Lithium suppresses elevated behavioural activity and brain catecholamines in developing hyperthyroid rats.

abstract：:Diazinon (DZN) is a common organophosphorus insecticide extensively used for agriculture and veterinary purposes. DZN toxicity is not limited to insects; it also induces harmful effects in mammals and birds. Our experiment evaluated the protective and antioxidant potential of sesame oil (SO) and (or) alpha-lipoic acid...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdel-Daim MM,Taha R,Ghazy EW,El-Sayed YS

更新日期：2016-01-01 00:00:00

abstract：:Intrinsic regulation of hepatic blood flow is mediated only through the hepatic artery because the liver is not able to directly regulate portal vein blood flow. Hepatic metabolic activity does not affect hepatic artery flow. Although the hepatic artery is affected by sympathetic nerves and blood-borne agents, the int...

journal_title：Canadian journal of physiology and pharmacology

authors： Lautt WW

更新日期：1996-03-01 00:00:00

abstract：:Hepatotoxicity and nephrotoxicity are important drawbacks of cisplatin. The objective of this study is to evaluate the ability of ambroxol in 2 different doses (35 and 70 mg/kg, i.p.) to protect liver and kidney from damage induced by a single dose of cisplatin (10 mg/kg, i.p.) in comparison with N-acetylcysteine (250...

journal_title：Canadian journal of physiology and pharmacology

authors： Bishr A,Sallam N,Nour El-Din M,Awad AS,Kenawy SA

更新日期：2019-01-01 00:00:00

abstract：:The level of circulating triacylglycerols is determined by the balance between their delivery into the plasma and their removal from it. Plasma triacylglycerols are derived either from dietary fat as chylomicrons or from endogenous hepatic synthesis as very low density lipoproteins. Their removal occurs through the ac...

journal_title：Canadian journal of physiology and pharmacology

authors： Herzberg GR

更新日期：1991-11-01 00:00:00

abstract：:The major hallmark of rotator cuff tendinopathies (RCT) is the disorganization of tendon extracellular matrix (ECM) which is due to decrease in the collagen I-to-collagen III ratio. In addition, the pathology of tendon matrisome remains asymptomatic and hypoxia has been identified to be the priming signal to initiate ...

journal_title：Canadian journal of physiology and pharmacology

authors： Thankam FG,Agrawal DK

更新日期：2020-08-15 00:00:00

abstract：:Effects of xanthine--xanthine oxidase produced oxygen radicals were studied in hypertrophied rat hearts in a Langendorff preparation. Heart hypertrophy was produced by banding of the abdominal aorta for 6 weeks. This resulted in a 22% increase in ventricle/body weight ratio compared with that of sham-operated controls...

journal_title：Canadian journal of physiology and pharmacology

authors： Gupta M,Gameiro A,Singal PK

更新日期：1987-06-01 00:00:00

abstract：:To investigate the contribution of pulmonary surfactant to a low airflow resistance through narrow conducting airways, a system was developed with which it was possible to determine the resistance meeting a steady flow of air at 0.5 mL/min. The airflow, delivered by an infusion pump, entered the extreme periphery of a...

journal_title：Canadian journal of physiology and pharmacology

authors： Enhorning G,Yarussi A,Rao P,Vargas I

更新日期：1996-06-01 00:00:00

abstract：:It has been proposed that medullary washout secondary to increased blood flow will limit maximal urine osmolality and reabsorption of salt and water from the inner medullary collecting duct. We have tested this prediction. The function of the inner medullary collecting duct was examined by microcatheterization. Acetyl...

journal_title：Canadian journal of physiology and pharmacology

authors： Cupples WA,Sonnenberg H

更新日期：1987-12-01 00:00:00

abstract：:This paper presents data showing that the sympathetic autonomic areas of the cat thoracolumbar spinal cord contain nerve terminals and fibres with immunoreactivity for at least seven neuropeptides. The distribution in the intermediolateral cell column of the terminals and fibres which contain enkephalin-, neuropeptide...

journal_title：Canadian journal of physiology and pharmacology

authors： Krukoff TL

更新日期：1987-08-01 00:00:00

abstract：:Negative chronotropic effects of beta-adrenoceptor (betaAR) antagonists on right atria from reserpine-treated rats and mice were determined as a test of their inverse agonist activities. BetaAR antagonist ICI-118,551 and nonselective betaAR antagonists alprenolol, propranolol, and timolol produced negative chronotropi...

journal_title：Canadian journal of physiology and pharmacology

authors： Varma DR

更新日期：1999-12-01 00:00:00

abstract：:Investigation of the relationship of diet to blood lipids and atherosclerosis has dominated the field of lipid nutritional biochemistry for the past 25 years. Although this subject has consumed considerable time, effort, and research funds, it has also proved beneficial to other areas of lipid biochemistry by attracti...

