Effects of tamoxifen citrate and cycloheximide on estradiol induction of rat myometrial gap junctions.

abstract：:Theanine and caffeine, 2 naturally occurring components in tea, have repeatedly been shown to deliver unique cognitive benefits when consumed in combination. In this study, we assessed the beneficial synergistic effects of concurrent treatment with theanine and caffeine against cerebral damage in rats. Theanine and ca...

journal_title：Canadian journal of physiology and pharmacology

authors： Sun L,Tian X,Gou L,Ling X,Wang L,Feng Y,Yin X,Liu Y

更新日期：2013-07-01 00:00:00

abstract：:In Western societies, the incidence of diet-related diseases is progressively increasing due to greater availability of hypercaloric food and a sedentary lifestyle. Obesity, diabetes, atherosclerosis, and neurodegeneration are major diet-related pathologies that share a common pathogenic denominator of low-grade infla...

journal_title：Canadian journal of physiology and pharmacology

authors： Magrone T,Perez de Heredia F,Jirillo E,Morabito G,Marcos A,Serafini M

更新日期：2013-06-01 00:00:00

abstract：:Phosphofructokinase activity was measured in the sciatic nerve of streptozotocin-induced diabetic and nondiabetic rats. Average steady-state phosphofructokinase activity was obtained from three consecutive segments of the mid-femoral region in the left sciatic nerve in both diabetic (4 and 24 weeks) and nondiabetic, a...

journal_title：Canadian journal of physiology and pharmacology

authors： Kilgour RD,Gardiner K,Gardiner PF

更新日期：1990-10-01 00:00:00

abstract：:Childhood cancer survivors can develop significant cardiac dysfunction in adulthood as a consequence of their cancer treatment. Studies have linked heart failure during pregnancy to childhood doxorubicin (DOX) exposure. We hypothesized that DOX injection would reduce cardiac function peripartum and that DOX-treated da...

journal_title：Canadian journal of physiology and pharmacology

authors： Calvé A,Noiles W,Sebag IA,Chalifour LE

更新日期：2012-11-01 00:00:00

abstract：:Pioglitazone (Pio) and swimming exercise (SE) are insulin sensitisers. This investigation was suggested because of the significant side effects associated with Pio treatment in metabolic syndrome (MetS). This study was, therefore, designed to investigate the preventive role of Pio treatment and SE in terms of efficien...

journal_title：Canadian journal of physiology and pharmacology

authors： Sakr HF,Al-Hashem FH,El-Naby WM,Alkhateeb MA,Zaki MS,Refaey HM,Morsy MD

更新日期：2014-02-01 00:00:00

abstract：:We used thermoluminescence, electron spin resonance, and viscosimetric measurements to establish whether or not a spice had been irradiated. Thermoluminescence, using the 1788 EN official protocol with an alternative method for the extraction of mineral impurities, led to proof of irradiation or proof of no treatment....

journal_title：Canadian journal of physiology and pharmacology

authors： Chabane S,Pouliquen-Sonaglia I,Raffi J

更新日期：2001-02-01 00:00:00

abstract：:Barbiturate actions on excitatory synaptic responses in CA 1 and dentate regions of hippocampal slices were studied to determine whether different effects occur on anatomically distinct synaptic pathways. Pentobarbital facilitated transmission between stratum radiatum inputs and CA 1 neurons at low concentrations (0.0...

journal_title：Canadian journal of physiology and pharmacology

authors： MacIver MB,Roth SH

更新日期：1987-03-01 00:00:00

abstract：:The role of nitric oxide (NO) on the vasorelaxant effect of atrial natriuretic peptide (ANP) on the basal tone of rabbit aortic rings conditioned to angiotensin II (Ang II) was studied. ANP aortic relaxation and nitrite release were measured in the presence and absence of endothelium and a NO-synthase inhibitor. Ang I...

journal_title：Canadian journal of physiology and pharmacology

authors： Romano L,Coviello A,Jerez S,Peral de Bruno M

更新日期：2002-10-01 00:00:00

abstract：:The responses of the circular muscle of canine colon to stimulation of intrinsic nerves and to the probable mediators of these nerves were studied in vivo. In vivo studies were carried out using close intra-arterial injections and local field stimulation of proximal, mid-, and distal colon while recording circumferent...

journal_title：Canadian journal of physiology and pharmacology

authors： Gonda T,Daniel EE,Kostolanska F,Oki M,Fox JE

更新日期：1988-04-01 00:00:00

abstract：:Hypothermia increases the sensitivity of isolated cardiac muscle to stimulation by beta-adrenoceptor agonists. The purpose of this study was to determine pharmacologically whether this supersensitivity is associated with a change in the affinity of agonists for the receptor. The positive inotropic and chronotropic res...

