Barbiturate effects on hippocampal excitatory synaptic responses are selective and pathway specific.

abstract：:Cold ischemia--warm reperfusion (CI/WR) injury of liver transplantation involves hepatocyte cell death, the nature and underlying mechanisms of which remain unclear. Isolated hepatocytes and isolated perfused livers were used to determine the prevalence of necrosis and apoptosis as well as mitochondrial dysfunction. I...

journal_title：Canadian journal of physiology and pharmacology

authors： Duval M,Plin C,Elimadi A,Vallerand D,Tillement JP,Morin D,Haddad PS

更新日期：2006-05-01 00:00:00

abstract：:Doxorubicin treatment causes delayed development of cardiotoxicity. Whether the doxorubicin-induced impairment of cardiac functions reverses or progresses with time after the cessation of the treatment was examined. The rats were injected with doxorubicin (2.5 mg/kg, i.v., once a week for 3 weeks) and sacrificed at 1 ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chugun A,Temma K,Oyamada T,Suzuki N,Kamiya Y,Hara Y,Sasaki T,Kondo H,Akera T

更新日期：2000-04-01 00:00:00

abstract：:Despite the widespread use of furosemide in the treatment of various fluid and electrolyte disorders in the preterm and term human infant and child, the physiological effects of this potent diuretic agent on renal function and renin release during postnatal maturation are poorly understood. To test the hypothesis that...

journal_title：Canadian journal of physiology and pharmacology

authors： Smith FG,Abraham J

更新日期：1995-01-01 00:00:00

abstract：:Canadian Aboriginal people encompass diverse cultural groups, whose daily food patterns vary in regard to the kinds and proportions of indigenous foods. Standard dietary methods of assessing food consumption sometimes require modification to be understandable and acceptable to Aboriginal communities. Depending upon th...

journal_title：Canadian journal of physiology and pharmacology

authors： Wein EE

更新日期：1995-06-01 00:00:00

abstract：:Long-lasting ischemia can result in cell loss; however, repeated episodes of brief ischemia increase the resistance of the heart against deleterious effects of subsequent prolonged ischemic insult and promote cell survival. Traditionally, it is believed that the supply of blood to the ischemic heart is associated with...

journal_title：Canadian journal of physiology and pharmacology

authors： Adameova A,Hrdlicka J,Szobi A,Farkasova V,Kopaskova K,Murarikova M,Neckar J,Kolar F,Ravingerova T,Dhalla NS

更新日期：2017-10-01 00:00:00

abstract：:The systemic and inotropic properties of prostaglandin E1 (PGE1) were investigated in 20 unanesthetized dogs. Pairs of ultrasonic dimension gauges and a micromanometer were implanted in the subendocardium and the apex of the left ventricle (LV), respectively. Seven to ten days later, increasing doses of PGE1 were infu...

journal_title：Canadian journal of physiology and pharmacology

authors： Roux S,Latour JG,Théroux P,Clozel JP,Bourassa MG

更新日期：1984-12-01 00:00:00

abstract：:Curare action on nicotinic acetylcholine receptors has a number of facets, of which the best known is competitive antagonism. Here we describe the weak agonist action of 10(-5) M curare on the murine skeletal muscle cell line, G8. Although curare induces no depolarization in G8 cells, single-channel recordings reveal ...

journal_title：Canadian journal of physiology and pharmacology

authors： Morris CE,Montpetit MR,Sigurdson WJ,Iwasa K

更新日期：1989-02-01 00:00:00

abstract：:Over the past few years, a number of cases of tendon injuries associated with statin therapy have been reported. In this study, we assessed whether statins can affect the extracellular matrix (ECM) of the deep digital flexor tendon (DDFT) and patellar tendon (PT). Wistar rats were assigned to groups treated with atorv...

journal_title：Canadian journal of physiology and pharmacology

authors： Oliveira LP,Vieira CP,Marques PP,Pimentel ER

更新日期：2017-04-01 00:00:00

abstract：:We studied the effects of Zn2+ and Cd2+ on the behaviour of IK(f), a transient outward potassium current in acutely dissociated melanotrophs of the pars intermedia of the rat pituitary gland. Micromolar concentrations of external Cd2+ or Zn2+ caused parallel and nearly equal rightward shifts along the voltage axis of ...

journal_title：Canadian journal of physiology and pharmacology

authors： Davidson JL,Kehl SJ

更新日期：1995-01-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are cardiac hormones synthesized in and secreted from the heart. ANP and BNP bind the common receptor guanylyl cyclase-A (GC-A) and possess biological actions. Based on their diuretic, natriuretic, and vasodilating activities, they are now widely us...

