The relationship between oxygen extraction and extravascular mean transit time in the canine heart.

abstract：:The present study focused on the interactive pain regulation of endokinin A/B (EKA/B, the common C-terminal decapeptide in EKA and EKB) or endokinin C/D (EKC/D, the common C-terminal duodecapeptide in EKC and EKD) on chimeric peptide MCRT (YPFPFRTic-NH2, based on YPFP-NH2 and PFRTic-NH2) at the supraspinal level in mi...

journal_title：Canadian journal of physiology and pharmacology

authors： He C,Gong J,Yang L,Zhang H,Dong S,Zhou L

更新日期：2016-09-01 00:00:00

abstract：:Steady state glucose kinetics were measured in 19 premature and 16 full-term piglets. Bodyweight, plasma glucose concentration, total body glucose turnover rate, and glucose pool size were not significantly different between the two groups. This suggests that the premature piglet is capable of maintaining glucose home...

journal_title：Canadian journal of physiology and pharmacology

authors： Flecknell PA,Wootton R,John M,Royston JP

更新日期：1981-10-01 00:00:00

abstract：:Two natriuretic peptides, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), are found principally in the heart. In preliminary experiments with mouse kidney cells or slices, we found mouse BNP1-45 much more potent than ANP1-28 in causing elevations of cGMP (>50-fold). The guanylyl cyclase-A (GC-A)...

journal_title：Canadian journal of physiology and pharmacology

authors： Kishimoto I,Hamra FK,Garbers DL

更新日期：2001-08-01 00:00:00

abstract：:Chronically elevated plasma norepinephrine has the potential for supporting function of diseased hearts, yet may also initiate harmful biochemical and (or) structural changes in the myocardium. The present study investigated the dosage-related effects of chronic norepinephrine infusion on markers of myocardial damage ...

journal_title：Canadian journal of physiology and pharmacology

authors： Siri FM,Smith RM

更新日期：1986-07-01 00:00:00

abstract：:The influence of external potassium Ko and tetraethylammonium on the cellular K content of hypoxic myocardium was investigated. Perfused rabbit hearts were submitted to 60 min hypoxia in medium containing 5 mM K throughout or either low (1.5 mM) or high (10 mM) K during the last 20 min of hypoxia. Paced electrical act...

journal_title：Canadian journal of physiology and pharmacology

authors： Leblanc N,Ruiz-Ceretti E,Chartier D

更新日期：1987-05-01 00:00:00

abstract：:Altered sympathetic nervous activity has been linked to the development and persistence of obesity, partly relating to overfeeding. Binding of the selective, positron-emitting phosphodiesterase-4 (PDE4) inhibitor (R)-[11C]rolipram provides a direct index of the cAMP-hydrolyzing enzyme PDE4. This study examines progres...

journal_title：Canadian journal of physiology and pharmacology

authors： Greene M,Thackeray JT,Kenk M,Thorn SL,Bevilacqua L,Harper ME,Beanlands RS,Dasilva JN

更新日期：2009-03-01 00:00:00

abstract：:Methimazole was previously shown to protect rats, mice, and (or) dogs against cisplatin-, cephaloridine-, 2-bromohydro-quinone-, and S-(1,2-dichlorovinyl)-L-cysteine-induced nephrotoxicity. In this study, methimazole effects on gentamicin (GM) induced nephrotoxicity were examined. Rats given GM (40 mg/kg) twice daily ...

journal_title：Canadian journal of physiology and pharmacology

authors： Elfarra AA,Duescher RJ,Sausen PJ,O'Hara TM,Cooley AJ

更新日期：1994-10-01 00:00:00

abstract：:New methods for chronic instrumentation of the newborn piglet are described, which allow continuous monitoring of not only pressures in the pulmonary artery and aorta but also in the left and right atria, pulmonary vein, as well as main branch pulmonary artery flows. Changes in pulmonary vascular tone to short-acting ...

journal_title：Canadian journal of physiology and pharmacology

authors： Coe JY,Olley PM,Hamilton F,Vanhelder T,Coceani F

更新日期：1987-05-01 00:00:00

abstract：:Glycine has been used to reduce oxidative stress and proinflammatory mediators in some metabolic disorders; however, its effect on the vasculature has been poorly studied. The aim of this work was to explore the effect of glycine on endothelial dysfunction in aged rats. Aortic rings with intact or denuded endothelium ...

journal_title：Canadian journal of physiology and pharmacology

authors： Gómez-Zamudio JH,García-Macedo R,Lázaro-Suárez M,Ibarra-Barajas M,Kumate J,Cruz M

更新日期：2015-06-01 00:00:00

abstract：:MicroRNA-146a (miR-146a) is reportedly implicated in the pathogenesis of ischemia-reperfusion (I/R) injury; however, its role in cerebral I/R injury is unclear and requires further investigation. In this study, cerebral I/R injury was established in mice via middle cerebral artery occlusion, and the expression of miR-...

