The effect of displacement current on the measurement of reversal potential in squid giant axon.

abstract：:The active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3 or calcitriol), is known to inhibit the proliferation and invasiveness of many types of cancer cells, including breast, colon, pancreatic, prostate, and liver cancer cells. These findings support the use of 1α,25(OH)2D3 for the treatment of these t...

journal_title：Canadian journal of physiology and pharmacology

authors： Matsumoto Y,Kittaka A,Chen TC

更新日期：2015-05-01 00:00:00

abstract：:A simple method using gas chromatography-mass spectrometry was developed to determine a low concentration of ethanol in urine. The detection limit was 0.02 mM ethanol. A mean +/- SD ethanol concentration in urine of 0.21 +/- 0.17 mM was measured in 11 alcoholics after 14 days abstention, a level at least 10 times high...

journal_title：Canadian journal of physiology and pharmacology

authors： Tang BK

更新日期：1987-06-01 00:00:00

abstract：:Spironolactone is a diuretic steroid which is capable of blocking the binding of aldosterone to its cytosol receptor at the distal convoluted tubule. In addition, it has been shown that spironolactone is a strong inhibitor of steroidogenesis. More recently, new aldosterone antagonists have been discovered. Some of the...

journal_title：Canadian journal of physiology and pharmacology

authors： Netchitailo P,Perroteau I,Delarue C,Leboulenger F,Capron MH,Vaudry H

更新日期：1983-01-01 00:00:00

abstract：:The electrophysiologist's view of brain astrocytes has changed markedly in recent years. In the past astrocytes were viewed as passive, K+ selective cells, but it is now evident that they are capable of expressing voltage- and ligand-activated channels previously thought to be restricted to neurons. The functional imp...

journal_title：Canadian journal of physiology and pharmacology

authors： Sontheimer H

更新日期：1992-01-01 00:00:00

abstract：:In vivo assessment of treatment efficacy on postinfarct left ventricular (LV) remodeling is crucial for experimental studies. We examined the technical feasibility of serial magnetic resonance imaging (MRI) for monitoring early postinfarct remodeling in rats. MRI studies were performed with a 7-Tesla unit, 1, 3, 8, 15...

journal_title：Canadian journal of physiology and pharmacology

authors： Prunier F,Marescaux L,Franconi F,Thia A,Legras P,Lejeune JJ,Furber A

更新日期：2005-12-01 00:00:00

abstract：:Previously, we reported that thromboxane A2 (TxA2) mediates heart rate, adrenocorticotropin (ACTH), cortisol, and blood gas responses, although the specific site of action was not identified. In the present study, we interrupted vagal nervous transmission in chronically instrumented conscious sheep and infused the TxA...

journal_title：Canadian journal of physiology and pharmacology

authors： Cudd TA

更新日期：1998-12-01 00:00:00

abstract：:The effect of 6-hydroxydopamine (6-OH-dopamine) and of a cholesterol rich diet on the plasma and aortic cholesterol of female rats were studied. Both the diet and the 6-OH-dopamine produced an important increase in plasmatic and aortic cholesterol. A synergistic effect of these two treatments was observed on the plasm...

journal_title：Canadian journal of physiology and pharmacology

authors： Lelorier J,Tremblay M,de Champlain J,Gattereau A,Davingnon J

更新日期：1976-04-01 00:00:00

abstract：:This study investigated the effects of prolonged exercise on muscle sarcoplasmic reticulum (SR) Ca2+ cycling properties and the metabolic responses with and without a session of exercise designed to reduce muscle glycogen reserves while on a normal carbohydrate (CHO) diet. Eight untrained males (VO(2peak) = 3.81 +/- 0...

journal_title：Canadian journal of physiology and pharmacology

authors： Duhamel TA,Green HJ,Perco JG,Ouyang J

更新日期：2005-07-01 00:00:00

abstract：:The aim of this study was to investigate the possible effects of captopril as a promoter in modulating the oxidant-antioxidant balance in rats with type 1 diabetes, and the influence of protein kinase C (PKC) pathways in the production of reactive oxygen species (ROS) induced by bradykinin in type 1 diabetic rats. Thi...

journal_title：Canadian journal of physiology and pharmacology

authors： Rodrigues de Araujo G,Granato de Faria K,Lima WG,Pádua Bda C,Rossoni JV Jr,Souza AA,Chianca-Júnior D,Silva ME,Pedrosa ML,Chaves MM,Costa DC

更新日期：2011-12-01 00:00:00

abstract：:Binding of [3H]nitrendipine, [3H]nimodipine, and (+)[3H]PN 200-110 to microsomal preparations of guinea pig smooth and cardiac muscle and brain synaptosomes revealed high affinity interaction with KD values in the sequence, (+)PN 200-110 greater than nitrendipine greater than nimodipine. Bmax values for a particular t...

