Abstract:
:The effects of localized distension of the pulmonary vein - left atrial junctions on plasma arginine vasopressin (AVP) have been examined in chloralose anaesthetized dogs. Pulmonary vein distension caused an increase in heart rate and a decrease in plasma AVP concentration. Cooling the vagosympathetic nerves to 10 degrees C caused an increase in arterial pressure and plasma AVP concentration and prevented the changes in heart rate and plasma AVP concentration caused by pulmonary vein distension. Cooling the vagus nerves to 16 degrees C did not change heart rate, arterial pressure, or plasma AVP concentration but significantly reduced the changes in heart rate and plasma AVP concentration caused by pulmonary vein distension. Propranolol (0.5 mg/kg) decreased heart rate and prevented the increase in heart rate associated with pulmonary vein distension but did not abolish the decrease in plasma AVP concentration. It is concluded that distension of the pulmonary vein - left atrial junctions causes a decrease in plasma AVP concentration by stimulating atrial receptors with myelinated afferent fibres. The decrease in plasma AVP concentration is not secondary to the reflex changes in heart rate caused by pulmonary vein distension.
journal_name
Can J Physiol Pharmacoljournal_title
Canadian journal of physiology and pharmacologyauthors
Wilson N,Ledsome JRdoi
10.1139/y83-136subject
Has Abstractpub_date
1983-08-01 00:00:00pages
905-10issue
8eissn
0008-4212issn
1205-7541journal_volume
61pub_type
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y77-076
更新日期:1977-06-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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更新日期:1996-09-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y92-034
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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更新日期:1988-05-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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更新日期:1988-04-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:
更新日期:2001-07-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:1999-02-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:1992-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-04-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:2019-05-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:2013-07-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y88-161
更新日期:1988-08-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 临床试验,杂志文章
doi:
更新日期:1999-07-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章,随机对照试验
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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更新日期:1992-10-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y80-030
更新日期:1980-02-01 00:00:00
abstract::Pertussis toxin (PTX) is a heterohexameric protein, which is divided into subunits A and B. The A-subunit (protomer) possesses adenine diphosphate (ADP) ribosyltransferase activity, and the B-oligomer confers cell surface binding specificity on the toxin. By virtue of the ADP-ribosylation activity in the A-subunit, PT...
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更新日期:1996-05-01 00:00:00
abstract::Altered sympathetic nervous activity has been linked to the development and persistence of obesity, partly relating to overfeeding. Binding of the selective, positron-emitting phosphodiesterase-4 (PDE4) inhibitor (R)-[11C]rolipram provides a direct index of the cAMP-hydrolyzing enzyme PDE4. This study examines progres...
journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y79-004
更新日期:1979-01-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y75-048
更新日期:1975-06-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y85-237
更新日期:1985-11-01 00:00:00
abstract::The blood volume of anesthetized rats was expanded acutely by 33% with donor blood while a caval snare was gradually tightened so that right atrial pressure (RAP) was prevented from rising (n = 6). In control experiments (n = 5) an aortic snare was used to hold mean arterial blood pressure near the values found in the...
journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y84-131
更新日期:1984-07-01 00:00:00