Temporal desensitization of rat uteri for the decidual cell reaction is abolished by cholera toxin acting by a mechanism apparently not involving adenosine 3':5'-cyclic monophosphate.

abstract：:In 2-kidney, 1-clip hypertensive rats, the time course of changes in blood pressure (BP), heart rate, activity of the sympathetic nervous system and the renin-angiotensin system, plasma and blood volumes, left ventricular (LV) and right ventricular (RV) weight, and LV dimensions were evaluated during treatment with hy...

journal_title：Canadian journal of physiology and pharmacology

authors： Tsoporis J,Leenen FH

更新日期：1986-12-01 00:00:00

abstract：:Norethandrolone (NE) and other androgenic steroids have been shown to be renotropic in various species and have also been reported to have salutary effects in patients with diminished renal function. Renal cortical slices prepared from rats pretreated with NE showed an increased capability to concentrate p-aminohippur...

journal_title：Canadian journal of physiology and pharmacology

authors： Watrous WM,Lacombe R,Brodeur J

更新日期：1975-10-01 00:00:00

abstract：:The vestibulo-ocular and vestibulo-collic reflexes are well-studied sensorimotor systems with dynamic properties that have been successfully modeled. Recently proposed matrix and tensorial models attempt to describe the spatial organization of these reflexes in three dimensions. Here we describe experiments that test ...

journal_title：Canadian journal of physiology and pharmacology

authors： Baker JF,Banovetz JM,Wickland CR

更新日期：1988-04-01 00:00:00

abstract：:Neural and paracrine agents, such as dopamine, epinephrine, and histamine, affect intestinal epithelial function, but it is unclear if these agents act on receptors directly at the enterocyte level. The cellular localization and villus-crypt distribution of adrenergic, dopamine, and histamine receptors within the inte...

journal_title：Canadian journal of physiology and pharmacology

authors： Baglole CJ,Davison JS,Meddings JB

更新日期：2005-05-01 00:00:00

abstract：:A simple method using gas chromatography-mass spectrometry was developed to determine a low concentration of ethanol in urine. The detection limit was 0.02 mM ethanol. A mean +/- SD ethanol concentration in urine of 0.21 +/- 0.17 mM was measured in 11 alcoholics after 14 days abstention, a level at least 10 times high...

journal_title：Canadian journal of physiology and pharmacology

authors： Tang BK

更新日期：1987-06-01 00:00:00

abstract：:In vitro coronary artery responsiveness to angiotensin I, angiotensin II, noradrenaline, phenylephrine, BHT 920, and potassium chloride together with functional relaxation to acetylcholine was investigated in dogs with pacing-induced heart failure treated with enalapril (oral administration of 10 mg.day-1) for a mean ...

journal_title：Canadian journal of physiology and pharmacology

authors： Forster C,Larosa G,Armstrong PW

更新日期：1992-10-01 00:00:00

abstract：:Previous studies have demonstrated that the D-enantiomer of isoidide dinitrate (IIDN) is 10-fold more potent than the L-enantiomer for relaxation and cyclic GMP accumulation in isolated rat aorta. To test whether preferential biotransformation of D-IIDN to a species that activates guanylate cyclase is the basis for th...

journal_title：Canadian journal of physiology and pharmacology

authors： Stewart DH,Hayward LD,Bennett BM

更新日期：1989-11-01 00:00:00

abstract：:Simple and complex cells of visual areas of cats may be reliably classified according to the modulatory index (MI) of their responses. This investigation is aimed at analysing the MI in area 18 when a small region (about 200-400 microm in diameter) of area 17 was inactivated with a microinjection of GABA, in anestheti...

journal_title：Canadian journal of physiology and pharmacology

authors： Chabli A,Fortin S,Shumikhina S,Molotchinikoff S

更新日期：1999-03-01 00:00:00

abstract：:The cause of embryonic thyroidal enlargement in the progeny of chickens fed goitrogenic rapeseed meal (RSM) has been investigated. It has been found that eggs from birds fed RSM are low in iodine. The low concentration of iodine in the eggs of the goitrous birds is apparently due to diversion of a large proportion of ...

journal_title：Canadian journal of physiology and pharmacology

authors： March BE,Leung P

更新日期：1976-06-01 00:00:00

abstract：:Endothelin-1 has emerged as an important participant in the pathophysiology of a variety of cardiovascular diseases, where it may act on endocrine, paracrine and autocrine bases. Here we review its regulated biosynthesis, receptor-mediated signaling, and functional consequences in the heart, with particular emphasis o...

journal_title：Canadian journal of physiology and pharmacology

authors： Yang LL,Arab S,Liu P,Stewart DJ,Husain M

更新日期：2005-01-01 00:00:00

abstract：:The electrical activity of the duodenum and proximal jejunum was studied in conscious healthy dogs implanted with unipolar silver electrodes. A computerized method was used for the calculation of the mean frequency of the slow wave for each consecutive minute of the electromyographic signal. A "slow wave frequency com...