journal_title：Canadian journal of physiology and pharmacology

authors： Rampe D,Luchowski E,Rutledge A,Janis RA,Triggle DJ

更新日期：1987-07-01 00:00:00

abstract：:The sarco(endo)plasmic reticulum calcium ATPase (SERCA) is responsible for transporting calcium (Ca(2+)) from the cytosol into the lumen of the sarcoplasmic reticulum (SR) following muscular contraction. The Ca(2+) sequestering activity of SERCA facilitates muscular relaxation in both cardiac and skeletal muscle. Ther...

journal_title：Canadian journal of physiology and pharmacology

authors： Stammers AN,Susser SE,Hamm NC,Hlynsky MW,Kimber DE,Kehler DS,Duhamel TA

更新日期：2015-10-01 00:00:00

abstract：:Effects of xanthine--xanthine oxidase produced oxygen radicals were studied in hypertrophied rat hearts in a Langendorff preparation. Heart hypertrophy was produced by banding of the abdominal aorta for 6 weeks. This resulted in a 22% increase in ventricle/body weight ratio compared with that of sham-operated controls...

journal_title：Canadian journal of physiology and pharmacology

authors： Gupta M,Gameiro A,Singal PK

更新日期：1987-06-01 00:00:00

abstract：:MicroRNA-146a (miR-146a) is reportedly implicated in the pathogenesis of ischemia-reperfusion (I/R) injury; however, its role in cerebral I/R injury is unclear and requires further investigation. In this study, cerebral I/R injury was established in mice via middle cerebral artery occlusion, and the expression of miR-...

journal_title：Canadian journal of physiology and pharmacology

authors： Chu B,Zhou Y,Zhai H,Li L,Sun L,Li Y

更新日期：2018-06-01 00:00:00

abstract：:The contractile recoverability of isolated portal veins made hypodynamic by removal of glucose from the perfusion medium by diverse exogenous substrates was studied. It was found that glucose, mannose, pyruvate, lactate, acetate, and butyrate readily restored contraction. The effects of anoxia and metabolic inhibitors...

journal_title：Canadian journal of physiology and pharmacology

authors： Cremer-Lacuara MG,Lacuara JL,Fiol de Cuneo M,Ruiz RD

更新日期：1980-06-01 00:00:00

abstract：:Liver blood flow and hepatic uptake of some indicator substances have been reported to fall with age in both rats and humans. We used an isolated liver system, which was perfused in one pass with hemoglobin free buffer, to investigate the effect of albumin concentration, buffer flow rate, and age upon hepatic clearanc...

journal_title：Canadian journal of physiology and pharmacology

authors： Montgomery PR,Sitar DS

更新日期：1988-05-01 00:00:00

abstract：:Since human thermoregulation at rest is altered by cold exposure, it was hypothesized that physical training under cold conditions would alter thermoregulation. Three groups (n = 8) of male subjects (mean age 24.3 +/- 0.9 years) were evaluated: group T (interval training at 21 degrees C), group CT (interval training a...

journal_title：Canadian journal of physiology and pharmacology

authors： Launay JC,Besnard Y,Guinet A,Hanniquet AM,Bittel J,Savourey G

更新日期：2002-09-01 00:00:00

abstract：:Although amiodarone is a highly efficacious antidysrhythmic agent, the drug produces numerous adverse effects. The most critical of these is pulmonary toxicity because of the potential for mortality. This review examines the experimental model systems used to study amiodarone toxicity, summarizes the current state of ...

journal_title：Canadian journal of physiology and pharmacology

authors： Massey TE,Leeder RG,Rafeiro E,Brien JF

更新日期：1995-12-01 00:00:00

abstract：:Inhibition of prostaglandin synthesis together with vagally mediated peristaltic contractions are essential if mucosal injury is to occur in the stomach of indomethacin-treated rats. The neomycin group of antibiotics has been shown to interfere with acetylcholine release. Agents blocking peristalsis have been demonstr...

journal_title：Canadian journal of physiology and pharmacology

authors： Mersereau WA,Hinchey EJ

更新日期：1989-09-01 00:00:00

abstract：:Prevention and treatment of Alzheimer disease are urgent problems for elderly people in developed countries. We previously reported that nobiletin, a poly-methoxylated flavone from the citrus peel, improved the symptoms in various types of animal models of memory loss and activated the cAMP responsive element (CRE)-de...

journal_title：Canadian journal of physiology and pharmacology

authors： Takito J,Kimura J,Kajima K,Uozumi N,Watanabe M,Yokosuka A,Mimaki Y,Nakamura M,Ohizumi Y

更新日期：2016-07-01 00:00:00

abstract：:Changes in metabolic characteristics of the liver and jejunal epithelia as a result of feeding the beta-agonist albuterol to chickens for 3 and 6 weeks were studied. Feeding albuterol resulted in a change in weights of the liver and small intestines. Chickens fed albuterol for 6 weeks had greater levels of plasma none...

