Effects of alterations in maternal thyroid metabolism on embryonic thyroid development in the chick.

abstract：:Recent evidence suggests that some Ca2+ channels are regulated by a tyrosine kinase pathway. The possibility that Ca2+ entry is regulated by tyrosine kinase was investigated in canine vascular muscles. Functional studies were carried out in the dog mesenteric arteries and saphenous veins. Nicardipine-insensitive refil...

journal_title：Canadian journal of physiology and pharmacology

authors： Low AM

更新日期：1996-03-01 00:00:00

abstract：:The beneficial hypolipidemic and antioxidant influences of the dietary spice compounds curcumin and capsaicin were evaluated. Curcumin, capsaicin, or their combination were included in the diet of high-(30%)-fat-fed rats for 8 weeks. Dietary high-fat-induced hypertriglyceridemia was countered by dietary curcumin, caps...

journal_title：Canadian journal of physiology and pharmacology

authors： Manjunatha H,Srinivasan K

更新日期：2007-06-01 00:00:00

abstract：:The mammalian daily (circadian) clock is located in the suprachiasmatic nuclei of the hypothalamus. Clock function can be detected by the measurement of the circadian change in spontaneous firing rate of suprachiasmatic nuclei cells in a brain slice preparation in vitro. We investigated the effects of neuropeptide Y o...

journal_title：Canadian journal of physiology and pharmacology

authors： Harrington ME,Schak KM

更新日期：2000-02-01 00:00:00

abstract：:The experiment examined biological responses produced by combined sequential exposure to low-level tritium contamination, followed by challenging irradiation with fast neutrons. Modifications of endogenous antioxidant potential of different organs in rats were discussed in relation to tissue radiosensitivity. Rats pre...

journal_title：Canadian journal of physiology and pharmacology

authors： Petcu I,Moisol N,Savu D,Constantinescu B

更新日期：2002-07-01 00:00:00

abstract：:Although ATP-MgCl2 enhances the recovery of renal function after ischemia and reperfusion, it is not known whether this agent has any beneficial effects on renal microcirculation and function in a nonheparinized model of trauma and severe hemorrhage. To study this, a midline laparotomy was performed (i.e., trauma indu...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang P,Zhou M,Rana MW,Singh G,Ba ZF,Ayala A,Chaudry IH

更新日期：1992-03-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a key pathogenic factor in sepsis, and its recognition by toll-like receptor 4 (TLR4) can activate two district signaling pathways, leading to activation of transcription factors including NF-κB and interferon regulatory factor 3 (IRF3). Chloroquine (CQ) has been shown to affect LPS-TLR4 co...

journal_title：Canadian journal of physiology and pharmacology

authors： Ding C,Li F,Long Y,Zheng J

更新日期：2017-05-01 00:00:00

abstract：:The effect of chlorpromazine on subcellular biosynthesis, hydrolysis, and transfer of lipids and liponucleotides participating in the biosynthesis of polyglycerophosphatides in guinea pig liver was studied. Chlorpromazine showed an apparent stimulation of accumulation of phosphatidic acid and CDP-diglycerides in micro...

journal_title：Canadian journal of physiology and pharmacology

authors： Stuhne-Sekalec L,Chudzik J,Stanacev NZ

更新日期：1987-03-01 00:00:00

abstract：:Thermal resistance as determined by survival time was examined in different age groups of spontaneously hypertensive (SHR) rats during terminal heating. A comparison with age or weight matched controls indicated that the thermal resistance of SHR animals was markedly inferior to that of normotensive animals as evidenc...

journal_title：Canadian journal of physiology and pharmacology

authors： Wright G,Iams S,Knecht E

更新日期：1977-10-01 00:00:00

abstract：:In anaesthetized rabbits blood volume was altered by infusion and withdrawal of donor blood over the range of +60 to -40% of the blood volume. Right and left atrial pressures were measured and it was shown that sonomicrometry allowed adequate measurement of phasic changes in atrial dimensions. Plasma immunoreactive at...

journal_title：Canadian journal of physiology and pharmacology

authors： Ledsome JR,King KA

更新日期：1991-10-01 00:00:00

abstract：:It has recently been demonstrated that the protein tyrosine phosphatase (PTP) PTP1B and the T-cell PTP (TC-PTP) target several substrates involved in immune cell signaling. Recent data have furthered the view of these 2 PTP members as key regulators of the immune response. This review will focus on the substrate speci...

journal_title：Canadian journal of physiology and pharmacology

authors： Simoncic PD,McGlade CJ,Tremblay ML

更新日期：2006-07-01 00:00:00

abstract：:Measurements of the presynaptic fiber volley (PSFV), the population excitatory postsynaptic potential (EPSP), and the extracellular pH in the dendritic CA1 layer of rat hippocampal slices were used to evaluate the effects of lactacidosis on central synaptic transmission. Replacement of NaCl with sodium lactate (up to ...

