Immediate hypersensitivity reactions in the guinea-pig conjunctiva: studies with a second-generation leukotriene D4 receptor antagonist, MK-571.

abstract：:Phosphofructokinase activity was measured in the sciatic nerve of streptozotocin-induced diabetic and nondiabetic rats. Average steady-state phosphofructokinase activity was obtained from three consecutive segments of the mid-femoral region in the left sciatic nerve in both diabetic (4 and 24 weeks) and nondiabetic, a...

journal_title：Canadian journal of physiology and pharmacology

authors： Kilgour RD,Gardiner K,Gardiner PF

更新日期：1990-10-01 00:00:00

abstract：:Oxidative stress plays a vital role in the pathogenesis of neurodegenerative diseases. Chikusetsu saponin V (CsV), the most abundant member of saponins from Panax japonicus (SPJ), has attracted increasing attention for its potential to treat neurodegenerative diseases. However, the mechanisms are unclear. Our study in...

journal_title：Canadian journal of physiology and pharmacology

authors： Wan J,Deng L,Zhang C,Yuan Q,Liu J,Dun Y,Zhou Z,Zhao H,Liu C,Yuan D,Wang T

更新日期：2016-09-01 00:00:00

abstract：:The effect of chemical sympathectomy with 6-hydroxydopamine (6-OHDA) on blood volume was studied in unanesthetized splenectomized and nonsplenectomized dogs. A significant increase in total blood volume essentially accounted for by a marked plasma volume expansion was found in both groups after 6-OHDA treatment (50 mg...

journal_title：Canadian journal of physiology and pharmacology

authors： Porlier GA,Nadeau RA,de Champlain J

更新日期：1977-06-01 00:00:00

abstract：:Neonatal hyperthyroidism in rats induced by daily administration of L-triiodothyronine for 30 days since birth resulted in a significant rise in mobility and the metabolism of brain norepinephrine and dopamine. Whereas administration of lithium carbonate (60 mg/kg ip) to normal rats for 6 days produced no effect on sp...

journal_title：Canadian journal of physiology and pharmacology

authors： Rastogi RB,Singhal RL

更新日期：1977-06-01 00:00:00

abstract：:Hypertrophic scar (HS) results from abnormal wound healing, accompanied by excessive hypercellularity, migration and extracellular matrix (ECM) deposition. Autophagy dysregulation plays crucial roles during HS formation. The overexpressed p75 neurotrophin receptor (p75NTR) in injured skin tissue after wound healing be...

journal_title：Canadian journal of physiology and pharmacology

authors： Shi W,Wu Y,Bian D

更新日期：2020-07-29 00:00:00

abstract：:Our objective was to produce reductions in the luminal volume of Henle's loop and increases in linear flow velocity through the loop. We did this in a recollection micropuncture study by collecting fluid with and without suction from early distal tubules. With suction, transit time of fast green dye through the loop d...

journal_title：Canadian journal of physiology and pharmacology

authors： Baines AD,Wu CK

更新日期：1975-04-01 00:00:00

abstract：:The binding of dantrolene to rabbit red blood cell (RBC) ghosts and bovine serum albumin as models of receptor sites was studied using fluorescence techniques. Dantrolene upon binding to rabbit RBC ghosts and bovine serum albumin showed fluorescence with emission maxima at 495 and 500 nm, respectively. Dantrolene boun...

journal_title：Canadian journal of physiology and pharmacology

authors： Dehpour AR,Mahmoudian M

更新日期：1982-10-01 00:00:00

abstract：:The hypocalcaemic action of ethanol (3 g/kg body weight) was investigated in intact, thyroparathyroidectomized and antrectomized rats. It was found that ethanol administered either intraperitoneally or orally reduced plasma calcium concentrations within 30 min and that this response lasted for 8 h. Additional studies ...

journal_title：Canadian journal of physiology and pharmacology

authors： Krishnamra N,Limlomwongse L

更新日期：1983-04-01 00:00:00

abstract：:Alterations in electrical conductivity between smooth muscle cells (SMCs) can alter the spread and effectiveness of electromechanical SMC contraction. We attempted to determine whether alterations in pressure-dependent constriction (PDC) occurring in relation to stroke development within the middle cerebral arteries (...

journal_title：Canadian journal of physiology and pharmacology

authors： Smeda JS,King SR

更新日期：1998-02-01 00:00:00

abstract：:The role of sympathetic innervation in the regulation of hindlimb skeletal muscle blood flow (QL) and metabolism was studied prior to and during acute anemia in anesthetized, paralyzed, and ventilated dogs (n = 8). Neural activity in the sciatic nerve was reversibly cold blocked for a 15-min period at control hematocr...

