Mast cell ionic channels: significance for stimulus-secretion coupling.

abstract：:Airway smooth muscle (ASM) contraction controls the airway caliber. Airway narrowing is exaggerated in obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD). The mechanism by which ASM tone is dysregulated in disease is not clearly understood. Recent research on ion channels, parti...

journal_title：Canadian journal of physiology and pharmacology

authors： Jha A,Sharma P,Anaparti V,Ryu MH,Halayko AJ

更新日期：2015-03-01 00:00:00

abstract：:The blood volume of anesthetized rats was expanded acutely by 33% with donor blood while a caval snare was gradually tightened so that right atrial pressure (RAP) was prevented from rising (n = 6). In control experiments (n = 5) an aortic snare was used to hold mean arterial blood pressure near the values found in the...

journal_title：Canadian journal of physiology and pharmacology

authors： Ackermann U,Rudolph JR

更新日期：1984-07-01 00:00:00

abstract：:High buffer cardioplegia may provide protection against ischemic damage by reducing the extent of intracellular acidosis. Secondary cardioplegia may improve postischemic recovery by restoration of high energy phosphates, ionic gradients, and intracellular pH. To test these hypotheses, pig hearts were arrested with hig...

journal_title：Canadian journal of physiology and pharmacology

authors： Tian GH,Mainwood GW,Biro GP,Smith KE,Butler KW,Lawrence D,Deslauriers R

更新日期：1991-11-01 00:00:00

abstract：:Initially the impetus to develop iron (Fe) chelators for clinical use was based upon the need for a drug to treat Fe-overload diseases such as beta-thalassemia. However, it has become clear that Fe chelators may be useful for the treatment of a wide variety of disease states, including cancer, malaria, and free radica...

journal_title：Canadian journal of physiology and pharmacology

authors： Richardson DR

更新日期：1997-10-01 00:00:00

abstract：:Our knowledge of the effects of exercise on the heart is limited by the predominant use of rats as an animal model. The rabbit has many advantages over the rat as an animal model to study. However, little work has characterized its capacity to exercise. The purposes of the present study were to determine if the rabbit...

journal_title：Canadian journal of physiology and pharmacology

authors： Meng H,Pierce GN

更新日期：1990-07-01 00:00:00

abstract：:Norethandrolone (NE) and other androgenic steroids have been shown to be renotropic in various species and have also been reported to have salutary effects in patients with diminished renal function. Renal cortical slices prepared from rats pretreated with NE showed an increased capability to concentrate p-aminohippur...

journal_title：Canadian journal of physiology and pharmacology

authors： Watrous WM,Lacombe R,Brodeur J

更新日期：1975-10-01 00:00:00

abstract：:The present study was undertaken to determine the beta-receptor subtype responsible for the enhanced anaphylactic histamine release from bovine leukocytes produced by isoprenaline. The selective beta 1 antagonist practolol competitively inhibited the enhancement of histamine release produced by isoprenaline. The selec...

journal_title：Canadian journal of physiology and pharmacology

authors： Perron R,Eyre P

更新日期：1982-07-01 00:00:00

abstract：:Resveratrol, a polyphenol compound with anti-inflammatory properties, has been previously evaluated for its beneficial effects in several ulcerative colitis models. However, the current study elucidates the effect of resveratrol on adhesion molecules, as well as its antioxidant efficacy in a trinitrobenzene sulfonic a...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdallah DM,Ismael NR

更新日期：2011-11-01 00:00:00

abstract：:Phosphorylation of the regulatory light chain of myosin catalyzed by myosin light-chain kinase (MLCK) is the key reaction in the regulation of actin-myosin interaction in smooth muscle. It is shown that this reaction is of an ordered type, whereby kinase first binds ATP and then the light chain, and following phosphat...

journal_title：Canadian journal of physiology and pharmacology

authors： Sobieszek A

更新日期：1994-11-01 00:00:00

abstract：:This study aimed to investigate the antiulcer and antioxidant activities of myrtle berry seed aqueous extract (MBSAE) in a peptic ulcer model induced by ethanol in male Wistar rats. MBSAE is rich in total polyphenols, total flavonoids, and unsaturated fatty acids, particularly linoleic (18:2) and oleic (18:1) acids. M...