journal_title：Canadian journal of physiology and pharmacology

authors： Walz W,Harold DE

更新日期：1990-02-01 00:00:00

abstract：:The purpose of this study was to investigate whether Ca2+ -Mg2+ ATPase in the distal tubule (where calcium transport is active, against a gradient, and hormone dependent) presents some characteristics different from those observed in the proximal tubule, and whether these characteristics are likely to shed light on th...

journal_title：Canadian journal of physiology and pharmacology

authors： Brunette MG,Blouin S,Chan M

更新日期：1987-10-01 00:00:00

abstract：:This study developed an animal model of gestational obesity and prediabetes in Sprague Dawley rats using 35% sucrose supplementation (SS). Postprandially, insulin stimulates glucose uptake and nutrient partitioning via insulin-dependent as well as Hepatic Insulin Sensitizing Substance (HISS)-dependent action. HISS is ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lovat NEJ,Legare DJ,Lautt WW

更新日期：2020-10-16 00:00:00

abstract：:This study aimed to investigate the interrelationship of plasma lipid profile, lipid peroxidation, and erythrocyte antioxidative defense in patients with insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. Plasma levels of total cholesterol, triglycerides, and lipid peroxides and the activiti...

journal_title：Canadian journal of physiology and pharmacology

authors： Cimbaljević B,Vasilijević A,Cimbaljević S,Buzadzić B,Korać A,Petrović V,Janković A,Korać B

更新日期：2007-10-01 00:00:00

abstract：:The aim of this study was to determine if there was a synergistic or additive effect of a thiazolidinedione derivative (rosiglitazone (ROS)) and a vanadium compound (bis(ethylmaltolato)oxovanadium(IV) (BEOV)) on plasma glucose and insulin levels following chronic oral administration to Zucker diabetic fatty (ZDF) rats...

journal_title：Canadian journal of physiology and pharmacology

authors： Yuen VG,Bhanot S,Battell ML,Orvig C,McNeill JH

更新日期：2003-11-01 00:00:00

abstract：:The effect of a novel antianginal agent, molsidomine (N-ethoxycarbonyl-3-morpholinosydnonimine) (SIN-10) and its metabolites, 3-morpholinosydnonimine (SIN-1) and N-nitroso-N-morpholinoaminoacetonitrile (SIN-1A) on isolated dog blood vessels were investigated. SIN-1 and SIN-1A elicited a concentration-dependent relaxat...

journal_title：Canadian journal of physiology and pharmacology

authors： Muramatsu I,Fujii K,Sakakibara Y,Fujiwara M

更新日期：1983-09-01 00:00:00

abstract：:Rats fed a polychlorinated biphenyl (PCB) mixture in a high- or low-iodine diet (HID or LID respectively) for 15 days had thyroid enlargement, low serum thyroxine (T4), and high serum thyrotropin concentrations. Although binding of thyroid hormones to serum proteins was reduced in PCB-fed animals, the free T4 index (r...

journal_title：Canadian journal of physiology and pharmacology

authors： Bastomsky CH

更新日期：1977-04-01 00:00:00

abstract：:Our previous studies have suggested that GATA-4 increases the differentiation of bone-marrow-derived mesenchymal stem cells (MSCs) into cardiac phenotypes. This study further investigated whether GATA-4 enhances MSC-mediated cardioprotection following hypoxia. MSCs were harvested from rat bone marrow and transduced wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Li HX,Zhou YF,Zhao X,Jiang B,Yang XJ

更新日期：2014-08-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are cardiac hormones synthesized in and secreted from the heart. ANP and BNP bind the common receptor guanylyl cyclase-A (GC-A) and possess biological actions. Based on their diuretic, natriuretic, and vasodilating activities, they are now widely us...

journal_title：Canadian journal of physiology and pharmacology

authors： Saito Y,Kishimoto I,Nakao K

更新日期：2011-08-01 00:00:00

abstract：:A systematic study has been performed in various segments of the intestine and in the urinary bladder of the mouse to identify tissues that respond to kinins and possess B1 and (or) B2 receptors. The stomach was found to contain B1 and B2 functional sites that show pharmacological profiles compatible with B1 and B2 re...

journal_title：Canadian journal of physiology and pharmacology

authors： Allogho SN,Gobeil F,Pheng LH,Nguyen-Le XK,Neugebauer W,Regoli D

更新日期：1995-12-01 00:00:00

abstract：:The effects of a number of peptides which are found in the gastrointestinal tract have been ascertained on the direct current recorded dorsal and ventral root responses of the isolated hemisected toad spinal cord. Motilin, substance P, bombesin, neurotensin, and thyrotropin releasing hormone had potent depolarizing ac...