journal_title：Canadian journal of physiology and pharmacology

authors： Chu B,Zhou Y,Zhai H,Li L,Sun L,Li Y

更新日期：2018-06-01 00:00:00

abstract：:In open-chest pentothal-chloralose anesthetized dogs, plasma catecholamine and cyclic AMP levels were evaluated in the aortic and coronary sinus blood, during stimulations of the left ansa subclavia (1, 2, and 4 Hz). Basal aortic and coronary sinus catecholamine levels were respectively 0.373 +/- 0.090 and 0.259 +/- 0...

journal_title：Canadian journal of physiology and pharmacology

authors： Lavallée M,Laurencin C,de Champlain J,Nadeau RA

更新日期：1981-06-01 00:00:00

abstract：:A single-dose administration of 6-hydroxydopamine (50 mg/kg body weight, sc) to infant rats resulted in an enlargement, higher fresh weight, markedly elevated lipid content, and higher total protein content of their interscapular and cervical brown adipose tissue. The protein kinase (EC 2.7.1.37) activation ratio in t...

journal_title：Canadian journal of physiology and pharmacology

authors： Skala JP,Hahn P

更新日期：1977-04-01 00:00:00

abstract：:Thermal resistance as determined by survival time was examined in different age groups of spontaneously hypertensive (SHR) rats during terminal heating. A comparison with age or weight matched controls indicated that the thermal resistance of SHR animals was markedly inferior to that of normotensive animals as evidenc...

journal_title：Canadian journal of physiology and pharmacology

authors： Wright G,Iams S,Knecht E

更新日期：1977-10-01 00:00:00

abstract：:To assess the physiological and clinical implications of the C-type natriuretic peptide (CNP)/guanylyl cyclase B (GC-B) system in the human vasculature, we have examined gene expressions of CNP and its receptor, GC-B, in human vascular endothelial cells (ECs) and smooth muscle cells (SMCs) and have also compared the e...

journal_title：Canadian journal of physiology and pharmacology

authors： Taura D,Nakao K,Nakagawa Y,Kinoshita H,Sone M,Nakao K

更新日期：2020-09-01 00:00:00

abstract：:Hormonal replacement therapy (HRT) has failed to provide a cardioprotective action in postmenopausal women, and thus alternative pharmacological approaches are required. The present study examined the therapeutic potential of the partial estrogen receptor agonist tamoxifen and the angiotensin II type-1 receptor antago...

journal_title：Canadian journal of physiology and pharmacology

authors： Pham-Dang ML,Clement R,Mercier I,Calderone A

更新日期：2003-09-01 00:00:00

abstract：:Alterations in calcium metabolism and calcium-regulating hormones have been described in essential hypertension. However, the mechanisms that mediate these responses are unknown. In previous studies, using the genetically spontaneously hypertensive rat and the mineralocorticoid-salt (DOC-salt) hypertensive rat model, ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wimalawansa SJ,Supowit SC,DiPette DJ

更新日期：1995-07-01 00:00:00

abstract：:A single-compartment model used in this laboratory for continuously calculating ACTH secretion rates from measured plasma ACTH concentrations has been tested for its ability to follow changing rates of ACTH entry (rapid departure from steady state). ACTH was infused at known moderately high but physiological rates int...

journal_title：Canadian journal of physiology and pharmacology

authors： Cowan JS

更新日期：1978-06-01 00:00:00

abstract：:The connections of area postrema include a set of nuclei with a common topographical location immediately deep to the ependyma or pia mater. These nuclei are all within two principal synapses of the area postrema and can be reached by more than one route from it. There is direct evidence that, like the area postrema, ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lawes IN

更新日期：1990-02-01 00:00:00

abstract：:In our previous study, l-carnitine was shown to have cytoprotective effect against hydrogen peroxide (H2O2)-induced injury in human normal HL7702 hepatocytes. The aim of this study was to investigate whether the protective effect of l-carnitine was associated with the nuclear factor erythroid 2 (NFE2)-related factor 2...

journal_title：Canadian journal of physiology and pharmacology

authors： Li J,Zhang Y,Luan H,Chen X,Han Y,Wang C

更新日期：2016-05-01 00:00:00

abstract：:The natural history of the disease of the dilated strain Bio TO-2 of cardiomyopathic hamsters (CMH) is not totally characterized. We investigated its hemodynamic and histomorphometric characteristics at 140, 180, 220, 260, and 300 days of age. Forty CMH and 40 controls were investigated (8 at each stage). Mean arteria...

