Differentiation of mechanisms for mobilization of calcium in smooth muscle.

abstract：:Lesion to the posterior parietal cortex in monkeys and humans produces spatial deficits in movement and perception. In recording experiments from area 7a, a cortical subdivision in the posterior parietal cortex in monkeys, we have found neurons whose responses are a function of both the retinal location of visual stim...

journal_title：Canadian journal of physiology and pharmacology

authors： Andersen RA,Zipser D

更新日期：1988-04-01 00:00:00

abstract：:We have previously demonstrated a 40% increase in myocardial blood flow (MBF) during hypercapnia but no significant decrease of MBF during hypocapnia. The present study was undertaken to evaluate if epinephrine infusion, which increases both myocardial oxygen consumption (MVo2) and myocardial performance, might influe...

journal_title：Canadian journal of physiology and pharmacology

authors： Wexels JC,Myhre ES,Mjøs OD

更新日期：1986-01-01 00:00:00

abstract：:Uroporphyrinogen decarboxylase (UROG-D) activity in the 10,000g supernatant of 17-day-old chick embryo liver homogenates was determined by measuring the conversion of pentacarboxylporphyrinogen I to coproporphyrinogen I. The optimum pH of the enzyme was found to be approximately 6.0 and enzyme activity was found to be...

journal_title：Canadian journal of physiology and pharmacology

authors： James CA,Marks GS

更新日期：1989-03-01 00:00:00

abstract：:Rhus tripartitum D.C., Anacardiaceae, has traditionally been used in Tunisia against many illnesses. The present study investigates, for the first time, the protective effects of the methanol extract of Rhus tripartitum fruit (MERT) against CCl4-induced hepatotoxicity and cisplatin-induced nephrotoxicty in Wistar rats...

journal_title：Canadian journal of physiology and pharmacology

authors： Tlili N,Feriani A,Allagui MS,Saadoui E,Khaldi A,Nasri N

更新日期：2016-08-01 00:00:00

abstract：:Studies are scant on the effects of short-term carvedilol treatment as an adjuvant to angiotensin-converting enzyme (ACE) inhibitor in patients with left ventricular (LV) systolic dysfunction. The objective of this study was to find the effects of short-term treatment of carvedilol on patients with ischemic LV systoli...

journal_title：Canadian journal of physiology and pharmacology

authors： Gandhi PS,Goyal RK,Jain AR,Mallya BS,Gupta VM,Shah DS,Trivedi BR,Shastri NA,Mehta CB,Jain KA,Bhavasar NS,Shah UJ

更新日期：2007-02-01 00:00:00

abstract：:In a Latin square design, nine New Zealand white male rabbits (2.8-4.8 kg) each received intravenous indocyanine green (ICG) in doses of 2.5, 12.5, and 25 mg/kg. A period of 4 weeks separated consecutive experiments. A specific high-pressure liquid chromatographic (HPLC) assay and the traditional spectrophotometric (S...

journal_title：Canadian journal of physiology and pharmacology

authors： Thiessen JJ,Rappaport PL,Eppel JG

更新日期：1984-09-01 00:00:00

abstract：:In hypertension, the relationship between atrial natriuretic peptide (ANP) and vasopressin (AVP) is not yet clear, although their renal actions are effectively autoregulation. To examine the possible interaction further, the responses to ANP infusion (75 ng x min (-1), i.v.) have been investigated in both hypertensive...

journal_title：Canadian journal of physiology and pharmacology

authors： Abu-Amarah I,Balment RJ

更新日期：1999-02-01 00:00:00

abstract：:Single-electrode voltage-clamp experiments were made on CA1 neurons in the presence of tetrodotoxin and K channel blockers. Applications of halothane (1-3% v/v) for 3-10 min caused a similar marked and reversible depression of slow inward currents (probably Ca currents) evoked by depolarizing pulses from a holding pot...

journal_title：Canadian journal of physiology and pharmacology

authors： Krnjević K,Puil E

更新日期：1988-12-01 00:00:00

abstract：:Early studies indicated that the baCl2-induced contractions in the guinea pig ileum longitudinal muscle strip (GPI-LMS) were, in part, neuronal in origin. However, recent studies have suggested that BaCl2-induced contractions were produced by an action directly on the smooth muscle membrane. The purpose of this study ...

journal_title：Canadian journal of physiology and pharmacology

authors： Clement JG

更新日期：1981-06-01 00:00:00

abstract：:Oxidative stress plays a vital role in the pathogenesis of neurodegenerative diseases. Chikusetsu saponin V (CsV), the most abundant member of saponins from Panax japonicus (SPJ), has attracted increasing attention for its potential to treat neurodegenerative diseases. However, the mechanisms are unclear. Our study in...

