituted solutions. Scatchard-coordinate plots of Ca2+ uptake, substitution of Sr2+ for Ca2+, and both desaturation and rate coefficient plots. Rabbit aortic smooth muscle i...

journal_title：Canadian journal of physiology and pharmacology

authors： Weiss GB,Karaki H,Murakami K

更新日期：1987-04-01 00:00:00

abstract：:Neonatal hyperthyroidism in rats induced by daily administration of L-triiodothyronine for 30 days since birth resulted in a significant rise in mobility and the metabolism of brain norepinephrine and dopamine. Whereas administration of lithium carbonate (60 mg/kg ip) to normal rats for 6 days produced no effect on sp...

journal_title：Canadian journal of physiology and pharmacology

authors： Rastogi RB,Singhal RL

更新日期：1977-06-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver conditions that are characterized by steatosis, inflammation, fibrosis, and liver injury. The global prevalence of NAFLD is rapidly increasing in proportion to the rising incidence of obesity and type 2 diabetes. Because NAFLD is a multifaceted di...

journal_title：Canadian journal of physiology and pharmacology

authors： Sid V,Siow YL,O K

更新日期：2017-10-01 00:00:00

abstract：:Although chronic cocaine use is cardiotoxic, its use remains problematic in athletics. Hence adaptive changes induced in the heart by superimposing chronic cocaine use on an exercise training are of interest but remain poorly understood. Therefore this study investigated the effects of cocaine treatment combined with ...

journal_title：Canadian journal of physiology and pharmacology

authors： Morris GS,Fiore PV,Hamlin RL,Sherman WM

更新日期：1994-01-01 00:00:00

abstract：:Norethandrolone (NE) and other androgenic steroids have been shown to be renotropic in various species and have also been reported to have salutary effects in patients with diminished renal function. Renal cortical slices prepared from rats pretreated with NE showed an increased capability to concentrate p-aminohippur...

journal_title：Canadian journal of physiology and pharmacology

authors： Watrous WM,Lacombe R,Brodeur J

更新日期：1975-10-01 00:00:00

abstract：:Sulforaphane, a natural isothiocyanate, demonstrates cardioprotection associated with its capacity to stimulate endogenous antioxidants and to inhibit inflammation. The aim of this study was to investigate whether sulforaphane is capable of attenuating oxidative stress and inflammatory responses through the TLR4/MyD88...

journal_title：Canadian journal of physiology and pharmacology

authors： Bonetto JH,Fernandes RO,Seolin BG,Müller DD,Teixeira RB,Araujo AS,Vassallo D,Schenkel PC,Belló-Klein A

更新日期：2016-05-01 00:00:00

abstract：:The disruption to glucose homeostasis upon glucocorticoid (GC) treatment in adult male rats has not been fully characterized in older rats or in females. Thus, we evaluated the age- and gender-related changes in glucose homeostasis in GC-treated rats. We injected male and female rats at 3 months and 12 months of age w...

journal_title：Canadian journal of physiology and pharmacology

authors： dos Santos C,Ferreira FB,Gonçalves-Neto LM,Taboga SR,Boschero AC,Rafacho A

更新日期：2014-10-01 00:00:00

abstract：:We studied the effect of pertussis toxin (PT) treatment on the ability of insulin to inhibit lipolysis and to stimulate glucose oxidation in isolated rat adipocytes. In cells maximally modified by PT (100% ADP ribosylation of a 41-kdalton protein in membranes), the ability of insulin to inhibit lipolysis stimulated ei...

journal_title：Canadian journal of physiology and pharmacology

authors： Goren HJ,Northup JK,Hollenberg MD

更新日期：1985-08-01 00:00:00

abstract：:Radiolabelled acetylsalicylic acid (ASA) and salicylic acid (SA) were given intravenously to four near-term ewes and their occurrence in both maternal and fetal plasma was ascertained using a specific thin-layer chromatographic analysis procedure. Findings proved that ASA and SA cross the placental barrier and reach d...

journal_title：Canadian journal of physiology and pharmacology

authors： Thiessen JJ,Salama RB,Coceani F,Olley PM

更新日期：1984-04-01 00:00:00

abstract：:Prevention and treatment of Alzheimer disease are urgent problems for elderly people in developed countries. We previously reported that nobiletin, a poly-methoxylated flavone from the citrus peel, improved the symptoms in various types of animal models of memory loss and activated the cAMP responsive element (CRE)-de...

