A commentary on the interpretation of in vitro biochemical measures of brown adipose tissue thermogenesis.

abstract：:Radiolabelled acetylsalicylic acid (ASA) and salicylic acid (SA) were given intravenously to four near-term ewes and their occurrence in both maternal and fetal plasma was ascertained using a specific thin-layer chromatographic analysis procedure. Findings proved that ASA and SA cross the placental barrier and reach d...

journal_title：Canadian journal of physiology and pharmacology

authors： Thiessen JJ,Salama RB,Coceani F,Olley PM

更新日期：1984-04-01 00:00:00

abstract：:Measurement of volume, pressure, and length were made on eight segments of human cerebral arteries perfused with chymotrypsin (CT) (EC 3.4.21.1) solution (pH = 7.8) for no more than 19 h, and on nine arterial segments perfused with combined enzyme (CT, trypsin (EC 3.4.21.4), elastase (EC 3.4.21.11)) solutions (pH = 7....

journal_title：Canadian journal of physiology and pharmacology

authors： Damude LC,Cope DA,Roach MR

更新日期：1977-04-01 00:00:00

abstract：:A knowledge of the mechanical properties of valve tissue is a necessary prerequisite for a better understanding of valvular behavior and design of prosthetic heart valves. Elastic response of chordae tendineae under strain rates of 0.05 cm min(-1)(6.25% min(-1)) to 12.7 cm min(-1)(1600% min(-1)) were obtained by the a...

journal_title：Canadian journal of physiology and pharmacology

authors： Lim KO,Boughner DR

更新日期：1975-06-01 00:00:00

abstract：:Prevention and treatment of Alzheimer disease are urgent problems for elderly people in developed countries. We previously reported that nobiletin, a poly-methoxylated flavone from the citrus peel, improved the symptoms in various types of animal models of memory loss and activated the cAMP responsive element (CRE)-de...

journal_title：Canadian journal of physiology and pharmacology

authors： Takito J,Kimura J,Kajima K,Uozumi N,Watanabe M,Yokosuka A,Mimaki Y,Nakamura M,Ohizumi Y

更新日期：2016-07-01 00:00:00

abstract：:In male Sprague--Dawley rats, hypertensive development was diminished for 10 weeks when parathyroidectomy (PTX) was performed 1 week before deoxycorticosterone plus saline (DOCA + NaCl) treatment. In young spontaneously hypertensive male rats (SHR, Okamoto strain) parathyroidectomy performed after weaning lessened hyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Gairard A,Berthelot A,Schleiffer R,Pernot F

更新日期：1982-02-01 00:00:00

abstract：:A brief summary is given of some of the key points of the individual contributions at this International Brain Research Organization satellite meeting, presenting up-to-date, expert knowledge of energy metabolism, ionic turnover, and cell swelling at the cellular level of the mammalian central nervous system. On the b...

journal_title：Canadian journal of physiology and pharmacology

authors： Hertz L,Code WE,Sykova E

更新日期：1992-01-01 00:00:00

abstract：:The metabolism of endogenous and exogenous diacylglycerol (DG) was studied in SM-3 cells derived from rabbit aortic smooth muscle to determine the biochemical step(s) responsible for degrading DG second messengers. Incubation of growth-arrested SM-3 cells with [3H]myristate for 2 h resulted in selective labelling of c...

journal_title：Canadian journal of physiology and pharmacology

authors： Migas I,Chuang M,Sasaki Y,Severson DL

更新日期：1997-10-01 00:00:00

abstract：:The whole-cell patch electrode voltage clamp technique was used to study the inactivation properties of the delayed rectifying potassium current of single cultured embryonic chick hepatocytes at 20 degrees C. The potassium current activates maximally within 250-500 ms of membrane depolarization, after which it decays ...

journal_title：Canadian journal of physiology and pharmacology

authors： Hill CE,Shrier A

更新日期：1991-06-01 00:00:00

abstract：:Previous work suggested that sulfhydryl groups and disulfide bridges have important functions in opioid binding to the delta opioid receptor. The question regarding which cysteines are essential for ligand binding was approached by replacement of cysteine residues in the cloned delta opioid receptor using site-directe...

journal_title：Canadian journal of physiology and pharmacology

authors： Ehrlich GK,Andria ML,Zheng X,Kieffer B,Gioannini TL,Hiller JM,Rosenkranz JE,Veksler BM,Zukin RS,Simon EJ

更新日期：1998-03-01 00:00:00

abstract：:The hypocalcaemic action of ethanol (3 g/kg body weight) was investigated in intact, thyroparathyroidectomized and antrectomized rats. It was found that ethanol administered either intraperitoneally or orally reduced plasma calcium concentrations within 30 min and that this response lasted for 8 h. Additional studies ...