journal_title：Canadian journal of physiology and pharmacology

authors： Wan J,Deng L,Zhang C,Yuan Q,Liu J,Dun Y,Zhou Z,Zhao H,Liu C,Yuan D,Wang T

更新日期：2016-09-01 00:00:00

abstract：:The influences of hypertension and hypothyroidism on diabetic cardiomyopathy are not clear. We studied this problem further by characterizing the effects of chronic triiodothyronine (T3) treatment on cardiac performance of diabetic renovascular hypertensive (RVH) rats. Hypertension was effected by clipping the left re...

journal_title：Canadian journal of physiology and pharmacology

authors： Rodgers RL,Davidoff AJ,Mariani MJ

更新日期：1991-03-01 00:00:00

abstract：:The effect of short-term exposure to homocysteine (Hcy) on the contractile characteristics of rat aortic tissue was assessed both in vitro and in vivo. The contractile response of Hcy-treated aortic rings in culture for 1 or 4 days was unchanged from control responses. By comparison, aortic rings from animals injected...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang S,Wright G,Harrah J,Touchon R,McCumbee W,Geng W,Fultz ME,Abdul-Jalil MN,Wright GL

更新日期：2000-06-01 00:00:00

abstract：:The effects of a vasopressin (AVP) pressor antagonist, d(CH2)5Tyr(Me)AVP, on mean arterial pressure (MAP), total peripheral resistance (TPR), cardiac output (CO), and the distribution of CO were investigated by the microsphere technique in three groups of pentobarbital anesthetized rats: intact (I), saralasin pretreat...

journal_title：Canadian journal of physiology and pharmacology

authors： Tabrizchi R,King KA,Pang CC

更新日期：1986-08-01 00:00:00

abstract：:The influence of variation in the extracellular concentrations of Na+, Mg2+, and Ca2+ in the depolarizing medium on isoproterenol-induced increases in cAMP levels and relaxation was studied in rat uterus. Isoproterenol (10(-8) M) failed to increase cAMP levels in the high-K+ medium containing no Na+. When 80 mM Na+ wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Meisheri KD,McNeill JH

更新日期：1979-10-01 00:00:00

abstract：:The major hallmark of rotator cuff tendinopathies (RCT) is the disorganization of tendon extracellular matrix (ECM) which is due to decrease in the collagen I-to-collagen III ratio. In addition, the pathology of tendon matrisome remains asymptomatic and hypoxia has been identified to be the priming signal to initiate ...

journal_title：Canadian journal of physiology and pharmacology

authors： Thankam FG,Agrawal DK

更新日期：2020-08-15 00:00:00

abstract：:This paper provides a brief overview of the adaptive control of prehension. Several primary issues for research in the field are considered. One pertains to the stages of prehensile activity, with particular concern for the kinematic control of precontact phases, and the coordination of load and grip forces following ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lederman SJ

更新日期：1994-05-01 00:00:00

abstract：:The direct effects of extrinsic nerve stimulation on coronary artery tone are unclear because of the complications arising from alterations in myocardial dynamics which themselves alter flow. An isolated and perfused nonbeating slab of beef ventricle was utilized in the present experiments to eliminate secondary compl...

journal_title：Canadian journal of physiology and pharmacology

authors： Kalsner S

更新日期：1979-03-01 00:00:00

abstract：:Disposition of the bis-pyridinium mono-oxime, HI-6, following intramuscular injection in rats (200 mg/kg bw), beagle dogs (10 and 50 mg/kg bw), and rhesus monkeys (50 mg/kg bw) revealed that the oxime was absorbed rapidly and completely from the site of injection, was distributed rapidly in the tissues, and that tissu...

journal_title：Canadian journal of physiology and pharmacology

authors： Ecobichon DJ,Comeau AM,O'Neil WM,Marshall WD

更新日期：1990-05-01 00:00:00

abstract：:Hyperglycemia in diabetes induces increased endothelin-1 (ET-1) production in the retina, kidney, and heart that may lead to hemodynamic impairment, permeability alteration, and increased extracellular matrix (ECM) protein production. Chronically elevated blood glucose levels may cause oxidative stress in these target...

journal_title：Canadian journal of physiology and pharmacology

authors： Chiu J,Xu BY,Chen S,Feng B,Chakrabarti S

更新日期：2008-06-01 00:00:00

abstract：:In male Sprague--Dawley rats, hypertensive development was diminished for 10 weeks when parathyroidectomy (PTX) was performed 1 week before deoxycorticosterone plus saline (DOCA + NaCl) treatment. In young spontaneously hypertensive male rats (SHR, Okamoto strain) parathyroidectomy performed after weaning lessened hyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Gairard A,Berthelot A,Schleiffer R,Pernot F

