Improved sensitivity of the mouse interstitial cell testosterone assay with the addition of forskolin.

abstract：:The major functional alpha1-adrenoceptor in the rat aorta is of the alpha1Dsubtype and that in the caudal artery is of the alpha1A subtype. In the present study, the participation of protein kinase C (PKC) and Rho kinase (RhoK) in contractile responses to stimulation of the alpha1-adrenoceptors in these two arteries w...

journal_title：Canadian journal of physiology and pharmacology

authors： Mueed I,Bains P,Zhang L,Macleod KM

更新日期：2004-10-01 00:00:00

abstract：:Immunocytochemistry, radioimmunoassay, chromatography, and biological assay using a rabbit isolated duodenal muscle strip preparation were used in attempting to characterize motilin from the rat small intestine. Several different antisera and monoclonal antibodies directed against natural porcine motilin were used. A ...

journal_title：Canadian journal of physiology and pharmacology

authors： Vogel LB,Brown JC

更新日期：1990-08-01 00:00:00

abstract：:Beneficial effects of an antioxidant (N-acetyl-L-cysteine, NAC) and an angiotensin I-converting enzyme (ACE) inhibitor (ramipril) were assessed in a rat model of insulin resistance induced by 10% glucose feeding for 20 weeks. Treatments with NAC (2 g/kg per day) and ramipril (1 mg/kg per day) were initiated at 16 week...

journal_title：Canadian journal of physiology and pharmacology

authors： El Midaoui A,Ismael MA,Lu H,Fantus IG,de Champlain J,Couture R

更新日期：2008-11-01 00:00:00

abstract：:The developing heart forms during the early stages of embryogenesis, and misregulated heart development results in congenital heart defects (CHDs). To understand the molecular basis of CHDs, a deep understanding of the morphological and genetic basis of heart development is necessary. Atrial Natriuretic Factor (ANF) i...

journal_title：Canadian journal of physiology and pharmacology

authors： Bruneau BG

更新日期：2011-08-01 00:00:00

abstract：:We investigated the influence of four different culture media: 20% fetal bovine serum (FBS), 5% FBS, 5% FBS supplemented with 10 mg x L(-1) linoleic acid (18:2(n-6)) or alpha-linolenic acid (18:3(n-3)) on alpha-linolenic acid apical uptake in clone TC7 of human intestinal Caco-2 cell line. Neither cellular viability n...

journal_title：Canadian journal of physiology and pharmacology

authors： Tranchant T,Besson P,Hoinard C,Pinault M,Alessandri JM,Delarue J,Couet C,Goré J

更新日期：1998-06-01 00:00:00

abstract：:Aortas were removed from six mature lambs and four sheep and pressure fixed at 100 and 120 mmHg pressure (1 mmHg = 133.322 Pa), respectively, in 10% buffered formalin. The numbers of elastin layers were counted from cross sections at different distances down the aorta, from the distal arch to the iliac bifurcation, an...

journal_title：Canadian journal of physiology and pharmacology

authors： van Baardwijk C,Roach MR

更新日期：1983-02-01 00:00:00

abstract：:The present study was conducted to evaluate the local antinociceptive actions of fluoxetine, a selective serotonin reuptake inhibitor, and the possible involvement of the l-arginine/NO/cGMP/KATP channel pathway in this effect using the formalin test in rats. To elucidate the underlying mechanisms, animals were pre-tre...

journal_title：Canadian journal of physiology and pharmacology

authors： Ghorbanzadeh B,Mansouri MT,Naghizadeh B,Alboghobeish S

更新日期：2018-02-01 00:00:00

abstract：:Endothelin 1 (ET-1) is a potent vasoconstrictor implicated in the control of blood pressure and renal function. Its effects can be modulated by nitric oxide (NO), which inhibits ET-1 production and action. Recently, we reported that ET-1 production can also be modulated by angiotensin II (AngII) in vivo. To investigat...

journal_title：Canadian journal of physiology and pharmacology

authors： D'Amours M,Lebel M,Grose JH,Larivière R

更新日期：1999-01-01 00:00:00

abstract：:The effects of haloperidol, an antipsychotic butyrophenone, on excitability and action potential production in frog's sartorius muscle fibers were studied. This drug produced a local-anestheticlike effect which developed slowly over 1 to 5 h with lower concentrations (2.7 to 5.3 X 10(-6 M) but was completely reversed ...

journal_title：Canadian journal of physiology and pharmacology

authors： Durham HD,Frank GB,Marwaha J

更新日期：1977-06-01 00:00:00

abstract：:The effects of localized distension of the pulmonary vein - left atrial junctions on plasma arginine vasopressin (AVP) have been examined in chloralose anaesthetized dogs. Pulmonary vein distension caused an increase in heart rate and a decrease in plasma AVP concentration. Cooling the vagosympathetic nerves to 10 deg...

