A role for transient receptor potential ankyrin 1 cation channel (TRPA1) in airway hyper-responsiveness?

Abstract:

:Airway smooth muscle (ASM) contraction controls the airway caliber. Airway narrowing is exaggerated in obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD). The mechanism by which ASM tone is dysregulated in disease is not clearly understood. Recent research on ion channels, particularly transient receptor potential cation channel, subfamily A, member 1 (TRPA1), is uncovering new understanding of altered airway function. TRPA1, a member of the TRP channel superfamily, is a chemo-sensitive cation channel that can be activated by a variety of external and internal stimuli, leading to the influx of Ca(2+). Functional TRPA1 channels have been identified in neuronal and non-neuronal tissues of the lung, including ASM. In the airways, these channels can regulate the release of mediators that are markers of airway inflammation in asthma and COPD. For, example, TRPA1 controls cigarette-smoke-induced inflammatory mediator release and Ca(2+) mobilization in vitro and in vivo, a response tied to disease pathology in COPD. Recent work has revealed that pharmacological or genetic inhibition of TRPA1 inhibits the allergen-induced airway inflammation in vitro and airway hyper-responsiveness (AHR) in vivo. Collectively, it appears that TRPA1 channels may be determinants of ASM contractility and local inflammation control, positioning them as part of novel mechanisms that control (patho)physiological function of airways and ASM.

authors

Jha A,Sharma P,Anaparti V,Ryu MH,Halayko AJ

doi

10.1139/cjpp-2014-0417

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

171-6

issue

3

eissn

0008-4212

issn

1205-7541

journal_volume

93

pub_type

杂志文章,评审
  • Effects of olive oil and its minor constituents on serum lipids, oxidative stress, and energy metabolism in cardiac muscle.

    abstract::Recent lines of evidence suggest that the beneficial effects of olive oil are not only related to its high content of oleic acid, but also to the antioxidant potential of its polyphenols. The aim of this work was determine the effects of olive oil and its components, oleic acid and the polyphenol dihydroxyphenylethano...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y05-124

    authors: Faine LA,Rodrigues HG,Galhardi CM,Ebaid GM,Diniz YS,Padovani CR,Novelli EL

    更新日期:2006-02-01 00:00:00

  • Intestinal calcium-binding protein in animals fed normal and rachitogenic diets: II. Pig studies.

    abstract::Experiments were carried out in pigs to investigate the relationship between concentration of intestinal calcium-binding protein (CaBP) and the presence of rickets. Pigs made rachitic by a diet deficient in calcium and in vitamin D had concentrations of intestinal CaBP no less than values obtained on control pigs. The...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y75-020

    authors: Harrison JE,Hitchman AJ,Brown RG

    更新日期:1975-02-01 00:00:00

  • Mechanical and electrophysiological effects of a hydroxyphenyl-substituted tetrahydroisoquinoline, SL-1, on isolated rat cardiac tissues.

    abstract::The mechanisms of the positive inotropic action of a new synthetic tetrahydroisoquinoline compound, SL-1, were investigated in isolated rat cardiac tissues and ventricular myocytes. SL-1 produced a rapidly developing, concentration-dependent positive inotropic response in both atrial and ventricular muscles and a nega...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y95-727

    authors: Chang GJ,SU MJ,Lee PH,Lee SS,Liu KC

    更新日期:1995-11-01 00:00:00

  • Differential alteration of cytochrome P450 isoenzymes in two experimental models of cirrhosis.

    abstract::Liver diseases are associated with a decrease in hepatic drug elimination, but there is evidence that cirrhosis does not result in uniform changes of cytochrome P450 (CYP) isoenzymes. The objective of this study was to determine the content and activity of four CYP isoenzymes in the bile duct ligation and carbon tetra...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Bastien MC,Leblond F,Pichette V,Villeneuve JP

    更新日期:2000-11-01 00:00:00

  • [Dosimetry with radiosensitive gels in radiotherapy. Methods].

    abstract::The goal of conformal radiotherapy is to concentrate the dose in a well-defined volume by avoiding the neighbouring healthy structures. This technique requires powerful treatment planning software and a rigorous control of estimated dosimetry. The usual dosimetric tools are not adapted to visualize and validate comple...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Gibon D,Bourel P,Castelain B,Marchandise X,Rousseau J

    更新日期:2001-02-01 00:00:00

  • Relaxant effect of atorvastatin on isolated rat gastric fundus strips: implications for Ca2+-signalling mechanisms.

