GATA-4 protects against hypoxia-induced cardiomyocyte injury: effects on mitochondrial membrane potential.

abstract：:A striking feature of the mammalian respiratory rhythm generator is the abruptness of the transitions between the inspiratory (I) and expiratory (E) phases ("phase-switching"). Although reciprocal inhibitory actions between I and E neurons are important for maintaining the alternation of respiratory phases, phase-swit...

journal_title：Canadian journal of physiology and pharmacology

authors： Cohen MI

更新日期：1981-07-01 00:00:00

abstract：:Benzodiazepine binding to brain membrane preparations obtained from epileptic and nonepileptic carrier fowl was compared. [3H]Flunitrazepam binding to whole brain homogenates from 2-day-old chicks and [3H]diazepam binding to synaptosomal membranes and homogenates from adult chickens were determined. Scatchard analysis...

journal_title：Canadian journal of physiology and pharmacology

authors： Fisher TE,Davis LG,Tuchek JM,Johnson DD,Crawford RD

更新日期：1985-02-01 00:00:00

abstract：:Simple and complex cells of visual areas of cats may be reliably classified according to the modulatory index (MI) of their responses. This investigation is aimed at analysing the MI in area 18 when a small region (about 200-400 microm in diameter) of area 17 was inactivated with a microinjection of GABA, in anestheti...

journal_title：Canadian journal of physiology and pharmacology

authors： Chabli A,Fortin S,Shumikhina S,Molotchinikoff S

更新日期：1999-03-01 00:00:00

abstract：:The effects of localized distension of the pulmonary vein - left atrial junctions on plasma arginine vasopressin (AVP) have been examined in chloralose anaesthetized dogs. Pulmonary vein distension caused an increase in heart rate and a decrease in plasma AVP concentration. Cooling the vagosympathetic nerves to 10 deg...

journal_title：Canadian journal of physiology and pharmacology

authors： Wilson N,Ledsome JR

更新日期：1983-08-01 00:00:00

abstract：:Neuronal factors co-released with neurotransmitters may play an important role in synapse development and function. Calcitonin gene related peptide (CGRP) and adenosine 5'-triphosphate (ATP), two principal neuromodulators present in the motor nerve terminals, were studied for their roles and mechanisms during early de...

journal_title：Canadian journal of physiology and pharmacology

authors： Lu B,Fu WM

更新日期：1995-07-01 00:00:00

abstract：:Inorganic vanadium has been shown, both in vivo and in vitro, to have insulin-mimetic properties. A new organic vanadium complex, bis(maltolato)oxovanadium(IV) (BMOV), was developed to increase the absorption of vanadium from the gastrointestinal tract, thereby reducing the dose of vanadium necessary to produce glucos...

journal_title：Canadian journal of physiology and pharmacology

authors： Yuen VG,Orvig C,McNeill JH

更新日期：1993-03-01 00:00:00

abstract：:Cold ischemia--warm reperfusion (CI/WR) injury of liver transplantation involves hepatocyte cell death, the nature and underlying mechanisms of which remain unclear. Isolated hepatocytes and isolated perfused livers were used to determine the prevalence of necrosis and apoptosis as well as mitochondrial dysfunction. I...

journal_title：Canadian journal of physiology and pharmacology

authors： Duval M,Plin C,Elimadi A,Vallerand D,Tillement JP,Morin D,Haddad PS

更新日期：2006-05-01 00:00:00

abstract：:Gemcitabine, a nucleoside analogue for treating lung cancer, is clinically administered as an intravenous infusion. To achieve better patient compliance and more direct effect on the lung, we explored a new gemcitabine pulmonary delivery route and evaluated the pharmacokinetics and acute lung injury aspects in animals...

journal_title：Canadian journal of physiology and pharmacology

authors： Min R,Li T,Du J,Zhang Y,Guo J,Lu WL

更新日期：2008-05-01 00:00:00

abstract：:In 2-kidney, 1-clip hypertensive rats, the time course of changes in blood pressure (BP), heart rate, activity of the sympathetic nervous system and the renin-angiotensin system, plasma and blood volumes, left ventricular (LV) and right ventricular (RV) weight, and LV dimensions were evaluated during treatment with hy...

journal_title：Canadian journal of physiology and pharmacology

authors： Tsoporis J,Leenen FH

更新日期：1986-12-01 00:00:00

abstract：:Acetylcholine (ACh)-mediated vagal transmission as well as nonneuronal ACh release are considered cardioprotective in pathological situations with increased sympathetic drive such as ischemia-reperfusion and cardiac remodeling. ACh action is terminated by hydrolysis by the cholinesterases (ChEs), acetylcholinesterase,...

