Increase in ventricular fibrillation threshold following blockade of atrioventricular conduction.

abstract：:The role of nitric oxide (NO) on the vasorelaxant effect of atrial natriuretic peptide (ANP) on the basal tone of rabbit aortic rings conditioned to angiotensin II (Ang II) was studied. ANP aortic relaxation and nitrite release were measured in the presence and absence of endothelium and a NO-synthase inhibitor. Ang I...

journal_title：Canadian journal of physiology and pharmacology

authors： Romano L,Coviello A,Jerez S,Peral de Bruno M

更新日期：2002-10-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are cardiac hormones synthesized in and secreted from the heart. ANP and BNP bind the common receptor guanylyl cyclase-A (GC-A) and possess biological actions. Based on their diuretic, natriuretic, and vasodilating activities, they are now widely us...

journal_title：Canadian journal of physiology and pharmacology

authors： Saito Y,Kishimoto I,Nakao K

更新日期：2011-08-01 00:00:00

abstract：:We have recently shown that vasoactive peptides such as angiotensin II (Ang II) and endothelin-1 (ET-1) increased the expression of G(i) proteins and proliferation of A10 vascular smooth muscle cells (VSMC) through MAP kinase / PI3 kinase pathways. The present study was undertaken to examine the implication of growth ...

journal_title：Canadian journal of physiology and pharmacology

authors： Gomez Sandoval YH,Lévesque LO,Anand-Srivastava MB

更新日期：2009-12-01 00:00:00

abstract：:Grains are global dietary staples that when consumed in whole grain form, offer considerable health benefits compared with milled grain foods, including reduced body weight gain and reduced cardiovascular and diabetes risks. Dietary patterns, functional foods, and other lifestyle factors play a fundamental role in the...

journal_title：Canadian journal of physiology and pharmacology

authors： Nelson K,Stojanovska L,Vasiljevic T,Mathai M

更新日期：2013-06-01 00:00:00

abstract：:It has been proposed that the adult castrated male rat may be used as a model of human postmenopausal osteoporosis. If such a model is valid then the total body calcium of castrated rats should progressively decrease compared with normal rats. To search for this age-related difference, it will be necessary to use a me...

journal_title：Canadian journal of physiology and pharmacology

authors： Beachey DJ,Wickham M,Webber CE

更新日期：1985-10-01 00:00:00

abstract：:Acetylcholine (ACh)-mediated vagal transmission as well as nonneuronal ACh release are considered cardioprotective in pathological situations with increased sympathetic drive such as ischemia-reperfusion and cardiac remodeling. ACh action is terminated by hydrolysis by the cholinesterases (ChEs), acetylcholinesterase,...

journal_title：Canadian journal of physiology and pharmacology

authors： Kilianova Z,Ciznarova N,Szmicsekova K,Slobodova L,Hrabovska A

更新日期：2020-07-01 00:00:00

abstract：:We found when L-type calcium current (ICa-L) was recorded with the perforated patch-clamp method in rat ventricular myocytes that bath application of phenylephrine (with propranolol) evoked a biphasic response characterized by an initial transient suppression followed by a sustained potentiation. The transient suppres...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang S,Lin J,Hirano Y,Hiraoka M

更新日期：2005-11-01 00:00:00

abstract：:The isometric potentiation associated with myosin phosphorylation is force dependent. The purpose of this study was to assess the influence of a pre-existing period of isometric force on the concentric force potentiation displayed by mouse muscles with and without the ability to phosphorylate myosin. We tested isometr...

journal_title：Canadian journal of physiology and pharmacology

authors： Gittings W,Aggarwal H,Stull JT,Vandenboom R

更新日期：2015-01-01 00:00:00

abstract：:Glutathione, a cysteine-containing tripeptide, is the most abundant nonprotein thiol in mammalian cells. Glutathione plays an important role in the detoxification of xenobiotic compounds and in the antioxidation of reactive oxygen species and free radicals. Because of its multiple functions in various tissues and its ...

journal_title：Canadian journal of physiology and pharmacology

authors： Bray TM,Taylor CG

更新日期：1993-09-01 00:00:00

abstract：:Canadian Aboriginal people encompass diverse cultural groups, whose daily food patterns vary in regard to the kinds and proportions of indigenous foods. Standard dietary methods of assessing food consumption sometimes require modification to be understandable and acceptable to Aboriginal communities. Depending upon th...

journal_title：Canadian journal of physiology and pharmacology

authors： Wein EE

更新日期：1995-06-01 00:00:00

abstract：:Despite the widespread use of furosemide in the treatment of various fluid and electrolyte disorders in the preterm and term human infant and child, the physiological effects of this potent diuretic agent on renal function and renin release during postnatal maturation are poorly understood. To test the hypothesis that...