journal_title：Canadian journal of physiology and pharmacology

authors： Saito Y,Kishimoto I,Nakao K

更新日期：2011-08-01 00:00:00

abstract：:Using a time-lapse cinephotomicrographic technique, the locomotory paths taken by lymphocytes have been shown to satisfy the requirements for a continuous-time Markov chain analysis consisting of four directional states defined by the four quadrants of a Cartesian plane and state 0 in which the cells are stationary. T...

journal_title：Canadian journal of physiology and pharmacology

authors： Noble PB,Boyarsky A,Bentley KC

更新日期：1979-01-01 00:00:00

abstract：:We have previously demonstrated a direct relationship between the activity of the arachidonic acid cascade in vivo and the extent of cellular damage following several types of experimental injury. Since phospholipase activity has been shown to regulate arachidonic acid availability, we tested the ability of circulatin...

journal_title：Canadian journal of physiology and pharmacology

authors： Flynn JT,Henry JM,Perkowski S

更新日期：1981-12-01 00:00:00

abstract：:This study aimed to investigate the interrelationship of plasma lipid profile, lipid peroxidation, and erythrocyte antioxidative defense in patients with insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. Plasma levels of total cholesterol, triglycerides, and lipid peroxides and the activiti...

journal_title：Canadian journal of physiology and pharmacology

authors： Cimbaljević B,Vasilijević A,Cimbaljević S,Buzadzić B,Korać A,Petrović V,Janković A,Korać B

更新日期：2007-10-01 00:00:00

abstract：:It has been proposed that medullary washout secondary to increased blood flow will limit maximal urine osmolality and reabsorption of salt and water from the inner medullary collecting duct. We have tested this prediction. The function of the inner medullary collecting duct was examined by microcatheterization. Acetyl...

journal_title：Canadian journal of physiology and pharmacology

authors： Cupples WA,Sonnenberg H

更新日期：1987-12-01 00:00:00

abstract：:In recent experiments in conscious lambs, we showed that in addition to its well-known natriuretic and diuretic effects, i.v. injection of 2 mg/kg of furosemide resulted in a sustained increase in heart rate and an age-dependent increase in plasma renin activity. To determine whether these responses were dose dependen...

journal_title：Canadian journal of physiology and pharmacology

authors： Patel A,Smith FG

更新日期：1997-09-01 00:00:00

abstract：:The effect of adrenaline on the membrane transport of 3-methylglucose was studied in perifused isolated rat left atria that had been fully arrested. In this preparation a high concentration of adrenaline stimulated and a low one decreased sugar transport. The stimulatory effect was strongly inhibited by the beta-adren...

journal_title：Canadian journal of physiology and pharmacology

authors： Bihler I,Sawh PC

更新日期：1976-10-01 00:00:00

abstract：:The present study was designed to evaluate the role of endothelial NO in the hemodynamics and vascular changes that occur in heart failure following myocardial infarction in rats. Left ventricular systolic pressure (LVSP), mean blood pressure (MBP), aortic morphology (media thickness) and reactivity were evaluated in ...

journal_title：Canadian journal of physiology and pharmacology

authors： da Cunha V,Stefanon I,Mill JG

更新日期：2004-06-01 00:00:00

abstract：:The objective of this study was to explore the action of angiotensin II (AII) on cardiac contractility and cyclic AMP (cAMP) generation by forskolin and isoproterenol in the hypertrophic myocardium of the salt-sensitive Dahl rat. Inbred Dahl S and Dahl R rats that had been on a diet supplemented with 6% NaCl were stud...

journal_title：Canadian journal of physiology and pharmacology

authors： Sunga PS,Rabkin SW

更新日期：1994-06-01 00:00:00

abstract：:Opioid and N-methyl-d-aspartate (NMDA) receptors mediate different effects of fluoxetine. We investigated whether opioid and NMDA receptors are involved in the protective effect of fluoxetine against the behavioral despair induced by acute physical stress in male mice. We used the forced swimming test (FST), tail susp...

journal_title：Canadian journal of physiology and pharmacology

authors： Haj-Mirzaian A,Kordjazy N,Ostadhadi S,Amiri S,Haj-Mirzaian A,Dehpour A

更新日期：2016-06-01 00:00:00

abstract：:The effects of a number of peptides which are found in the gastrointestinal tract have been ascertained on the direct current recorded dorsal and ventral root responses of the isolated hemisected toad spinal cord. Motilin, substance P, bombesin, neurotensin, and thyrotropin releasing hormone had potent depolarizing ac...