journal_title：Canadian journal of physiology and pharmacology

authors： Walker BL

更新日期：1983-03-01 00:00:00

abstract：:The present study was undertaken to determine the beta-receptor subtype responsible for the enhanced anaphylactic histamine release from bovine leukocytes produced by isoprenaline. The selective beta 1 antagonist practolol competitively inhibited the enhancement of histamine release produced by isoprenaline. The selec...

journal_title：Canadian journal of physiology and pharmacology

authors： Perron R,Eyre P

更新日期：1982-07-01 00:00:00

abstract：:We investigated potential sex differences in bone resorption and the conservation of whole body bone mass in 24-week-old Sprague-Dawley rats maintained on a 1.0% calcium diet and then fed diets containing 0.02, 0.5, 1.0, or 1.75% calcium for 31 days. Lowering dietary calcium from 1.00% to 0.02% doubled whole skeleton ...

journal_title：Canadian journal of physiology and pharmacology

authors： Geng W,Wright GL

更新日期：2001-05-01 00:00:00

abstract：:The major functional alpha1-adrenoceptor in the rat aorta is of the alpha1Dsubtype and that in the caudal artery is of the alpha1A subtype. In the present study, the participation of protein kinase C (PKC) and Rho kinase (RhoK) in contractile responses to stimulation of the alpha1-adrenoceptors in these two arteries w...

journal_title：Canadian journal of physiology and pharmacology

authors： Mueed I,Bains P,Zhang L,Macleod KM

更新日期：2004-10-01 00:00:00

abstract：:Rats received a daily injection of 2, 6, or 12 mg kg-1 bethanechol for 7 or 14 days. Pancreatic weight and content of protein, amylase, and chymotrypsinogen were increased in a dose and time dependent fashion by bethanechol. After 14 days of treatment with the highest dose, pancreatic weight and total pancreatic DNA c...

journal_title：Canadian journal of physiology and pharmacology

authors： Morisset J,Jolicoeur L,Caussignac Y,Solomon TE

更新日期：1982-07-01 00:00:00

abstract：:Agelasimine A and agelasimine B, two novel compounds related to adenine, have been isolated from the orange sponge, Agelas mauritiana, and have been tested for a variety of biological activities. Both compounds inhibited proliferation of cultured L1210 leukemia cells at nanomolar concentrations with accumulation in th...

journal_title：Canadian journal of physiology and pharmacology

authors： Fathi-Afshar R,Allen TM,Krueger CA,Cook DA,Clanachan AS,Vriend R,Baer HP,Cass CE

更新日期：1989-04-01 00:00:00

abstract：:Electrical stimulation of the diencephalon and rostral mesencephalon produced a biphasic pressor response consisting of an initial sharp rise followed by a more prolonged elevation in blood pressure. Active sites from which comparable responses could be evoked were found in the ventral medial and lateral hypothalamus,...

journal_title：Canadian journal of physiology and pharmacology

authors： Gauthier P

更新日期：1981-05-01 00:00:00

abstract：:Chronic elevated lactate levels are associated with insulin resistance in patients with type 2 diabetes mellitus (T2DM). Furthermore, lactacidosis plays a role in limiting physical performance. Erythrocytes, which take up lactate via monocarboxylate transporter (MCT) proteins, may help transport lactate within the blo...

journal_title：Canadian journal of physiology and pharmacology

authors： Opitz D,Lenzen E,Opiolka A,Redmann M,Hellmich M,Bloch W,Brixius K,Brinkmann C

更新日期：2015-06-01 00:00:00

abstract：:The effects of some components of ischemia on the oscillatory (Vos) and nonoscillatory (V(ex)) potentials and respective currents (Ios and Iex), as well as their mechanisms, were studied in guinea pig isolated ventricular myocytes by means of a single-microelectrode, discontinuous voltage clamp method. Repetitive acti...

journal_title：Canadian journal of physiology and pharmacology

authors： Liu QY,Vassalle M

更新日期：1994-04-01 00:00:00

abstract：:Ablation of the anteroventral third ventricle (AV3V) region, which includes the organum vasculosum laminae terminalis (OVLT), blocks the febrile response of guinea pigs to systemically injected endotoxin; by contrast, discrete lesions of the OVLT transiently enhance fever in rabbits and rats. To assess whether separat...