更新日期：1982-02-01 00:00:00

abstract：:Glucose utilization and insulin and growth hormone responses were evaluated in eight obese women by three rapid intravenous glucose tolerance tests (IVGTT): during a control period, and after 1 and 3 weeks of a 750 kcal/day protein-lipid diet (1 kcal = 4.1855 kJ). Weight loss averaged 454 g/day during the 1st week and...

journal_title：Canadian journal of physiology and pharmacology

authors： Reid D,Rasio E

更新日期：1982-03-01 00:00:00

abstract：:While conducting studies on the prevention of mortality from acute iron intoxication in rats, diazepam, given to prevent animal suffering, was observed to be associated with reduced mortality in a limited number of animals. The objective was to assess whether diazepam reduces mortality following acute iron intoxicatio...

journal_title：Canadian journal of physiology and pharmacology

authors： Fassos FF,Berkovitch M,Daneman N,Koren L,Cameron R,Klein J,Falcitelli C,St Louis P,Daneman R,Koren G

更新日期：1998-09-01 00:00:00

abstract：:Normal mammalian sexual maturation and reproductive functions require the integration and precise coordination of hormones at the hypothalamic, pituitary, and gonadal levels. Hypothalamic gonadotropin-releasing hormone (GnRH) is a key regulator in this system; after binding to its receptor (GnRHR), it stimulates de no...

journal_title：Canadian journal of physiology and pharmacology

authors： Cheng KW,Leung PC

更新日期：2000-12-01 00:00:00

abstract：:We compared some of our latest experiments on blood pressure control and erythrocytosis in spontaneously hypertensive rats with Gaar's computer-simulated studies, which suggest that erythrocytosis is a key to understanding the hemodynamic changes in hypertension. We tested two of Gaar's several predictions: (i) periph...

journal_title：Canadian journal of physiology and pharmacology

authors： Gould AB,Goodman S,Swartz C

更新日期：1994-06-01 00:00:00

abstract：:The mammalian daily (circadian) clock is located in the suprachiasmatic nuclei of the hypothalamus. Clock function can be detected by the measurement of the circadian change in spontaneous firing rate of suprachiasmatic nuclei cells in a brain slice preparation in vitro. We investigated the effects of neuropeptide Y o...

journal_title：Canadian journal of physiology and pharmacology

authors： Harrington ME,Schak KM

更新日期：2000-02-01 00:00:00

abstract：:The precise role of microglia in stroke and cerebral ischemia has been the subject of debate for a number of years. Microglia are capable of synthesizing numerous soluble and membrane-bound biomolecules, some known to be neuroprotective, some neurotoxic, whereas others have less definitive bioactivities. The molecular...

journal_title：Canadian journal of physiology and pharmacology

authors： Lai AY,Todd KG

更新日期：2006-01-01 00:00:00

abstract：:The most important reason for the non-approval and withdrawal of drugs by the Food and Drug Administration is hepatotoxicity. Therefore, this study was undertaken to evaluate the protective effects of hesperidin against cyclophosphamide (CYP)-induced hepatotoxicity in Wistar rats. The rats received a single intraperit...

journal_title：Canadian journal of physiology and pharmacology

authors： Mahmoud AM

更新日期：2014-09-01 00:00:00

abstract：:D-Serine, a recently identified gliotransmitter, serves as an endogenous coagonist binding to the glycine site of N-methyl-D-aspartate (NMDA) receptors. However, it is not clear whether this native ligand is able to bind to and modulate alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate (AMPA) receptors. In the pre...

journal_title：Canadian journal of physiology and pharmacology

authors： Gong XQ,Zabek RL,Bai D

更新日期：2007-05-01 00:00:00

abstract：:Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain. In this study, we investigated the antiseptic effects and underlying mechanisms of vicenin-2 and scolymoside, which are 2 active compounds from C. subternata that act against high mobility group box 1 (HMGB1)-mediated septi...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee W,Yoon EK,Kim KM,Park DH,Bae JS

更新日期：2015-08-01 00:00:00

abstract：:To determine the effects of chronic hyperinsulinemia on glucagon release, rats were made hyperinsulinemic for 14 days by supplementation of drinking water with sucrose (10%; sucrose-fed) to increase endogenous release or by implantation of osmotic minipumps (subcutaneous, s.c.; or intraperitoneal, i.p.) to deliver exo...

journal_title：Canadian journal of physiology and pharmacology

authors： Brubaker PL,Kazumi T,Hirano T,Vranic M,Steiner G

更新日期：1991-03-01 00:00:00