journal_title：Canadian journal of physiology and pharmacology

authors： Pousse A,Mendel C,Aprahamian M,Kachelhoffer J,Balboni G,Plas A

更新日期：1987-06-01 00:00:00

abstract：:The aim of this study was to determine if there was a synergistic or additive effect of a thiazolidinedione derivative (rosiglitazone (ROS)) and a vanadium compound (bis(ethylmaltolato)oxovanadium(IV) (BEOV)) on plasma glucose and insulin levels following chronic oral administration to Zucker diabetic fatty (ZDF) rats...

journal_title：Canadian journal of physiology and pharmacology

authors： Yuen VG,Bhanot S,Battell ML,Orvig C,McNeill JH

更新日期：2003-11-01 00:00:00

abstract：:We studied the in vitro effect of corticosterone on insulin binding, uptake of 2-deoxy-D-glucose, glycolysis, and glycogenesis in the soleus and extensor digitorum longus (EDL) of Swiss-Webster mice. In each experiment, one muscle (soleus/EDL) was incubated with corticosterone (0.1, 1, 50, and 100 micrograms/mL) and t...

journal_title：Canadian journal of physiology and pharmacology

authors： Tan MH,Bonen A

更新日期：1985-09-01 00:00:00

abstract：:In anesthetized rats micropuncture and microcatheterization were used to collect tubular fluid from end proximal and distal tubules and from the outer medullary collecting duct. Urine was collected at the papilla tip. Samples were taken from the same sites before and after intravenous injection of atrial tissue extrac...

journal_title：Canadian journal of physiology and pharmacology

authors： Sonnenberg H,Cupples WA,de Bold AJ,Veress AT

更新日期：1982-09-01 00:00:00

abstract：:The effects of modafinil on heat thermoregulatory responses were studied in 10 male subjects submitted to a sweating test after taking 200 mg of modafinil or placebo. Sweating tests were performed in a hot climatic chamber (45 degrees C, relative humidity <15%, wind speed = 0.8 m x s(-1), duration 1.5 h). Body tempera...

journal_title：Canadian journal of physiology and pharmacology

authors： Launay JC,Besnard Y,Guinet A,Bessard G,Raphel C,Savourey G

更新日期：2002-08-01 00:00:00

abstract：:Cumulative data suggest the significant role of the renin-angiotensin system in the development of the pathological consequences of diabetes mellitus (DM). Newly synthesized AT2 receptor agonists gained importance as a target for creating new antihypertensives. The aim of the present work was to study the effects of p...

journal_title：Canadian journal of physiology and pharmacology

authors： Pechlivanova D,Petrov K,Grozdanov P,Nenchovska Z,Tchekalarova J,Stoynev A

更新日期：2018-05-01 00:00:00

abstract：:This study was designed to investigate whether and how triiodothyronine (T3) affects renal function in an experimental model of chronic kidney disease. Twenty-four female rats were divided into the following groups: sham-operated control group (n = 8), 5/6 nephrectomized group (Nx, n = 8), and 5/6 nephrectomized group...

journal_title：Canadian journal of physiology and pharmacology

authors： El Agaty SM

更新日期：2018-06-01 00:00:00

abstract：:Immediately following exposure to thiocyanate (SCN-)-containing solutions, the cystic fibrosis conductance regulator Cl- channel exhibits high unitary SCN conductance and anomalous mole fraction behaviour, suggesting the presence of multiple anion binding sites within the channel pore. However, under steady-state cond...

journal_title：Canadian journal of physiology and pharmacology

authors： Linsdell P

更新日期：2001-07-01 00:00:00

abstract：:The present study was designed to examine the possible neuroprotective and antiepileptic effects of metformin (Metf) in a rat model of pentylenetetrazole (PTZ)-induced epilepsy and its possible underlying mechanisms. Forty male albino rats were assigned to 4 groups of equal size: (1) normal control (NC) group, (2) Met...

journal_title：Canadian journal of physiology and pharmacology

authors： Hussein AM,Eldosoky M,El-Shafey M,El-Mesery M,Ali AN,Abbas KM,Abulseoud OA

更新日期：2019-01-01 00:00:00

abstract：:Heme oxygenase (HO) has a central role in cellular antioxidant defences and vascular protection, and it may mediate pleiotropic actions of drugs used in cardiovascular therapy. We investigated whether long-term use of statins upregulates HO activity and increases carbon monoxide (CO) and bilirubin levels in vivo. Adul...

journal_title：Canadian journal of physiology and pharmacology

authors： Muchova L,Wong RJ,Hsu M,Morioka I,Vitek L,Zelenka J,Schröder H,Stevenson DK