journal_title：Canadian journal of physiology and pharmacology

authors： Kilianova Z,Ciznarova N,Szmicsekova K,Slobodova L,Hrabovska A

更新日期：2020-07-01 00:00:00

abstract：:Single ventricular cells have been isolated from adult guinea pig heart using a collagenase enzyme method. The procedure is straightforward, takes about 20 min, and yields 40-65% rod-shaped cells which are quiescent in millimolar Ca2+ solution. Electrophysiological studies involving external ion changes and ionic chan...

journal_title：Canadian journal of physiology and pharmacology

authors： Bustamante JO,Watanabe T,McDonald TF

更新日期：1981-08-01 00:00:00

abstract：:The active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3 or calcitriol), is known to inhibit the proliferation and invasiveness of many types of cancer cells, including breast, colon, pancreatic, prostate, and liver cancer cells. These findings support the use of 1α,25(OH)2D3 for the treatment of these t...

journal_title：Canadian journal of physiology and pharmacology

authors： Matsumoto Y,Kittaka A,Chen TC

更新日期：2015-05-01 00:00:00

abstract：:Epinephrine caused hyperglycemia in part by increasing gluconeogenesis. However, the mechanism of its gluconeogenic effects has not been studied in ruminants. This study was undertaken to examine the effect of epinephrine on the net hepatic uptake of selected glucose precursors in sheep. The major abdominal blood vess...

journal_title：Canadian journal of physiology and pharmacology

authors： Brockman RP

更新日期：1991-04-01 00:00:00

abstract：:Radioactively labelled microspheres (15 micron diameter) were used to measure cardiac output (CO) distribution and blood flows in spleen, kidneys, and skeletal muscle before and after normovolemic anemia or polycythemia in anesthetized rats. Hematocrits were changed from 45 to 33% or from 45 to 59% by an exchange tran...

journal_title：Canadian journal of physiology and pharmacology

authors： Ackermann U,Veress AT

更新日期：1980-04-01 00:00:00

abstract：:Chronically elevated plasma norepinephrine has the potential for supporting function of diseased hearts, yet may also initiate harmful biochemical and (or) structural changes in the myocardium. The present study investigated the dosage-related effects of chronic norepinephrine infusion on markers of myocardial damage ...

journal_title：Canadian journal of physiology and pharmacology

authors： Siri FM,Smith RM

更新日期：1986-07-01 00:00:00

abstract：:Vanadium (V) as sodium orthovanadate induces an increase in lipid peroxidation in the kidneys after a single subcutaneous or intraperitoneal injection to rats or mice. The rate of malondialdehyde (MDA) formation, an index of lipid peroxidation, by kidney homogenates increased by more than 100% 1 h after injection. Chr...

journal_title：Canadian journal of physiology and pharmacology

authors： Donaldson J,Hemming R,LaBella F

更新日期：1985-03-01 00:00:00

abstract：:This study investigated the effects of prolonged exercise on muscle sarcoplasmic reticulum (SR) Ca2+ cycling properties and the metabolic responses with and without a session of exercise designed to reduce muscle glycogen reserves while on a normal carbohydrate (CHO) diet. Eight untrained males (VO(2peak) = 3.81 +/- 0...

journal_title：Canadian journal of physiology and pharmacology

authors： Duhamel TA,Green HJ,Perco JG,Ouyang J

更新日期：2005-07-01 00:00:00

abstract：:A simple method using gas chromatography-mass spectrometry was developed to determine a low concentration of ethanol in urine. The detection limit was 0.02 mM ethanol. A mean +/- SD ethanol concentration in urine of 0.21 +/- 0.17 mM was measured in 11 alcoholics after 14 days abstention, a level at least 10 times high...

journal_title：Canadian journal of physiology and pharmacology

authors： Tang BK

更新日期：1987-06-01 00:00:00

abstract：:While conducting studies on the prevention of mortality from acute iron intoxication in rats, diazepam, given to prevent animal suffering, was observed to be associated with reduced mortality in a limited number of animals. The objective was to assess whether diazepam reduces mortality following acute iron intoxicatio...

journal_title：Canadian journal of physiology and pharmacology

authors： Fassos FF,Berkovitch M,Daneman N,Koren L,Cameron R,Klein J,Falcitelli C,St Louis P,Daneman R,Koren G

更新日期：1998-09-01 00:00:00

abstract：:Normal penile erectile function is dependent on arterial adequacy, appropriate venous occlusion, neurohumoral factors, and finally the relaxation of penile cavernous trabecular smooth muscle. The present experiments were designed to test whether compounds related to endothelium-derived relaxing factor have a role in p...