journal_title：Canadian journal of physiology and pharmacology

authors： Krishnamra N,Limlomwongse L

更新日期：1983-04-01 00:00:00

abstract：:The pulmonary vascular resistance in a peripheral portion of the pulmonary vascular bed can be determined with a catheter wedged in a peripheral branch of the pulmonary artery, from the pressure increase induced by infusion of mixed venous blood at known flow rates. The volume of the wedged vascular bed can be estimat...

journal_title：Canadian journal of physiology and pharmacology

authors： Chabot F,Saunier C,Schrijen F

更新日期：1997-01-01 00:00:00

abstract：:We tested the effects of inhibiting the carbonic anhydrase activity of rat soleus and extensor digitorum longus muscles on the isometric contractile properties and the resistance to fatigue. SOL and EDL muscles from female rats were incubated in vitro in the presence of methazolamide, a specific inhibitor of carbonic ...

journal_title：Canadian journal of physiology and pharmacology

authors： Côté C,Tremblay D,Riverin H,Frémont P,Rogers PA

更新日期：1989-06-01 00:00:00

abstract：:The intraperitoneal administration of insulin has been recommended because it was found to effectively control the plasma glucose level. Several authors have suggested that intraperitoneal insulin administration may be more "physiological" and therefore preferable because the insulin is absorbed into the portal venous...

journal_title：Canadian journal of physiology and pharmacology

authors： Zingg W,Rappaport AM,Leibel BS

更新日期：1986-03-01 00:00:00

abstract：:The aim of this study was to demonstrate that within a population of healthy men (n = 15) of varying levels of aerobic fitness (VO2max = 36-74 mL.kg-1.min-1), (i) there are high and low responders with respect to carotid-cardiac baroreflex responsiveness, despite similar baseline heart rates (HRs) both at rest and dur...

journal_title：Canadian journal of physiology and pharmacology

authors： Savard GK,Lundie MJ

更新日期：1995-01-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs), including endothelin receptor A (ETA) and B (ETB), may form dimers or higher-order oligomers that profoundly influence signaling. Here we examined a PDZ finger motif within the C-terminus of ETA and its role in heterodimerization with ETB, and in homodimerization with itself, when ...

journal_title：Canadian journal of physiology and pharmacology

authors： Evans NJ,Walker JW

更新日期：2008-08-01 00:00:00

abstract：:Tension responses to ramp shortening of varying speed in whole muscle or single fibres from the plateau of an isometric tetanus, revealed at least two distinct phases. There was a fast initial drop in tension followed by a change of slope and a definite inflexion on the tension record. As the velocity of the imposed l...

journal_title：Canadian journal of physiology and pharmacology

authors： Bressler BH

更新日期：1985-12-01 00:00:00

abstract：:Previous studies have demonstrated that the D-enantiomer of isoidide dinitrate (IIDN) is 10-fold more potent than the L-enantiomer for relaxation and cyclic GMP accumulation in isolated rat aorta. To test whether preferential biotransformation of D-IIDN to a species that activates guanylate cyclase is the basis for th...

journal_title：Canadian journal of physiology and pharmacology

authors： Stewart DH,Hayward LD,Bennett BM

更新日期：1989-11-01 00:00:00

abstract：:Hydroxytyrosol (HT), a phenolic compound in olive oil, exerts an anti-inflammatory effect in cardiovascular diseases. Recent studies found that autophagy was a therapeutic target of diseases. However, the effect of HT on autophagy in vascular adventitial fibroblasts (VAFs) remains unknown. Thus, in this study, we aime...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang W,Jing T,Yang X,He Y,Wang B,Xiao Y,Shang C,Zhang J,Lin R

更新日期：2018-01-01 00:00:00

abstract：:Administration of d-fenfluramine, a serotonin-releasing drug, to male rats induced a dose-dependent increase in both serum prolactin and corticosterone concentrations. Serum growth hormone levels increased, but not significantly, at a dose of 1.25 mg/kg i.p. and decreased significantly at higher doses. When rats were ...

journal_title：Canadian journal of physiology and pharmacology

authors： Serri O,Rasio E

更新日期：1987-12-01 00:00:00

abstract：:Selected topics on the roles of sarcoplasmic reticulum (SR) in the control of vascular smooth muscle (VSM) tone are briefly reviewed with particular reference to the regulation of cytosolic concentration of free calcium ions, [Ca2+]i. Although morphological evidence and subcellular membrane studies indicate a relative...

journal_title：Canadian journal of physiology and pharmacology

authors： Daniel EE,van Breemen C,Schilling WP,Kwan CY

更新日期：1995-05-01 00:00:00

abstract：:The goal of the present study was to assess the effects of a restricted feeding schedule (RFS) on postischemic contractile recovery in relation to triacylglycerol (TAG), glycogen, and ATP content. Glucose-6-phosphate dehydrogenase (G6PDH) activity, reduced/oxidized glutathione ratio (GSH/GSSG), and thiobarbituric acid...

