Fentanyl decreases catecholamine metabolism measured by in vivo voltammetry in the rat locus coeruleus.

abstract：:The combined effect of a beta 2-antagonist and an alpha 2-agonist on the release of adrenal catecholamines was studied in the anaesthetized and vagotomized dog. The electrical stimulation of the splanchnic nerve (5-V pulses of 2 ms duration for 3 min at a frequency of 3 Hz) produced a significant rise in adrenal catec...

journal_title：Canadian journal of physiology and pharmacology

authors： Foucart S,de Champlain J,Nadeau R

更新日期：1988-10-01 00:00:00

abstract：:The effects of L-641,953 (R-8-fluoro-dibenzo[b, f]thiepin-3-carboxylic acid-5-oxide) have been studied on pulmonary and other smooth muscle preparations in vitro and in vivo. When studied in vitro on guinea-pig tracheal chains, L-641,933 produced significant shifts in the dose-response curves to the prostaglandin endo...

journal_title：Canadian journal of physiology and pharmacology

authors： Hall RA,Rokach JR,Bélanger P,Bianchi L,Ethier D,Ford-Hutchinson AW,Girard Y,Hamel P,Hamel R,Lord A

更新日期：1987-04-01 00:00:00

abstract：:The effect of sex hormones on vascular reactivity is considered one of the underlying factors contributing to gender differences in cardiovascular functions and diseases. Experiments were designed to investigate the role of androgens in salt-induced hypertension by assessing the relaxation response of isolated aortic ...

journal_title：Canadian journal of physiology and pharmacology

authors： Oloyo AK,Sofola OA,Anigbogu CN

更新日期：2011-04-01 00:00:00

abstract：:To assess development changes in kinetic properties of the cardiac sodium current, whole-cell voltage-clamp experiments were conducted using 3-, 10-, and 17-day-old embryonic chick ventricular heart cells. Experimental data were quantified according to the Hodgkin-Huxley model. While the Na current density, as examine...

journal_title：Canadian journal of physiology and pharmacology

authors： Sada H,Ban T,Fujita T,Ebina Y,Sperelakis N

更新日期：1995-10-01 00:00:00

abstract：:Newborn hearts have restricted functional reserve and variable responsiveness to inotropes that could be partly due to differences in myocardial beta-adrenoceptors (beta-AR). To clarify this issue, this study documented ventricle-specific changes in myocardial beta-AR density and affinity during postnatal maturation. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wittnich C,Belanger MP,Bandali K

更新日期：2006-08-01 00:00:00

abstract：:The most important reason for the non-approval and withdrawal of drugs by the Food and Drug Administration is hepatotoxicity. Therefore, this study was undertaken to evaluate the protective effects of hesperidin against cyclophosphamide (CYP)-induced hepatotoxicity in Wistar rats. The rats received a single intraperit...

journal_title：Canadian journal of physiology and pharmacology

authors： Mahmoud AM

更新日期：2014-09-01 00:00:00

abstract：:The influence of external potassium Ko and tetraethylammonium on the cellular K content of hypoxic myocardium was investigated. Perfused rabbit hearts were submitted to 60 min hypoxia in medium containing 5 mM K throughout or either low (1.5 mM) or high (10 mM) K during the last 20 min of hypoxia. Paced electrical act...

journal_title：Canadian journal of physiology and pharmacology

authors： Leblanc N,Ruiz-Ceretti E,Chartier D

更新日期：1987-05-01 00:00:00

abstract：:The direct effects of extrinsic nerve stimulation on coronary artery tone are unclear because of the complications arising from alterations in myocardial dynamics which themselves alter flow. An isolated and perfused nonbeating slab of beef ventricle was utilized in the present experiments to eliminate secondary compl...

journal_title：Canadian journal of physiology and pharmacology

authors： Kalsner S

更新日期：1979-03-01 00:00:00

abstract：:The objective of this work was to evaluate whether changes in respiratory status of isolated brown-fat mitochondria influence synthesis and degradation of proteins within the organelles. Mitochondrial protein synthesis is subject to regulation, as a 24-h fast in mice reduced [35S]methionine incorporation without affec...

journal_title：Canadian journal of physiology and pharmacology

authors： Desautels M,Dulos RA

更新日期：1993-01-01 00:00:00

abstract：:The combined and separate effects of exercise training and bisphosphonate (etidronate) therapy on bone mineral in postmenopausal women were compared. Forty-eight postmenopausal women were randomly assigned (double blind) to groups that took intermittent cyclical etidronate; performed strength training (3 d/week) and r...

journal_title：Canadian journal of physiology and pharmacology

authors： Chilibeck PD,Davison KS,Whiting SJ,Suzuki Y,Janzen CL,Peloso P

更新日期：2002-10-01 00:00:00

abstract：:Physical and lifestyle data were collected from 62 postmenopausal women who had declined hormone replacement therapy. Potential predictor variables were examined for their associations with bone mineral density (BMD) of the lumbar spine and femoral neck as assessed by dual x-ray absorptiometry. Body weight demonstrate...