journal_title：Canadian journal of physiology and pharmacology

authors： Blatteis CM,Hales JR,McKinley MJ,Fawcett AA

更新日期：1987-06-01 00:00:00

abstract：:Many studies have demonstrated that chronic intermittent hypobaric hypoxia (CIHH) can reduce blood pressure in spontaneously hypertensive rats and renovascular hypertensive (RVH) rats in which endothelial dysfunction is determined as a critical factor. However, whether CIHH can regulate vasodilation of the aorta in RV...

journal_title：Canadian journal of physiology and pharmacology

authors： Fu C,Li N,Yuan Y,Wang R,Chen J,Yang J,Guo Z,Wang S,Zhang Y,Liu Y,Dong J

更新日期：2018-08-01 00:00:00

abstract：:Cyclic AMP response element (CRE) binding protein (CREB) is a nuclear transcription factor that regulates the transcription of several genes containing the CRE sites on their promoters. CREB is activated by phosphorylation on a key serine residue, Ser311, in response to a wide variety of extracellular stimuli includin...

journal_title：Canadian journal of physiology and pharmacology

authors： Truong V,Anand-Srivastava MB,Srivastava AK

更新日期：2021-01-01 00:00:00

abstract：:For 10 days, dogs were fed a normal salt diet containing 70 mequiv. Na+/day (NSD) followed by a high salt diet containing 170 mequiv. Na+/day (HSD) or 240 mequiv. Na+/day (VHSD), or the order was reversed. K+ in these diets was fixed at 40 mequiv./day. The different diets did not influence the basal level of serum cat...

journal_title：Canadian journal of physiology and pharmacology

authors： Carrière S,Cardinal J,Le Grimellec C

更新日期：1980-09-01 00:00:00

abstract：:The effect of chronic consumption of diets containing either different sources of dietary fibre (8% guar, 8% pectin, or 8% multifibre) or low carbohydrate upon carbohydrate tolerance was examined in rats. Weight gain was significantly lower throughout the entire 28-day study period with the guar group and after 20 day...

journal_title：Canadian journal of physiology and pharmacology

authors： Track NS,Cannon MM,Flenniken A,Katamay S,Woods EF

更新日期：1982-06-01 00:00:00

abstract：:The novel biological effect of statins in alleviating myocardium fibrosis following infarction has been increasingly recognized, yet the underlying mechanisms are not fully understood. The purpose of this study was to characterize the effect of simvastatin on myocardial fibrosis and collagen I deposition in the non-in...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang J,Xu Y,Pan L,Chen T,Chen Z,Zhao R

更新日期：2010-11-01 00:00:00

abstract：:The world-wide increase in cancer incidence imposes a corresponding significant increase in the use of chemotherapeutic agents. Nephrotoxicity is a side effect frequently encountered with cyclophosphamide (CP), which is also well-known to cause acute and chronic lung toxicities. The current study focuses on the evalua...

journal_title：Canadian journal of physiology and pharmacology

authors： Said E,Elkashef WF,Abdelaziz RR

更新日期：2016-04-01 00:00:00

abstract：:The effect of hepoxilin A, a newly isolated hydroxyepoxide metabolite of arachidonic acid, on calcium transport across the visceral yolk sac membrane of the guinea pig was investigated in vitro in Ussing chambers. While 1-14C-labelled hepoxilin A itself was not transported across the membrane, it increased the rate of...

journal_title：Canadian journal of physiology and pharmacology

authors： Derewlany LO,Pace-Asciak CR,Radde IC

更新日期：1984-12-01 00:00:00

abstract：:To elucidate the mechanism of enhanced insulin sensitivity by muscle after exercise, we studied insulin binding, 2-deoxy-D-[1-14C]glucose (2-DOG) uptake and [5-3H]glucose utilization in glycolysis and glycogenesis in soleus and extensor digitorum longus (EDL) muscles of mice after 60 min of treadmill exercise. In the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Bonen A,Tan MH,Watson-Wright WM

更新日期：1984-12-01 00:00:00

abstract：:Pial arteriolar diameter changes inversely with changes in systemic arterial blood pressure. Such changes are consistent with autoregulatory functions. These responses are reduced by a brief period of hypoxia followed by reoxygenation. By using an open cranial window preparation we assessed the changes in pial arterio...

journal_title：Canadian journal of physiology and pharmacology

authors： Kettler J,Ong BY,Bose D

更新日期：1989-05-01 00:00:00

abstract：:Input to the nucleus medianus of the preoptic region has been suggested to be involved in both the drinking and pressor responses elicited by the central administration of angiotensin II. Evidence in support of this suggestion has been gained principally from electrical lesion experiments. This lesion procedure does n...

journal_title：Canadian journal of physiology and pharmacology

authors： Jones DL

更新日期：1988-08-01 00:00:00