journal_title：Canadian journal of physiology and pharmacology

authors： Heaton JP

更新日期：1989-01-01 00:00:00

abstract：:A single-compartment model used in this laboratory for continuously calculating ACTH secretion rates from measured plasma ACTH concentrations has been tested for its ability to follow changing rates of ACTH entry (rapid departure from steady state). ACTH was infused at known moderately high but physiological rates int...

journal_title：Canadian journal of physiology and pharmacology

authors： Cowan JS

更新日期：1978-06-01 00:00:00

abstract：:The isometric potentiation associated with myosin phosphorylation is force dependent. The purpose of this study was to assess the influence of a pre-existing period of isometric force on the concentric force potentiation displayed by mouse muscles with and without the ability to phosphorylate myosin. We tested isometr...

journal_title：Canadian journal of physiology and pharmacology

authors： Gittings W,Aggarwal H,Stull JT,Vandenboom R

更新日期：2015-01-01 00:00:00

abstract：:When carbon tetrachloride (CCl4) was administered to rats, a localized region of hepatic edema could be detected within 1 h by in vivo proton magnetic resonance imaging. However, if rats were pretreated with gadolinium chloride (GdCl3), an inhibitor of Kupffer cell function, the CCl4-induced edema was greatly decrease...

journal_title：Canadian journal of physiology and pharmacology

authors： Towner RA,Reinke LA,Janzen EG,Yamashiro S

更新日期：1994-05-01 00:00:00

abstract：:We examined whether there was a threshold for change in fetal arterial PO2 to elicit alterations in plasma adrenocorticotropic hormone, arginine vasopressin, or cortisol, or to affect the incidence of fetal breathing movements or eye movements and we determined whether such a threshold changed with gestational age. Fe...

journal_title：Canadian journal of physiology and pharmacology

authors： Akagi K,Challis JR

更新日期：1990-05-01 00:00:00

abstract：:The ability of human skeletal muscle to provide anaerobically derived ATP during short-term, intense activity is examined. The paper emphasizes the information obtained from direct measurements of substrates, intermediates, and products of the pathways in muscle that provide anaerobically derived ATP. The capacity of ...

journal_title：Canadian journal of physiology and pharmacology

authors： Spriet LL

更新日期：1992-01-01 00:00:00

abstract：:Damage to the stomach results in excessive movement of hydrogen ion (H+) out of the lumen, and increased movement of sodium (Na+) and potassium (K+) into the lumen. Histamine liberation during damage probably adds to the destruction by increased capillary permeability and formation of edema. Previous reports have show...

journal_title：Canadian journal of physiology and pharmacology

authors： Tepperman BL

更新日期：1979-03-01 00:00:00

abstract：:The effects of a number of peptides which are found in the gastrointestinal tract have been ascertained on the direct current recorded dorsal and ventral root responses of the isolated hemisected toad spinal cord. Motilin, substance P, bombesin, neurotensin, and thyrotropin releasing hormone had potent depolarizing ac...

journal_title：Canadian journal of physiology and pharmacology

authors： Phillis JW,Kirkpatrick JR

更新日期：1979-08-01 00:00:00

abstract：:Techniques to dissociate different sites or stores important for Ca2+ entry or release in smooth muscle include washouts of 45Ca in cold La3+ -substituted solutions. Scatchard-coordinate plots of Ca2+ uptake, substitution of Sr2+ for Ca2+, and both desaturation and rate coefficient plots. Rabbit aortic smooth muscle i...

journal_title：Canadian journal of physiology and pharmacology

authors： Weiss GB,Karaki H,Murakami K

更新日期：1987-04-01 00:00:00

abstract：:Pioglitazone (Pio) and swimming exercise (SE) are insulin sensitisers. This investigation was suggested because of the significant side effects associated with Pio treatment in metabolic syndrome (MetS). This study was, therefore, designed to investigate the preventive role of Pio treatment and SE in terms of efficien...

journal_title：Canadian journal of physiology and pharmacology

authors： Sakr HF,Al-Hashem FH,El-Naby WM,Alkhateeb MA,Zaki MS,Refaey HM,Morsy MD

更新日期：2014-02-01 00:00:00

abstract：:The purposes of this review were twofold: to apply modern physicochemical principles to explain changes in acid-base regulation and the control of ventilation in human pregnancy; and to demonstrate the value of pregnancy as a model for the study of endocrine effects on physiological control systems. Application of P.A...

journal_title：Canadian journal of physiology and pharmacology

authors： Wolfe LA,Kemp JG,Heenan AP,Preston RJ,Ohtake PJ

更新日期：1998-09-01 00:00:00