Preparation and properties of poly(N alpha, N epsilon-L-lysinediylterephthaloyl) microcapsules containing hemolysate in the nanometer range.

abstract：:A variety of porphyrinogenic xenobiotics cause mechanism-based inactivation of a number of rat hepatic cytochrome P450 isozymes. As a result, a mixture of four N-alkylprotoporphyin IX (N-alkylPP) regioisomers, with ferrochelatase-inhibitory properties, are formed. This study was designed to determine whether all four ...

journal_title：Canadian journal of physiology and pharmacology

authors： McNamee JP,Kobus SM,Marks GS

更新日期：1996-08-01 00:00:00

abstract：:Epinephrine caused hyperglycemia in part by increasing gluconeogenesis. However, the mechanism of its gluconeogenic effects has not been studied in ruminants. This study was undertaken to examine the effect of epinephrine on the net hepatic uptake of selected glucose precursors in sheep. The major abdominal blood vess...

journal_title：Canadian journal of physiology and pharmacology

authors： Brockman RP

更新日期：1991-04-01 00:00:00

abstract：:Thermal resistance as determined by survival time was examined in different age groups of spontaneously hypertensive (SHR) rats during terminal heating. A comparison with age or weight matched controls indicated that the thermal resistance of SHR animals was markedly inferior to that of normotensive animals as evidenc...

journal_title：Canadian journal of physiology and pharmacology

authors： Wright G,Iams S,Knecht E

更新日期：1977-10-01 00:00:00

abstract：:Natural products from plants such as flavonoids are potential drugs to overcome multidrug resistance (MDR) in cancer treatments. However, their modes of action are still unclear. In this study, the effects of quercetin on mitochondrial membrane potential (DeltaPsim) change as well as quercetin's ability to induce apop...

journal_title：Canadian journal of physiology and pharmacology

authors： Kothan S,Dechsupa S,Leger G,Moretti JL,Vergote J,Mankhetkorn S

更新日期：2004-12-01 00:00:00

abstract：:It is commonly thought that central nervous system depressant drugs exert their actions through enhancement of gamma-aminobutyrate (GABA)-mediated mechanisms. Recently, the cellular electrophysiological evidence from this laboratory and others suggests that both sedative hypnotics and general anaesthetics inhibit cent...

journal_title：Canadian journal of physiology and pharmacology

authors： Carlen PL,Gurevich N,Davies MF,Blaxter TJ,O'Beirne M

更新日期：1985-07-01 00:00:00

abstract：:The leaves and bark of Cassia glauca Lam., a glabrous tree in the family Fabaceae, are used in folk medicine for the treatment of diabetes. The aim of this study was to investigate the antidiabetic activity of the aqueous extract of C. glauca bark. The various parameters that were studied in treated or untreated normo...

journal_title：Canadian journal of physiology and pharmacology

authors： Salahuddin M,Jalalpure SS,Gadge NB

更新日期：2010-02-01 00:00:00

abstract：:Changes in metabolic characteristics of the liver and jejunal epithelia as a result of feeding the beta-agonist albuterol to chickens for 3 and 6 weeks were studied. Feeding albuterol resulted in a change in weights of the liver and small intestines. Chickens fed albuterol for 6 weeks had greater levels of plasma none...

journal_title：Canadian journal of physiology and pharmacology

authors： Rompala RE,Darre MJ

更新日期：1989-05-01 00:00:00

abstract：:A new antagonist of the vasoconstrictor eicosanoids, L-640,035, was studied in a standardized model of myocardial ischemia (MI) in anesthetized cats. This eicosanoid antagonist was not found to exert any overt hemodynamic action in cats subjected to a sham myocardial ischemia protocol. However, the antagonist markedly...

journal_title：Canadian journal of physiology and pharmacology

authors： Lefer AM,Burke SE,Lepran I

更新日期：1984-12-01 00:00:00

abstract：:The role of nitric oxide (NO) on the vasorelaxant effect of atrial natriuretic peptide (ANP) on the basal tone of rabbit aortic rings conditioned to angiotensin II (Ang II) was studied. ANP aortic relaxation and nitrite release were measured in the presence and absence of endothelium and a NO-synthase inhibitor. Ang I...

journal_title：Canadian journal of physiology and pharmacology

authors： Romano L,Coviello A,Jerez S,Peral de Bruno M

更新日期：2002-10-01 00:00:00

abstract：:The area postrema (AP) is one of the circumventricular organs of the brain and as such it is highly vascular and lacks the normal blood-brain barrier. Anatomical tracing studies have demonstrated afferent projections to AP originating from the paraventricular nucleus, lateral parabrachial nucleus (l-PBN), nucleus trac...

