Lingonberry anthocyanins protect cardiac cells from oxidative-stress-induced apoptosis.

abstract：:The direct effects of extrinsic nerve stimulation on coronary artery tone are unclear because of the complications arising from alterations in myocardial dynamics which themselves alter flow. An isolated and perfused nonbeating slab of beef ventricle was utilized in the present experiments to eliminate secondary compl...

journal_title：Canadian journal of physiology and pharmacology

authors： Kalsner S

更新日期：1979-03-01 00:00:00

abstract：:Physical activity and training have some potential as tools for examining immune responses to inflammation and trauma. Contributors to the present symposium review various aspects of the inflammatory process, including issues of lymphocyte recirculation and endotoxemia. They examine also the extent and nature of the i...

journal_title：Canadian journal of physiology and pharmacology

authors： Shephard RJ,Shek PN

更新日期：1998-05-01 00:00:00

abstract：:Acetylcholine (ACh)-mediated vagal transmission as well as nonneuronal ACh release are considered cardioprotective in pathological situations with increased sympathetic drive such as ischemia-reperfusion and cardiac remodeling. ACh action is terminated by hydrolysis by the cholinesterases (ChEs), acetylcholinesterase,...

journal_title：Canadian journal of physiology and pharmacology

authors： Kilianova Z,Ciznarova N,Szmicsekova K,Slobodova L,Hrabovska A

更新日期：2020-07-01 00:00:00

abstract：:The mesangial cell is a contractile secreting cell found in a key position in the renal glomerulus. Several kidney and systemic diseases are associated with dysfunctions of the mesangial cells. We compared the effect of bradykinin (BK; B2 agonist) and des-Arg9-bradykinin (DBK; B1 agonist) on intracellular calcium mobi...

journal_title：Canadian journal of physiology and pharmacology

authors： Girolami JP,Ouardani M,Bascands JL,Pécher C,Bompart G,Leung-Tack J

更新日期：1995-07-01 00:00:00

abstract：:The effects of beta-cyclodextrin (betaCD) inclusion complexation on the ability of violacein to prevent gastric ulceration in mice were studied. Violacein-betaCD inclusion complexes were prepared in 1:1 and 1:2 molar ratios and analysed by differential scanning calorimetry and powder X-ray diffractometry. Violacein pr...

journal_title：Canadian journal of physiology and pharmacology

authors： Durán N,Justo GZ,Melo PS,De Azevedo MB,Brito AR,Almeida AB,Haun M

更新日期：2003-04-01 00:00:00

abstract：:The present paper reviews current knowledge of the development and plasticity of the inhibitory gamma-aminobutyric acid (GABA) containing circuitry of the cerebral neocortex, in particular, the rat somatosensory barrel field cortex. Recent studies reveal a delayed and protracted maturation of the inhibitory compared w...

journal_title：Canadian journal of physiology and pharmacology

authors： Micheva KD,Beaulieu C

更新日期：1997-05-01 00:00:00

abstract：:The vasculature of the mammalian renal medulla is complex, having neither discrete input nor output. There is also efficient countercurrent exchange between ascending and descending vasa recta in the vascular bundles. These considerations have hampered measurement of medullary blood flow since they impose pronounced c...

journal_title：Canadian journal of physiology and pharmacology

authors： Cupples WA

更新日期：1986-07-01 00:00:00

abstract：:We recently reported that the two-chain form of human high molecular weight kininogen (HKa) inhibits angiogenesis by inducing endothelial cell apoptosis (Zhang et al. 2000). This property appears to be primarily conferred by HKa domain 5 (HKa D5). In this manuscript, we further characterize the activity of these polyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang JC,Qi X,Juarez J,Plunkett M,Donaté F,Sakthivel R,Mazar AP,McCrae KR

更新日期：2002-02-01 00:00:00

abstract：:The objective of this study was to explore the action of angiotensin II (AII) on cardiac contractility and cyclic AMP (cAMP) generation by forskolin and isoproterenol in the hypertrophic myocardium of the salt-sensitive Dahl rat. Inbred Dahl S and Dahl R rats that had been on a diet supplemented with 6% NaCl were stud...

journal_title：Canadian journal of physiology and pharmacology

authors： Sunga PS,Rabkin SW

更新日期：1994-06-01 00:00:00

abstract：:Many functions of the brain and the sympathetic adrenal system are influenced by those amino acids that exert precursor control over neurotransmitter synthesis. One of the functions affected is regulation of blood pressure. Therefore, the purpose of this review is to describe how food proteins and amino acids affect t...

