Abstract:
:Electrical stimulation of the diencephalon and rostral mesencephalon produced a biphasic pressor response consisting of an initial sharp rise followed by a more prolonged elevation in blood pressure. Active sites from which comparable responses could be evoked were found in the ventral medial and lateral hypothalamus, in the region of the parafascicularis nucleus, and in the central gray matter and the tegmentum of the mesencephalon. Together with the biphasic pressor response brain stimulation also increased plasma catecholamine (CA) concentrations 10-fold. Either bilateral adrenalectomy or demedullation selectively abolished the secondary phase of the pressor response and greatly reduced the plasma CA response to stimulation. After chemical destruction of the terminals of the sympathetic neurones by intravenous administration of 6-hydroxydopamine (6-OHDA), the primary pressor phase was eliminated whereas the secondary phase as well as plasma CA concentration reached higher levels than in normal rats. 6-OHDA treatment combined with adrenalectomy completely abolished both pressor and CA responses. The results demonstrate that adrenomedullary mechanisms capable of increasing blood pressure significantly can be activated by electrical stimulation of different sites in the diencephalon and mesencephalon.
journal_name
Can J Physiol Pharmacoljournal_title
Canadian journal of physiology and pharmacologyauthors
Gauthier Pdoi
10.1139/y81-072subject
Has Abstractpub_date
1981-05-01 00:00:00pages
485-92issue
5eissn
0008-4212issn
1205-7541journal_volume
59pub_type
杂志文章abstract::We used the clearance ratio test to determine whether the presence of albumin enhances the uptake of palmitate by hepatocyte monolayers. If uptake is facilitated, then the ratio of palmitate clearance by hepatocytes in the presence of 600 and 300 microM albumin (i.e., Clt600/Clt300) will exceed the square root of the ...
journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y93-130
更新日期:1993-12-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y92-232
更新日期:1992-12-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:1987-05-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/Y09-134
更新日期:2010-03-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:1979-06-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:1988-09-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章,评审
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更新日期:1994-08-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:2012-10-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章,评审
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更新日期:1989-08-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y88-219
更新日期:1988-10-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/cjpp-2017-0171
更新日期:2018-05-01 00:00:00
abstract::To determine whether the renal responses to atrial natriuretic factor (ANF) are altered in the diabetic state, the diuretic and natriuretic responses to ANF (0.25 microgram.kg-1.min-1, i.v.) were measured in streptozotocin (STZ) induced diabetic (DIA) rats. Urine flow and sodium excretion were measured before and afte...
journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y90-060
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pub_type: 杂志文章
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:
更新日期:2001-06-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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更新日期:2002-07-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y85-167
更新日期:1985-08-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y88-005
更新日期:1988-01-01 00:00:00