The effect of d-fenfluramine on anterior pituitary hormone release in the rat: in vivo and in vitro studies.

abstract：:This report reviews the research and mentoring career of Richard B. Stein (1940-). In 1962, he completed a B.S. degree in physics at the Massachusetts Institute of Technology, USA, and thereafter an M.A. (1964), Ph.D. (1966), and postdoctoral training (1966-68) at the University of Oxford, UK. He subsequently assumed ...

journal_title：Canadian journal of physiology and pharmacology

authors： Stuart DG

更新日期：2004-08-01 00:00:00

abstract：:Modification of the mouse interstitial cell testosterone assay by the addition of 1.5 microM forskolin to the incubation medium has improved the sensitivity of this luteinizing hormone bioassay from approximately 100 to 3 pg/tube of NIH rLH RP-2. Luteinizing hormone can be clearly detected in 1 microL of serum from ra...

journal_title：Canadian journal of physiology and pharmacology

authors： Debertin WJ,Pomerantz DK

更新日期：1992-06-01 00:00:00

abstract：:Over the last 2 decades, mi(cro)RNAs have emerged as one of the key regulators of metabolic homeostasis. Most of the studies have highlighted that, in the cytoplasm, miRNAs directly bind to the 3'-UTR (untranslated region) of a mRNA. Conventional RNA-induced silencing complex (RISC) formation results in the post-trans...

journal_title：Canadian journal of physiology and pharmacology

authors： Baradan R,Hollander JM,Das S

更新日期：2017-10-01 00:00:00

abstract：:Xerostomia is a self-conscious symptom. High-mobility group box 1 (HMGB1) promotes pro-inflammatory effects in many diseases. This study aimed to clarify the role of HMGB1 in Sjögren syndrome (SS)-triggered xerostomia. Nonobese diabetic (NOD)/Ltj mice were used to establish an SS-triggered xerostomia model. The result...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang D,Zhou M,Wang Y,Sun S

更新日期：2020-06-01 00:00:00

abstract：:Administration of naloxone to morphine-dependent rats results in an elevation of tail skin temperature and a fall in core temperature. Previous studies have demonstrated a role of the adrenal gland in the thermal responses that accompany morphine withdrawal in the rat. In the present study, experiments were designed t...

journal_title：Canadian journal of physiology and pharmacology

authors： Katovich MJ,Pitman D,Schechtman O

更新日期：1992-08-01 00:00:00

abstract：:Curare action on nicotinic acetylcholine receptors has a number of facets, of which the best known is competitive antagonism. Here we describe the weak agonist action of 10(-5) M curare on the murine skeletal muscle cell line, G8. Although curare induces no depolarization in G8 cells, single-channel recordings reveal ...

journal_title：Canadian journal of physiology and pharmacology

authors： Morris CE,Montpetit MR,Sigurdson WJ,Iwasa K

更新日期：1989-02-01 00:00:00

abstract：:We tested the hypothesis that ethanol consumption would aggravate the renal damage induced by cyclophosphamide (CYP). Male C57BL/6J mice from control (n=8) and CYP (n=12) groups had free access to filtered water and standard rodent chow for 12 weeks. Then, 24 h before euthanasia mice received an intraperitoneal inject...

journal_title：Canadian journal of physiology and pharmacology

authors： Sousa AH,Do Vale GT,Silva CB,Awata WM,Pinheiro LC,Tirapelli CR

更新日期：2020-11-11 00:00:00

abstract：:Newborn hearts have restricted functional reserve and variable responsiveness to inotropes that could be partly due to differences in myocardial beta-adrenoceptors (beta-AR). To clarify this issue, this study documented ventricle-specific changes in myocardial beta-AR density and affinity during postnatal maturation. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wittnich C,Belanger MP,Bandali K

更新日期：2006-08-01 00:00:00

abstract：:The effect of varying dietary levels of zinc was evaluated in mice fed T-2 toxin. A semipurified diet was used to produce a low zinc (less than 2 parts per million (ppm], a zinc replete (100 ppm), and a high zinc (2500 ppm) diet. T-2 toxin was added to the three zinc diets at a concentration of 10 ppm. The mice were f...

journal_title：Canadian journal of physiology and pharmacology

authors： Chanin BE,Hamilton DL,Hancock DS,Schiefer HB

更新日期：1984-10-01 00:00:00

abstract：:The effect of chronic consumption of diets containing either different sources of dietary fibre (8% guar, 8% pectin, or 8% multifibre) or low carbohydrate upon carbohydrate tolerance was examined in rats. Weight gain was significantly lower throughout the entire 28-day study period with the guar group and after 20 day...