journal_title：Canadian journal of physiology and pharmacology

authors： Wilson N,Ledsome JR

更新日期：1983-08-01 00:00:00

abstract：:The goal of the present study was to assess the effects of a restricted feeding schedule (RFS) on postischemic contractile recovery in relation to triacylglycerol (TAG), glycogen, and ATP content. Glucose-6-phosphate dehydrogenase (G6PDH) activity, reduced/oxidized glutathione ratio (GSH/GSSG), and thiobarbituric acid...

journal_title：Canadian journal of physiology and pharmacology

authors： Jaitovich MM,Varela A,Sbarbati C,Hermann R,Torresín ME,Savino EA,Marina Prendes MG

更新日期：2010-10-01 00:00:00

abstract：:Pathogenic mechanisms for essential hypertension are unclear despite striking efforts from numerous research teams over several decades. Increased production of reactive oxygen species (ROS) has been associated with the development of hypertension and the role of ROS in hypertension has been well documented in recent ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chang T,Wu L

更新日期：2006-12-01 00:00:00

abstract：:Isoprenaline and forskolin both inhibit contractions induced by antigen or by the calcium ionophore A23187 of guinea pig tracheal spirals and parenchymal strips. Antigen-induced airway contraction is considerably more sensitive to the inhibitory effects of isoprenaline than is A23187-induced contraction. In contrast, ...

journal_title：Canadian journal of physiology and pharmacology

authors： Burka JF

更新日期：1983-06-01 00:00:00

abstract：:The Na+/H+ exchanger isoform 1 is an integral membrane protein that regulates intracellular pH. It extrudes 1 intracellular H+ in exchange for 1 extracellular Na+. It has 2 large domains, an N-terminal membrane domain of 12 transmembrane segments and an intracellular C-terminal regulatory domain. We characterized the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Ding J,Ng RW,Fliegel L

更新日期：2007-03-01 00:00:00

abstract：:Normal mammalian sexual maturation and reproductive functions require the integration and precise coordination of hormones at the hypothalamic, pituitary, and gonadal levels. Hypothalamic gonadotropin-releasing hormone (GnRH) is a key regulator in this system; after binding to its receptor (GnRHR), it stimulates de no...

journal_title：Canadian journal of physiology and pharmacology

authors： Cheng KW,Leung PC

更新日期：2000-12-01 00:00:00

abstract：:Geraniol, a plant-derived monoterpene, has been extensively studied and showed a wide variety of beneficial effects. The aim of this study was to investigate the therapeutic effect of geraniol on functional recovery and neuropathic pain in rats with spinal cord injury (SCI). Rats received a clip-compression SCI and we...

journal_title：Canadian journal of physiology and pharmacology

authors： Lv Y,Zhang L,Li N,Mai N,Zhang Y,Pan S

更新日期：2017-12-01 00:00:00

abstract：:The intramuscular injection of aminooxyacetic acid (AOAA) into mice elevated the concentration of gamma-aminobutyric acid (GABA) in the brain, inhibited glutamic acid decarboxylase activity and delayed the onset of isonicotinic acid hydrazide induced seizures. Analyses of these results and of those obtained previously...

journal_title：Canadian journal of physiology and pharmacology

authors： Wood JD,Peesker SJ

更新日期：1976-08-01 00:00:00

abstract：:We studied the role of enteric opioid neurons in the spontaneous motility of the longitudinal muscle in the isolated puppy ileum. Regular fluctuations in tone that rose above and returned to the basal level occurred at an interval of 4.7 +/- 0.3 min. Naloxone (10(-8) and 10(-7) M) reduced the spontaneous tonic contrac...

journal_title：Canadian journal of physiology and pharmacology

authors： Neya T,Mizutani M,Nakayama S

更新日期：1987-09-01 00:00:00

abstract：:To determine the effects of chronic hyperinsulinemia on glucagon release, rats were made hyperinsulinemic for 14 days by supplementation of drinking water with sucrose (10%; sucrose-fed) to increase endogenous release or by implantation of osmotic minipumps (subcutaneous, s.c.; or intraperitoneal, i.p.) to deliver exo...

journal_title：Canadian journal of physiology and pharmacology

authors： Brubaker PL,Kazumi T,Hirano T,Vranic M,Steiner G

更新日期：1991-03-01 00:00:00

abstract：:The main factors of myocardial ischemia are hypoxia, substrate deprivation, acidosis, and high extracellular potassium concentration ([K+]e), but the influence of each of these factors has not yet been evaluated in a cardiomyocyte (CM) culture system. Electromechanical responses to the individual and combined componen...