journal_title：Canadian journal of physiology and pharmacology

authors： Phillis JW,Kirkpatrick JR

更新日期：1979-08-01 00:00:00

abstract：:The novel biological effect of statins in alleviating myocardium fibrosis following infarction has been increasingly recognized, yet the underlying mechanisms are not fully understood. The purpose of this study was to characterize the effect of simvastatin on myocardial fibrosis and collagen I deposition in the non-in...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang J,Xu Y,Pan L,Chen T,Chen Z,Zhao R

更新日期：2010-11-01 00:00:00

abstract：:Rats were treated daily with atropine (2.5 mg/kg), imipramine (5 mg/kg), viloxazine (5 mg/kg), or saline for 14 days. Thirty-six hours following the final injection the rats were anaesthetized with urethane and the sensitivity of neurones in the somatosensory cortex to iontophoretically applied acetylcholine (ACh) was...

journal_title：Canadian journal of physiology and pharmacology

authors： Jones RS

更新日期：1980-05-01 00:00:00

abstract：:Our purpose was to determine the effect of eight different combinations of contraction intensity, duration, and rest on the rate of fatigue in vastus lateralis muscle. A single combination consisted of contractions at 30 or 70% maximal voluntary contraction (MVC), held for 3 or 7 s with 3- or 7-s rest intervals. Contr...

journal_title：Canadian journal of physiology and pharmacology

authors： Dolmage T,Cafarelli E

更新日期：1991-10-01 00:00:00

abstract：:Delta 9-Tetrahydrocannabinol (20 mg/kg i.p.) and propranolol (20 and 50 mg/kg i.p.) produced marked falls in the rectal temperatures of mice kept at an ambient temperature of 22 degrees C. Propranolol (50 mg/kg i.p.) also decreased the thermogenic activity of brown fat, as measured by a decrease in the level of [3H]GD...

journal_title：Canadian journal of physiology and pharmacology

authors： Pertwee RG,Nash K,Trayhurn P

更新日期：1991-06-01 00:00:00

abstract：:Animals treated with nitric oxide synthase (NOS) inhibitors exhibit marked hypersensitivity to the blood pressure lowering effects of exogenous nitric oxide (NO) donors. We used this model as a sensitive index to evaluate the relative importance of reduced biotransformation of glyceryl trinitrate (GTN) to NO in the de...

journal_title：Canadian journal of physiology and pharmacology

authors： Ratz JD,Adams MA,Bennett BM

更新日期：2002-11-01 00:00:00

abstract：:The aim of this study was to demonstrate that within a population of healthy men (n = 15) of varying levels of aerobic fitness (VO2max = 36-74 mL.kg-1.min-1), (i) there are high and low responders with respect to carotid-cardiac baroreflex responsiveness, despite similar baseline heart rates (HRs) both at rest and dur...

journal_title：Canadian journal of physiology and pharmacology

authors： Savard GK,Lundie MJ

更新日期：1995-01-01 00:00:00

abstract：:The activation of mast cells (MC) due to immunological stimulation causes an immediate and dramatic inflammatory response. We review current evidence indicating that the membrane permeabilities for calcium, chloride, sodium, and potassium have a significant role in the activation of these cells, and in some cases, spe...

journal_title：Canadian journal of physiology and pharmacology

authors： Janiszewski J,Huizinga JD,Blennerhassett MG

更新日期：1992-01-01 00:00:00

abstract：:The study was designed to characterize restitution kinetics in atrial repolarization of rabbits and to examine effects of K+ or Ca2+ channel blockers on restitution. Action potentials were recorded from rabbit atrial tissue. Restitution curves of phase I amplitude and action potential duration at 50 and 90% repolariza...

journal_title：Canadian journal of physiology and pharmacology

authors： Qi A,Tang C,Yeung-Lai-Wah JA,Kerr CR

更新日期：1997-04-01 00:00:00

abstract：:The objective of this study was to determine the influence of age on the learning and memory dysfunction induced by cranial radiation in the male Wistar rat. Ninety-six 45-day-old, 70 4-month-old, and 78 18-month-old male rats were divided in two equal groups: (i) irradiated and (ii) control. A course of whole-brain r...

journal_title：Canadian journal of physiology and pharmacology

authors： Lamproglou I,Baillet F,Boisserie G,Mazeron JJ,Delattre JY

更新日期：2002-07-01 00:00:00

abstract：:The recognition of chylomicrons as dietary lipid transporters dates back to more than 70 years and marks a milestone in lipoprotein history. Conventionally, three phases constitute the process of absorption of exogenous fat: intraluminal, intestinal, and delivery. The intraluminal phase includes chemical hydrolysis by...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy E

更新日期：1992-04-01 00:00:00