The apoprotein of cytochrome P450 3A2 does not selectively direct alkylation to one of four pyrrole rings of N-vinylprotoporphyrin IX.

abstract：:Lumbar spine and mid-radius bone mineral density was measured repeatedly in 48 postmenopausal women who completed 7 years of taking either a 500 mg x day(-1) calcium supplement (n = 22) or calcium supplementation with hormone replacement therapy. The hormone replacement was either a low dose (n = 15) or a moderate dos...

journal_title：Canadian journal of physiology and pharmacology

authors： Blake JM,Ryan ED,Beaumont LF,Webber CE

更新日期：1999-07-01 00:00:00

abstract：:The effects of lithium chloride on ornithine decarboxylase (ODC) activity were compared in the adrenal and kidney of control (saline treated) and prolactin-treated rats. ODC activity was decreased in kidney of both groups of animals, the magnitude of the effect of lithium in the hormone-treated group varying with the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Strümpfer A,Hsiao J,Peng T,Richards J

更新日期：1992-09-01 00:00:00

abstract：:Infusion of glucose alone or glucose with insulin in cats subjected to acute myocardial ischemia did not alter the hemodynamic response of the cats to coronary artery ligation. Furthermore, determination of myocardial creatine phosphokinase (CPK) (ATP:creatine N-phosphotransferase, EC 2.7.3.2) activities failed to rev...

journal_title：Canadian journal of physiology and pharmacology

authors： Spath JA,Ogletree ML,Lefer AM

更新日期：1976-08-01 00:00:00

abstract：:The disruption to glucose homeostasis upon glucocorticoid (GC) treatment in adult male rats has not been fully characterized in older rats or in females. Thus, we evaluated the age- and gender-related changes in glucose homeostasis in GC-treated rats. We injected male and female rats at 3 months and 12 months of age w...

journal_title：Canadian journal of physiology and pharmacology

authors： dos Santos C,Ferreira FB,Gonçalves-Neto LM,Taboga SR,Boschero AC,Rafacho A

更新日期：2014-10-01 00:00:00

abstract：:A new approach for the purification of rat mesenteric arterial bed (MAB) elastase-2 has been developed using the chromogenic substrates N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide and N-succinyl-Ala-Ala-Pro-Leu-p-nitroanilide to monitor the enzymatic activity during various stages of purification. The purified enzyme wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Santos CF,Greene AS,Salgado MC,Oliveira EB

更新日期：2004-11-01 00:00:00

abstract：:Many studies have demonstrated that chronic intermittent hypobaric hypoxia (CIHH) can reduce blood pressure in spontaneously hypertensive rats and renovascular hypertensive (RVH) rats in which endothelial dysfunction is determined as a critical factor. However, whether CIHH can regulate vasodilation of the aorta in RV...

journal_title：Canadian journal of physiology and pharmacology

authors： Fu C,Li N,Yuan Y,Wang R,Chen J,Yang J,Guo Z,Wang S,Zhang Y,Liu Y,Dong J

更新日期：2018-08-01 00:00:00

abstract：:In open-chest pentothal-chloralose anesthetized dogs, plasma catecholamine and cyclic AMP levels were evaluated in the aortic and coronary sinus blood, during stimulations of the left ansa subclavia (1, 2, and 4 Hz). Basal aortic and coronary sinus catecholamine levels were respectively 0.373 +/- 0.090 and 0.259 +/- 0...

journal_title：Canadian journal of physiology and pharmacology

authors： Lavallée M,Laurencin C,de Champlain J,Nadeau RA

更新日期：1981-06-01 00:00:00

abstract：:Using a time-lapse cinephotomicrographic technique, the locomotory paths taken by lymphocytes have been shown to satisfy the requirements for a continuous-time Markov chain analysis consisting of four directional states defined by the four quadrants of a Cartesian plane and state 0 in which the cells are stationary. T...

journal_title：Canadian journal of physiology and pharmacology

authors： Noble PB,Boyarsky A,Bentley KC

更新日期：1979-01-01 00:00:00

abstract：:In the literature there appears to be variability in reported levels of certain hormones during haemorrhage, specifically adrenocorticotrophic hormone (ACTH) and β-endorphin. It is possible that this variability may be due to the choice of anaesthetic. Therefore, the effect of 3 common research-only anaesthetic agents...

journal_title：Canadian journal of physiology and pharmacology

authors： Ruane-O'Hora T,Hall WJ,Markos F

更新日期：2011-07-01 00:00:00

abstract：:This study was conducted to examine the protective role of crude polysaccharide from brown seaweed Sargassum polycystum against acetaminophen-induced abnormality in blood glucose, serum albumin/globulin ratio, and liver glycogen, lactate, and pyruvate. Liver and renal tissue histology was performed to confirm the effi...

