Renal medullary plasma flow rate and reabsorption of salt and water from inner medullary collecting duct.

abstract：:This study examined whether the effects of FK506-binding protein dissociation from sarcoplasmic reticulum (SR) Ca(2+) release channels on excitation-contraction (EC) coupling changed when SR Ca(2+) reuptake and (or) the trans-sarcolemmal Ca(2+) extrusion were altered. The steady-state twitch Ca(2+) transient (CaT), ce...

journal_title：Canadian journal of physiology and pharmacology

authors： Yoshihara S,Satoh H,Saotome M,Katoh H,Terada H,Watanabe H,Hayashi H

更新日期：2005-04-01 00:00:00

abstract：:The postprandial release of immunoreactive insulin, glucagon, gastrin, somatostatin, pancreatic polypeptide (PP), and gastric inhibitory polypeptide (GIP) was studied in parallel with the absorption of sugars and amino acids in conscious pigs. Six pigs fitted with permanent catheters in the portal vein and arterial bl...

journal_title：Canadian journal of physiology and pharmacology

authors： Rérat A,Chayvialle JA,Kandé J,Vaissade P,Vaugelade P,Bourrier T

更新日期：1985-12-01 00:00:00

abstract：:Intra- and extra-cellular concentrations of calcium were measured in hippocampal neurons of areas CA1 and CA3 during 8 min ischaemia and short-term (up to 60 min) recovery. During an ischaemic insult, [Ca2+]i increased progressively and [Ca2+]e decreased. There were large interneuronal differences, although, in genera...

journal_title：Canadian journal of physiology and pharmacology

authors： Erecińska M,Silver IA

更新日期：1992-01-01 00:00:00

abstract：:It has been reported that the intraportal infusion of glutamine in Munich-Wistar rats will cause depression of renal perfusion and the urinary excretion of salt and water. We have attempted to reproduce these findings in anaesthetized dogs. L-Glutamine was infused at doses between 120 and 150 mumol/min into the portal...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy M

更新日期：1992-10-01 00:00:00

abstract：:Plasma and serum of healthy subjects apparently contain a precursor form of renin, or 'prorenin,' which can be activated by the ice-cold temperature at which samples are customarily handled for prolonged periods in laboratories and blood banks. The effect of such prior cryoactivation for 9 days at 4 degrees C is to in...

journal_title：Canadian journal of physiology and pharmacology

authors： Osmond DH,Cooper RM

更新日期：1978-10-01 00:00:00

abstract：:The measurement of the sodium reversal potential (Erev), as that potential where the early current reverses during voltage clamp, was found to exceed the true Erev by 4.1 +/- 2.4 mV (mean +/- SD) in squid giant axon. This error was found in both intact and internally perfused axons and is due to interference from the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wodlinger H,Kunov H,Atwood HL

更新日期：1982-12-01 00:00:00

abstract：:Taurine status and pregnancy outcome were assessed in rats fed low dietary taurine and varying doses of guanidinoethyl sulfonate (GES), a structural analogue of taurine. Female Sprague-Dawley rats (225-270 g) were mated overnight and assigned to one of four groups from day 0 to 20 of gestation. Taurine-deficient anima...

journal_title：Canadian journal of physiology and pharmacology

authors： Gottschall-Pass KT,Gorecki DK,Paterson PG

更新日期：1995-08-01 00:00:00

abstract：:The study was designed to characterize restitution kinetics in atrial repolarization of rabbits and to examine effects of K+ or Ca2+ channel blockers on restitution. Action potentials were recorded from rabbit atrial tissue. Restitution curves of phase I amplitude and action potential duration at 50 and 90% repolariza...

journal_title：Canadian journal of physiology and pharmacology

authors： Qi A,Tang C,Yeung-Lai-Wah JA,Kerr CR

更新日期：1997-04-01 00:00:00

abstract：:This study aimed to investigate the interrelationship of plasma lipid profile, lipid peroxidation, and erythrocyte antioxidative defense in patients with insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. Plasma levels of total cholesterol, triglycerides, and lipid peroxides and the activiti...

journal_title：Canadian journal of physiology and pharmacology

authors： Cimbaljević B,Vasilijević A,Cimbaljević S,Buzadzić B,Korać A,Petrović V,Janković A,Korać B

更新日期：2007-10-01 00:00:00

abstract：:The effects of L-641,953 (R-8-fluoro-dibenzo[b, f]thiepin-3-carboxylic acid-5-oxide) have been studied on pulmonary and other smooth muscle preparations in vitro and in vivo. When studied in vitro on guinea-pig tracheal chains, L-641,933 produced significant shifts in the dose-response curves to the prostaglandin endo...

journal_title：Canadian journal of physiology and pharmacology

authors： Hall RA,Rokach JR,Bélanger P,Bianchi L,Ethier D,Ford-Hutchinson AW,Girard Y,Hamel P,Hamel R,Lord A