    abstract::Statins are determined to have various pleiotropic effects apart from their lipid-lowering properties. Herein, we investigated the direct effects of atorvastatin on gastric smooth muscle tone. Atorvastatin effectively relaxed isolated rat gastric fundus strips precontracted with acetylcholine, potassium chloride, and ...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/cjpp-2018-0723

    authors: Kaleli-Durman D,Alp-Yıldırım Fİ,Özdemir O,Uydeş-Doğan BS

    更新日期:2019-05-01 00:00:00

  • The effects of an ASA-like hydroperoxide compound on adenosine diphosphate induced platelet aggregation.

    abstract::A hydroperoxide compound structurally related to acetylsalicylic acid, 3-hydroperoxy-3-methylphthalide, inhibits both the first and second phases of adenosine diphosphate induced, biphasic, human platelet aggregation. This occurs over the same concentration range (0.05-0.5 mM) that acetylsalicylic acid inhibits second...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y84-053

    authors: Killackey JJ,Killackey BA,Cerskus I,Philp RB

    更新日期:1984-03-01 00:00:00

  • Lingonberry anthocyanins protect cardiac cells from oxidative-stress-induced apoptosis.

    abstract::Lingonberry grown in northern Manitoba, Canada, contains exceptionally high levels of anthocyanins and other polyphenols. Previous studies from our lab have shown that lingonberry anthocyanins can protect H9c2 cells from ischemia-reperfusion injury and anthocyanin-rich diets have been shown to be associated with decre...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/cjpp-2016-0667

    authors: Isaak CK,Petkau JC,Blewett H,O K,Siow YL

    更新日期:2017-08-01 00:00:00

  • Pharmacological evaluation of GABAergic and glutamatergic inputs to the nucleus basalis--cortical and the septal-hippocampal cholinergic projections.

    abstract::The presence of different receptor populations within a given brain area can be effectively evaluated via the local injections of defined receptor agonists and antagonists. Using this approach, it has become evident that the nucleus basalis - cortical cholinergic pathway possesses an inhibitory GABAergic input to the ...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y86-053

    authors: Wood PL

    更新日期:1986-03-01 00:00:00

  • Effects of K-channel blockers, calcium, and verapamil suggest different pacemaker mechanisms in cultured neonatal rat and embryonic chick ventricle cells.

    abstract::We compared the determinants of spontaneous activity in explanted neonatal (2-day-old) rat ventricle cells and in reaggregates derived from 15-day-old chick embryos. We studied the beating rate with an optical recording method and the underlying electrical activity with glass microelectrodes using the K current blocke...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y89-126

    authors: Schanne OF,Boutin L,Derosiers J

    更新日期:1989-07-01 00:00:00

  • Freezing point and melting point of barnacle muscle fibers.

    abstract::The freezing point and the melting point of myoplasm were measured with two experimental models. In all samples, a supercooled stage was reached by lowering the temperature of the sample to approximately - 7 degrees C, and the freezing of the sample was mechanically induced. The freezing process was associated with a ...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y83-167

    authors: Caillé JP

    更新日期:1983-10-01 00:00:00

  • Inhibitory effects of tetramethyl and tetraethyl derivatives of pyrazine on dog saphenous vein.

    abstract::The effects of two structurally similar pyrazine derivatives, tetramethylpyrazine (TMP) and tetraethylpyrazine (TEP) on the contractile responses of dog saphenous vein to KCl (via membrane depolarization), phenylephrine (PHE, alpha 1-adrenergic agonist), and B-HT 920 (alpha 2-adrenergic agonist) were investigated. The...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y91-173

    authors: Wang ZL,Kwan CY,Ohta A,Chen MC

    更新日期:1991-08-01 00:00:00

  • A tubule cell model for ifosfamide nephrotoxicity.

    abstract::Mechanisms leading to ifosfamide (IF)-induced renal damage have not been fully elucidated. Recent work suggests that localized renal tubular metabolism of IF and the production of the nephrotoxic chloroacetaldehyde may lead to nephrotoxicity. Presently no pharmacological method to reduce IF nephrotoxicity has been ide...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y05-036

    authors: Aleksa K,Halachmi N,Ito S,Koren G

    更新日期:2005-06-01 00:00:00

  • Effect of chlorpromazine on the synthesis, hydrolysis, and transfer of microsomal cytidine liponucleotides and mitochondrial polyglycerophosphatides.