journal_title：Canadian journal of physiology and pharmacology

authors： Goineau S,Pape D,Guillo P,Ramée MP,Bellissant E

更新日期：2001-04-01 00:00:00

abstract：:Premature weaning of rats to high carbohydrate diets causes a variety of short- and long-term changes in lipid metabolism, but the mechanisms involved are unclear. It is likely that interaction of diet with certain emerging hormonal control patterns during weaning might condition metabolic control and (or) subsequent ...

journal_title：Canadian journal of physiology and pharmacology

authors： Angel JF,Back DW

更新日期：1985-05-01 00:00:00

abstract：:Physical exercise is essential for the amelioration of insulin resistance. The mechanisms in charge of improved insulin resistance, regulated by exercise, are insufficient inquired. Previous researches revealed that SIRT6-mediated insulin signaling acts a crucial character in hepatic IR. The objective of our research ...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang Y,Yang Z,Xu Z,Wan J,Hua T,Sun Q

更新日期：2020-09-24 00:00:00

abstract：:Muscle pain and poor sleep commonly occur together. Whether pain induces poor sleep or vice versa is difficult to know. Muscle pain is also observed in the presence of some types of dyskinesia or movement disorders. The interaction between sleep, movement disorders, and some musculoskeletal pain appears to be complex ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lavigne GJ,Velly-Miguel AM,Montplaisir J

更新日期：1991-05-01 00:00:00

abstract：:Barbiturate actions on excitatory synaptic responses in CA 1 and dentate regions of hippocampal slices were studied to determine whether different effects occur on anatomically distinct synaptic pathways. Pentobarbital facilitated transmission between stratum radiatum inputs and CA 1 neurons at low concentrations (0.0...

journal_title：Canadian journal of physiology and pharmacology

authors： MacIver MB,Roth SH

更新日期：1987-03-01 00:00:00

abstract：:The present study was designed to investigate the effects of YC-1, a nitric oxide (NO)-independent soluble guanylate cyclase (sGC) activator, and DEA/NO, a NO donor, on smooth muscle responses in the preeclampsia model with suramin-treated rats and on the levels of cyclic guanosine monophosphate (cGMP) of thoracic aor...

journal_title：Canadian journal of physiology and pharmacology

authors： Turgut NH,Temiz TK,Turgut B,Karadas B,Parlak M,Bagcivan I

更新日期：2013-10-01 00:00:00

abstract：:Effects of 6-hydroxydopamine (6-OHDA) on rat brain and blood adrenaline (A), noradrenaline (NA), ammonia (NH3), gamma-aminobutyric acid (GABA), and amino acid metabolism prior to and after high pressure oxygen (OHP) induced convulsions have been studied. 6-OHDA reduces GABA and glutamate (Glu) rior to OHP exposure in ...

journal_title：Canadian journal of physiology and pharmacology

authors： Singh AK,Banister EW

更新日期：1978-04-01 00:00:00

abstract：:The vasoconstrictors norepinephrine (NE) and angiotensin II (AII) mediate increases in oxygen uptake (VO2) by the constant flow perfused rat hind limb that are inhibited by quinidine-like membrane-stabilizing effects (involving the interruption of action potential) of (+/-)-propranolol with little effect on vasoconstr...

journal_title：Canadian journal of physiology and pharmacology

authors： Tong AC,Rattigan S,Clark MG

更新日期：1998-02-01 00:00:00

abstract：:Using conventional intracellular microelectrode techniques, the membrane potential (Em) of vascular smooth muscle cells in isolated segments of thoracic rat aorta was measured. The influence of exogenous and of endothelium-derived nitric oxide on the Em was assessed, and the involvement of glibenclamide-sensitive chan...

journal_title：Canadian journal of physiology and pharmacology

authors： Vanheel B,Van de Voorde J

更新日期：1997-12-01 00:00:00

abstract：:Sarcoplasmic reticulum (SR) calcium handling in diaphragm was compared between mdx mice (7-8 weeks old) and age-matched controls. The total SR Ca2+ load was released from the SR by rapidly cooling muscle bundles from 22 to -1 degree C. The plateau amplitude of the rapid cooling contracture (RCC) was considered as an i...

journal_title：Canadian journal of physiology and pharmacology

authors： Khammari A,Péréon Y,Baudet S,Noireaud J

更新日期：1998-12-01 00:00:00

abstract：:The systemic and inotropic properties of prostaglandin E1 (PGE1) were investigated in 20 unanesthetized dogs. Pairs of ultrasonic dimension gauges and a micromanometer were implanted in the subendocardium and the apex of the left ventricle (LV), respectively. Seven to ten days later, increasing doses of PGE1 were infu...

journal_title：Canadian journal of physiology and pharmacology

authors： Roux S,Latour JG,Théroux P,Clozel JP,Bourassa MG

更新日期：1984-12-01 00:00:00