更新日期：1987-04-01 00:00:00

abstract：:The effects of the dopamine type-2 receptor (D-2) antagonist domperidone on pituitary and brain amine concentrations and serum gonadotropin levels in the goldfish were investigated. Domperidone caused a long-lasting, dose-dependent depletion of dopamine in the goldfish pituitary. Pituitary concentrations of 5-hydroxyt...

journal_title：Canadian journal of physiology and pharmacology

authors： Sloley BD,Trudeau VL,Dulka JG,Peter RE

更新日期：1991-06-01 00:00:00

abstract：:Heparin was introduced into the stomach or duodenum of mice separately in doses of ca. 250 mg/kg. A slight anticoagulant effect in the systemic circulation was detected in whole blood clotting times and factor X inhibition. In contrast to most drugs, more heparin was absorbed from the stomach than from the intestine. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Sue TK,Jaques LB,Yuen E

更新日期：1976-08-01 00:00:00

abstract：:The kinetics of sodium gradient dependent phosphate uptake by the renal brush border membrane vesicles of the rat have ben studied under various conditions of temperature and pH. From 7 to 30 degrees C the Lineweaver-Burk plots are linear, and the apparent Km progressively increases from 54 to 91 microM. Above 30 degr...

journal_title：Canadian journal of physiology and pharmacology

authors： Brunette MG,Beliveau R,Chan M

更新日期：1984-02-01 00:00:00

abstract：:The force generated by tracheal spirals and lung parenchymal strips from normal and ovalbumin-sensitized guinea pigs was measured in vitro, after challenge with histamine, carbachol, leukotriene (LT) C4, LTD4, or a prostaglandin endoperoxide analog (U-44069). The responses and sensitivity of airway tissues to the abov...

journal_title：Canadian journal of physiology and pharmacology

authors： Saad MH,Burka JF

更新日期：1983-08-01 00:00:00

abstract：:The aim of this study was to elucidate the variables of gastroduodenal motility determining gastric emptying. For this purpose the effects of exogenous cholecystokinin, secretin, and gastric inhibitory polypeptide on motility and gastric emptying were studied during a meal. Motility was measured with extraluminal stra...

journal_title：Canadian journal of physiology and pharmacology

authors： Keinke O,Ehrlein HJ,Wulschke S

更新日期：1987-03-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent vasoactive peptide that exerts hypertrophic, migratory, and mitogenic effects in vascular smooth muscle cells. ET-1-induced activation of several signaling events has been shown to mediate the cellular effects of ET-1. In the past several years, transactivation of growth factor receptor...

journal_title：Canadian journal of physiology and pharmacology

authors： Bouallegue A,Vardatsikos G,Srivastava AK

更新日期：2010-05-01 00:00:00

abstract：:Phosphorylation of the regulatory light chain of myosin catalyzed by myosin light-chain kinase (MLCK) is the key reaction in the regulation of actin-myosin interaction in smooth muscle. It is shown that this reaction is of an ordered type, whereby kinase first binds ATP and then the light chain, and following phosphat...

journal_title：Canadian journal of physiology and pharmacology

authors： Sobieszek A

更新日期：1994-11-01 00:00:00

abstract：:The arterio--alveolar nitrogen difference (aADN2) has been associated in 27 normal adult subjects aged 20--60 years. As it may be assumed that venous and arterial PN2 are identical, we have used a sample of venous blood. There is a significant positive correlation between aADN2 and age. As the increase of aADN2 with a...

journal_title：Canadian journal of physiology and pharmacology

authors： Corbet AJ,Ross JA,Beaudry PH

更新日期：1975-02-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of bosentan, a mixed endothelin receptor A and B subtype antagonist, on myocardial ischemia-reperfusion injury and to explore the influence of the timing of bosentan administration on its cardioprotective effects. Adult rat hearts were perfused by the Langendorf...

journal_title：Canadian journal of physiology and pharmacology

authors： Xia Z,Kuo KH,McNeill JH,Ansley DM

更新日期：2005-03-01 00:00:00

abstract：:Serotonin (5-HT) acts as a neuromodulator and plays a critical role in brain development. Changes in 5-HT signaling during the perinatal period can affect neural development and may result in behavioral changes in adulthood. However, further investigations are necessary including both sexes to study possible differenc...

journal_title：Canadian journal of physiology and pharmacology

authors： Campos RMM,Toscano AE,Gouveia HJCB,Lacerda DC,Pereira SDC,Paz IAASG,Dantas-Alves JS,Manhaes-de-Castro R

