In vivo interactions between prejunctional alpha 2- and beta 2-adrenoceptors at the level of the adrenal medulla.

abstract：:The effects of magnesium (from 1.2 to 7.2 mM) were investigated in isolated perfused rat heart subjected to coronary artery ligation and reperfusion. Increasing magnesium concentrations, of the medium containing 3.00 mM of calcium, induced a significant bradycardia and a protective effect towards reperfusion arrhythmi...

journal_title：Canadian journal of physiology and pharmacology

authors： Bril A,Rochette L

更新日期：1990-06-01 00:00:00

abstract：:Female rats subjected to 48 h of water deprivation drank more than similarly deprived males. There was no sexual difference in the dipsogenic responses to intracellular dehydration produced by intravenous hypertonic NaCl but females drank considerably more than males in response to the extracellular stimuli of hyperon...

journal_title：Canadian journal of physiology and pharmacology

authors： Kaufman S

更新日期：1980-10-01 00:00:00

abstract：:Immature female quails were treated for 6 days with estradiol benzoate at daily 0.01-, 0.02-, 0.01-, and 1-mg dosages. At the end of treatment, bile outflow, biliary cholesterol (CST), and bile acid (BA) secretory rates and liver, bile, and serum CST and BA levels were determined. Some quails were used to measure the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Laugier C,Pageaux JF,Duperray B,Pacheco H,Brard E

更新日期：1979-04-01 00:00:00

abstract：:A knowledge of the mechanical properties of valve tissue is a necessary prerequisite for a better understanding of valvular behavior and design of prosthetic heart valves. Elastic response of chordae tendineae under strain rates of 0.05 cm min(-1)(6.25% min(-1)) to 12.7 cm min(-1)(1600% min(-1)) were obtained by the a...

journal_title：Canadian journal of physiology and pharmacology

authors： Lim KO,Boughner DR

更新日期：1975-06-01 00:00:00

abstract：:Cardiac adenosine receptors are coupled to adenylate cyclase inhibition. In the guinea pig heart, the relative agonist potencies observed for adenylate cyclase inhibition were R-N6-phenylisopropyladenosine (R-PIA) = N6-cyclohexyladenosine greater than 5'-N-ethylcarboxamidoadenosine much greater than S-PIA. In both atr...

journal_title：Canadian journal of physiology and pharmacology

authors： Leung E,Woodcock EA

更新日期：1986-12-01 00:00:00

abstract：:The precise role of microglia in stroke and cerebral ischemia has been the subject of debate for a number of years. Microglia are capable of synthesizing numerous soluble and membrane-bound biomolecules, some known to be neuroprotective, some neurotoxic, whereas others have less definitive bioactivities. The molecular...

journal_title：Canadian journal of physiology and pharmacology

authors： Lai AY,Todd KG

更新日期：2006-01-01 00:00:00

abstract：:The purpose of this article is to review the current state of knowledge of ethanol neurobehavioural teratogenesis and its postulated mechanisms. The review comprises an examination of ethanol teratogenesis in the human, including the fetal alcohol syndrome, and in experimental animals. Several current proposed mechani...

journal_title：Canadian journal of physiology and pharmacology

authors： Reynolds JD,Brien JF

更新日期：1995-09-01 00:00:00

abstract：:Wave speed (c) must be known to separate forward- and backward-going waves during wave-intensity analysis, which measures the energy transported by the waves in the circulation. c is related to elastance; the present study was performed to measure right ventricular (RV) c during the cardiac cycle and to compare c with...

journal_title：Canadian journal of physiology and pharmacology

authors： Sun Y,Wang JJ,Belenkie I,Tyberg JV

更新日期：2006-08-01 00:00:00

abstract：:Small, sinusoidal length changes were superimposed on isometric contractions of fast- and slow-twitch mouse muscles, which were stimulated maximally via their nerves. Stiffness increased with increasing frequency of sinusoidal stimulation, but the relative time course of force and stiffness changes during twitch, teta...

journal_title：Canadian journal of physiology and pharmacology

authors： Stein RB,Gordon T

更新日期：1986-09-01 00:00:00

abstract：:The rate of glucose oxidation of fresh corneas of guinea pigs at different ages has been determined. Full-thickness corneal discs, 4 mm in diameter, were incubated in radioactive glucose solution. The quantity of the released CO2 was expressed in terms of the corneal discs, their dry weights, and DNA and protein conte...

journal_title：Canadian journal of physiology and pharmacology

authors： Liao HM,Lin BJ,Hasany SM,Basu PK

更新日期：1979-10-01 00:00:00

abstract：:Radiolabelled acetylsalicylic acid (ASA) and salicylic acid (SA) were given intravenously to four near-term ewes and their occurrence in both maternal and fetal plasma was ascertained using a specific thin-layer chromatographic analysis procedure. Findings proved that ASA and SA cross the placental barrier and reach d...

