Epileptiform seizures in domestic fowl. V. The anticonvulsant activity of delta9-tetrahydrocannabinol.

abstract：:The effects of magnesium (from 1.2 to 7.2 mM) were investigated in isolated perfused rat heart subjected to coronary artery ligation and reperfusion. Increasing magnesium concentrations, of the medium containing 3.00 mM of calcium, induced a significant bradycardia and a protective effect towards reperfusion arrhythmi...

journal_title：Canadian journal of physiology and pharmacology

authors： Bril A,Rochette L

更新日期：1990-06-01 00:00:00

abstract：:The effects of some components of ischemia on the oscillatory (Vos) and nonoscillatory (V(ex)) potentials and respective currents (Ios and Iex), as well as their mechanisms, were studied in guinea pig isolated ventricular myocytes by means of a single-microelectrode, discontinuous voltage clamp method. Repetitive acti...

journal_title：Canadian journal of physiology and pharmacology

authors： Liu QY,Vassalle M

更新日期：1994-04-01 00:00:00

abstract：:The expression of tissue factor (TF) in tumors reportedly exacerbates the aggressiveness of several types of cancers. The shedding of TF-containing membrane particles is believed to influence the ability of tumors to expand and metastasize, and these microparticles may also be harmful in the onset of disseminated intr...

journal_title：Canadian journal of physiology and pharmacology

authors： Brousseau C,Morissette G,Fortin JP,Marceau F,Petitclerc E

更新日期：2009-09-01 00:00:00

abstract：:In Sprague-Dawley rats, we attempted to develop an experimental model to stimulate the cardiac sympathetic nerve. After transverse thoracotomy under anesthesia, a miniature, bipolar electrode was placed on the right ansa subclavia and it was stimulated electrically. The nerve stimulation at 2, 4, and 8.3 Hz (2 ms in d...

journal_title：Canadian journal of physiology and pharmacology

authors： Masuda Y,Matsuoka H

更新日期：1997-02-01 00:00:00

abstract：:A variety of porphyrinogenic xenobiotics cause mechanism-based inactivation of a number of rat hepatic cytochrome P450 isozymes. As a result, a mixture of four N-alkylprotoporphyin IX (N-alkylPP) regioisomers, with ferrochelatase-inhibitory properties, are formed. This study was designed to determine whether all four ...

journal_title：Canadian journal of physiology and pharmacology

authors： McNamee JP,Kobus SM,Marks GS

更新日期：1996-08-01 00:00:00

abstract：:The antioxidant glutathione-S-transferase (GST) is a crucial determinant of the development of ischaemic-reperfusion (I/R) injury, and plays a pivotal role in the regulation of the mitogen activated protein kinase (MAPK) pathways involved in stress response and apoptosis. The aim of this study was to investigate wheth...

journal_title：Canadian journal of physiology and pharmacology

authors： Balatonyi B,Gasz B,Kovács V,Lantos J,Jancsó G,Marczin N,Rőth E

更新日期：2013-08-01 00:00:00

abstract：:We examined whether there was a threshold for change in fetal arterial PO2 to elicit alterations in plasma adrenocorticotropic hormone, arginine vasopressin, or cortisol, or to affect the incidence of fetal breathing movements or eye movements and we determined whether such a threshold changed with gestational age. Fe...

journal_title：Canadian journal of physiology and pharmacology

authors： Akagi K,Challis JR

更新日期：1990-05-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a key pathogenic factor in sepsis, and its recognition by toll-like receptor 4 (TLR4) can activate two district signaling pathways, leading to activation of transcription factors including NF-κB and interferon regulatory factor 3 (IRF3). Chloroquine (CQ) has been shown to affect LPS-TLR4 co...

journal_title：Canadian journal of physiology and pharmacology

authors： Ding C,Li F,Long Y,Zheng J

更新日期：2017-05-01 00:00:00

abstract：:Beneficial effects of an antioxidant (N-acetyl-L-cysteine, NAC) and an angiotensin I-converting enzyme (ACE) inhibitor (ramipril) were assessed in a rat model of insulin resistance induced by 10% glucose feeding for 20 weeks. Treatments with NAC (2 g/kg per day) and ramipril (1 mg/kg per day) were initiated at 16 week...

journal_title：Canadian journal of physiology and pharmacology

authors： El Midaoui A,Ismael MA,Lu H,Fantus IG,de Champlain J,Couture R

更新日期：2008-11-01 00:00:00

abstract：:Tachykinin receptors in guinea-pig airways were examined using radioligand binding techniques in lung homogenates, and using isolated bronchial segments. Binding of the NK1 selective radioligand 125I-labelled Bolton-Hunter [Sar9,Met(O2)11]substance P ([125I]BHSarSP) was saturable and of high affinity (KD, 0.26 nM). Th...