journal_title：Canadian journal of physiology and pharmacology

authors： Kubes P,Cain SM,Chapler CK

更新日期：1988-09-01 00:00:00

abstract：:Plasma and serum of healthy subjects apparently contain a precursor form of renin, or 'prorenin,' which can be activated by the ice-cold temperature at which samples are customarily handled for prolonged periods in laboratories and blood banks. The effect of such prior cryoactivation for 9 days at 4 degrees C is to in...

journal_title：Canadian journal of physiology and pharmacology

authors： Osmond DH,Cooper RM

更新日期：1978-10-01 00:00:00

abstract：:To elucidate the mechanism of enhanced insulin sensitivity by muscle after exercise, we studied insulin binding, 2-deoxy-D-[1-14C]glucose (2-DOG) uptake and [5-3H]glucose utilization in glycolysis and glycogenesis in soleus and extensor digitorum longus (EDL) muscles of mice after 60 min of treadmill exercise. In the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Bonen A,Tan MH,Watson-Wright WM

更新日期：1984-12-01 00:00:00

abstract：:Natural rodent grooming and other instinctive behavior serves as a natural model of complex movement sequences. Rodent grooming has syntactic (rule-driven) sequences and more random movement patterns. Both incorporate the same movements--only the serial structure differs. Recordings of neural activity in the dorsolate...

journal_title：Canadian journal of physiology and pharmacology

authors： Aldridge JW,Berridge KC,Rosen AR

更新日期：2004-08-01 00:00:00

abstract：:Natural products from plants such as flavonoids are potential drugs to overcome multidrug resistance (MDR) in cancer treatments. However, their modes of action are still unclear. In this study, the effects of quercetin on mitochondrial membrane potential (DeltaPsim) change as well as quercetin's ability to induce apop...

journal_title：Canadian journal of physiology and pharmacology

authors： Kothan S,Dechsupa S,Leger G,Moretti JL,Vergote J,Mankhetkorn S

更新日期：2004-12-01 00:00:00

abstract：:Thermal resistance as determined by survival time was examined in different age groups of spontaneously hypertensive (SHR) rats during terminal heating. A comparison with age or weight matched controls indicated that the thermal resistance of SHR animals was markedly inferior to that of normotensive animals as evidenc...

journal_title：Canadian journal of physiology and pharmacology

authors： Wright G,Iams S,Knecht E

更新日期：1977-10-01 00:00:00

abstract：:Normal penile erectile function is dependent on arterial adequacy, appropriate venous occlusion, neurohumoral factors, and finally the relaxation of penile cavernous trabecular smooth muscle. The present experiments were designed to test whether compounds related to endothelium-derived relaxing factor have a role in p...

journal_title：Canadian journal of physiology and pharmacology

authors： Heaton JP

更新日期：1989-01-01 00:00:00

abstract：:Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain. In this study, we investigated the antiseptic effects and underlying mechanisms of vicenin-2 and scolymoside, which are 2 active compounds from C. subternata that act against high mobility group box 1 (HMGB1)-mediated septi...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee W,Yoon EK,Kim KM,Park DH,Bae JS

更新日期：2015-08-01 00:00:00

abstract：:Our previous results showed that addition of agonists, such as vasopressin and angiotensin, added to incubation medium with freshly excised rat atria caused marked release of atrial natriuretic factor (ANF). This release was in the form of prohormone rather than active peptide. Since others had difficulty reproducing ...

journal_title：Canadian journal of physiology and pharmacology

authors： Sonnenberg H,Milojevic S,Yip C,Veress AT

更新日期：1989-10-01 00:00:00

abstract：:Measurements of the presynaptic fiber volley (PSFV), the population excitatory postsynaptic potential (EPSP), and the extracellular pH in the dendritic CA1 layer of rat hippocampal slices were used to evaluate the effects of lactacidosis on central synaptic transmission. Replacement of NaCl with sodium lactate (up to ...

journal_title：Canadian journal of physiology and pharmacology

authors： Walz W,Harold DE

更新日期：1990-02-01 00:00:00

abstract：:Neural and paracrine agents, such as dopamine, epinephrine, and histamine, affect intestinal epithelial function, but it is unclear if these agents act on receptors directly at the enterocyte level. The cellular localization and villus-crypt distribution of adrenergic, dopamine, and histamine receptors within the inte...

journal_title：Canadian journal of physiology and pharmacology

authors： Baglole CJ,Davison JS,Meddings JB

更新日期：2005-05-01 00:00:00

abstract：:In male Sprague--Dawley rats, hypertensive development was diminished for 10 weeks when parathyroidectomy (PTX) was performed 1 week before deoxycorticosterone plus saline (DOCA + NaCl) treatment. In young spontaneously hypertensive male rats (SHR, Okamoto strain) parathyroidectomy performed after weaning lessened hyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Gairard A,Berthelot A,Schleiffer R,Pernot F