journal_title：Canadian journal of physiology and pharmacology

authors： Broadley KJ,McNeill JH

更新日期：1983-06-01 00:00:00

abstract：:A brief summary is given of some of the key points of the individual contributions at this International Brain Research Organization satellite meeting, presenting up-to-date, expert knowledge of energy metabolism, ionic turnover, and cell swelling at the cellular level of the mammalian central nervous system. On the b...

journal_title：Canadian journal of physiology and pharmacology

authors： Hertz L,Code WE,Sykova E

更新日期：1992-01-01 00:00:00

abstract：:Transactivation of epidermal growth factor receptor (EGFR) is a well-documented mechanism by which vasoactive peptides and H2O2 elicit their cellular responses. However, a role for the insulin-like growth factor type-1 receptor (IGF-1R) transactivation in mediating the effects of angiotensin II (Ang II) and H2O2 in va...

journal_title：Canadian journal of physiology and pharmacology

authors： Azar ZM,Mehdi MZ,Srivastava AK

更新日期：2007-01-01 00:00:00

abstract：:This study investigated the glucose response to insulin infused after hepatic denervation. Hepatic denervations were performed on 13 anesthetized cats at different levels: (i) surgical hepatic anterior plexus denervation, (ii) chemical total hepatic denervation by painting phenol on the tissues around the portal vein,...

journal_title：Canadian journal of physiology and pharmacology

authors： Xie H,Tsybenko VA,Johnson MV,Lautt WW

更新日期：1993-02-01 00:00:00

abstract：:A new method is developed using Fluoro-Gold (FG) as a vital stain to label the nuclei of donor myoblasts in myoblast transfer studies. In vitro incubation with 0.01% FG for 16 h resulted in 100% nuclei labelling. Intensive fluorescence persisted following 9 days of subculture, when the human myoblasts were injected in...

journal_title：Canadian journal of physiology and pharmacology

authors： Fang QW,Chen M,Li HJ,Goodwin TG,Law PK

更新日期：1991-01-01 00:00:00

abstract：:Increased expression of DNA methyltransferase-1 (DNMT1) associates with the progression of many human diseases. Because DNMT1 induces cell proliferation, drugs that inhibit DNMT1 have been used to treat proliferative diseases. Because these drugs are nonspecific inhibitors of DNMT1, subsidiary events or the compensato...

journal_title：Canadian journal of physiology and pharmacology

authors： Boosani CS,Gunasekar P,Block M,Jiang W,Zhang Z,Radwan MM,Agrawal DK

更新日期：2018-10-01 00:00:00

abstract：:The active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3 or calcitriol), is known to inhibit the proliferation and invasiveness of many types of cancer cells, including breast, colon, pancreatic, prostate, and liver cancer cells. These findings support the use of 1α,25(OH)2D3 for the treatment of these t...

journal_title：Canadian journal of physiology and pharmacology

authors： Matsumoto Y,Kittaka A,Chen TC

更新日期：2015-05-01 00:00:00

abstract：:Changes in dietary omega-6/3 polyunsaturated fatty acids (PUFA) ratios affect anti- and proinflammatory equilibrium. As reperfused myocardial infarction (MI) is an inflammatory pathology that alters the cell integrity of the myocardium but also of other tissues, such as the hippocampus and amygdala, attenuation of the...

journal_title：Canadian journal of physiology and pharmacology

authors： Rondeau I,Picard S,Bah TM,Roy L,Godbout R,Rousseau G

更新日期：2011-03-01 00:00:00

abstract：:The endothelin receptors in rabbit isolated rings of saphenous artery and saphenous vein have been characterized using endothelin-1, endothelin-2, endothelin-3, sarafotoxin S6c, and BQ123. Although artery rings were more sensitive than those from vein to the contractile action of phenylephrine, endothelin-1 was about ...

journal_title：Canadian journal of physiology and pharmacology

authors： Auguet M,Delaflotte S,Chabrier PE,Braquet P

更新日期：1993-10-01 00:00:00

abstract：:We investigated the role of receptor tyrosine kinases in Ang II-stimulated generation of reactive oxygen species (ROS) and assessed whether MAP kinase signaling by Ang II is mediated via redox-sensitive pathways. Production of ROS and activation of NADPH oxidase were determined by DCFDA (dichlorodihydrofluorescein dia...

journal_title：Canadian journal of physiology and pharmacology

authors： Touyz RM,Cruzado M,Tabet F,Yao G,Salomon S,Schiffrin EL

更新日期：2003-02-01 00:00:00

abstract：:Newborn hearts have restricted functional reserve and variable responsiveness to inotropes that could be partly due to differences in myocardial beta-adrenoceptors (beta-AR). To clarify this issue, this study documented ventricle-specific changes in myocardial beta-AR density and affinity during postnatal maturation. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wittnich C,Belanger MP,Bandali K