journal_title：Canadian journal of physiology and pharmacology

authors： Hoover PA,Webber CE,Beaumont LF,Blake JM

更新日期：1996-08-01 00:00:00

abstract：:Delta 9-Tetrahydrocannabinol (20 mg/kg i.p.) and propranolol (20 and 50 mg/kg i.p.) produced marked falls in the rectal temperatures of mice kept at an ambient temperature of 22 degrees C. Propranolol (50 mg/kg i.p.) also decreased the thermogenic activity of brown fat, as measured by a decrease in the level of [3H]GD...

journal_title：Canadian journal of physiology and pharmacology

authors： Pertwee RG,Nash K,Trayhurn P

更新日期：1991-06-01 00:00:00

abstract：:Nitric oxide (NO) production occurs through oxidation of the amino acid L-arginine by NO synthase (NOS). NO inhibits platelet activation by increasing the levels of cyclic guanosine monophosphate (cGMP), thus maintaining vascular homeostasis. Our group previously demonstrated (da Silva et al. 2005) an enhancement of t...

journal_title：Canadian journal of physiology and pharmacology

authors： Siqueira MA,Brunini TM,Pereira NR,Martins MA,Moss MB,Santos SF,Lugon JR,Mendes-Ribeiro AC

更新日期：2011-02-01 00:00:00

abstract：:The disruption to glucose homeostasis upon glucocorticoid (GC) treatment in adult male rats has not been fully characterized in older rats or in females. Thus, we evaluated the age- and gender-related changes in glucose homeostasis in GC-treated rats. We injected male and female rats at 3 months and 12 months of age w...

journal_title：Canadian journal of physiology and pharmacology

authors： dos Santos C,Ferreira FB,Gonçalves-Neto LM,Taboga SR,Boschero AC,Rafacho A

更新日期：2014-10-01 00:00:00

abstract：:Tachykinin receptors in guinea-pig airways were examined using radioligand binding techniques in lung homogenates, and using isolated bronchial segments. Binding of the NK1 selective radioligand 125I-labelled Bolton-Hunter [Sar9,Met(O2)11]substance P ([125I]BHSarSP) was saturable and of high affinity (KD, 0.26 nM). Th...

journal_title：Canadian journal of physiology and pharmacology

authors： Burcher E,Zeng XP,Strigas J,Geraghty DP,Lavielle S

更新日期：1995-07-01 00:00:00

abstract：:For 10 days, dogs were fed a normal salt diet containing 70 mequiv. Na+/day (NSD) followed by a high salt diet containing 170 mequiv. Na+/day (HSD) or 240 mequiv. Na+/day (VHSD), or the order was reversed. K+ in these diets was fixed at 40 mequiv./day. The different diets did not influence the basal level of serum cat...

journal_title：Canadian journal of physiology and pharmacology

authors： Carrière S,Cardinal J,Le Grimellec C

更新日期：1980-09-01 00:00:00

abstract：:Since the discovery that apolipoprotein E, a cholesterol transport protein, is a major risk factor for Alzheimer's disease (AD) development, there has been a remarkable interest in understanding the many facets of the relationship between cholesterol and AD. Several lines of evidence have demonstrated the importance o...

journal_title：Canadian journal of physiology and pharmacology

authors： Posse de Chaves E

更新日期：2012-06-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effect of total flavones of rhododendra (TFR) pharmacological preconditioning against myocardial ischemia-reperfusion (I/R) injury and its probable mechanisms in rats. Rat myocardial I/R injury was induced by ligating and untying the left anterior descendi...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang JH,Chen ZW,Wu Z

更新日期：2008-03-01 00:00:00

abstract：:The adenylate cyclase activity induced by norepinephrine (10(-8)-10(-9) M) was studied in hypothalamic particulate fractions from female rats. The effect of estradiol on this activity was studied in rats that were ovariectomized in diestrus 1, injected with estradiol benzoate (50 micrograms/kg body weight), and killed...

journal_title：Canadian journal of physiology and pharmacology

authors： Zubin P,Defagot C

更新日期：1994-11-01 00:00:00

abstract：:Neuronal factors co-released with neurotransmitters may play an important role in synapse development and function. Calcitonin gene related peptide (CGRP) and adenosine 5'-triphosphate (ATP), two principal neuromodulators present in the motor nerve terminals, were studied for their roles and mechanisms during early de...

journal_title：Canadian journal of physiology and pharmacology

authors： Lu B,Fu WM

更新日期：1995-07-01 00:00:00

abstract：:The world-wide increase in cancer incidence imposes a corresponding significant increase in the use of chemotherapeutic agents. Nephrotoxicity is a side effect frequently encountered with cyclophosphamide (CP), which is also well-known to cause acute and chronic lung toxicities. The current study focuses on the evalua...

