Inhibition of angiogenesis by two-chain high molecular weight kininogen (HKa) and kininogen-derived polypeptides.

abstract：:The role of sympathetic innervation in the regulation of hindlimb skeletal muscle blood flow (QL) and metabolism was studied prior to and during acute anemia in anesthetized, paralyzed, and ventilated dogs (n = 8). Neural activity in the sciatic nerve was reversibly cold blocked for a 15-min period at control hematocr...

journal_title：Canadian journal of physiology and pharmacology

authors： Kubes P,Cain SM,Chapler CK

更新日期：1988-09-01 00:00:00

abstract：:Geniposide (GP) is one of main compounds in Gardenia jasminoides Ellis, with both medicinal and nutritional value. This study was designed to determine, for the first time, how GP from G. jasminoides protects against acute alcohol-induced liver injury, and the underlying mechanisms. Mice were orally administered alcoh...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang J,Zhang Y,Liu R,Li X,Cui Y,Qu L

更新日期：2015-04-01 00:00:00

abstract：:Excitation-contraction coupling in crab muscle fibers was studied in voltage-clamp conditions. Extracellular calcium is essential for the mechanical activity. Two calcium influxes induced by membrane depolarization contribute to tension development: one is the inward calcium current responsible for the phasic tension,...

journal_title：Canadian journal of physiology and pharmacology

authors： Mounier Y,Goblet C

更新日期：1987-04-01 00:00:00

abstract：:This study has investigated the oral activity, following intragastric administration, of three potent and long-acting peptide-based bradykinin antagonists, HOE-140, B9430, and CP-0597, in the anesthetized rat, using bradykinin-induced hypotension. Two of the three bradykinin antagonists, B9430 and HOE-140, but not CP-...

journal_title：Canadian journal of physiology and pharmacology

authors： Whalley ET,Hanson WL,Stewart JM,Gera L

更新日期：1997-06-01 00:00:00

abstract：:The responses of the circular muscle of canine colon to stimulation of intrinsic nerves and to the probable mediators of these nerves were studied in vivo. In vivo studies were carried out using close intra-arterial injections and local field stimulation of proximal, mid-, and distal colon while recording circumferent...

journal_title：Canadian journal of physiology and pharmacology

authors： Gonda T,Daniel EE,Kostolanska F,Oki M,Fox JE

更新日期：1988-04-01 00:00:00

abstract：:A new approach for the purification of rat mesenteric arterial bed (MAB) elastase-2 has been developed using the chromogenic substrates N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide and N-succinyl-Ala-Ala-Pro-Leu-p-nitroanilide to monitor the enzymatic activity during various stages of purification. The purified enzyme wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Santos CF,Greene AS,Salgado MC,Oliveira EB

更新日期：2004-11-01 00:00:00

abstract：:Anesthetized dogs were prepared for the measurement of compliance of the inferior vena cava by placement of a catheter for pressure measurement and a pair of ultrasonic dimension transducers for the measurement of transverse diameter. Measurements of compliance were made in a control state, after the induction of carb...

journal_title：Canadian journal of physiology and pharmacology

authors： Biro GP

更新日期：1986-05-01 00:00:00

abstract：:We used thermoluminescence, electron spin resonance, and viscosimetric measurements to establish whether or not a spice had been irradiated. Thermoluminescence, using the 1788 EN official protocol with an alternative method for the extraction of mineral impurities, led to proof of irradiation or proof of no treatment....

journal_title：Canadian journal of physiology and pharmacology

authors： Chabane S,Pouliquen-Sonaglia I,Raffi J

更新日期：2001-02-01 00:00:00

abstract：:Complexes of vanadyl(IV) with 4 monosaccharides and 5 disaccharides were tested in 2 osteoblast-like cell lines (MC3T3E1 and UMR106). Many complexes caused stimulation of UMR106 proliferation (120% basal) in the range of 2.5 to 25 micromol/L. In the nontransformed osteoblasts, some vanadyl-saccharide complexes stimula...

journal_title：Canadian journal of physiology and pharmacology

authors： Barrio DA,Cattáneo ER,Apezteguía MC,Etcheverry SB

更新日期：2006-07-01 00:00:00

abstract：:We examined whether there was a threshold for change in fetal arterial PO2 to elicit alterations in plasma adrenocorticotropic hormone, arginine vasopressin, or cortisol, or to affect the incidence of fetal breathing movements or eye movements and we determined whether such a threshold changed with gestational age. Fe...