journal_title：Canadian journal of physiology and pharmacology

authors： Tissier C,Bes S,Vandroux D,Fantini E,Rochette L,Athias P

更新日期：2002-12-01 00:00:00

abstract：:The effect of chlorpromazine on subcellular biosynthesis, hydrolysis, and transfer of lipids and liponucleotides participating in the biosynthesis of polyglycerophosphatides in guinea pig liver was studied. Chlorpromazine showed an apparent stimulation of accumulation of phosphatidic acid and CDP-diglycerides in micro...

journal_title：Canadian journal of physiology and pharmacology

authors： Stuhne-Sekalec L,Chudzik J,Stanacev NZ

更新日期：1987-03-01 00:00:00

abstract：:The binding of 125I-labelled human chorionic gonadotropin (HCG) was studied using thick slices (300 micron) of rabbit ovarian tissue. Binding was saturable, reversible, stereospecific, and of high affinity. The amount of binding was proportional to the number of slices used and could be destroyed by boiling. Ovarian s...

journal_title：Canadian journal of physiology and pharmacology

authors： YoungLai EV,Wilkinson M,Hibbert P,McMahon A,Jarrell JF

更新日期：1988-04-01 00:00:00

abstract：:The contractile recoverability of isolated portal veins made hypodynamic by removal of glucose from the perfusion medium by diverse exogenous substrates was studied. It was found that glucose, mannose, pyruvate, lactate, acetate, and butyrate readily restored contraction. The effects of anoxia and metabolic inhibitors...

journal_title：Canadian journal of physiology and pharmacology

authors： Cremer-Lacuara MG,Lacuara JL,Fiol de Cuneo M,Ruiz RD

更新日期：1980-06-01 00:00:00

abstract：:The effects of atorvastatin and carboxymethylated β-glucan (CMG) on the lipoprotein-cholesterol (LP-C) and lipoprotein-triglyceride (LP-TG) fractions and subfractions at the early stage of murine hyperlipidemia, and its pleiotropic anti-inflammatory effects, were studied. Atorvastatin and CMG were administered in ICR ...

journal_title：Canadian journal of physiology and pharmacology

authors： Korolenko TA,Tuzikov FV,Cherkanova MS,Johnston TP,Tuzikova NA,Loginova VM,Filjushina EE,Kaledin VI

更新日期：2012-02-01 00:00:00

abstract：:Induced ketosis may acutely prolong hypoxic tolerance by altering glucose and (or) beta-hydroxybutyrate extraction by the brain. Anesthetized dogs were ventilated and instrumental for arterial and cerebral venous blood sampling, taken during baseline, infusion, test, and recovery periods. Each dog received one of four...

journal_title：Canadian journal of physiology and pharmacology

authors： Chang AS,D'Alecy LG

更新日期：1993-07-01 00:00:00

abstract：:The distribution of atrial natriuretic factor (ANF) binding sites in Wistar rat tissues, as well as tissues from other species was studied. Using autoradiography of slide mounted tissue sections incubated with 125I-labelled ANF, high densities of binding sites were found in the renal glomeruli and papilla, aortic smoo...

journal_title：Canadian journal of physiology and pharmacology

authors： von Schroeder HP,Nishimura E,McIntosh CH,Buchan AM,Wilson N,Ledsome JR

更新日期：1985-11-01 00:00:00

abstract：:We studied the effects of Zn2+ and Cd2+ on the behaviour of IK(f), a transient outward potassium current in acutely dissociated melanotrophs of the pars intermedia of the rat pituitary gland. Micromolar concentrations of external Cd2+ or Zn2+ caused parallel and nearly equal rightward shifts along the voltage axis of ...

journal_title：Canadian journal of physiology and pharmacology

authors： Davidson JL,Kehl SJ

更新日期：1995-01-01 00:00:00

abstract：:In embryonic chick hearts during development, there are three inward current systems which are involved in the rising phases of the action potentials (APs): fast INa, slow ICa, and tetrodotoxin-insensitive slow INa. To assess reactivation processes for these three types of inward current channels (fast Na+, slow Ca2+,...

journal_title：Canadian journal of physiology and pharmacology

authors： Sada H,Sada S,Sperelakis N

更新日期：1986-02-01 00:00:00

abstract：:The recognition of chylomicrons as dietary lipid transporters dates back to more than 70 years and marks a milestone in lipoprotein history. Conventionally, three phases constitute the process of absorption of exogenous fat: intraluminal, intestinal, and delivery. The intraluminal phase includes chemical hydrolysis by...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy E

更新日期：1992-04-01 00:00:00

abstract：:The purpose of the present investigation was to determine the nature of the functional interaction of muscarinic agonists with cAMP-generating and cAMP-independent agonists in left atria. Negative inotropic responses of rabbit isolated left atrial strips to the muscarinic agonist carbachol were measured in the absence...

journal_title：Canadian journal of physiology and pharmacology

authors： MacLeod KM

更新日期：1986-05-01 00:00:00