The effect of adrenal denervation on the metabolic effects of hyperammonemia in sheep.

abstract：:The isolated human vas deferens (HVD) has been the subject of a limited number of pharmacological studies. Furthermore, it has not been established whether the local or general anesthetics used in obtaining the HVD affect the responses of this isolated tissue. Therefore, the aim of this study was to determine if the l...

journal_title：Canadian journal of physiology and pharmacology

authors： Kawamoto JH,Owen JA,Morales A,Nakatsu K

更新日期：1986-04-01 00:00:00

abstract：:The mechanism whereby chronic rapid ventricular pacing induces severe heart failure is unclear, but the phenomenon is associated with a reduction in left ventricular ATP levels. Accordingly, the current study was undertaken to evaluate the acute effects of rapid ventricular pacing on hemodynamics, left ventricular ade...

journal_title：Canadian journal of physiology and pharmacology

authors： Simmons WW,Moe GW,Grima EA,Howard RJ,Armstrong PW

更新日期：1994-01-01 00:00:00

abstract：:The release of endothelium-derived relaxing factor (EDRF), prostacyclin (PGI2), and endothelin-1 (ET-1) was measured from endothelial cells (EC) cultured from either bovine vena cava (BVCEC) or bovine aorta (BAEC). EDRF release was determined by using the superfusion bioassay technique, whereas ET-1 and PGI2 were meas...

journal_title：Canadian journal of physiology and pharmacology

authors： D'Orleans-Juste P,Mitchell JA,Wood EG,Hecker M,Vane JR

更新日期：1992-05-01 00:00:00

abstract：:The purpose of this study was to determine the interaction of three factors that modify twitch contraction amplitude in the rat gastrocnemius muscle in situ: posttetanic potentiation, fatigue, and caffeine. Posttetanic (200 Hz for 1 s) twitch responses were observed before and after 15 Hz stimulation for 6 min (group ...

journal_title：Canadian journal of physiology and pharmacology

authors： MacIntosh BR,Gardiner PF

更新日期：1987-02-01 00:00:00

abstract：:This report reviews the research and mentoring career of Richard B. Stein (1940-). In 1962, he completed a B.S. degree in physics at the Massachusetts Institute of Technology, USA, and thereafter an M.A. (1964), Ph.D. (1966), and postdoctoral training (1966-68) at the University of Oxford, UK. He subsequently assumed ...

journal_title：Canadian journal of physiology and pharmacology

authors： Stuart DG

更新日期：2004-08-01 00:00:00

abstract：:The guanylin family of peptides has 3 subclasses of peptides containing either 3 intramolecular disulfide bonds found in bacterial heat-stable enterotoxins (ST), or 2 disulfides observed in guanylin and uroguanylin, or a single disulfide exemplified by lymphoguanylin. These peptides bind to and activate cell-surface r...

journal_title：Canadian journal of physiology and pharmacology

authors： Fonteles MC,do Nascimento NR

更新日期：2011-08-01 00:00:00

abstract：:Experiments in right atria isolated from adult male rats were designed to determine which of the alpha 1-adrenergic receptor (alpha 1-AR) subtypes are involved in the positive chronotropic effect of phenylephrine, an alpha 1-AR agonist. Chloroethylclonidine (CEC), an irreversible alpha 1b-, alpha 1c-, and alpha 1d-AR ...

journal_title：Canadian journal of physiology and pharmacology

authors： Williamson AP,Seifen E,Lindemann JP,Kennedy RH

更新日期：1994-12-01 00:00:00

abstract：:For 10 days, dogs were fed a normal salt diet containing 70 mequiv. Na+/day (NSD) followed by a high salt diet containing 170 mequiv. Na+/day (HSD) or 240 mequiv. Na+/day (VHSD), or the order was reversed. K+ in these diets was fixed at 40 mequiv./day. The different diets did not influence the basal level of serum cat...

journal_title：Canadian journal of physiology and pharmacology

authors： Carrière S,Cardinal J,Le Grimellec C

更新日期：1980-09-01 00:00:00

abstract：:To assess development changes in kinetic properties of the cardiac sodium current, whole-cell voltage-clamp experiments were conducted using 3-, 10-, and 17-day-old embryonic chick ventricular heart cells. Experimental data were quantified according to the Hodgkin-Huxley model. While the Na current density, as examine...

journal_title：Canadian journal of physiology and pharmacology

authors： Sada H,Ban T,Fujita T,Ebina Y,Sperelakis N

更新日期：1995-10-01 00:00:00

abstract：:The direct effects of extrinsic nerve stimulation on coronary artery tone are unclear because of the complications arising from alterations in myocardial dynamics which themselves alter flow. An isolated and perfused nonbeating slab of beef ventricle was utilized in the present experiments to eliminate secondary compl...