journal_title：Canadian journal of physiology and pharmacology

authors： Akagi K,Challis JR

更新日期：1990-05-01 00:00:00

abstract：:Natural rodent grooming and other instinctive behavior serves as a natural model of complex movement sequences. Rodent grooming has syntactic (rule-driven) sequences and more random movement patterns. Both incorporate the same movements--only the serial structure differs. Recordings of neural activity in the dorsolate...

journal_title：Canadian journal of physiology and pharmacology

authors： Aldridge JW,Berridge KC,Rosen AR

更新日期：2004-08-01 00:00:00

abstract：:The effects of isoproterenol and forskolin on tension, cyclic AMP levels, and cyclic AMP dependent protein kinase activity were compared in helical strips of bovine coronary artery. Elevation of cyclic AMP and activation of the protein kinase appeared to be well correlated with relaxation of potassium-contracted arter...

journal_title：Canadian journal of physiology and pharmacology

authors： Vegesna RV,Diamond J

更新日期：1984-09-01 00:00:00

abstract：:The aim of the present investigation was to elucidate the pharmacological mechanism by which U44069, a stable PGH2 analogue, contracts the rat aorta. The results obtained demonstrate that while the contractile effect of potassium chloride is obliterated by removal of extracellular calcium, a substantial proportion of ...

journal_title：Canadian journal of physiology and pharmacology

authors： Heaslip RJ,Rahwan RG

更新日期：1982-05-01 00:00:00

abstract：:The anticonvulsant activity of delta9-tetrahydrocannabinol (delta9-THC) has been determined against seizures induced in epileptic chickens by intermittent photic stimulation (IPS) and in epileptic and nonepileptic chickens by Metrazol. Intravenous administration of the drug reduced both the severity and incidence of s...

journal_title：Canadian journal of physiology and pharmacology

authors： Johnson DD,McNeill JR,Crawford RD,Wilcox WC

更新日期：1975-12-01 00:00:00

abstract：:Although dual endothelin receptor antagonists (ERAs) show great promise for treating various conditions, their propensity to induce liver injury limits their clinical usage. Inflammation and fibrosis are important processes in liver responses to injury and it has been suggested that they and dual ERA-induced liver inj...

journal_title：Canadian journal of physiology and pharmacology

authors： Ryanto GRT,Yorifuji K,Ikeda K,Emoto N

更新日期：2020-09-01 00:00:00

abstract：:Measurements of the presynaptic fiber volley (PSFV), the population excitatory postsynaptic potential (EPSP), and the extracellular pH in the dendritic CA1 layer of rat hippocampal slices were used to evaluate the effects of lactacidosis on central synaptic transmission. Replacement of NaCl with sodium lactate (up to ...

journal_title：Canadian journal of physiology and pharmacology

authors： Walz W,Harold DE

更新日期：1990-02-01 00:00:00

abstract：:The disruption to glucose homeostasis upon glucocorticoid (GC) treatment in adult male rats has not been fully characterized in older rats or in females. Thus, we evaluated the age- and gender-related changes in glucose homeostasis in GC-treated rats. We injected male and female rats at 3 months and 12 months of age w...

journal_title：Canadian journal of physiology and pharmacology

authors： dos Santos C,Ferreira FB,Gonçalves-Neto LM,Taboga SR,Boschero AC,Rafacho A

更新日期：2014-10-01 00:00:00

abstract：:As an activator of AMPK, the effect of AICAR on insulin signaling has not been investigated extensively. PI3K-Akt is a critical node involved in the insulin signaling pathway. We observed that concomitant with the activation of AMPK by AICAR, the protein level of PI3K p85α and the insulin-induced phosphorylation of Ak...

journal_title：Canadian journal of physiology and pharmacology

authors： Liu J,Ye C,Liu W,Zhao W,Zhang YJ,Zhang H,Ying H

更新日期：2016-02-01 00:00:00

abstract：:Physical exercise is essential for the amelioration of insulin resistance. The mechanisms in charge of improved insulin resistance, regulated by exercise, are insufficient inquired. Previous researches revealed that SIRT6-mediated insulin signaling acts a crucial character in hepatic IR. The objective of our research ...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang Y,Yang Z,Xu Z,Wan J,Hua T,Sun Q

更新日期：2020-09-24 00:00:00

abstract：:Small, sinusoidal length changes were superimposed on isometric contractions of fast- and slow-twitch mouse muscles, which were stimulated maximally via their nerves. Stiffness increased with increasing frequency of sinusoidal stimulation, but the relative time course of force and stiffness changes during twitch, teta...