更新日期：1982-02-01 00:00:00

abstract：:The present study focused on the interactive pain regulation of endokinin A/B (EKA/B, the common C-terminal decapeptide in EKA and EKB) or endokinin C/D (EKC/D, the common C-terminal duodecapeptide in EKC and EKD) on chimeric peptide MCRT (YPFPFRTic-NH2, based on YPFP-NH2 and PFRTic-NH2) at the supraspinal level in mi...

journal_title：Canadian journal of physiology and pharmacology

authors： He C,Gong J,Yang L,Zhang H,Dong S,Zhou L

更新日期：2016-09-01 00:00:00

abstract：:The effect of oleate (0.3 and 1.2 mM) and the combined effect of beta-hydroxybutyrate (4 and 8 mM) and acetoacetate (1 and 2 mM) on rates of lipolysis (glycerol output) was determined with calcium-tolerant myocytes isolated from the hearts of normal rats and hearts from acutely (2-3 days; 100 mg/kg streptozotocin) dia...

journal_title：Canadian journal of physiology and pharmacology

authors： Larsen TS,Severson DL

更新日期：1990-09-01 00:00:00

abstract：:The development of cardiac hypertrophy was examined in rats given ethanol in a nutritionally adequate, liquid diet mixture, by intubation, in severely intoxicating doses at 8-h intervals for up to 96 h, alone or in combination with prazosin. Other groups of rats received isocalorically paired quantities of maltose-dex...

journal_title：Canadian journal of physiology and pharmacology

authors： Adams MA,Hirst M

更新日期：1989-03-01 00:00:00

abstract：:Tolerance to ethanol was induced in male Sprague-Dawley rats (225-250 g) by chronic feeding with a liquid diet containing 6.5% ethanol (v/v). Control rats were pair-fed with a liquid diet in which the ethanol was replaced by an equicaloric concentration of sucrose. Immediately following sacrifice of the animals the ne...

journal_title：Canadian journal of physiology and pharmacology

authors： Gianoulakis C,Chan JS,Kalant H,Chrétien M

更新日期：1983-09-01 00:00:00

abstract：:The present study was conducted to evaluate the local antinociceptive actions of fluoxetine, a selective serotonin reuptake inhibitor, and the possible involvement of the l-arginine/NO/cGMP/KATP channel pathway in this effect using the formalin test in rats. To elucidate the underlying mechanisms, animals were pre-tre...

journal_title：Canadian journal of physiology and pharmacology

authors： Ghorbanzadeh B,Mansouri MT,Naghizadeh B,Alboghobeish S

更新日期：2018-02-01 00:00:00

abstract：:Animals treated with nitric oxide synthase (NOS) inhibitors exhibit marked hypersensitivity to the blood pressure lowering effects of exogenous nitric oxide (NO) donors. We used this model as a sensitive index to evaluate the relative importance of reduced biotransformation of glyceryl trinitrate (GTN) to NO in the de...

journal_title：Canadian journal of physiology and pharmacology

authors： Ratz JD,Adams MA,Bennett BM

更新日期：2002-11-01 00:00:00

abstract：:The mammalian daily (circadian) clock is located in the suprachiasmatic nuclei of the hypothalamus. Clock function can be detected by the measurement of the circadian change in spontaneous firing rate of suprachiasmatic nuclei cells in a brain slice preparation in vitro. We investigated the effects of neuropeptide Y o...

journal_title：Canadian journal of physiology and pharmacology

authors： Harrington ME,Schak KM

更新日期：2000-02-01 00:00:00

abstract：:Because the excessive apoptosis of articular chondrocytes contributes to extracellular matrix (ECM) loss and cartilage damage in rheumatoid arthritis (RA), inhibiting chondrocyte apoptosis might be a promising strategy for RA. Aquaporin1 (AQP1) is overexpressed in RA cartilage and synovial tissues, and play a vital pa...

journal_title：Canadian journal of physiology and pharmacology

authors： Cai L,Chen WN,Li R,Liu MM,Lei C,Li CM,Qiu YY

更新日期：2018-11-01 00:00:00

abstract：:Doxepin binds to intact astrocytes in primary cultures. The binding is competitively displaceable by excess cold doxepin and it is pronounced (Bmax = 27 nmol/mg protein) but the affinity is rather low (KD = 30 microM). The binding is inhibited by other antidepressants (amitriptyline, desipramine, tranylcypromine, ipri...

journal_title：Canadian journal of physiology and pharmacology

authors： Hertz L,Richardson JS,Mukerji S

更新日期：1980-12-01 00:00:00