journal_title：Canadian journal of physiology and pharmacology

authors： Kalsner S

更新日期：1979-03-01 00:00:00

abstract：:The aim of this study was to identify the key genes involved in the cardiac hypertrophy (CH) induced by pressure overload. mRNA microarray data sets GSE5500 and GSE18801 were downloaded from the Gene Expression Omnibus database, and differentially expressed genes (DEGs) were screened using the Limma package; then, fun...

journal_title：Canadian journal of physiology and pharmacology

authors： Gao J,Li Y,Wang T,Shi Z,Zhang Y,Liu S,Wen P,Ma C

更新日期：2018-08-01 00:00:00

abstract：:Using immunofluorescence and real 3-D confocal microscopy, our results showed the presence of ET-1, ETA, and ETB receptors in isolated human aortic vascular endothelial cells (hVECs). The level of the peptide and its receptors was significantly higher in the nucleus (including the nuclear envelope membranes) than in t...

journal_title：Canadian journal of physiology and pharmacology

authors： Avedanian L,Riopel J,Bkaily G,Nader M,D'Orleans-Juste P,Jacques D

更新日期：2010-08-01 00:00:00

abstract：:The purpose of this study was to investigate whether Ca2+ -Mg2+ ATPase in the distal tubule (where calcium transport is active, against a gradient, and hormone dependent) presents some characteristics different from those observed in the proximal tubule, and whether these characteristics are likely to shed light on th...

journal_title：Canadian journal of physiology and pharmacology

authors： Brunette MG,Blouin S,Chan M

更新日期：1987-10-01 00:00:00

abstract：:The threshold for electrically induced ventricular fibrillation was determined in anesthetized open-chest dogs, before and after blockade of atrioventricular (A-V) conduction. Without exception, the threshold was significantly elevated after creation of the block. The precise mechanism of this effect is not known at t...

journal_title：Canadian journal of physiology and pharmacology

authors： Reynolds AK,Dresel PE

更新日期：1983-09-01 00:00:00

abstract：:In embryonic chick hearts during development, there are three inward current systems which are involved in the rising phases of the action potentials (APs): fast INa, slow ICa, and tetrodotoxin-insensitive slow INa. To assess reactivation processes for these three types of inward current channels (fast Na+, slow Ca2+,...

journal_title：Canadian journal of physiology and pharmacology

authors： Sada H,Sada S,Sperelakis N

更新日期：1986-02-01 00:00:00

abstract：:The volatile oil (VO), extracted from the stems of Schisandra chinensis Baill. (SCS), was separated and identified by gas chromatography - mass spectrometry. The study was devised to investigate the effects of VO on oxidative stress and cognitive deficits induced by amyloid-β (Aβ(1-42)). Alzheimer's disease (AD) model...

journal_title：Canadian journal of physiology and pharmacology

authors： Yang B,Liu B,Liu Y,Han H,Kuang H

更新日期：2018-06-01 00:00:00

abstract：:The sarco(endo)plasmic reticulum calcium ATPase (SERCA) is responsible for transporting calcium (Ca(2+)) from the cytosol into the lumen of the sarcoplasmic reticulum (SR) following muscular contraction. The Ca(2+) sequestering activity of SERCA facilitates muscular relaxation in both cardiac and skeletal muscle. Ther...

journal_title：Canadian journal of physiology and pharmacology

authors： Stammers AN,Susser SE,Hamm NC,Hlynsky MW,Kimber DE,Kehler DS,Duhamel TA

更新日期：2015-10-01 00:00:00

abstract：:Slow alpha2-globulin (salpha2G), a high molecular weight glycoprotein, appears as a component of rat serum in a wide variety of both physiologic and pathologic conditions, including pregnancy; it is also present in the neonate. In the present study, the protein was detectable in serum after 6 to 10 days, and was prese...

journal_title：Canadian journal of physiology and pharmacology

authors： Kirkcaldy M,Beaton GH

更新日期：1977-06-01 00:00:00

abstract：:Epigallocatechin-3-gallate (EGCG), a polyphenol in green tea, is an effective antioxidant and possesses neuroprotective effects. Brain-derived neurotrophic factor (BDNF) and cyclic AMP response element-binding protein (CREB) are crucial for neurogenesis and synaptic plasticity. In this study, we aimed to assess the pr...