    abstract::The effect of chlorpromazine on subcellular biosynthesis, hydrolysis, and transfer of lipids and liponucleotides participating in the biosynthesis of polyglycerophosphatides in guinea pig liver was studied. Chlorpromazine showed an apparent stimulation of accumulation of phosphatidic acid and CDP-diglycerides in micro...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y87-064

    authors: Stuhne-Sekalec L,Chudzik J,Stanacev NZ

    更新日期:1987-03-01 00:00:00

  • Characterization of the beta receptor responsible for enhanced histamine release from bovine leukocytes.

    abstract::The present study was undertaken to determine the beta-receptor subtype responsible for the enhanced anaphylactic histamine release from bovine leukocytes produced by isoprenaline. The selective beta 1 antagonist practolol competitively inhibited the enhancement of histamine release produced by isoprenaline. The selec...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y82-130

    authors: Perron R,Eyre P

    更新日期:1982-07-01 00:00:00

  • Effects produced by local applications of harmaline in the inferior olive.

    abstract::Local microinjections of harmaline evoked sustained rhythmic activity in the inferior olive of decerebrate cats. Harmaline appears to exert its action within restricted areas of the inferior olivary complex: the caudal halves of the dorsal and medial accessory nuclei. Since the highly synchronized activity generated b...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y75-116

    authors: De Montigny C,Lamarre Y

    更新日期:1975-10-01 00:00:00

  • Influence of exogenous fatty acids and ketone bodies on rates of lipolysis in isolated ventricular myocytes from normal and diabetic rats.

    abstract::The effect of oleate (0.3 and 1.2 mM) and the combined effect of beta-hydroxybutyrate (4 and 8 mM) and acetoacetate (1 and 2 mM) on rates of lipolysis (glycerol output) was determined with calcium-tolerant myocytes isolated from the hearts of normal rats and hearts from acutely (2-3 days; 100 mg/kg streptozotocin) dia...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y90-176

    authors: Larsen TS,Severson DL

    更新日期:1990-09-01 00:00:00

  • Alterations in hypertensive arteries.

    abstract::Mentoring in academia is often carried out in an informal way depending on individuals and circumstances. I was quite fortunate to make the acquaintance of Professor E.E. Daniel when I was making a transition from my research in entomology to biomedical sciences. Here I recount some of that experience, and describe so...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y05-064

    authors: Lee RM

    更新日期:2005-08-01 00:00:00

  • Prevention of reperfusion-induced ventricular arrhythmias in isolated rat heart with magnesium.

    abstract::The effects of magnesium (from 1.2 to 7.2 mM) were investigated in isolated perfused rat heart subjected to coronary artery ligation and reperfusion. Increasing magnesium concentrations, of the medium containing 3.00 mM of calcium, induced a significant bradycardia and a protective effect towards reperfusion arrhythmi...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y90-105

    authors: Bril A,Rochette L

    更新日期:1990-06-01 00:00:00

  • Effects of enalaprilat on neointimal growth of cultured rabbit aorta following balloon injury.

    abstract::Our objective was to determine if the ability of an angiotensin-converting enzyme (ACE) inhibitor to attenuate neointima formation in balloon-damaged vessel is expressed in an isolated organ culture model of neointimal growth. In vivo balloon angioplasty in combination with in vitro organ culture was used to produce a...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Dale WE,Blaine EH

    更新日期:1999-10-01 00:00:00

  • Studies on transhepatic insulin absorption.

    abstract::The intraperitoneal administration of insulin has been recommended because it was found to effectively control the plasma glucose level. Several authors have suggested that intraperitoneal insulin administration may be more "physiological" and therefore preferable because the insulin is absorbed into the portal venous...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y86-036

    authors: Zingg W,Rappaport AM,Leibel BS

    更新日期:1986-03-01 00:00:00

  • The area postrema: a cardiovascular control centre at the blood-brain interface?

    abstract::The area postrema (AP) is one of the circumventricular organs of the brain and as such it is highly vascular and lacks the normal blood-brain barrier. Anatomical tracing studies have demonstrated afferent projections to AP originating from the paraventricular nucleus, lateral parabrachial nucleus (l-PBN), nucleus trac...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章,评审

    doi:10.1139/y91-153

    authors: Ferguson AV

    更新日期:1991-07-01 00:00:00

  • The effect of displacement current on the measurement of reversal potential in squid giant axon.