journal_title：Canadian journal of physiology and pharmacology

authors： Raghavendran HR,Srinivasan P

更新日期：2008-10-01 00:00:00

abstract：:The aim of this study was to demonstrate that within a population of healthy men (n = 15) of varying levels of aerobic fitness (VO2max = 36-74 mL.kg-1.min-1), (i) there are high and low responders with respect to carotid-cardiac baroreflex responsiveness, despite similar baseline heart rates (HRs) both at rest and dur...

journal_title：Canadian journal of physiology and pharmacology

authors： Savard GK,Lundie MJ

更新日期：1995-01-01 00:00:00

abstract：:Glucagon causes marked elevations of glomerular filtration rate (GFR) in dogs when administered intravenously (i.v.) in small doses. The associated natriuresis is thought to be entirely due to increments in the filtered sodium load. In this study, renal denervation, thyroparathyroidectomy, and blockade of cholinergic,...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy M

更新日期：1975-02-01 00:00:00

abstract：:Curare action on nicotinic acetylcholine receptors has a number of facets, of which the best known is competitive antagonism. Here we describe the weak agonist action of 10(-5) M curare on the murine skeletal muscle cell line, G8. Although curare induces no depolarization in G8 cells, single-channel recordings reveal ...

journal_title：Canadian journal of physiology and pharmacology

authors： Morris CE,Montpetit MR,Sigurdson WJ,Iwasa K

更新日期：1989-02-01 00:00:00

abstract：:We have investigated the influence of dopaminergic agents on the expression of brain-derived neurotrophic factor (BDNF) gene in relation with lipid levels in chronic mild stress (CMS). Mice subjected to CMS were treated with simvastatin (10 mg/kg, per os (orally)) along with bromocriptine (2 mg/kg, intraperitoneally (...

journal_title：Canadian journal of physiology and pharmacology

authors： Rana DG,Patel AK,Joshi CG,Jhala MK,Goyal RK

更新日期：2014-12-01 00:00:00

abstract：:In rats anesthetized with alpha-chloralose, doses of 0.1, 0.5, and 1 g/kg of ethanol produced an upward shift of baroreflex curves constructed by plotting the heart rate response against mean arterial pressure following evoked rises in mean arterial pressures by phenylephrine or angiotensin II. Whereas the upward shif...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdel-Rahman AR,Russ R,Strickland JA,Wooles WR

更新日期：1987-05-01 00:00:00

abstract：:Total renal blood flow, glomerular filtration rate, and renal excretory function were determined in anesthetized rats treated with intravenous infusion of ethacrynic acid, 0.36 mg.min-1.kg-1, alone or in combination with cysteine. Simultaneously, the corticomedullary electrolyte gradient was evaluated in vivo from mea...

journal_title：Canadian journal of physiology and pharmacology

authors： Kompanowska-Jezierska E,Dobrowolski L,Sadowski J

更新日期：1990-09-01 00:00:00

abstract：:In embryonic chick hearts during development, there are three inward current systems which are involved in the rising phases of the action potentials (APs): fast INa, slow ICa, and tetrodotoxin-insensitive slow INa. To assess reactivation processes for these three types of inward current channels (fast Na+, slow Ca2+,...

journal_title：Canadian journal of physiology and pharmacology

authors： Sada H,Sada S,Sperelakis N

更新日期：1986-02-01 00:00:00

abstract：:A systematic study has been performed in various segments of the intestine and in the urinary bladder of the mouse to identify tissues that respond to kinins and possess B1 and (or) B2 receptors. The stomach was found to contain B1 and B2 functional sites that show pharmacological profiles compatible with B1 and B2 re...

journal_title：Canadian journal of physiology and pharmacology

authors： Allogho SN,Gobeil F,Pheng LH,Nguyen-Le XK,Neugebauer W,Regoli D

更新日期：1995-12-01 00:00:00

abstract：:Electrophysiological studies were performed on in vitro slice preparations of sympathetic ganglia excised from peripherally perfused, brain-dead human donors. The intracellular recordings in 16 neurons showed resting potentials and input resistances mostly in the ranges reported for sympathetic neurons in other mammal...

journal_title：Canadian journal of physiology and pharmacology

authors： Puil E,el-Beheiry H,Spigelman I

更新日期：1988-06-01 00:00:00

abstract：:Muramyl peptides derived from bacterial peptidoglycan are detected intracellularly by Nod1 and Nod2, 2 members of the newly characterized nod-like receptor (NLR) family of pattern recognition molecules. In the absence of bacterial invasion into the host cytosolic compartment, it remains unclear whether muramyl peptide...

journal_title：Canadian journal of physiology and pharmacology

authors： Ismair MG,Vavricka SR,Kullak-Ublick GA,Fried M,Mengin-Lecreulx D,Girardin SE