journal_title：Canadian journal of physiology and pharmacology

authors： Ding ML,Ma H,Man YG,Lv HY

更新日期：2017-12-01 00:00:00

abstract：:17 beta-Hydroxy-11 beta(4-dimethylaminophenyl)-17 alpha-(1-propynyl)estra-4, 9-dien-3-one (RU486) inhibited the in vitro development of different stages of mouse preimplantation embryos under study. Two-celled embryos, morulae, and early blastocysts were obtained from B6D2F1 mice. The embryos were grown in Ham F-10 nu...

journal_title：Canadian journal of physiology and pharmacology

authors： Juneja SC,Dodson MG

更新日期：1990-11-01 00:00:00

abstract：:This study was conducted to examine the protective role of crude polysaccharide from brown seaweed Sargassum polycystum against acetaminophen-induced abnormality in blood glucose, serum albumin/globulin ratio, and liver glycogen, lactate, and pyruvate. Liver and renal tissue histology was performed to confirm the effi...

journal_title：Canadian journal of physiology and pharmacology

authors： Raghavendran HR,Srinivasan P

更新日期：2008-10-01 00:00:00

abstract：:Noradrenaline spillover from skeletal muscle vascular areas increases during exercise but the underlying mechanisms are not well understood. Muscle contraction itself causes changes in many factors that could affect noradrenaline spillover. For instance, it has been reported that bradykinin is synthesized in skeletal ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lavoie JL,Béliveau L

更新日期：2001-10-01 00:00:00

abstract：:The aim of this study was to investigate the effects of melatonin on rat gastric fundus smooth muscle. Melatonin (10(-4) to 10(-3) M) had no effect on the basal tone of gastric smooth muscle. After precontraction with carbachol (10(-6) M) or serotonin (10(-7) M), melatonin caused a concentration dependent inhibitory a...

journal_title：Canadian journal of physiology and pharmacology

authors： Storr M,Schusdziarra V,Allescher HD

更新日期：2000-10-01 00:00:00

abstract：:The calyx-type synapse of the embryonic chick ciliary ganglion is reviewed as a model of transmitter release from a vertebrate presynaptic nerve terminal. This nerve terminal is extensive in area, enabling the penetration with microelectrodes and the application of patch-clamp techniques. In other respects the calyx s...

journal_title：Canadian journal of physiology and pharmacology

authors： Stanley EF

更新日期：1992-01-01 00:00:00

abstract：:Newborn hearts have restricted functional reserve and variable responsiveness to inotropes that could be partly due to differences in myocardial beta-adrenoceptors (beta-AR). To clarify this issue, this study documented ventricle-specific changes in myocardial beta-AR density and affinity during postnatal maturation. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wittnich C,Belanger MP,Bandali K

更新日期：2006-08-01 00:00:00

abstract：:Input to the nucleus medianus of the preoptic region has been suggested to be involved in both the drinking and pressor responses elicited by the central administration of angiotensin II. Evidence in support of this suggestion has been gained principally from electrical lesion experiments. This lesion procedure does n...

journal_title：Canadian journal of physiology and pharmacology

authors： Jones DL

更新日期：1988-08-01 00:00:00

abstract：:Excitation-contraction coupling in crab muscle fibers was studied in voltage-clamp conditions. Extracellular calcium is essential for the mechanical activity. Two calcium influxes induced by membrane depolarization contribute to tension development: one is the inward calcium current responsible for the phasic tension,...

journal_title：Canadian journal of physiology and pharmacology

authors： Mounier Y,Goblet C

更新日期：1987-04-01 00:00:00

abstract：:This study developed an animal model of gestational obesity and prediabetes in Sprague Dawley rats using 35% sucrose supplementation (SS). Postprandially, insulin stimulates glucose uptake and nutrient partitioning via insulin-dependent as well as Hepatic Insulin Sensitizing Substance (HISS)-dependent action. HISS is ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lovat NEJ,Legare DJ,Lautt WW

更新日期：2020-10-16 00:00:00

abstract：:The effect of chlorpromazine on subcellular biosynthesis, hydrolysis, and transfer of lipids and liponucleotides participating in the biosynthesis of polyglycerophosphatides in guinea pig liver was studied. Chlorpromazine showed an apparent stimulation of accumulation of phosphatidic acid and CDP-diglycerides in micro...

journal_title：Canadian journal of physiology and pharmacology

authors： Stuhne-Sekalec L,Chudzik J,Stanacev NZ

更新日期：1987-03-01 00:00:00

abstract：:Liver blood flow and hepatic uptake of some indicator substances have been reported to fall with age in both rats and humans. We used an isolated liver system, which was perfused in one pass with hemoglobin free buffer, to investigate the effect of albumin concentration, buffer flow rate, and age upon hepatic clearanc...

journal_title：Canadian journal of physiology and pharmacology

authors： Montgomery PR,Sitar DS

更新日期：1988-05-01 00:00:00