journal_title：Canadian journal of physiology and pharmacology

authors： Track NS,Cannon MM,Flenniken A,Katamay S,Woods EF

更新日期：1982-06-01 00:00:00

abstract：:The bioavailabilities of aspirin (acetylsalicylic acid) and of salicylic acid were studied in male Wistar rats after acute and chronic administration of a Capsicum annuum extract, containing 100 mg of capsaicin per gram. With a single administration of 100 mg/kg of the extract, aspirin blood levels remained unchanged,...

journal_title：Canadian journal of physiology and pharmacology

authors： Cruz L,Castañeda-Hernández G,Navarrete A

更新日期：1999-06-01 00:00:00

abstract：:Using radioligand binding techniques, the effect of reserpine pretreatment on ventricular adrenergic receptors from guinea pig was studied. [3H]Prazosin and [3H]dihydroalprenolol were used to label alpha 1- and beta-adrenergic receptors, respectively. Administration of 2.5 mg/kg reserpine for 2 days caused a significa...

journal_title：Canadian journal of physiology and pharmacology

authors： Latifpour J,McNeill JH

更新日期：1984-01-01 00:00:00

abstract：:The long noncoding RNA (lncRNA) GAS5 has been found to act as a decoy for the glucocorticoid receptor (GR), thus implicating GAS5 as a potential regulator of glucocorticoid sensitivity and resistance. Airway smooth muscle (ASM) cells and airway epithelial cells (AEC) play an important role in the pathogenesis and pers...

journal_title：Canadian journal of physiology and pharmacology

authors： Keenan CR,Schuliga MJ,Stewart AG

更新日期：2015-03-01 00:00:00

abstract：:There is now evidence for the involvement of four beta-adrenoceptor populations in the regulation of cardiac function by catecholamines. Beta1- and beta2-adrenoceptor stimulation classically produces an increase in contractility. A fourth beta-adrenoceptor, as yet uncloned and designated provisionally as a beta4-adren...

journal_title：Canadian journal of physiology and pharmacology

authors： Gauthier C,Leblais V,Moniotte S,Langin D,Balligand JL

更新日期：2000-09-01 00:00:00

abstract：:MicroRNA-146a (miR-146a) is reportedly implicated in the pathogenesis of ischemia-reperfusion (I/R) injury; however, its role in cerebral I/R injury is unclear and requires further investigation. In this study, cerebral I/R injury was established in mice via middle cerebral artery occlusion, and the expression of miR-...

journal_title：Canadian journal of physiology and pharmacology

authors： Chu B,Zhou Y,Zhai H,Li L,Sun L,Li Y

更新日期：2018-06-01 00:00:00

abstract：:Investigation of the relationship of diet to blood lipids and atherosclerosis has dominated the field of lipid nutritional biochemistry for the past 25 years. Although this subject has consumed considerable time, effort, and research funds, it has also proved beneficial to other areas of lipid biochemistry by attracti...

journal_title：Canadian journal of physiology and pharmacology

authors： Walker BL

更新日期：1983-03-01 00:00:00

abstract：:Longitudinal muscle of myometrial tissues from immature rats were examined by quantitative thin section electron microscopy for the presence of gap junctions after treatment with estradiol with and without tamoxifen, and cycloheximide for 1-6 days. Gap junctions were present between myometrial cells on days 4, 5, and ...

journal_title：Canadian journal of physiology and pharmacology

authors： MacKenzie LW,Garfield RE

更新日期：1986-06-01 00:00:00

abstract：:The potential of nickel chloride to prevent streptozotocin-induced hyperglycemia was tested in rats in vivo. To induce diabetes, streptozotocin (100 mg/kg body weight) was injected as a single dose. Streptozotocin treatment resulted in a significant decrease in plasma insulin and ceruloplasmin, and pancreatic Cu, prot...

journal_title：Canadian journal of physiology and pharmacology

authors： Novelli EL,Rodrigues NL,Ribas BO

更新日期：1988-05-01 00:00:00

abstract：:Previous studies have demonstrated that abdominal irradiation alters intestinal uptake of nutrients. The purpose of this study was to determine the effect of an orally administered synthetic prostaglandin E2, enprostil, given on three occasions shortly prior to a single exposure to 600 cGy external abdominal irradiati...

journal_title：Canadian journal of physiology and pharmacology

authors： Thomson AB,Keelan M,Clandinin MT,Tavernini M,Lam T,Walker K,Cheeseman CI

更新日期：1989-10-01 00:00:00

abstract：:Although amiodarone is a highly efficacious antidysrhythmic agent, the drug produces numerous adverse effects. The most critical of these is pulmonary toxicity because of the potential for mortality. This review examines the experimental model systems used to study amiodarone toxicity, summarizes the current state of ...