journal_title：Canadian journal of physiology and pharmacology

authors： Thiessen JJ,Salama RB,Coceani F,Olley PM

更新日期：1984-04-01 00:00:00

abstract：:The present study was designed to examine the possible neuroprotective and antiepileptic effects of metformin (Metf) in a rat model of pentylenetetrazole (PTZ)-induced epilepsy and its possible underlying mechanisms. Forty male albino rats were assigned to 4 groups of equal size: (1) normal control (NC) group, (2) Met...

journal_title：Canadian journal of physiology and pharmacology

authors： Hussein AM,Eldosoky M,El-Shafey M,El-Mesery M,Ali AN,Abbas KM,Abulseoud OA

更新日期：2019-01-01 00:00:00

abstract：:Glucosamine sulfate is a dietary supplement that is marketed as a treatment for osteoarthritis. Recent evidence from animal and cell culture models have suggested that glucosamine treatment can promote the misfolding of proteins and the activation of the unfolded protein response (UPR). We investigated whether glucosa...

journal_title：Canadian journal of physiology and pharmacology

authors： McAlpine CS,Beriault DR,Behdinan T,Shi Y,Werstuck GH

更新日期：2014-04-01 00:00:00

abstract：:The present research was to assess the relationship between ABCB1 (G2677T/A, C3435T) polymorphisms and lipid homeostasis as well as risk of liver injury induced by atorvastatin in in-patients from China. The lipid levels (total cholesterol, high-density lipoprotein, triglycerides) as well as metabolic enzymes of hepar...

journal_title：Canadian journal of physiology and pharmacology

authors： Qu KK,Zhang CN,Dong LX,Wang SS,Zhang ZD,Zhang L

更新日期：2020-01-01 00:00:00

abstract：:The aim of the present study was to characterize the effects of pituitary adenylate cyclase activating polypeptide (PACAP) on the endocrine pancreas in anesthetized dogs. PACAP(1-27) and a PACAP receptor (PAC(1)) blocker, PACAP(6-27), were locally administered to the pancreas. PACAP(1-27) (0.005-5 microg) increased ba...

journal_title：Canadian journal of physiology and pharmacology

authors： Yamaguchi N,Minassian TR,Yamaguchi S

更新日期：2003-07-01 00:00:00

abstract：:Several experimental data document an activation of the mitogen-activated protein kinases Erk1 and Erk2 by bradykinin (BK), an agonist of the kinin B2 receptor (B2R). In contrast, other reports showed an inhibitory modulation of mitogenesis by BK. Therefore, we explored in the isolated glomeruli the effect of B2R acti...

journal_title：Canadian journal of physiology and pharmacology

authors： Cellier E,Duchêne J,Pécher C,Alric C,Bascands JL,Schanstra JP,Girolami JP

更新日期：2002-04-01 00:00:00

abstract：:Excitation-contraction coupling in crab muscle fibers was studied in voltage-clamp conditions. Extracellular calcium is essential for the mechanical activity. Two calcium influxes induced by membrane depolarization contribute to tension development: one is the inward calcium current responsible for the phasic tension,...

journal_title：Canadian journal of physiology and pharmacology

authors： Mounier Y,Goblet C

更新日期：1987-04-01 00:00:00

abstract：:Coronary flow was recorded from spontaneously beating isolated perfused hearts of rats and guinea pigs. Arachidonic acid (AA), in single bolus doses, produced a fast short lasting coronary constriction followed by a slow developing but persisting vasodilation. These reactions (biphasic type) were characteristic of the...

journal_title：Canadian journal of physiology and pharmacology

authors： Talesnik J,Tsoporis JN

更新日期：1984-10-01 00:00:00

abstract：:To develop a mathematical model of the distribution and metabolism of rat corticotropin-releasing factor (rCRF), the time course of 125I-labelled rCRF in plasma was measured in male Sprague-Dawley rats (i) following a rapid injection of 24 ng rCRF/100 g body weight (BW), or (ii) following a rapid injection of 424 ng r...

journal_title：Canadian journal of physiology and pharmacology

authors： Candas B,Lalonde J,Normand M

更新日期：1986-06-01 00:00:00

abstract：:The purpose of this study was to examine the effects of norepinephrine infusion alone and during alkalosis on oxygen uptake in the dog gastrocnemius-plantaris muscle group under conditions of constant muscle blood flow. The animals were not cold acclimatized. Blood flow was pump controlled, alkalosis was produced by h...