更新日期：2006-08-01 00:00:00

abstract：:Previous studies have shown that when atrial natriuretic peptide (ANF) is given to anaesthetized dogs with hypovolemic acute pancreatitis, it will produce a diuresis and natriuresis but will not elevate the glomerular filtration rate (GFR). When the same dose of peptide is given to dogs equally hypovolemic (hemorrhage...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy M,Cernacek P

更新日期：1990-06-01 00:00:00

abstract：:To evaluate the clinical efficacy of azithromycin, cefaclor, and amoxicillin in treatment of pediatric tonsillitis, a total of 256 children with Group A β-hemolytic streptococcus (GAS) tonsillitis were randomly divided into 3 groups. Only patients assessed with streptococcus-positive tonsillitis, considered to be comp...

journal_title：Canadian journal of physiology and pharmacology

authors： Li P,Jiang G,Shen X

更新日期：2019-10-01 00:00:00

abstract：:Methionine sulfoximine (MSO) is a rare amino acid. It occurs in nature or as a by-product of some forms of food processing. A notable example of the latter was a former method for bleaching wheat flour, using nitrogen trichloride, the "agene process," in use for most of the first 50 years of this century. "Agenized" f...

journal_title：Canadian journal of physiology and pharmacology

authors： Shaw CA,Bains JS,Pasqualotto BA,Curry K

更新日期：1999-11-01 00:00:00

abstract：:The aim of this study was to determine if there was a synergistic or additive effect of a thiazolidinedione derivative (rosiglitazone (ROS)) and a vanadium compound (bis(ethylmaltolato)oxovanadium(IV) (BEOV)) on plasma glucose and insulin levels following chronic oral administration to Zucker diabetic fatty (ZDF) rats...

journal_title：Canadian journal of physiology and pharmacology

authors： Yuen VG,Bhanot S,Battell ML,Orvig C,McNeill JH

更新日期：2003-11-01 00:00:00

abstract：:Several studies have utilized the spontaneously hypertensive (SHR) diabetic rat to document the synergistic deleterious consequences of diabetes and hypertension on various organ systems. However, whether these effects are due entirely to the overlapping pathological states or partially result from a greater susceptib...

journal_title：Canadian journal of physiology and pharmacology

authors： Jian K,Fok E,Cam MC,Sambandam N,Yao J,Rodrigues B

更新日期：1996-11-01 00:00:00

abstract：:The role of iron-loaded transferrin in xanthine-xanthine oxidase (X-XO) induced cardiac injury in isolated perfused rat hearts was examined. X (2 mM) - XO (10 U/L) perfusion resulted in contractile failure, a rise in resting tension, an increase in lipid peroxidation, and myocardial cell damage. The addition of transf...

journal_title：Canadian journal of physiology and pharmacology

authors： Tiede R,Sareen S,Singal PK

更新日期：1990-04-01 00:00:00

abstract：:Geraniol, a plant-derived monoterpene, has been extensively studied and showed a wide variety of beneficial effects. The aim of this study was to investigate the therapeutic effect of geraniol on functional recovery and neuropathic pain in rats with spinal cord injury (SCI). Rats received a clip-compression SCI and we...

journal_title：Canadian journal of physiology and pharmacology

authors： Lv Y,Zhang L,Li N,Mai N,Zhang Y,Pan S

更新日期：2017-12-01 00:00:00

abstract：:To elucidate the mechanism of enhanced insulin sensitivity by muscle after exercise, we studied insulin binding, 2-deoxy-D-[1-14C]glucose (2-DOG) uptake and [5-3H]glucose utilization in glycolysis and glycogenesis in soleus and extensor digitorum longus (EDL) muscles of mice after 60 min of treadmill exercise. In the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Bonen A,Tan MH,Watson-Wright WM

更新日期：1984-12-01 00:00:00

abstract：:The effects of acute hypercapnia on human thermoregulation during cold exposure were investigated by immersion of eight male subjects to the neck in a 15 degrees C water bath until their core temperatures dropped to 35 degrees C or until 1 h of immersion had elapsed. Air was inspired throughout each experiment, with t...

journal_title：Canadian journal of physiology and pharmacology

authors： Lun V,Sun JC,Giesbrecht GG,Mekjavić IB

更新日期：1994-03-01 00:00:00

abstract：:We investigated the effect of Ginkgo biloba extracts and some of its individual constituents on the oxidative metabolism of valproic acid (VPA) in hepatic microsomes from donors with the CYP2C9*1/*1 genotype. G. biloba extract decreased 4-ene-VPA, 3-OH-VPA, 4-OH-VPA, and 5-OH-VPA formation with mean (+/- SE) IC50 valu...

journal_title：Canadian journal of physiology and pharmacology

authors： Numa AM,Abbott FS,Chang TK

更新日期：2007-09-01 00:00:00