journal_title：Canadian journal of physiology and pharmacology

authors： Jabri MA,Rtibi K,Tounsi H,Hosni K,Marzouki L,Sakly M,Sebai H

更新日期：2017-05-01 00:00:00

abstract：:The objective of this study was to investigate the protective effects of pomegranate (Punica granatum) juice (PGJ) on oxidative damages in liver tissue and erythrocytes of rats intoxicated by sodium fluoride (NaF). Rats were randomly divided into two groups: group I received standard diet and group II received orally ...

journal_title：Canadian journal of physiology and pharmacology

authors： Bouasla A,Bouasla I,Boumendjel A,Abdennour C,El Feki A,Messarah M

更新日期：2016-07-01 00:00:00

abstract：:The purpose of this article is to review the current state of knowledge of ethanol neurobehavioural teratogenesis and its postulated mechanisms. The review comprises an examination of ethanol teratogenesis in the human, including the fetal alcohol syndrome, and in experimental animals. Several current proposed mechani...

journal_title：Canadian journal of physiology and pharmacology

authors： Reynolds JD,Brien JF

更新日期：1995-09-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of bosentan, a mixed endothelin receptor A and B subtype antagonist, on myocardial ischemia-reperfusion injury and to explore the influence of the timing of bosentan administration on its cardioprotective effects. Adult rat hearts were perfused by the Langendorf...

journal_title：Canadian journal of physiology and pharmacology

authors： Xia Z,Kuo KH,McNeill JH,Ansley DM

更新日期：2005-03-01 00:00:00

abstract：:Alterations in electrical conductivity between smooth muscle cells (SMCs) can alter the spread and effectiveness of electromechanical SMC contraction. We attempted to determine whether alterations in pressure-dependent constriction (PDC) occurring in relation to stroke development within the middle cerebral arteries (...

journal_title：Canadian journal of physiology and pharmacology

authors： Smeda JS,King SR

更新日期：1998-02-01 00:00:00

abstract：:This review presents, from the author's viewpoint, avenues of histamine research likely to produce new information. One potentially useful approach may be to attempt to relate histamine's function to its occurrence in different body tissues such as the pituitary and hypothalamus, the gastrointestinal mucosa, and the b...

journal_title：Canadian journal of physiology and pharmacology

authors： Code CF

更新日期：1985-06-01 00:00:00

abstract：:Ovalbumin (OA) and the calcium ionophore A23187 induced a dose-dependent contraction of guinea pig tracheal strips. The OA-induced contraction (of sensitized trachea) consisted of an initial peak concentration, maximal between 5 and 10 min, followed by a very gradual decline from the peak. On the other hand, A23187 in...

journal_title：Canadian journal of physiology and pharmacology

authors： Burka JF,Paterson NA

更新日期：1981-10-01 00:00:00

abstract：:Spironolactone is a diuretic steroid which is capable of blocking the binding of aldosterone to its cytosol receptor at the distal convoluted tubule. In addition, it has been shown that spironolactone is a strong inhibitor of steroidogenesis. More recently, new aldosterone antagonists have been discovered. Some of the...

journal_title：Canadian journal of physiology and pharmacology

authors： Netchitailo P,Perroteau I,Delarue C,Leboulenger F,Capron MH,Vaudry H

更新日期：1983-01-01 00:00:00

abstract：:Two natriuretic peptides, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), are found principally in the heart. In preliminary experiments with mouse kidney cells or slices, we found mouse BNP1-45 much more potent than ANP1-28 in causing elevations of cGMP (>50-fold). The guanylyl cyclase-A (GC-A)...

journal_title：Canadian journal of physiology and pharmacology

authors： Kishimoto I,Hamra FK,Garbers DL

更新日期：2001-08-01 00:00:00

abstract：:The influence of a program of high intensity training and of a combined program of high intensity training and prolonged submaximal training on adaptations to the vastus lateralis muscle was investigated in two groups of elite athletes. The high intensity training (H) consisted of ice hockey practices and games over a...

journal_title：Canadian journal of physiology and pharmacology

authors： Daub WD,Green HJ,Houston ME,Thomson JA,Fraser IG,Ranney DA

更新日期：1982-05-01 00:00:00

abstract：:This study has investigated the oral activity, following intragastric administration, of three potent and long-acting peptide-based bradykinin antagonists, HOE-140, B9430, and CP-0597, in the anesthetized rat, using bradykinin-induced hypotension. Two of the three bradykinin antagonists, B9430 and HOE-140, but not CP-...