journal_title：Canadian journal of physiology and pharmacology

authors： Takito J,Kimura J,Kajima K,Uozumi N,Watanabe M,Yokosuka A,Mimaki Y,Nakamura M,Ohizumi Y

更新日期：2016-07-01 00:00:00

abstract：:The effects of beta-adrenergic blocking agents, timolol and atenolol (1-1000 microM), were studied on rat heart sarcolemmal ATPase and Ca2+ binding activities. Timolol, unlike atenolol, increased both Ca2+-stimulated ATPase and ATP-dependent Ca2+ binding; the maximal effects were seen at 1 microM concentration of timo...

journal_title：Canadian journal of physiology and pharmacology

authors： Dzurba A,Ganguly PK,Beamish RE,Dhalla NS

更新日期：1983-03-01 00:00:00

abstract：:In open-chest pentothal-chloralose anesthetized dogs, plasma catecholamine and cyclic AMP levels were evaluated in the aortic and coronary sinus blood, during stimulations of the left ansa subclavia (1, 2, and 4 Hz). Basal aortic and coronary sinus catecholamine levels were respectively 0.373 +/- 0.090 and 0.259 +/- 0...

journal_title：Canadian journal of physiology and pharmacology

authors： Lavallée M,Laurencin C,de Champlain J,Nadeau RA

更新日期：1981-06-01 00:00:00

abstract：:The effects of Bay K8644, a Ca2+ channel agonist, on the mechanical and electrical properties of frog skeletal muscle fibers were investigated. At relatively low concentrations, such as 10(-6) and 10(-5) M, Bay K8644 significantly potentiated the maximum amplitudes of twitch responses, and this effect was not reversed...

journal_title：Canadian journal of physiology and pharmacology

authors： Oz M,Frank GB

更新日期：1994-10-01 00:00:00

abstract：:Mechanisms leading to ifosfamide (IF)-induced renal damage have not been fully elucidated. Recent work suggests that localized renal tubular metabolism of IF and the production of the nephrotoxic chloroacetaldehyde may lead to nephrotoxicity. Presently no pharmacological method to reduce IF nephrotoxicity has been ide...

journal_title：Canadian journal of physiology and pharmacology

authors： Aleksa K,Halachmi N,Ito S,Koren G

更新日期：2005-06-01 00:00:00

abstract：:Idiopathic pulmonary arterial hypertension (IPAH) is a rare and devastating condition. There is no known cure for IPAH, and current treatment options are not always effective. Autologous myeloid angiogenic cells (MACs) have been explored as a novel therapy for IPAH, but preliminary data from clinical trials show limit...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang Q,Zucco L,Toshner M,Morrell NW,Granton J,Stewart DJ,Kutryk MJB

更新日期：2019-04-01 00:00:00

abstract：:This Symposium includes 15 presentations and an editorial review dealing with prorenin activation and function. It comes 20 years after prorenin was first reported in various contexts and attracted attention because of its connection with renin--angiotensin, its high concentration relative to renin in the blood, and i...

journal_title：Canadian journal of physiology and pharmacology

authors： Osmond DH,Sealey JE,McKenzie JK

更新日期：1991-09-01 00:00:00

abstract：:The effects of iontophoretically applied Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors (ouabain, digitoxin, digitoxigenin, strophanthin K, strophanthidin, thevetin A and B, ethacrynate, and harmaline) on the depression of rat cerebral cortical neurones by noradrenaline, 5-hydroxytr...

journal_title：Canadian journal of physiology and pharmacology

authors： Sastry BS,Phillis JW

更新日期：1977-04-01 00:00:00

abstract：:In Western societies, the incidence of diet-related diseases is progressively increasing due to greater availability of hypercaloric food and a sedentary lifestyle. Obesity, diabetes, atherosclerosis, and neurodegeneration are major diet-related pathologies that share a common pathogenic denominator of low-grade infla...