journal_title：Canadian journal of physiology and pharmacology

authors： Rompala RE,Darre MJ

更新日期：1989-05-01 00:00:00

abstract：:Impaired nitric oxide (NO) activity is associated with an increase in blood pressure in rats. Voltage-regulated calcium channels are believed to participate in this hemodynamic event. To further test this hypothesis, we examined the effect of nimodipine and verapamil (calcium antagonists) on the pressor activity of di...

journal_title：Canadian journal of physiology and pharmacology

authors： Rioux F,St-Pierre M,Harvey N,Moisan S,Burhop KE,Drapeau G

更新日期：1998-10-01 00:00:00

abstract：:We characterized the innervation of isolated circular and longitudinal-oriented muscle strips from the nulliparous rabbit uterus and cervix by field stimulation (FS). FS with increasing frequency (2.5-50 pps) and voltage (2.5-70 V) caused graded increases in isometric contraction with no relaxation or inhibition of sp...

journal_title：Canadian journal of physiology and pharmacology

authors： Bulat R,Kannan MS,Garfield RE

更新日期：1989-08-01 00:00:00

abstract：:We used the clearance ratio test to determine whether the presence of albumin enhances the uptake of palmitate by hepatocyte monolayers. If uptake is facilitated, then the ratio of palmitate clearance by hepatocytes in the presence of 600 and 300 microM albumin (i.e., Clt600/Clt300) will exceed the square root of the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Burczynski FJ,Moran JB,Cai ZS

更新日期：1993-12-01 00:00:00

abstract：:Using conventional intracellular microelectrode techniques, the membrane potential (Em) of vascular smooth muscle cells in isolated segments of thoracic rat aorta was measured. The influence of exogenous and of endothelium-derived nitric oxide on the Em was assessed, and the involvement of glibenclamide-sensitive chan...

journal_title：Canadian journal of physiology and pharmacology

authors： Vanheel B,Van de Voorde J

更新日期：1997-12-01 00:00:00

abstract：:The airway smooth muscle from asthmatic airways produces increased amounts and an altered composition of extracellular matrix proteins. The extracellular matrix can in turn influence the phenotype and function of airway smooth muscle cells, affecting the biochemical, geometric, and mechanical properties of the airway ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tran T,Halayko AJ

更新日期：2007-07-01 00:00:00

abstract：:Opioid and N-methyl-d-aspartate (NMDA) receptors mediate different effects of fluoxetine. We investigated whether opioid and NMDA receptors are involved in the protective effect of fluoxetine against the behavioral despair induced by acute physical stress in male mice. We used the forced swimming test (FST), tail susp...

journal_title：Canadian journal of physiology and pharmacology

authors： Haj-Mirzaian A,Kordjazy N,Ostadhadi S,Amiri S,Haj-Mirzaian A,Dehpour A

更新日期：2016-06-01 00:00:00

abstract：:The force generated by tracheal spirals and lung parenchymal strips from normal and ovalbumin-sensitized guinea pigs was measured in vitro, after challenge with histamine, carbachol, leukotriene (LT) C4, LTD4, or a prostaglandin endoperoxide analog (U-44069). The responses and sensitivity of airway tissues to the abov...

journal_title：Canadian journal of physiology and pharmacology

authors： Saad MH,Burka JF

更新日期：1983-08-01 00:00:00

abstract：:Tea is perceived as more relaxing than coffee, even though both contain caffeine. L-theanine in tea may account for the difference. Consumed together, caffeine and theanine exert similar cognitive effects to that of caffeine alone, but exert opposite effects on arousal, in that caffeine accentuates and theanine mitiga...

journal_title：Canadian journal of physiology and pharmacology

authors： Giles GE,Mahoney CR,Brunyé TT,Taylor HA,Kanarek RB

更新日期：2017-01-01 00:00:00

abstract：:Electrical stimulation of the diencephalon and rostral mesencephalon produced a biphasic pressor response consisting of an initial sharp rise followed by a more prolonged elevation in blood pressure. Active sites from which comparable responses could be evoked were found in the ventral medial and lateral hypothalamus,...

journal_title：Canadian journal of physiology and pharmacology

authors： Gauthier P

更新日期：1981-05-01 00:00:00

abstract：:Acrolein, a highly reactive alpha,beta-unsaturated aldehyde, is an omnipresent environmental pollutant. Chronic and acute human exposures occur through exogenous and endogenous sources, including food, vapors of overheated cooking oil, house and forest fires, cigarette smoke, and automobile exhaust. Acrolein is a toxi...

journal_title：Canadian journal of physiology and pharmacology

authors： Roy J,Pallepati P,Bettaieb A,Averill-Bates DA

更新日期：2010-03-01 00:00:00