journal_title：Canadian journal of physiology and pharmacology

authors： Whalley ET,Hanson WL,Stewart JM,Gera L

更新日期：1997-06-01 00:00:00

abstract：:Lectins, known to recognize endothelial cell adhesion molecules, have been shown to release endothelium-derived relaxing factor (EDRF) from blood vessels. We investigated the effects of different leukocyte-type cells to determine if these cells, by interacting with the endothelium, could release EDRF from the circumfl...

journal_title：Canadian journal of physiology and pharmacology

authors： Kleha JF,Devesly P,Johns A

更新日期：1995-03-01 00:00:00

abstract：:Geniposide (GP) is one of main compounds in Gardenia jasminoides Ellis, with both medicinal and nutritional value. This study was designed to determine, for the first time, how GP from G. jasminoides protects against acute alcohol-induced liver injury, and the underlying mechanisms. Mice were orally administered alcoh...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang J,Zhang Y,Liu R,Li X,Cui Y,Qu L

更新日期：2015-04-01 00:00:00

abstract：:In recent decades, the complexity of the endothelium and its major role in maintaining or altering blood vessel architecture are being revealed. In contrast, the vascular smooth muscle cell previously received the most attention. I suggest support of the hypothesis that the endothelium is the key to vascular disease. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Todd ME

更新日期：1992-04-01 00:00:00

abstract：:Tissues from the duodenum and vas deferens of Sprague-Dawley rats were examined of the rat vas deferens and gap junctions. Can. J. Physiol. Pharmacol. 54, 412-416. by electron microscopy after glutaraldehyde fixation and postosmication. Gap junctions (nexuses) were readily demonstrated in the duodenum in both control ...

journal_title：Canadian journal of physiology and pharmacology

authors： Paton DM,Buckland-Nicks J,Johns A

更新日期：1976-06-01 00:00:00

abstract：:In male Sprague--Dawley rats, hypertensive development was diminished for 10 weeks when parathyroidectomy (PTX) was performed 1 week before deoxycorticosterone plus saline (DOCA + NaCl) treatment. In young spontaneously hypertensive male rats (SHR, Okamoto strain) parathyroidectomy performed after weaning lessened hyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Gairard A,Berthelot A,Schleiffer R,Pernot F

更新日期：1982-02-01 00:00:00

abstract：:Damage to the stomach results in excessive movement of hydrogen ion (H+) out of the lumen, and increased movement of sodium (Na+) and potassium (K+) into the lumen. Histamine liberation during damage probably adds to the destruction by increased capillary permeability and formation of edema. Previous reports have show...

journal_title：Canadian journal of physiology and pharmacology

authors： Tepperman BL

更新日期：1979-03-01 00:00:00

abstract：:Cold ischemia--warm reperfusion (CI/WR) injury of liver transplantation involves hepatocyte cell death, the nature and underlying mechanisms of which remain unclear. Isolated hepatocytes and isolated perfused livers were used to determine the prevalence of necrosis and apoptosis as well as mitochondrial dysfunction. I...

journal_title：Canadian journal of physiology and pharmacology

authors： Duval M,Plin C,Elimadi A,Vallerand D,Tillement JP,Morin D,Haddad PS

更新日期：2006-05-01 00:00:00

abstract：:Blood pressure fluctuates continuously throughout life and autoregulation is the primary mechanism that isolates the kidney from this fluctuation. Compared with Wistar rats, Brown Norway (B-N) rats display impaired renal myogenic autoregulation when blood pressure fluctuation is increased. They also are very susceptib...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang X,Cupples WA

更新日期：2001-03-01 00:00:00

abstract：:Changes in metabolic characteristics of the liver and jejunal epithelia as a result of feeding the beta-agonist albuterol to chickens for 3 and 6 weeks were studied. Feeding albuterol resulted in a change in weights of the liver and small intestines. Chickens fed albuterol for 6 weeks had greater levels of plasma none...

journal_title：Canadian journal of physiology and pharmacology

authors： Rompala RE,Darre MJ

更新日期：1989-05-01 00:00:00

abstract：:Previous reports demonstrated that cilostazol, a phosphodiesterase 3 inhibitor, affected cellular electrophysiology and reduced episodes of ventricular fibrillation (VF) in patients with Brugada syndrome. However, its effects on VF induction and defibrillation efficacy have never been investigated. We tested the hypot...

journal_title：Canadian journal of physiology and pharmacology

authors： Kanlop N,Shinlapawittayatorn K,Sungnoon R,Weerateerangkul P,Chattipakorn S,Chattipakorn N

更新日期：2010-04-01 00:00:00