journal_title：Canadian journal of physiology and pharmacology

authors： Massey TE,Leeder RG,Rafeiro E,Brien JF

更新日期：1995-12-01 00:00:00

abstract：:This study was designed to determine if tonic beta-adrenergic control of plasma renin activity (PRA) during dietary sodium restriction is due to stimulation of renal beta-adrenoceptors, extrarenal beta-adrenoceptors, or both. Experiments were performed in six conscious resting uninephrectomized dogs with chronically i...

journal_title：Canadian journal of physiology and pharmacology

authors： Blair ML,Gengo FM

更新日期：1995-08-01 00:00:00

abstract：:In recent decades, the complexity of the endothelium and its major role in maintaining or altering blood vessel architecture are being revealed. In contrast, the vascular smooth muscle cell previously received the most attention. I suggest support of the hypothesis that the endothelium is the key to vascular disease. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Todd ME

更新日期：1992-04-01 00:00:00

abstract：:The effect of high potassium depolarization on the release of exogenously supplied [3H]glutamate and endogenous glutamate from tissue slices of the cestode Hymenolepis diminuta was examined. Increasing concentrations of potassium stimulated the release of radiolabel from tissues preloaded with [3H]glutamate. This rele...

journal_title：Canadian journal of physiology and pharmacology

authors： Webb RA

更新日期：1988-07-01 00:00:00

abstract：:The sodium-hydrogen exchanger (NHE) helps the cell to recover from intracellular acidosis. In this study, we have investigated the effect of HOE 642 (a specific NHE1 blocker) on papillary muscles from rats and guinea pigs during transient acidosis and PKC activation by recording developed force (DF), action potential ...

journal_title：Canadian journal of physiology and pharmacology

authors： Sundset R,Bertelsen G,Ytrehus K

更新日期：2003-10-01 00:00:00

abstract：:The influence of a program of high intensity training and of a combined program of high intensity training and prolonged submaximal training on adaptations to the vastus lateralis muscle was investigated in two groups of elite athletes. The high intensity training (H) consisted of ice hockey practices and games over a...

journal_title：Canadian journal of physiology and pharmacology

authors： Daub WD,Green HJ,Houston ME,Thomson JA,Fraser IG,Ranney DA

更新日期：1982-05-01 00:00:00

abstract：:We studied the effects of Zn2+ and Cd2+ on the behaviour of IK(f), a transient outward potassium current in acutely dissociated melanotrophs of the pars intermedia of the rat pituitary gland. Micromolar concentrations of external Cd2+ or Zn2+ caused parallel and nearly equal rightward shifts along the voltage axis of ...

journal_title：Canadian journal of physiology and pharmacology

authors： Davidson JL,Kehl SJ

更新日期：1995-01-01 00:00:00

abstract：:A significant relationship was observed between myocardial oxygen extraction and the extravascular mean time transit time. This relationship implies that oxygen extraction by the myocardium is a time-dependent process, and emphasizes the critical link between blood flow and myocardial oxygen consumption. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Mildenberger RR,L'Abbate A,Zborowska-Sluis DT,Klassen GA

更新日期：1977-06-01 00:00:00

abstract：:The enhancement of the response of an isolated strip of lactating mouse mammary gland to oxytocin, resulting from dilution of the Tyrode solution in which oxytocin is administered, is due to the effects of hypotonicity per se and not to changes in concentration of any of the ions in the bathing solution. Inhibition of...

journal_title：Canadian journal of physiology and pharmacology

authors： Ferrier BM

更新日期：1979-03-01 00:00:00

abstract：:The intestinal uptake of 0.5 and 40 mM glucose, galactose, and 3-O-methyl glucose (3-O-MG) was examined in vitro in rabbits fed a high (HS) or a low (LS) sucrose diet. In animals with an intact intestinal tract, the jejunal uptake of 0.5 mM 3-O-MG was unaffected by the dietary content of sucrose, whereas the uptake of...

journal_title：Canadian journal of physiology and pharmacology

authors： Thomson AB

更新日期：1987-11-01 00:00:00

abstract：:Radioactively labelled microspheres (15 micron diameter) were used to measure cardiac output (CO) distribution and blood flows in spleen, kidneys, and skeletal muscle before and after normovolemic anemia or polycythemia in anesthetized rats. Hematocrits were changed from 45 to 33% or from 45 to 59% by an exchange tran...

journal_title：Canadian journal of physiology and pharmacology

authors： Ackermann U,Veress AT

更新日期：1980-04-01 00:00:00