journal_title：Canadian journal of physiology and pharmacology

authors： Stein RB,Gordon T

更新日期：1986-09-01 00:00:00

abstract：:The expression of tissue factor (TF) in tumors reportedly exacerbates the aggressiveness of several types of cancers. The shedding of TF-containing membrane particles is believed to influence the ability of tumors to expand and metastasize, and these microparticles may also be harmful in the onset of disseminated intr...

journal_title：Canadian journal of physiology and pharmacology

authors： Brousseau C,Morissette G,Fortin JP,Marceau F,Petitclerc E

更新日期：2009-09-01 00:00:00

abstract：:This study investigated the effects of melatonin treatment on adrenal catecholamine content, synthesis, uptake, and vesicular transport induced by the chronic unpredictable mild stress (CUMS) model of depression in rats. This entailed quantifying the norepinephrine, epinephrine, mRNA, and protein levels of tyrosine hy...

journal_title：Canadian journal of physiology and pharmacology

authors： Stefanovic B,Spasojevic N,Jovanovic P,Dronjak S

更新日期：2019-07-01 00:00:00

abstract：:Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain. In this study, we investigated the antiseptic effects and underlying mechanisms of vicenin-2 and scolymoside, which are 2 active compounds from C. subternata that act against high mobility group box 1 (HMGB1)-mediated septi...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee W,Yoon EK,Kim KM,Park DH,Bae JS

更新日期：2015-08-01 00:00:00

abstract：:The effect of sex hormones on vascular reactivity is considered one of the underlying factors contributing to gender differences in cardiovascular functions and diseases. Experiments were designed to investigate the role of androgens in salt-induced hypertension by assessing the relaxation response of isolated aortic ...

journal_title：Canadian journal of physiology and pharmacology

authors： Oloyo AK,Sofola OA,Anigbogu CN

更新日期：2011-04-01 00:00:00

abstract：:The effect of neural inhibition on the electrical activities of circular and longitudinal colonic smooth muscle was investigated. In addition, a comparative study was carried out between circular muscle preparations with and without the "submucosal" and "myenteric plexus" network of interstitial cells of Cajal (ICC) t...

journal_title：Canadian journal of physiology and pharmacology

authors： Huizinga JD,Berezin I,Daniel EE,Chow E

更新日期：1990-03-01 00:00:00

abstract：:Sarcoplasmic reticulum (SR) calcium handling in diaphragm was compared between mdx mice (7-8 weeks old) and age-matched controls. The total SR Ca2+ load was released from the SR by rapidly cooling muscle bundles from 22 to -1 degree C. The plateau amplitude of the rapid cooling contracture (RCC) was considered as an i...

journal_title：Canadian journal of physiology and pharmacology

authors： Khammari A,Péréon Y,Baudet S,Noireaud J

更新日期：1998-12-01 00:00:00

abstract：:Alterations in calcium metabolism and calcium-regulating hormones have been described in essential hypertension. However, the mechanisms that mediate these responses are unknown. In previous studies, using the genetically spontaneously hypertensive rat and the mineralocorticoid-salt (DOC-salt) hypertensive rat model, ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wimalawansa SJ,Supowit SC,DiPette DJ

更新日期：1995-07-01 00:00:00

abstract：:The arterio--alveolar nitrogen difference (aADN2) has been associated in 27 normal adult subjects aged 20--60 years. As it may be assumed that venous and arterial PN2 are identical, we have used a sample of venous blood. There is a significant positive correlation between aADN2 and age. As the increase of aADN2 with a...

journal_title：Canadian journal of physiology and pharmacology

authors： Corbet AJ,Ross JA,Beaudry PH

更新日期：1975-02-01 00:00:00

abstract：:We have measured the responses to endurance exercise training on body composition and glucose regulation, as well as cardiovascular and liver structure and function in rats fed a high carbohydrate and high fat (HCHF) diet as a model of human metabolic syndrome. Male Wistar rats (9-10 weeks old) were randomly allocated...

journal_title：Canadian journal of physiology and pharmacology

authors： Cameron I,Alam MA,Wang J,Brown L

更新日期：2012-11-01 00:00:00

abstract：:The purpose of this article is to review the current state of knowledge of ethanol neurobehavioural teratogenesis and its postulated mechanisms. The review comprises an examination of ethanol teratogenesis in the human, including the fetal alcohol syndrome, and in experimental animals. Several current proposed mechani...

journal_title：Canadian journal of physiology and pharmacology

authors： Reynolds JD,Brien JF

更新日期：1995-09-01 00:00:00