更新日期：2007-08-01 00:00:00

abstract：:This study was conducted to examine the protective role of crude polysaccharide from brown seaweed Sargassum polycystum against acetaminophen-induced abnormality in blood glucose, serum albumin/globulin ratio, and liver glycogen, lactate, and pyruvate. Liver and renal tissue histology was performed to confirm the effi...

journal_title：Canadian journal of physiology and pharmacology

authors： Raghavendran HR,Srinivasan P

更新日期：2008-10-01 00:00:00

abstract：:Gripp-Heel is a homeopathic preparation frequently used in the treatment of respiratory viral infections such as various types of influenza and the common cold. The antiviral activity of Gripp-Heel was studied in vitro on human pathogenic enveloped and nonenveloped RNA and DNA viruses. Before the antiviral assays, in ...

journal_title：Canadian journal of physiology and pharmacology

authors： Glatthaar-Saalmüller B

更新日期：2007-11-01 00:00:00

abstract：:Noradrenaline spillover from skeletal muscle vascular areas increases during exercise but the underlying mechanisms are not well understood. Muscle contraction itself causes changes in many factors that could affect noradrenaline spillover. For instance, it has been reported that bradykinin is synthesized in skeletal ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lavoie JL,Béliveau L

更新日期：2001-10-01 00:00:00

abstract：:Tachykinin receptors in guinea-pig airways were examined using radioligand binding techniques in lung homogenates, and using isolated bronchial segments. Binding of the NK1 selective radioligand 125I-labelled Bolton-Hunter [Sar9,Met(O2)11]substance P ([125I]BHSarSP) was saturable and of high affinity (KD, 0.26 nM). Th...

journal_title：Canadian journal of physiology and pharmacology

authors： Burcher E,Zeng XP,Strigas J,Geraghty DP,Lavielle S

更新日期：1995-07-01 00:00:00

abstract：:The isometric potentiation associated with myosin phosphorylation is force dependent. The purpose of this study was to assess the influence of a pre-existing period of isometric force on the concentric force potentiation displayed by mouse muscles with and without the ability to phosphorylate myosin. We tested isometr...

journal_title：Canadian journal of physiology and pharmacology

authors： Gittings W,Aggarwal H,Stull JT,Vandenboom R

更新日期：2015-01-01 00:00:00

abstract：:The main factors of myocardial ischemia are hypoxia, substrate deprivation, acidosis, and high extracellular potassium concentration ([K+]e), but the influence of each of these factors has not yet been evaluated in a cardiomyocyte (CM) culture system. Electromechanical responses to the individual and combined componen...

journal_title：Canadian journal of physiology and pharmacology

authors： Tissier C,Bes S,Vandroux D,Fantini E,Rochette L,Athias P

更新日期：2002-12-01 00:00:00

abstract：:The antioxidant glutathione-S-transferase (GST) is a crucial determinant of the development of ischaemic-reperfusion (I/R) injury, and plays a pivotal role in the regulation of the mitogen activated protein kinase (MAPK) pathways involved in stress response and apoptosis. The aim of this study was to investigate wheth...

journal_title：Canadian journal of physiology and pharmacology

authors： Balatonyi B,Gasz B,Kovács V,Lantos J,Jancsó G,Marczin N,Rőth E

更新日期：2013-08-01 00:00:00

abstract：:The effect of chemical sympathectomy with 6-hydroxydopamine (6-OHDA) on blood volume was studied in unanesthetized splenectomized and nonsplenectomized dogs. A significant increase in total blood volume essentially accounted for by a marked plasma volume expansion was found in both groups after 6-OHDA treatment (50 mg...

journal_title：Canadian journal of physiology and pharmacology

authors： Porlier GA,Nadeau RA,de Champlain J

更新日期：1977-06-01 00:00:00

abstract：:The rat atrium contains a potent natriuretic factor which appears to inhibit the sodium reabsorption in the collecting tubules of the kidneys. We examined the effects of the injection of partially purified atrial natriuretic factor (ANF) and synthetic ANF (8-33) into rats with simultaneous infusions of dextrose or apr...

journal_title：Canadian journal of physiology and pharmacology

authors： Thibault G,Garcia R,Cantin M,Genest J

更新日期：1984-06-01 00:00:00

abstract：:Liver diseases are associated with a decrease in hepatic drug elimination, but there is evidence that cirrhosis does not result in uniform changes of cytochrome P450 (CYP) isoenzymes. The objective of this study was to determine the content and activity of four CYP isoenzymes in the bile duct ligation and carbon tetra...

journal_title：Canadian journal of physiology and pharmacology

authors： Bastien MC,Leblond F,Pichette V,Villeneuve JP

更新日期：2000-11-01 00:00:00