更新日期：2006-12-01 00:00:00

abstract：:The purpose of this study was to investigate the cardiac adrenergic neuronal changes induced by diabetes and hypertension by using an analogue of norepinephrine, meta-iodobenzylguanidine (MIBG), and to compare these changes with the contractile state of ventricular papillary muscle. The tissue concentration of norepin...

journal_title：Canadian journal of physiology and pharmacology

authors： Herman LM,Dai S,Hartman NG,McNeill JH

更新日期：1994-10-01 00:00:00

abstract：:The effect of intracerebroventricular (i.c.v.) injection of the alpha 2-adrenoceptor agonists clonidine and B-HT 920 on mean arterial pressure (MAP), heart rate (HR), and plasma concentrations of noradrenaline and adrenaline was examined in conscious unrestrained rats. The injection of 1.0 microgram clonidine signific...

journal_title：Canadian journal of physiology and pharmacology

authors： King KA,Pang CC

更新日期：1988-11-01 00:00:00

abstract：:Our objective was to produce reductions in the luminal volume of Henle's loop and increases in linear flow velocity through the loop. We did this in a recollection micropuncture study by collecting fluid with and without suction from early distal tubules. With suction, transit time of fast green dye through the loop d...

journal_title：Canadian journal of physiology and pharmacology

authors： Baines AD,Wu CK

更新日期：1975-04-01 00:00:00

abstract：:There are conflicting reports concerning the existence of severe hypermethioninemia in rats made diabetic with the pancreotoxin, streptozotocin. To determine whether this discrepancy is due to experimental differences in the severity of diabetes or the diet fed to the animals, streptozotocin-diabetic and control rats ...

journal_title：Canadian journal of physiology and pharmacology

authors： Dyer JR,Greenwood CE,McBurney MI

更新日期：1988-02-01 00:00:00

abstract：:To determine if increased endometrial vascular permeability (a response which precedes decidualization) could be obtained in temporally nonsensitized uteri by treatments designed to increase endometrial adenosine 3':5'-cyclic monophosphate (cAMP) concentrations, cholera toxin (an activator of adenylate cyclase) was in...

journal_title：Canadian journal of physiology and pharmacology

authors： Johnston ME,Kennedy TG

更新日期：1985-09-01 00:00:00

abstract：:We have studied during 30 days the effect of a low dose of NG-nitro-L-arginine methyl ester (1 mg.kg-1.day-1 in drinking water) in the presence of D- or L-arginine (1 mg.kg-1.day-1 in drinking water) in comparison with D- or L-arginine alone on blood pressure and renal function in conscious uninephrectomized female sp...

journal_title：Canadian journal of physiology and pharmacology

authors： Reverte M,Flores O,Gallego B,Lestón A,López-Novoa JM

更新日期：1998-01-01 00:00:00

abstract：:The isolated human vas deferens (HVD) has been the subject of a limited number of pharmacological studies. Furthermore, it has not been established whether the local or general anesthetics used in obtaining the HVD affect the responses of this isolated tissue. Therefore, the aim of this study was to determine if the l...

journal_title：Canadian journal of physiology and pharmacology

authors： Kawamoto JH,Owen JA,Morales A,Nakatsu K

更新日期：1986-04-01 00:00:00

abstract：:Delta 9-Tetrahydrocannabinol (20 mg/kg i.p.) and propranolol (20 and 50 mg/kg i.p.) produced marked falls in the rectal temperatures of mice kept at an ambient temperature of 22 degrees C. Propranolol (50 mg/kg i.p.) also decreased the thermogenic activity of brown fat, as measured by a decrease in the level of [3H]GD...

journal_title：Canadian journal of physiology and pharmacology

authors： Pertwee RG,Nash K,Trayhurn P

更新日期：1991-06-01 00:00:00

abstract：:Cardiac dysfunction due to ischemia-reperfusion (I/R) is associated with marked changes in membrane function and subsequent Ca2+-handling abnormalities in cardiomyocytes. The membrane abnormalities in hearts subjected to I/R arise primarily from oxidative stress as a consequence of increased formation of reactive oxyg...

journal_title：Canadian journal of physiology and pharmacology

authors： Tappia PS,Asemu G,Rodriguez-Leyva D

更新日期：2010-03-01 00:00:00

abstract：:The role of iron-loaded transferrin in xanthine-xanthine oxidase (X-XO) induced cardiac injury in isolated perfused rat hearts was examined. X (2 mM) - XO (10 U/L) perfusion resulted in contractile failure, a rise in resting tension, an increase in lipid peroxidation, and myocardial cell damage. The addition of transf...

journal_title：Canadian journal of physiology and pharmacology

authors： Tiede R,Sareen S,Singal PK

更新日期：1990-04-01 00:00:00