journal_title：Canadian journal of physiology and pharmacology

authors： Ferguson AV

更新日期：1991-07-01 00:00:00

abstract：:The effects of 5-hydroxytryptamine (5-HT) on spinal motoneurons were examined in pentobarbital-anaesthetized cats and in nonanaesthetized decerebrate cats by intracellular recording and extracellular iontophoresis of 5-HT. 5-HT first induced a depolarization and then a long-lasting hyperpolarization (up to 60 min) wit...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang L

更新日期：1991-02-01 00:00:00

abstract：:Salvianolic acid B (Sal B) exerts strong antioxidant activity and eliminates the free radical effect. However, how it affects the antioxidant pathway is not very clear. The objective of this study was to investigate the underlying mechanism of Sal B in CCl4-induced acute liver injury, especially its effect on the Nrf2...

journal_title：Canadian journal of physiology and pharmacology

authors： Jin YM,Tao XM,Shi YN,Lu Y,Mei JY

更新日期：2020-03-01 00:00:00

abstract：:The arterio--alveolar nitrogen difference (aADN2) has been associated in 27 normal adult subjects aged 20--60 years. As it may be assumed that venous and arterial PN2 are identical, we have used a sample of venous blood. There is a significant positive correlation between aADN2 and age. As the increase of aADN2 with a...

journal_title：Canadian journal of physiology and pharmacology

authors： Corbet AJ,Ross JA,Beaudry PH

更新日期：1975-02-01 00:00:00

abstract：:An account is given of the current state of knowledge of the contributions of the cerebellum and the forelimb motor cortex (MC) to the neural control of walking movements in the cat. The main emphasis is on information obtained by recording from single MC and cerebellar neurones in chronically instrumented cats engage...

journal_title：Canadian journal of physiology and pharmacology

authors： Armstrong DM,Marple-Horvat DE

更新日期：1996-04-01 00:00:00

abstract：:Grains are global dietary staples that when consumed in whole grain form, offer considerable health benefits compared with milled grain foods, including reduced body weight gain and reduced cardiovascular and diabetes risks. Dietary patterns, functional foods, and other lifestyle factors play a fundamental role in the...

journal_title：Canadian journal of physiology and pharmacology

authors： Nelson K,Stojanovska L,Vasiljevic T,Mathai M

更新日期：2013-06-01 00:00:00

abstract：:The reported efficiencies of drug encapsulation into liposomes range from less than 0.1% to more than 10% per micromole phospholipid, depending on the nature of the drug and of the liposome employed. We have sought to investigate some of the factors which control the efficiency of drug encapsulation. We have found tha...

journal_title：Canadian journal of physiology and pharmacology

authors： Stamp D,Juliano RL

更新日期：1979-05-01 00:00:00

abstract：:Single-electrode voltage-clamp experiments were made on CA1 neurons in the presence of tetrodotoxin and K channel blockers. Applications of halothane (1-3% v/v) for 3-10 min caused a similar marked and reversible depression of slow inward currents (probably Ca currents) evoked by depolarizing pulses from a holding pot...

journal_title：Canadian journal of physiology and pharmacology

authors： Krnjević K,Puil E

更新日期：1988-12-01 00:00:00

abstract：:Thyrotoxicosis, a condition in which there is an excessive amount of circulating thyroid hormones, leads to reduced glycogen content in different tissues. In this study we analyzed the effects of aerobic swimming training on liver, heart, and skeletal muscle glycogen content in experimentally induced thyrotoxicosis. W...

journal_title：Canadian journal of physiology and pharmacology

authors： Ribeiro LF,Teixeira IP,Aparecido da Silva G,Dalia RA,Júnior MC,Bertolini NO,Rostom de Mello MA,Luciano E

更新日期：2012-05-01 00:00:00

abstract：:Investigation of the relationship of diet to blood lipids and atherosclerosis has dominated the field of lipid nutritional biochemistry for the past 25 years. Although this subject has consumed considerable time, effort, and research funds, it has also proved beneficial to other areas of lipid biochemistry by attracti...

journal_title：Canadian journal of physiology and pharmacology

authors： Walker BL

更新日期：1983-03-01 00:00:00

abstract：:We studied the effect of lowering the extracellular potassium concentration ([K+]o) on the electrophysiological actions of disopyramide phosphate, a new antiarrhythmic drug. At low [K+]o, therapeutic concentrations of disopyramide phosphate caused significantly less depression of action potential amplitude and maximum...