journal_title：Canadian journal of physiology and pharmacology

authors： Anderson GH

更新日期：1986-06-01 00:00:00

abstract：:Recent studies demonstrate the critical role of the extracellular matrix in the organization of parenchymal cells in the heart. Thus, an understanding of the modes of regulation of matrix production by cardiac myofibroblasts is essential. Transforming growth factor beta (TGF-beta) signaling is transduced through the c...

journal_title：Canadian journal of physiology and pharmacology

authors： Cunnington RH,Nazari M,Dixon IM

更新日期：2009-10-01 00:00:00

abstract：:Remote ischemia-reperfusion detrimentally affects myocardial function by initially interfering with the rate of contraction. We investigated the usefulness of isoproterenol versus external electrical pacing in attenuating secondary functional damage of isolated Wistar rat atria. Atrial strips (n = 10/group) were bathe...

journal_title：Canadian journal of physiology and pharmacology

authors： Ben-Abraham R,Shapira I,Szold A,Weinbroum AA

更新日期：2004-01-01 00:00:00

abstract：:The role of sodium and calcium on strophanthidin inotropy was studied in canine cardiac Purkinje fibers perfused in vitro under conditions that vary cellular sodium and calcium. With high concentrations of strophanthidin (greater than or equal to 10(-7) M), force increases more in the presence of low [Ca]0 or high [Na...

journal_title：Canadian journal of physiology and pharmacology

authors： Li T,Bernabei R,Carbonin P,Vassalle M

更新日期：1986-11-01 00:00:00

abstract：:Effects of 6-hydroxydopamine (6-OHDA) on rat brain and blood adrenaline (A), noradrenaline (NA), ammonia (NH3), gamma-aminobutyric acid (GABA), and amino acid metabolism prior to and after high pressure oxygen (OHP) induced convulsions have been studied. 6-OHDA reduces GABA and glutamate (Glu) rior to OHP exposure in ...

journal_title：Canadian journal of physiology and pharmacology

authors： Singh AK,Banister EW

更新日期：1978-04-01 00:00:00

abstract：:Taurine status and pregnancy outcome were assessed in rats fed low dietary taurine and varying doses of guanidinoethyl sulfonate (GES), a structural analogue of taurine. Female Sprague-Dawley rats (225-270 g) were mated overnight and assigned to one of four groups from day 0 to 20 of gestation. Taurine-deficient anima...

journal_title：Canadian journal of physiology and pharmacology

authors： Gottschall-Pass KT,Gorecki DK,Paterson PG

更新日期：1995-08-01 00:00:00

abstract：:Hypothermia increases the sensitivity of isolated cardiac muscle to stimulation by beta-adrenoceptor agonists. The purpose of this study was to determine pharmacologically whether this supersensitivity is associated with a change in the affinity of agonists for the receptor. The positive inotropic and chronotropic res...

journal_title：Canadian journal of physiology and pharmacology

authors： Broadley KJ,McNeill JH

更新日期：1983-06-01 00:00:00

abstract：:In previous studies we have been able to demonstrate tighter metabolic control of muscle metabolism during prolonged steady-state exercise 5 to 6 days after the initiation of training and well before changes in oxidative potential. To examine whether the metabolic adaptations are manifested during the non-steady-state...

journal_title：Canadian journal of physiology and pharmacology

authors： Green HJ,Cadefau J,Cussó R,Ball-Burnett M,Jamieson G

更新日期：1995-04-01 00:00:00

abstract：:Pathogenic mechanisms for essential hypertension are unclear despite striking efforts from numerous research teams over several decades. Increased production of reactive oxygen species (ROS) has been associated with the development of hypertension and the role of ROS in hypertension has been well documented in recent ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chang T,Wu L

更新日期：2006-12-01 00:00:00

abstract：:The mechanisms responsible for microbially induced epithelial apoptosis and increased intestinal permeability remain unclear. This study assessed whether purified bacterial lipopolysaccharide (LPS) increases epithelial apoptosis and permeability and whether these changes are dependent on caspase-3 activation. In nontu...

journal_title：Canadian journal of physiology and pharmacology

authors： Chin AC,Flynn AN,Fedwick JP,Buret AG

更新日期：2006-10-01 00:00:00

abstract：:The effects of haloperidol, an antipsychotic butyrophenone, on excitability and action potential production in frog's sartorius muscle fibers were studied. This drug produced a local-anestheticlike effect which developed slowly over 1 to 5 h with lower concentrations (2.7 to 5.3 X 10(-6 M) but was completely reversed ...

journal_title：Canadian journal of physiology and pharmacology

authors： Durham HD,Frank GB,Marwaha J

更新日期：1977-06-01 00:00:00

abstract：:1. To examine whether different local anesthetics act on different or similar sites in the nerve membrane, the effects of combinations of lipid-soluble anesthetics and tetrodotoxin (TTX) were studied on the compound action potential of the frog sciatic nerve. 2. The nerve-blocking potency of TTX was potentiated 5-fold...