journal_title：Canadian journal of physiology and pharmacology

authors： Chapler CK,Stainsby WN,Gladden LB

更新日期：1980-01-01 00:00:00

abstract：:D-Serine, a recently identified gliotransmitter, serves as an endogenous coagonist binding to the glycine site of N-methyl-D-aspartate (NMDA) receptors. However, it is not clear whether this native ligand is able to bind to and modulate alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate (AMPA) receptors. In the pre...

journal_title：Canadian journal of physiology and pharmacology

authors： Gong XQ,Zabek RL,Bai D

更新日期：2007-05-01 00:00:00

abstract：:Amiodarone is a new antiarrhythmic drug, commonly coadministered with digoxin in various cardiac disorders. Amiodarone caused a 10-fold increase of serum digoxin in rats, when the two drugs were simultaneously administered. Amiodarone significantly reduced digoxin uptake by renal cortical slices in the rat, and failed...

journal_title：Canadian journal of physiology and pharmacology

authors： Koren G,Soldin S,Macleod SM

更新日期：1983-12-01 00:00:00

abstract：:The isolated brachial spinal cord of the mudpuppy is useful for studies of neural networks underlying forelimb locomotion, but information about its anatomy is scarce. We addressed this issue by combining retrograde labeling with fluorescent tracers and confocal microscopy. Remarkably, the central region of gray matte...

journal_title：Canadian journal of physiology and pharmacology

authors： Jovanovic K,Burke RE

更新日期：2004-08-01 00:00:00

abstract：:The airway smooth muscle from asthmatic airways produces increased amounts and an altered composition of extracellular matrix proteins. The extracellular matrix can in turn influence the phenotype and function of airway smooth muscle cells, affecting the biochemical, geometric, and mechanical properties of the airway ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tran T,Halayko AJ

更新日期：2007-07-01 00:00:00

abstract：:In experiments on isolated guinea pig papillary muscles the effects of verapamil (5 mg/L) and caffeine (1 g/L) on the two-component contraction were investigated. The muscles were continuously superfused with normal Tyrode's solution containing 2 mg of noradrenaline/L at 20--22 degrees C. The first derivative of contr...

journal_title：Canadian journal of physiology and pharmacology

authors： Bogdanov KY,Zakharov SI,Rosenshtraukh LV

更新日期：1979-08-01 00:00:00

abstract：:Over the last 2 decades, mi(cro)RNAs have emerged as one of the key regulators of metabolic homeostasis. Most of the studies have highlighted that, in the cytoplasm, miRNAs directly bind to the 3'-UTR (untranslated region) of a mRNA. Conventional RNA-induced silencing complex (RISC) formation results in the post-trans...

journal_title：Canadian journal of physiology and pharmacology

authors： Baradan R,Hollander JM,Das S

更新日期：2017-10-01 00:00:00

abstract：:Over the past few years, a number of cases of tendon injuries associated with statin therapy have been reported. In this study, we assessed whether statins can affect the extracellular matrix (ECM) of the deep digital flexor tendon (DDFT) and patellar tendon (PT). Wistar rats were assigned to groups treated with atorv...

journal_title：Canadian journal of physiology and pharmacology

authors： Oliveira LP,Vieira CP,Marques PP,Pimentel ER

更新日期：2017-04-01 00:00:00

abstract：:We hypothesized that the respiratory baroreflex in conscious rats is either more transient, or has a higher pressure threshold than in other species. To characterize the effect of arterial pressure changes on respiration in conscious rats, ventilation (V) was measured by the plethysmographic technique during injection...

journal_title：Canadian journal of physiology and pharmacology

authors： Walker JK,Jennings DB

更新日期：1998-07-01 00:00:00

abstract：:To elucidate the involvement of the brain renin-angiotensin system and the brain atrial natriuretic polypeptide (ANP) system in the regulation of ANP secretion from the heart, the effects of intracerebroventricular administration of angiotensin II and ANP on the plasma ANP level were examined in conscious unrestrained...

journal_title：Canadian journal of physiology and pharmacology

authors： Itoh H,Nakao K,Yamada T,Morii N,Shiono S,Sugawara A,Saito Y,Mukoyama M,Arai H,Imura H

更新日期：1988-03-01 00:00:00

abstract：:The ability of the heart to respond to adrenergic stimulation diminishes with aging, and this may be one of the factors contributing to the age-associated decline in cardiac stress responsiveness. On the other hand, little is known about the impact of aging on the responsiveness of the heart to cholinergic stimulation...

journal_title：Canadian journal of physiology and pharmacology

authors： Su N,Narayanan N

更新日期：1992-12-01 00:00:00