更新日期：2020-09-17 00:00:00

abstract：:In open-chest pentothal-chloralose anesthetized dogs, plasma catecholamine and cyclic AMP levels were evaluated in the aortic and coronary sinus blood, during stimulations of the left ansa subclavia (1, 2, and 4 Hz). Basal aortic and coronary sinus catecholamine levels were respectively 0.373 +/- 0.090 and 0.259 +/- 0...

journal_title：Canadian journal of physiology and pharmacology

authors： Lavallée M,Laurencin C,de Champlain J,Nadeau RA

更新日期：1981-06-01 00:00:00

abstract：:In vitro coronary artery responsiveness to angiotensin I, angiotensin II, noradrenaline, phenylephrine, BHT 920, and potassium chloride together with functional relaxation to acetylcholine was investigated in dogs with pacing-induced heart failure treated with enalapril (oral administration of 10 mg.day-1) for a mean ...

journal_title：Canadian journal of physiology and pharmacology

authors： Forster C,Larosa G,Armstrong PW

更新日期：1992-10-01 00:00:00

abstract：:Barbital-sedated, warm-acclimated (WA) or cold-acclimated (CA) rats were infused intravenously with noradrenaline (NA) at doses that elicited graded calorigenic responses. Blood flow (Q) to the various bodies of brown adipose tissue (BAT), the major sites of the NA-induced calorigenesis, was measured with labeled micr...

journal_title：Canadian journal of physiology and pharmacology

authors： Foster DO,Depocas F,Frydman ML

更新日期：1980-08-01 00:00:00

abstract：:Cardiac adenosine receptors are coupled to adenylate cyclase inhibition. In the guinea pig heart, the relative agonist potencies observed for adenylate cyclase inhibition were R-N6-phenylisopropyladenosine (R-PIA) = N6-cyclohexyladenosine greater than 5'-N-ethylcarboxamidoadenosine much greater than S-PIA. In both atr...

journal_title：Canadian journal of physiology and pharmacology

authors： Leung E,Woodcock EA

更新日期：1986-12-01 00:00:00

abstract：:The effects of atorvastatin and carboxymethylated β-glucan (CMG) on the lipoprotein-cholesterol (LP-C) and lipoprotein-triglyceride (LP-TG) fractions and subfractions at the early stage of murine hyperlipidemia, and its pleiotropic anti-inflammatory effects, were studied. Atorvastatin and CMG were administered in ICR ...

journal_title：Canadian journal of physiology and pharmacology

authors： Korolenko TA,Tuzikov FV,Cherkanova MS,Johnston TP,Tuzikova NA,Loginova VM,Filjushina EE,Kaledin VI

更新日期：2012-02-01 00:00:00

abstract：:Alterations in calcium metabolism and calcium-regulating hormones have been described in essential hypertension. However, the mechanisms that mediate these responses are unknown. In previous studies, using the genetically spontaneously hypertensive rat and the mineralocorticoid-salt (DOC-salt) hypertensive rat model, ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wimalawansa SJ,Supowit SC,DiPette DJ

更新日期：1995-07-01 00:00:00

abstract：:The effects of modulators of Ca-ATPase and alkaline phosphatase (AP) activity on placental calcium and phosphorus transfer were studied using the in situ perfused guinea pig placenta. The diuretics ethacrynic acid and furosemide had no significant effect on placental calcium and phosphorus transfer when injected into ...

journal_title：Canadian journal of physiology and pharmacology

authors： McKercher HG,Derewlany LO,Radde IC

更新日期：1983-11-01 00:00:00

abstract：:Electrophysiological studies were performed on in vitro slice preparations of sympathetic ganglia excised from peripherally perfused, brain-dead human donors. The intracellular recordings in 16 neurons showed resting potentials and input resistances mostly in the ranges reported for sympathetic neurons in other mammal...

journal_title：Canadian journal of physiology and pharmacology

authors： Puil E,el-Beheiry H,Spigelman I

更新日期：1988-06-01 00:00:00

abstract：:Electrophysiological studies were performed on slowly adapting cells of the crayfish (Astacus astacus) stretch receptor to examine some aspects of the operation of the sodium pump. Intracellular sodium activity (aiNa) and pH (pHi) were measured with liquid ion exchanger microelectrodes and the effects of NH3/NH+4 were...

journal_title：Canadian journal of physiology and pharmacology

authors： Moser H

更新日期：1987-02-01 00:00:00

abstract：:The effects of gallopamil, D600, a methoxy derivative of verapamil, on the mechanical and electrophysiological parameters of isolated guinea-pig myocardial preparations were compared with those of verapamil. Both gallopamil and verapamil produced concentration-dependent negative chronotropic and negative inotropic eff...

journal_title：Canadian journal of physiology and pharmacology

authors： Noguchi K,Masumiya H,Takahashi K,Kaneko K,Higuchi S,Tanaka H,Shigenobu K

更新日期：1997-12-01 00:00:00