journal_title：Canadian journal of physiology and pharmacology

authors： Smith FG,Abraham J

更新日期：1995-01-01 00:00:00

abstract：:Neonatal hyperthyroidism (NH) in the rat is associated with permanent reductions in serum thyroxine (T4), triiodothyronine (T3), and thyroid-stimulating hormone (TSH) concentrations in the adult, changes suggestive of a hypothyroid state. In the adult NH rat, the thyrotroph appears to be more sensitive to the feedback...

journal_title：Canadian journal of physiology and pharmacology

authors： Walker P

更新日期：1985-09-01 00:00:00

abstract：:A variety of xenobiotics, viz., 3,3',4,4'-tetrachlorobiphenyl (TCBP), sodium phenobarbital (PB), 3,5-diethoxycarbonyl-2, 4,6-trimethylpyridine (OX-DDC), and nifedipine, cause a decrease in uroporphyrinogen decarboxylase (UROG-D) activity, accompanied by uroporphyrin accumulation, in chick embryo hepatocytes in culture...

journal_title：Canadian journal of physiology and pharmacology

authors： Green-Thompson RP,Kimmett SM,Marks GS

更新日期：1992-07-01 00:00:00

abstract：:The metabolism of endogenous and exogenous diacylglycerol (DG) was studied in SM-3 cells derived from rabbit aortic smooth muscle to determine the biochemical step(s) responsible for degrading DG second messengers. Incubation of growth-arrested SM-3 cells with [3H]myristate for 2 h resulted in selective labelling of c...

journal_title：Canadian journal of physiology and pharmacology

authors： Migas I,Chuang M,Sasaki Y,Severson DL

更新日期：1997-10-01 00:00:00

abstract：:The responses of the circular muscle of canine colon to stimulation of intrinsic nerves and to the probable mediators of these nerves were studied in vivo. In vivo studies were carried out using close intra-arterial injections and local field stimulation of proximal, mid-, and distal colon while recording circumferent...

journal_title：Canadian journal of physiology and pharmacology

authors： Gonda T,Daniel EE,Kostolanska F,Oki M,Fox JE

更新日期：1988-04-01 00:00:00

abstract：:The objective of the present study was to assess the cardioprotective effect of dual NEP-ACE inhibition in relation to endogenous cardiac bradykinin (BK), its active metabolite des-Arg9-BK, endogenous brain natriuretic peptides (BNP), and cGMP. Rats were treated with the dual metallopeptidase inhibitor, omapatrilat, o...

journal_title：Canadian journal of physiology and pharmacology

authors： Dumoulin MJ,Adam A,Burnett J,Heublein D,Yamaguchi N,Lamontagne D

更新日期：2005-02-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) was reported to induce mast cell proliferation and aggravate allergic reactions through activation of mouse double minute 2 (MDM2). We aimed to ascertain that β-sitosterol (SI), which is one of the several phytosterols found mostly in foods, would regulate TSLP-induced mast cell pro...

journal_title：Canadian journal of physiology and pharmacology

authors： Han NR,Kim HM,Jeong HJ

更新日期：2015-11-01 00:00:00

abstract：:The beneficial hypolipidemic and antioxidant influences of the dietary spice compounds curcumin and capsaicin were evaluated. Curcumin, capsaicin, or their combination were included in the diet of high-(30%)-fat-fed rats for 8 weeks. Dietary high-fat-induced hypertriglyceridemia was countered by dietary curcumin, caps...

journal_title：Canadian journal of physiology and pharmacology

authors： Manjunatha H,Srinivasan K

更新日期：2007-06-01 00:00:00

abstract：:We previously reported that calpain, the Ca2+-sensitive cysteine protease, gets involved in atherogenesis. This study aimed to investigate the effects of calpain inhibitor I (CAI, 5 mg/kg per day) with or without NG-nitro-l-arginine-methyl ester (l-NAME) (100 mg/kg per day), the inhibitor of nitric oxide synthase (NOS...

journal_title：Canadian journal of physiology and pharmacology

authors： Yu L,Yin M,Yang X,Lu M,Tang F,Wang H

更新日期：2018-01-01 00:00:00

abstract：:The isometric contractile properties of frog (Rana pipiens) and toad (Bufo bufo) sartorii have been studied over the temperature range from 0 to 20 degrees C. The isometric twitch tension was found to vary considerably between these two species and between muscles in the same species. Between 0 and 4 degrees C there w...