journal_title：Canadian journal of physiology and pharmacology

authors： Jaitovich MM,Varela A,Sbarbati C,Hermann R,Torresín ME,Savino EA,Marina Prendes MG

更新日期：2010-10-01 00:00:00

abstract：:Coronary flow was recorded from spontaneously beating isolated perfused hearts of rats and guinea pigs. Arachidonic acid (AA), in single bolus doses, produced a fast short lasting coronary constriction followed by a slow developing but persisting vasodilation. These reactions (biphasic type) were characteristic of the...

journal_title：Canadian journal of physiology and pharmacology

authors： Talesnik J,Tsoporis JN

更新日期：1984-10-01 00:00:00

abstract：:Pertussis toxin (PTX) is a heterohexameric protein, which is divided into subunits A and B. The A-subunit (protomer) possesses adenine diphosphate (ADP) ribosyltransferase activity, and the B-oligomer confers cell surface binding specificity on the toxin. By virtue of the ADP-ribosylation activity in the A-subunit, PT...

journal_title：Canadian journal of physiology and pharmacology

authors： Wong WS,Rosoff PM

更新日期：1996-05-01 00:00:00

abstract：:Cold ischemia--warm reperfusion (CI/WR) injury of liver transplantation involves hepatocyte cell death, the nature and underlying mechanisms of which remain unclear. Isolated hepatocytes and isolated perfused livers were used to determine the prevalence of necrosis and apoptosis as well as mitochondrial dysfunction. I...

journal_title：Canadian journal of physiology and pharmacology

authors： Duval M,Plin C,Elimadi A,Vallerand D,Tillement JP,Morin D,Haddad PS

更新日期：2006-05-01 00:00:00

abstract：:Salvianolic acid B (Sal B) exerts strong antioxidant activity and eliminates the free radical effect. However, how it affects the antioxidant pathway is not very clear. The objective of this study was to investigate the underlying mechanism of Sal B in CCl4-induced acute liver injury, especially its effect on the Nrf2...

journal_title：Canadian journal of physiology and pharmacology

authors： Jin YM,Tao XM,Shi YN,Lu Y,Mei JY

更新日期：2020-03-01 00:00:00

abstract：:The area postrema (AP) is one of the circumventricular organs of the brain and as such it is highly vascular and lacks the normal blood-brain barrier. Anatomical tracing studies have demonstrated afferent projections to AP originating from the paraventricular nucleus, lateral parabrachial nucleus (l-PBN), nucleus trac...

journal_title：Canadian journal of physiology and pharmacology

authors： Ferguson AV

更新日期：1991-07-01 00:00:00

abstract：:When isolated rat adipocytes were incubated with increasing concentrations of levamisole (0.5-5 mM), basal glucose oxidation decreased by almost 50% and insulin-stimulated glucose oxidation decreased by 90%. The decrease in glucose oxidation correlated with an inhibition of glucose transport, since levamisole at 5.0 m...

journal_title：Canadian journal of physiology and pharmacology

authors： Basi NS,Thomaskutty KG,Pointer RH

更新日期：1992-08-01 00:00:00

abstract：:Malnutrition and inflammation are associated with end-stage renal disease (ESRD). Interleukin (IL)-6 and tumor necrosis factor alpha (TNF-alpha) powerfully predict death from cardiovascular disease. The aim of our study was to establish an association between markers of inflammation and parameters of malnutrition in p...

journal_title：Canadian journal of physiology and pharmacology

authors： Perunicic-Pekovic G,Pljesa S,Rasic-Milutinovic Z,Stankovic S,Ilic M,Maletic R

更新日期：2008-04-01 00:00:00

abstract：:The present study was designed to evaluate the role of endothelial NO in the hemodynamics and vascular changes that occur in heart failure following myocardial infarction in rats. Left ventricular systolic pressure (LVSP), mean blood pressure (MBP), aortic morphology (media thickness) and reactivity were evaluated in ...

journal_title：Canadian journal of physiology and pharmacology

authors： da Cunha V,Stefanon I,Mill JG

更新日期：2004-06-01 00:00:00

abstract：:A hydroperoxide compound structurally related to acetylsalicylic acid, 3-hydroperoxy-3-methylphthalide, inhibits both the first and second phases of adenosine diphosphate induced, biphasic, human platelet aggregation. This occurs over the same concentration range (0.05-0.5 mM) that acetylsalicylic acid inhibits second...

journal_title：Canadian journal of physiology and pharmacology

authors： Killackey JJ,Killackey BA,Cerskus I,Philp RB

更新日期：1984-03-01 00:00:00