journal_title：Canadian journal of physiology and pharmacology

authors： Burcher E,Zeng XP,Strigas J,Geraghty DP,Lavielle S

更新日期：1995-07-01 00:00:00

abstract：:The electrical activity of the duodenum and proximal jejunum was studied in conscious healthy dogs implanted with unipolar silver electrodes. A computerized method was used for the calculation of the mean frequency of the slow wave for each consecutive minute of the electromyographic signal. A "slow wave frequency com...

journal_title：Canadian journal of physiology and pharmacology

authors： Pousse A,Mendel C,Aprahamian M,Kachelhoffer J,Balboni G,Plas A

更新日期：1987-06-01 00:00:00

abstract：:Hypothermia increases the sensitivity of isolated cardiac muscle to stimulation by beta-adrenoceptor agonists. The purpose of this study was to determine pharmacologically whether this supersensitivity is associated with a change in the affinity of agonists for the receptor. The positive inotropic and chronotropic res...

journal_title：Canadian journal of physiology and pharmacology

authors： Broadley KJ,McNeill JH

更新日期：1983-06-01 00:00:00

abstract：:The turnover rate of glucose, the irreversible disposal rate of lactate, and the rate of gluconeogenesis from lactate were calculated by tracer methods in four normal and four alloxan-diabetic dogs under control conditions as well as in chronic, stable metabolic acidosis and alkalosis. Acidosis was produced by feeding...

journal_title：Canadian journal of physiology and pharmacology

authors： Hetenyi G Jr,Paradis H,Kucharczyk J

更新日期：1988-02-01 00:00:00

abstract：:The response pattern of the isolated longitudinal muscle of the rabbit ileum to adenosine-5'-alpha, beta-methylenediphosphonate (APCP) was found to differ from that caused by adenosine or ATP in that the rapid initial phase of relaxation is absent and that at doses above 10 muM a secondary increase of contractile acti...

journal_title：Canadian journal of physiology and pharmacology

authors： Frew R,McKenzie SG,Bär HP,Hutchison KJ

更新日期：1976-08-01 00:00:00

abstract：:The effects of forskolin, Ro 20-1724, rolipram, and 3-isobutyl-1-methylxanthine (IBMX) on morphine-evoked release of adenosine from dorsal spinal cord synaptosomes were evaluated to examine the potential involvement of cyclic AMP in this action of morphine. Ro 20-1724 (1-100 microM), rolipram (1-100 microM), and forsk...

journal_title：Canadian journal of physiology and pharmacology

authors： Nicholson D,White TD,Sawynok J

更新日期：1991-06-01 00:00:00

abstract：:Histamine and specific H1- and H2-receptor agonists and antagonists in conjunction with phentolamine and (or) reserpine pretreatment were used to characterize histamine receptor(s) in the seminal vesicle of rat and guinea pig. Stimulation of H1 receptors produced a contraction whereas that of H2 receptors inhibited th...

journal_title：Canadian journal of physiology and pharmacology

authors： MacIntosh CM,Vohra MM

更新日期：1981-08-01 00:00:00

abstract：:It is commonly thought that central nervous system depressant drugs exert their actions through enhancement of gamma-aminobutyrate (GABA)-mediated mechanisms. Recently, the cellular electrophysiological evidence from this laboratory and others suggests that both sedative hypnotics and general anaesthetics inhibit cent...

journal_title：Canadian journal of physiology and pharmacology

authors： Carlen PL,Gurevich N,Davies MF,Blaxter TJ,O'Beirne M

更新日期：1985-07-01 00:00:00

abstract：:The adenylate cyclase activity induced by norepinephrine (10(-8)-10(-9) M) was studied in hypothalamic particulate fractions from female rats. The effect of estradiol on this activity was studied in rats that were ovariectomized in diestrus 1, injected with estradiol benzoate (50 micrograms/kg body weight), and killed...

journal_title：Canadian journal of physiology and pharmacology

authors： Zubin P,Defagot C

更新日期：1994-11-01 00:00:00

abstract：:The objective of this work was to evaluate whether changes in respiratory status of isolated brown-fat mitochondria influence synthesis and degradation of proteins within the organelles. Mitochondrial protein synthesis is subject to regulation, as a 24-h fast in mice reduced [35S]methionine incorporation without affec...

journal_title：Canadian journal of physiology and pharmacology

authors： Desautels M,Dulos RA

更新日期：1993-01-01 00:00:00

abstract：:The shear-stress sensor function of vascular glycocalyx heparan sulphate and hyaluronic acid was investigated in vivo by assessing flow-mediated dilation before and after their removal. Heparinase III exposure (100 mU·mL-1 for 20 min;n = 6) did not significantly affect flow-mediated dilation of the iliac, from 0.42 ± ...