journal_title：Canadian journal of physiology and pharmacology

authors： Bressler BH

更新日期：1981-06-01 00:00:00

abstract：:Ah receptor in hepatic cytosols from adult cynomolgus monkeys (Macaca fasicularis) was identified and quantitated by its binding of the highly toxic chemical 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the carcinogens 3-methylcholanthrene, benzo[a]pyrene, and dibenz[a,h]anthracene. The concentration of Ah receptor ...

journal_title：Canadian journal of physiology and pharmacology

authors： Okey AB,Vella LM,Iverson F

更新日期：1984-10-01 00:00:00

abstract：:Cardiac injury and loss of cardiomyocytes is a causative as well as a resultant condition of cardiovascular disorders, which are the leading cause of death throughout the world. This loss of cardiomyocytes cannot be completely addressed through the currently available drugs being administered, which mainly function on...

journal_title：Canadian journal of physiology and pharmacology

authors： Padda J,Sequiera GL,Sareen N,Dhingra S

更新日期：2015-10-01 00:00:00

abstract：:New methods for chronic instrumentation of the newborn piglet are described, which allow continuous monitoring of not only pressures in the pulmonary artery and aorta but also in the left and right atria, pulmonary vein, as well as main branch pulmonary artery flows. Changes in pulmonary vascular tone to short-acting ...

journal_title：Canadian journal of physiology and pharmacology

authors： Coe JY,Olley PM,Hamilton F,Vanhelder T,Coceani F

更新日期：1987-05-01 00:00:00

abstract：:Liver blood flow and hepatic uptake of some indicator substances have been reported to fall with age in both rats and humans. We used an isolated liver system, which was perfused in one pass with hemoglobin free buffer, to investigate the effect of albumin concentration, buffer flow rate, and age upon hepatic clearanc...

journal_title：Canadian journal of physiology and pharmacology

authors： Montgomery PR,Sitar DS

更新日期：1988-05-01 00:00:00

abstract：:In recent experiments in conscious lambs, we showed that in addition to its well-known natriuretic and diuretic effects, i.v. injection of 2 mg/kg of furosemide resulted in a sustained increase in heart rate and an age-dependent increase in plasma renin activity. To determine whether these responses were dose dependen...

journal_title：Canadian journal of physiology and pharmacology

authors： Patel A,Smith FG

更新日期：1997-09-01 00:00:00

abstract：:Chronically elevated plasma norepinephrine has the potential for supporting function of diseased hearts, yet may also initiate harmful biochemical and (or) structural changes in the myocardium. The present study investigated the dosage-related effects of chronic norepinephrine infusion on markers of myocardial damage ...

journal_title：Canadian journal of physiology and pharmacology

authors： Siri FM,Smith RM

更新日期：1986-07-01 00:00:00

abstract：:Our objective was to produce reductions in the luminal volume of Henle's loop and increases in linear flow velocity through the loop. We did this in a recollection micropuncture study by collecting fluid with and without suction from early distal tubules. With suction, transit time of fast green dye through the loop d...

journal_title：Canadian journal of physiology and pharmacology

authors： Baines AD,Wu CK

更新日期：1975-04-01 00:00:00

abstract：:Previous reports demonstrated that cilostazol, a phosphodiesterase 3 inhibitor, affected cellular electrophysiology and reduced episodes of ventricular fibrillation (VF) in patients with Brugada syndrome. However, its effects on VF induction and defibrillation efficacy have never been investigated. We tested the hypot...

journal_title：Canadian journal of physiology and pharmacology

authors： Kanlop N,Shinlapawittayatorn K,Sungnoon R,Weerateerangkul P,Chattipakorn S,Chattipakorn N

更新日期：2010-04-01 00:00:00

abstract：:In male Sprague--Dawley rats, hypertensive development was diminished for 10 weeks when parathyroidectomy (PTX) was performed 1 week before deoxycorticosterone plus saline (DOCA + NaCl) treatment. In young spontaneously hypertensive male rats (SHR, Okamoto strain) parathyroidectomy performed after weaning lessened hyp...

journal_title：Canadian journal of physiology and pharmacology

authors： Gairard A,Berthelot A,Schleiffer R,Pernot F

更新日期：1982-02-01 00:00:00

abstract：:The effects of modulators of Ca-ATPase and alkaline phosphatase (AP) activity on placental calcium and phosphorus transfer were studied using the in situ perfused guinea pig placenta. The diuretics ethacrynic acid and furosemide had no significant effect on placental calcium and phosphorus transfer when injected into ...

journal_title：Canadian journal of physiology and pharmacology

authors： McKercher HG,Derewlany LO,Radde IC

更新日期：1983-11-01 00:00:00