journal_title：Canadian journal of physiology and pharmacology

authors： Kus T,Sasyniuk BI

更新日期：1978-02-01 00:00:00

abstract：:The secretion of cyclic AMP, cyclic GMP, protein, calcium, and bicarbonate in the pancreatic juice of three nonanesthetized dogs with chronic gastric and duodenal Thomas cannulae has been studied. Intravenous infusions of increasing doses of cholecystokinin-pancreozymin (CCK) (1.5, 3, 6, 12, 24 Crick Harper-Raper (CHR...

journal_title：Canadian journal of physiology and pharmacology

authors： Cailla HL,Sarles H,Singer MV

更新日期：1979-06-01 00:00:00

abstract：:We examined the interaction of smooth muscle myosin with alpha-actin and beta-actin isoforms during the contraction of A7r5 smooth muscle cells and rat aortic smooth muscle. The techniques of confocal microscopy and fluorescence resonance energy transfer (FRET) analysis were utilized in examining A7r5 cells and rat ao...

journal_title：Canadian journal of physiology and pharmacology

authors： Black J,Dykes A,Thatcher S,Brown D,Bryda EC,Wright GL

更新日期：2009-05-01 00:00:00

abstract：:The enhancement of the response of an isolated strip of lactating mouse mammary gland to oxytocin, resulting from dilution of the Tyrode solution in which oxytocin is administered, is due to the effects of hypotonicity per se and not to changes in concentration of any of the ions in the bathing solution. Inhibition of...

journal_title：Canadian journal of physiology and pharmacology

authors： Ferrier BM

更新日期：1979-03-01 00:00:00

abstract：:Glucose utilization and insulin and growth hormone responses were evaluated in eight obese women by three rapid intravenous glucose tolerance tests (IVGTT): during a control period, and after 1 and 3 weeks of a 750 kcal/day protein-lipid diet (1 kcal = 4.1855 kJ). Weight loss averaged 454 g/day during the 1st week and...

journal_title：Canadian journal of physiology and pharmacology

authors： Reid D,Rasio E

更新日期：1982-03-01 00:00:00

abstract：:In the mesenteric circulation of the rat a myogenic autoregulatory system operates at 0.1-0.15 Hz. Negative admittance phase in the region above 0.2 Hz suggested operation of an arterial baroreflex. The present study was designed to test this interpretation and to identify the neurotransmitter involved. In rats anesth...

journal_title：Canadian journal of physiology and pharmacology

authors： Abu-Amarah I,Cupples WA

更新日期：2000-01-01 00:00:00

abstract：:Eight pure triterpenoid saponin compounds isolated from the root of Polygala senega L., a plant indigenous to the Canadian prairies, were evaluated for their immunological activity in mouse models. The specific antibody responses of the IgG2a subclass increased significantly when isolated P. senega saponins were used ...

journal_title：Canadian journal of physiology and pharmacology

authors： Katselis GS,Estrada A,Gorecki DK,Barl B

更新日期：2007-11-01 00:00:00

abstract：:When using microelectrodes for intracellular ion activity studies, some uncertainties such as interference from cytosolic components at the microelectrode, cell damage, and cell contamination may arise. A model, which treats kinetic processes of the loss of carriers from the membrane phase of microelectrodes into the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Oesch U,Ammann D,Simon W

更新日期：1987-05-01 00:00:00

abstract：:This study developed an animal model of gestational obesity and prediabetes in Sprague Dawley rats using 35% sucrose supplementation (SS). Postprandially, insulin stimulates glucose uptake and nutrient partitioning via insulin-dependent as well as Hepatic Insulin Sensitizing Substance (HISS)-dependent action. HISS is ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lovat NEJ,Legare DJ,Lautt WW

更新日期：2020-10-16 00:00:00

abstract：:Prevention and treatment of Alzheimer disease are urgent problems for elderly people in developed countries. We previously reported that nobiletin, a poly-methoxylated flavone from the citrus peel, improved the symptoms in various types of animal models of memory loss and activated the cAMP responsive element (CRE)-de...

journal_title：Canadian journal of physiology and pharmacology

authors： Takito J,Kimura J,Kajima K,Uozumi N,Watanabe M,Yokosuka A,Mimaki Y,Nakamura M,Ohizumi Y

更新日期：2016-07-01 00:00:00

abstract：:The effects of Bay K8644, a Ca2+ channel agonist, on the mechanical and electrical properties of frog skeletal muscle fibers were investigated. At relatively low concentrations, such as 10(-6) and 10(-5) M, Bay K8644 significantly potentiated the maximum amplitudes of twitch responses, and this effect was not reversed...

journal_title：Canadian journal of physiology and pharmacology

authors： Oz M,Frank GB

更新日期：1994-10-01 00:00:00