journal_title：Canadian journal of physiology and pharmacology

authors： Ruane-O'Hora T,O'Malley D,Buckley MM,Markos F

更新日期：2019-08-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effect of total flavones of rhododendra (TFR) pharmacological preconditioning against myocardial ischemia-reperfusion (I/R) injury and its probable mechanisms in rats. Rat myocardial I/R injury was induced by ligating and untying the left anterior descendi...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang JH,Chen ZW,Wu Z

更新日期：2008-03-01 00:00:00

abstract：:Increased expression of DNA methyltransferase-1 (DNMT1) associates with the progression of many human diseases. Because DNMT1 induces cell proliferation, drugs that inhibit DNMT1 have been used to treat proliferative diseases. Because these drugs are nonspecific inhibitors of DNMT1, subsidiary events or the compensato...

journal_title：Canadian journal of physiology and pharmacology

authors： Boosani CS,Gunasekar P,Block M,Jiang W,Zhang Z,Radwan MM,Agrawal DK

更新日期：2018-10-01 00:00:00

abstract：:We studied the effects of Zn2+ and Cd2+ on the behaviour of IK(f), a transient outward potassium current in acutely dissociated melanotrophs of the pars intermedia of the rat pituitary gland. Micromolar concentrations of external Cd2+ or Zn2+ caused parallel and nearly equal rightward shifts along the voltage axis of ...

journal_title：Canadian journal of physiology and pharmacology

authors： Davidson JL,Kehl SJ

更新日期：1995-01-01 00:00:00

abstract：:In the literature there appears to be variability in reported levels of certain hormones during haemorrhage, specifically adrenocorticotrophic hormone (ACTH) and β-endorphin. It is possible that this variability may be due to the choice of anaesthetic. Therefore, the effect of 3 common research-only anaesthetic agents...

journal_title：Canadian journal of physiology and pharmacology

authors： Ruane-O'Hora T,Hall WJ,Markos F

更新日期：2011-07-01 00:00:00

abstract：:We studied the in vitro effect of corticosterone on insulin binding, uptake of 2-deoxy-D-glucose, glycolysis, and glycogenesis in the soleus and extensor digitorum longus (EDL) of Swiss-Webster mice. In each experiment, one muscle (soleus/EDL) was incubated with corticosterone (0.1, 1, 50, and 100 micrograms/mL) and t...

journal_title：Canadian journal of physiology and pharmacology

authors： Tan MH,Bonen A

更新日期：1985-09-01 00:00:00

abstract：:The study was designed to characterize restitution kinetics in atrial repolarization of rabbits and to examine effects of K+ or Ca2+ channel blockers on restitution. Action potentials were recorded from rabbit atrial tissue. Restitution curves of phase I amplitude and action potential duration at 50 and 90% repolariza...

journal_title：Canadian journal of physiology and pharmacology

authors： Qi A,Tang C,Yeung-Lai-Wah JA,Kerr CR

更新日期：1997-04-01 00:00:00

abstract：:Angiotensin II (ANG II) causes a systemic pressor effect when injected into the cerebral ventricles. In the rat fourth ventricle, the effective doses for the ANG II pressor effect are over 100 times larger than in the systemic circulation. Considering the discrepancy of doses, the possibility that ANG II may reach the...

journal_title：Canadian journal of physiology and pharmacology

authors： Pesquero JB,Fior-Chadi DR,Yu YG,Merjan AJ,Lindsey CJ,Paiva AC

更新日期：2002-05-01 00:00:00

abstract：:In anesthetized dogs, 60-min occlusions of either the proximal (n = 14), distal (n = 8) left circumflex (LCX), or left anterior descending (LAD, n = 10) arteries were followed by reperfusion. Coronary sinus and aortic norepinephrine and epinephrine plasma concentrations were measured. The ventricular arrhythmias were ...

journal_title：Canadian journal of physiology and pharmacology

authors： Godin D,Campeau N,Nadeau R,Cardinal R,de Champlain J

更新日期：1985-09-01 00:00:00

abstract：:The effects of a vasopressin (AVP) pressor antagonist, d(CH2)5Tyr(Me)AVP, on mean arterial pressure (MAP), total peripheral resistance (TPR), cardiac output (CO), and the distribution of CO were investigated by the microsphere technique in three groups of pentobarbital anesthetized rats: intact (I), saralasin pretreat...

journal_title：Canadian journal of physiology and pharmacology

authors： Tabrizchi R,King KA,Pang CC

更新日期：1986-08-01 00:00:00

abstract：:The effects of Bay K8644, a Ca2+ channel agonist, on the mechanical and electrical properties of frog skeletal muscle fibers were investigated. At relatively low concentrations, such as 10(-6) and 10(-5) M, Bay K8644 significantly potentiated the maximum amplitudes of twitch responses, and this effect was not reversed...

journal_title：Canadian journal of physiology and pharmacology

authors： Oz M,Frank GB

更新日期：1994-10-01 00:00:00