    abstract::The measurement of the sodium reversal potential (Erev), as that potential where the early current reverses during voltage clamp, was found to exceed the true Erev by 4.1 +/- 2.4 mV (mean +/- SD) in squid giant axon. This error was found in both intact and internally perfused axons and is due to interference from the ...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y82-227

    authors: Wodlinger H,Kunov H,Atwood HL

    更新日期:1982-12-01 00:00:00

  • Doxepin, a tricyclic antidepressant, binds to normal, intact astroglial cells in cultures and inhibits the isoproterenol-induced increase in cyclic AMP production.

    abstract::Doxepin binds to intact astrocytes in primary cultures. The binding is competitively displaceable by excess cold doxepin and it is pronounced (Bmax = 27 nmol/mg protein) but the affinity is rather low (KD = 30 microM). The binding is inhibited by other antidepressants (amitriptyline, desipramine, tranylcypromine, ipri...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y80-230

    authors: Hertz L,Richardson JS,Mukerji S

    更新日期:1980-12-01 00:00:00

  • Fentanyl decreases catecholamine metabolism measured by in vivo voltammetry in the rat locus coeruleus.

    abstract::The objective of this study was to investigate under controlled conditions the effects of fentanyl on the rat locus coeruleus catechol oxidation current. Using differential normal pulse voltammetry combined with electrochemically treated carbon fiber electrodes to measure the catechol oxidation current, catecholamine ...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y89-085

    authors: Milne B,Quintin L,Gillon JY,Pujol JF

    更新日期:1989-05-01 00:00:00

  • Endothelial cell-specific ETB receptor knockout: autoradiographic and histological characterisation and crucial role in the clearance of endothelin-1.

    abstract::Inactivation of endothelin B receptors (ETB), either through selective pharmacological antagonism or genetic mutation, increases the circulating concentration of endothelin-1 (ET-1), suggesting ETB plays an important role in clearance of this peptide. However, the cellular site of ETB-mediated clearance has not yet be...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/Y10-041

    authors: Kelland NF,Kuc RE,McLean DL,Azfer A,Bagnall AJ,Gray GA,Gulliver-Sloan FH,Maguire JJ,Davenport AP,Kotelevtsev YV,Webb DJ

    更新日期:2010-06-01 00:00:00

  • Melatonin treatment affects changes in adrenal gene expression of catecholamine biosynthesizing enzymes and norepinephrine transporter in the rat model of chronic-stress-induced depression.

    abstract::This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats. This entailed quantifying the norepinephrine, epinephrine, mRNA, and protein levels of tyrosine hy...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/cjpp-2018-0612

    authors: Stefanovic B,Spasojevic N,Jovanovic P,Dronjak S

    更新日期:2019-07-01 00:00:00

  • Beta-blockade and oxygen delivery to muscle during exercise.

    abstract::The most commonly observed effect of beta-blockade on cardiovascular function has been a reduction in heart rate both at rest and during exercise. The body attempts to compensate by increasing stroke volume and (or) increasing the extraction of O2 from the blood to maintain O2 delivery to the muscle. This paper examin...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y91-044

    authors: Hughson RL,Kowalchuk JM

    更新日期:1991-02-01 00:00:00

  • Vital marker for muscle nuclei in myoblast transfer.

    abstract::A new method is developed using Fluoro-Gold (FG) as a vital stain to label the nuclei of donor myoblasts in myoblast transfer studies. In vitro incubation with 0.01% FG for 16 h resulted in 100% nuclei labelling. Intensive fluorescence persisted following 9 days of subculture, when the human myoblasts were injected in...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:10.1139/y91-008

    authors: Fang QW,Chen M,Li HJ,Goodwin TG,Law PK

    更新日期:1991-01-01 00:00:00

  • [The effect of estradiol benzoate on liver function, cholesterol metabolism and bile acids in the quail].

    abstract::Immature female quails were treated for 6 days with estradiol benzoate at daily 0.01-, 0.02-, 0.01-, and 1-mg dosages. At the end of treatment, bile outflow, biliary cholesterol (CST), and bile acid (BA) secretory rates and liver, bile, and serum CST and BA levels were determined. Some quails were used to measure the ...

    journal_title:Canadian journal of physiology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Laugier C,Pageaux JF,Duperray B,Pacheco H,Brard E

    更新日期:1979-04-01 00:00:00