journal_title：Canadian journal of physiology and pharmacology

authors： Said E,Elkashef WF,Abdelaziz RR

更新日期：2016-04-01 00:00:00

abstract：:Angiotensin II (ANG II) causes a systemic pressor effect when injected into the cerebral ventricles. In the rat fourth ventricle, the effective doses for the ANG II pressor effect are over 100 times larger than in the systemic circulation. Considering the discrepancy of doses, the possibility that ANG II may reach the...

journal_title：Canadian journal of physiology and pharmacology

authors： Pesquero JB,Fior-Chadi DR,Yu YG,Merjan AJ,Lindsey CJ,Paiva AC

更新日期：2002-05-01 00:00:00

abstract：:Salvianolic acid B (Sal B) exerts strong antioxidant activity and eliminates the free radical effect. However, how it affects the antioxidant pathway is not very clear. The objective of this study was to investigate the underlying mechanism of Sal B in CCl4-induced acute liver injury, especially its effect on the Nrf2...

journal_title：Canadian journal of physiology and pharmacology

authors： Jin YM,Tao XM,Shi YN,Lu Y,Mei JY

更新日期：2020-03-01 00:00:00

abstract：:Negative chronotropic effects of beta-adrenoceptor (betaAR) antagonists on right atria from reserpine-treated rats and mice were determined as a test of their inverse agonist activities. BetaAR antagonist ICI-118,551 and nonselective betaAR antagonists alprenolol, propranolol, and timolol produced negative chronotropi...

journal_title：Canadian journal of physiology and pharmacology

authors： Varma DR

更新日期：1999-12-01 00:00:00

abstract：:We have measured the responses to endurance exercise training on body composition and glucose regulation, as well as cardiovascular and liver structure and function in rats fed a high carbohydrate and high fat (HCHF) diet as a model of human metabolic syndrome. Male Wistar rats (9-10 weeks old) were randomly allocated...

journal_title：Canadian journal of physiology and pharmacology

authors： Cameron I,Alam MA,Wang J,Brown L

更新日期：2012-11-01 00:00:00

abstract：:Cyclocarya paliurus (CP; qing qian liu), which is used as an herbal tea in China, has been confirmed to have therapeutic effects on hyperlipidemia and obesity, and therefore it is widely consumed to prevent metabolic diseases such as hyperlipidemia and diabetes. In this study, we investigated the preventive effects of...

journal_title：Canadian journal of physiology and pharmacology

authors： Yao X,Lin Z,Jiang C,Gao M,Wang Q,Yao N,Ma Y,Li Y,Fang S,Shang X,Ni Y,Zhang J,Yin Z

更新日期：2015-08-01 00:00:00

abstract：:ARHGAP21 is a Rho-GAP that controls GTPases activity in several tissues, but its role on liver lipid metabolism is unknown. Thus, to achieve the Rho-GAP role in the liver, control and ARHGAP21-haplodeficient mice were fed chow (Ctl and Het) or high-fat diet (Ctl-HFD and Het-HFD) for 12 weeks, and pyruvate and insulin ...

journal_title：Canadian journal of physiology and pharmacology

authors： Zangerolamo L,Soares GM,Vettorazzi JF,do Amaral ME,Carneiro EM,Olalla-Saad ST,Boschero AC,Barbosa-Sampaio HC

更新日期：2019-11-01 00:00:00

abstract：:Garlic is a commonly used spice in folk medicine that can exert adverse health effects when given at a high dose. Grape seed and skin extract (GSSE) exhibits a variety of beneficial effects even at a high dose. In the present study we evaluated the toxicity of high-dose garlic treatment on liver and the protective eff...

journal_title：Canadian journal of physiology and pharmacology

authors： Hamlaoui-Gasmi S,Mokni M,Limam N,N'guessan P,Carrier A,Limam F,Amri M,Aouani E,Marzouki L

更新日期：2012-05-01 00:00:00

abstract：:Diazinon (DZN) is a common organophosphorus insecticide extensively used for agriculture and veterinary purposes. DZN toxicity is not limited to insects; it also induces harmful effects in mammals and birds. Our experiment evaluated the protective and antioxidant potential of sesame oil (SO) and (or) alpha-lipoic acid...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdel-Daim MM,Taha R,Ghazy EW,El-Sayed YS

更新日期：2016-01-01 00:00:00

abstract：:It has been proposed that medullary washout secondary to increased blood flow will limit maximal urine osmolality and reabsorption of salt and water from the inner medullary collecting duct. We have tested this prediction. The function of the inner medullary collecting duct was examined by microcatheterization. Acetyl...

journal_title：Canadian journal of physiology and pharmacology

authors： Cupples WA,Sonnenberg H

更新日期：1987-12-01 00:00:00