journal_title：Canadian journal of physiology and pharmacology

authors： Magrone T,Perez de Heredia F,Jirillo E,Morabito G,Marcos A,Serafini M

更新日期：2013-06-01 00:00:00

abstract：:In rats anesthetized with alpha-chloralose, doses of 0.1, 0.5, and 1 g/kg of ethanol produced an upward shift of baroreflex curves constructed by plotting the heart rate response against mean arterial pressure following evoked rises in mean arterial pressures by phenylephrine or angiotensin II. Whereas the upward shif...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdel-Rahman AR,Russ R,Strickland JA,Wooles WR

更新日期：1987-05-01 00:00:00

abstract：:The development of the febrile response to E. coli lipopolysaccharide (1.5 micrograms/kg, i.v.) in thyroid-deficient rabbits has been studied. Twenty-eight New Zealand White rabbits weighing 2.1-2.3 kg were used. Hypothyroidism was induced by treatment with propylthiouracil (100 or 200 mg/kg body wt./15 days). Thyroid...

journal_title：Canadian journal of physiology and pharmacology

authors： Macari M,Pelá IR,Silva CA

更新日期：1987-06-01 00:00:00

abstract：:Ethanol was administered to rats by oral intubation 3 h after intraperitoneal administration of calcium carbimide. Increased blood acetaldehyde concentration and the presence of acetaldehyde in brain were found for the calcium carbimide--ethanol interaction. There was no detectable brain acetaldehyde for ethanol admin...

journal_title：Canadian journal of physiology and pharmacology

authors： Hoover DJ,Brien JF

更新日期：1981-01-01 00:00:00

abstract：:Longitudinal muscle of myometrial tissues from immature rats were examined by quantitative thin section electron microscopy for the presence of gap junctions after treatment with estradiol with and without tamoxifen, and cycloheximide for 1-6 days. Gap junctions were present between myometrial cells on days 4, 5, and ...

journal_title：Canadian journal of physiology and pharmacology

authors： MacKenzie LW,Garfield RE

更新日期：1986-06-01 00:00:00

abstract：:The effects of gallopamil, D600, a methoxy derivative of verapamil, on the mechanical and electrophysiological parameters of isolated guinea-pig myocardial preparations were compared with those of verapamil. Both gallopamil and verapamil produced concentration-dependent negative chronotropic and negative inotropic eff...

journal_title：Canadian journal of physiology and pharmacology

authors： Noguchi K,Masumiya H,Takahashi K,Kaneko K,Higuchi S,Tanaka H,Shigenobu K

更新日期：1997-12-01 00:00:00

abstract：:The role of leukotriene D4 (LTD4) as a mediator of immediate hypersensitivity reactions in the guinea-pig conjunctiva was examined using a potent, second-generation LTD4 receptor antagonist, MK-571 (also known as L-660,711). The microvascular permeability changes in the guinea-pig conjunctiva following challenge with ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chan CC,Dagenais F,Firby P,Foster A,Ford-Hutchinson AW

更新日期：1989-08-01 00:00:00

abstract：:The mechanisms responsible for microbially induced epithelial apoptosis and increased intestinal permeability remain unclear. This study assessed whether purified bacterial lipopolysaccharide (LPS) increases epithelial apoptosis and permeability and whether these changes are dependent on caspase-3 activation. In nontu...

journal_title：Canadian journal of physiology and pharmacology

authors： Chin AC,Flynn AN,Fedwick JP,Buret AG

更新日期：2006-10-01 00:00:00

abstract：:The effects of lithium chloride on ornithine decarboxylase (ODC) activity were compared in the adrenal and kidney of control (saline treated) and prolactin-treated rats. ODC activity was decreased in kidney of both groups of animals, the magnitude of the effect of lithium in the hormone-treated group varying with the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Strümpfer A,Hsiao J,Peng T,Richards J

更新日期：1992-09-01 00:00:00

abstract：:The rate of glucose oxidation of fresh corneas of guinea pigs at different ages has been determined. Full-thickness corneal discs, 4 mm in diameter, were incubated in radioactive glucose solution. The quantity of the released CO2 was expressed in terms of the corneal discs, their dry weights, and DNA and protein conte...

journal_title：Canadian journal of physiology and pharmacology

authors： Liao HM,Lin BJ,Hasany SM,Basu PK

更新日期：1979-10-01 00:00:00