journal_title：Canadian journal of physiology and pharmacology

authors： Staiman AL,Seeman P

更新日期：1975-08-01 00:00:00

abstract：:The hypotensive effect of clonidine in anaesthetised (pentobarbitone) cat has been analysed with the help of pharmacological tools. Application of clonidine (0.1%) to the exposed ventral surface of medulla oblongata produced hypotension (28.6%) and bradycardia (18%). Similar application of glycine (5%) and GABA (10%) ...

journal_title：Canadian journal of physiology and pharmacology

authors： Srimal RC,Gulati K,Dhawan BN

更新日期：1977-10-01 00:00:00

abstract：:Hypertrophic scar (HS) results from abnormal wound healing, accompanied by excessive hypercellularity, migration and extracellular matrix (ECM) deposition. Autophagy dysregulation plays crucial roles during HS formation. The overexpressed p75 neurotrophin receptor (p75NTR) in injured skin tissue after wound healing be...

journal_title：Canadian journal of physiology and pharmacology

authors： Shi W,Wu Y,Bian D

更新日期：2020-07-29 00:00:00

abstract：:Cumulative data suggest the significant role of the renin-angiotensin system in the development of the pathological consequences of diabetes mellitus (DM). Newly synthesized AT2 receptor agonists gained importance as a target for creating new antihypertensives. The aim of the present work was to study the effects of p...

journal_title：Canadian journal of physiology and pharmacology

authors： Pechlivanova D,Petrov K,Grozdanov P,Nenchovska Z,Tchekalarova J,Stoynev A

更新日期：2018-05-01 00:00:00

abstract：:Calcium-activated chloride channels (ClCa) are ligand-gated anion channels as they have been shown to be activated by a rise in intracellular Ca2+ concentration in various cell types including cardiac, skeletal and vascular smooth muscle cells, endothelial and epithelial cells, as well as neurons. Because ClCa channel...

journal_title：Canadian journal of physiology and pharmacology

authors： Leblanc N,Ledoux J,Saleh S,Sanguinetti A,Angermann J,O'Driscoll K,Britton F,Perrino BA,Greenwood IA

更新日期：2005-07-01 00:00:00

abstract：:Since the discovery that apolipoprotein E, a cholesterol transport protein, is a major risk factor for Alzheimer's disease (AD) development, there has been a remarkable interest in understanding the many facets of the relationship between cholesterol and AD. Several lines of evidence have demonstrated the importance o...

journal_title：Canadian journal of physiology and pharmacology

authors： Posse de Chaves E

更新日期：2012-06-01 00:00:00

abstract：:Heme oxygenase (HO) has a central role in cellular antioxidant defences and vascular protection, and it may mediate pleiotropic actions of drugs used in cardiovascular therapy. We investigated whether long-term use of statins upregulates HO activity and increases carbon monoxide (CO) and bilirubin levels in vivo. Adul...

journal_title：Canadian journal of physiology and pharmacology

authors： Muchova L,Wong RJ,Hsu M,Morioka I,Vitek L,Zelenka J,Schröder H,Stevenson DK

更新日期：2007-08-01 00:00:00

abstract：:The sarco(endo)plasmic reticulum calcium ATPase (SERCA) is responsible for transporting calcium (Ca(2+)) from the cytosol into the lumen of the sarcoplasmic reticulum (SR) following muscular contraction. The Ca(2+) sequestering activity of SERCA facilitates muscular relaxation in both cardiac and skeletal muscle. Ther...

journal_title：Canadian journal of physiology and pharmacology

authors： Stammers AN,Susser SE,Hamm NC,Hlynsky MW,Kimber DE,Kehler DS,Duhamel TA

更新日期：2015-10-01 00:00:00

abstract：:Our previous results showed that addition of agonists, such as vasopressin and angiotensin, added to incubation medium with freshly excised rat atria caused marked release of atrial natriuretic factor (ANF). This release was in the form of prohormone rather than active peptide. Since others had difficulty reproducing ...

journal_title：Canadian journal of physiology and pharmacology

authors： Sonnenberg H,Milojevic S,Yip C,Veress AT

更新日期：1989-10-01 00:00:00

abstract：:Cerebrocrast is a novel lipophilic dihydropyridine derivative with potential neuroprotective and antidiabetic properties. We have analyzed its interaction with L-type (CaV1.2b) and T-type (CaV3.1) calcium channels using a whole-cell patch clamp in HEK 293 cells. Cerebrocrast inhibited current flux through both CaV1.2b...

journal_title：Canadian journal of physiology and pharmacology

authors： Drígelová M,Tarabová B,Duburs G,Lacinová L

更新日期：2009-11-01 00:00:00