journal_title：Canadian journal of physiology and pharmacology

authors： Phillis JW,Kirkpatrick JR

更新日期：1979-08-01 00:00:00

abstract：:Sensorimotor mechanisms were studied on the basis of kinematic and electromyographic data as well as the static torque developed by the muscles as a function of joint angle. The latter relationship is known as the torque/angle characteristic. Fast single-joint movement may result from a shift in this characteristic an...

journal_title：Canadian journal of physiology and pharmacology

authors： Levin MF,Lamarre Y,Feldman AG

更新日期：1995-02-01 00:00:00

abstract：:Impaired nitric oxide (NO) activity is associated with an increase in blood pressure in rats. Voltage-regulated calcium channels are believed to participate in this hemodynamic event. To further test this hypothesis, we examined the effect of nimodipine and verapamil (calcium antagonists) on the pressor activity of di...

journal_title：Canadian journal of physiology and pharmacology

authors： Rioux F,St-Pierre M,Harvey N,Moisan S,Burhop KE,Drapeau G

更新日期：1998-10-01 00:00:00

abstract：:The cannabinoid system has been suspected to play a role in the mechanisms of action of dipyrone and paracetamol. Our purpose was to measure the local endocannabinoid and N-acylethanolamide levels in the brain and spinal cord of rats following dipyrone and paracetamol administration. Nociception was assessed 1, 5, and...

journal_title：Canadian journal of physiology and pharmacology

authors： Topuz RD,Gunduz O,Karadag CH,Dokmeci D,Ulugol A

更新日期：2019-11-01 00:00:00

abstract：:Tissues from the duodenum and vas deferens of Sprague-Dawley rats were examined of the rat vas deferens and gap junctions. Can. J. Physiol. Pharmacol. 54, 412-416. by electron microscopy after glutaraldehyde fixation and postosmication. Gap junctions (nexuses) were readily demonstrated in the duodenum in both control ...

journal_title：Canadian journal of physiology and pharmacology

authors： Paton DM,Buckland-Nicks J,Johns A

更新日期：1976-06-01 00:00:00

abstract：:We investigated the influence of four different culture media: 20% fetal bovine serum (FBS), 5% FBS, 5% FBS supplemented with 10 mg x L(-1) linoleic acid (18:2(n-6)) or alpha-linolenic acid (18:3(n-3)) on alpha-linolenic acid apical uptake in clone TC7 of human intestinal Caco-2 cell line. Neither cellular viability n...

journal_title：Canadian journal of physiology and pharmacology

authors： Tranchant T,Besson P,Hoinard C,Pinault M,Alessandri JM,Delarue J,Couet C,Goré J

更新日期：1998-06-01 00:00:00

abstract：:This review updates our current knowledge on the regulation of Na+/H+ exchanger, Na+,K+,Cl- cotransporter, Na+,Pi cotransporter, and Na+,K+ pump in isolated epithelial cells from mammalian kidney by protein kinase C (PKC). In cells derived from different tubule segments, an activator of PKC, 4beta-phorbol 12-myristate...

journal_title：Canadian journal of physiology and pharmacology

authors： Gagnon F,Hamet P,Orlov SN

更新日期：1999-05-01 00:00:00

abstract：:Both gonadotropin-releasing hormone (GnRH) and prostaglandin F2 alpha (PGF2 alpha) can inhibit cAMP and progesterone production in the corpus luteum; however, their mechanism of action is not known. GnRH or PGF2 alpha causes a rapid and marked increase of labelling of phosphatidylinositol (PI) and phosphatidic acid (P...

journal_title：Canadian journal of physiology and pharmacology

authors： Leung PC

更新日期：1985-03-01 00:00:00

abstract：:The 3,5-pyrazolidinedione (3,5-P) drugs, phenylbutazone and sulfinpyrazone, have been reported to bind to receptors for the chemotactic peptide, f-Met-Leu-Phe, and to behave as functional antagonists of f-Met-Leu-Phe in human and rabbit neutrophils. To explore the structure-activity relationship of this family of drug...

journal_title：Canadian journal of physiology and pharmacology

authors： Levesque L,Gaudreault RC,Marceau F

更新日期：1991-03-01 00:00:00

abstract：:Aspirin consumption has been reported to be able to reduce colorectal cancer risk in humans and in animal models of colon carcinogenesis. Although the mechanism involved in such an effect is not yet clear, both prostaglandin-dependent and -independent effects have been proposed. Using HT-29 Glc(-/+)cells, which origin...

journal_title：Canadian journal of physiology and pharmacology

authors： Eklou-Kalonji E,Andriamihaja M,Reinaud P,Mayeur C,Camous S,Robert V,Charpigny G,Blachier F

更新日期：2003-05-01 00:00:00