Baroreceptors, alpha1-adrenergic receptors, and regulation of mesenteric blood flow.

abstract：:The effects of isoproterenol and forskolin on tension, cyclic AMP levels, and cyclic AMP dependent protein kinase activity were compared in helical strips of bovine coronary artery. Elevation of cyclic AMP and activation of the protein kinase appeared to be well correlated with relaxation of potassium-contracted arter...

journal_title：Canadian journal of physiology and pharmacology

authors： Vegesna RV,Diamond J

更新日期：1984-09-01 00:00:00

abstract：:Some current questions regarding muscle afferent receptors are discussed. These include the significance of variable distribution patterns of muscle spindles in different muscles and of differences in intrinsic spindle morphology. The significance of the very large and variable population of small myelinated afferent ...

journal_title：Canadian journal of physiology and pharmacology

authors： Abrahams VC

更新日期：1981-07-01 00:00:00

abstract：:The 3,5-pyrazolidinedione (3,5-P) drugs, phenylbutazone and sulfinpyrazone, have been reported to bind to receptors for the chemotactic peptide, f-Met-Leu-Phe, and to behave as functional antagonists of f-Met-Leu-Phe in human and rabbit neutrophils. To explore the structure-activity relationship of this family of drug...

journal_title：Canadian journal of physiology and pharmacology

authors： Levesque L,Gaudreault RC,Marceau F

更新日期：1991-03-01 00:00:00

abstract：:The adenylate cyclase activity induced by norepinephrine (10(-8)-10(-9) M) was studied in hypothalamic particulate fractions from female rats. The effect of estradiol on this activity was studied in rats that were ovariectomized in diestrus 1, injected with estradiol benzoate (50 micrograms/kg body weight), and killed...

journal_title：Canadian journal of physiology and pharmacology

authors： Zubin P,Defagot C

更新日期：1994-11-01 00:00:00

abstract：:NTPDase is one of the principal enzymes involved in the sequential hydrolysis of ATP. In the present study, the presence and functionality of NTPDase in the mesenteric vein and artery were examined. Adenosine triphosphate (ATP) (0.01-1000 pmol) induces a dose-dependent vasodilation in the isolated arterial and venous ...

journal_title：Canadian journal of physiology and pharmacology

authors： Duval M,Beaudoin AR,Bkaily G,Gendron FP,D' Orléans-Juste P

更新日期：2003-03-01 00:00:00

abstract：:The aim of this study was to determine if there was a synergistic or additive effect of a thiazolidinedione derivative (rosiglitazone (ROS)) and a vanadium compound (bis(ethylmaltolato)oxovanadium(IV) (BEOV)) on plasma glucose and insulin levels following chronic oral administration to Zucker diabetic fatty (ZDF) rats...

journal_title：Canadian journal of physiology and pharmacology

authors： Yuen VG,Bhanot S,Battell ML,Orvig C,McNeill JH

更新日期：2003-11-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver conditions that are characterized by steatosis, inflammation, fibrosis, and liver injury. The global prevalence of NAFLD is rapidly increasing in proportion to the rising incidence of obesity and type 2 diabetes. Because NAFLD is a multifaceted di...

journal_title：Canadian journal of physiology and pharmacology

authors： Sid V,Siow YL,O K

更新日期：2017-10-01 00:00:00

abstract：:Metformin (MET) is widely used in the correction of insulin (INS) resistance and metabolic abnormalities in type 2 diabetes. However, its effect on INS resistance and metabolic disorders associated with cancer cachexia is not established. We investigated the MET effects, isolated or associated with INS, on INS resista...

journal_title：Canadian journal of physiology and pharmacology

authors： de Fatima Silva F,Ortiz-Silva M,Galia WBS,Cassolla P,da Silva FG,Graciano MFR,Carpinelli AR,de Souza HM

更新日期：2018-05-01 00:00:00

abstract：:A hydroperoxide compound structurally related to acetylsalicylic acid, 3-hydroperoxy-3-methylphthalide, inhibits both the first and second phases of adenosine diphosphate induced, biphasic, human platelet aggregation. This occurs over the same concentration range (0.05-0.5 mM) that acetylsalicylic acid inhibits second...

journal_title：Canadian journal of physiology and pharmacology

authors： Killackey JJ,Killackey BA,Cerskus I,Philp RB

更新日期：1984-03-01 00:00:00

abstract：:Ablation of the anteroventral third ventricle (AV3V) region, which includes the organum vasculosum laminae terminalis (OVLT), blocks the febrile response of guinea pigs to systemically injected endotoxin; by contrast, discrete lesions of the OVLT transiently enhance fever in rabbits and rats. To assess whether separat...

journal_title：Canadian journal of physiology and pharmacology

authors： Blatteis CM,Hales JR,McKinley MJ,Fawcett AA

更新日期：1987-06-01 00:00:00

abstract：:This Symposium includes 15 presentations and an editorial review dealing with prorenin activation and function. It comes 20 years after prorenin was first reported in various contexts and attracted attention because of its connection with renin--angiotensin, its high concentration relative to renin in the blood, and i...

journal_title：Canadian journal of physiology and pharmacology

authors： Osmond DH,Sealey JE,McKenzie JK

更新日期：1991-09-01 00:00:00

abstract：:The effect of pinaverium was electrophysiologically characterized and compared with the established L-type calcium channel blockers diltiazem, D600, and nitrendipine on canine colonic circular smooth muscle. Effects were studied on the electrical activity of the smooth muscle cells, in particular the spontaneously occ...

journal_title：Canadian journal of physiology and pharmacology

authors： Malysz J,Farraway LA,Christen MO,Huizinga JD

更新日期：1997-08-01 00:00:00

abstract：:The most commonly observed effect of beta-blockade on cardiovascular function has been a reduction in heart rate both at rest and during exercise. The body attempts to compensate by increasing stroke volume and (or) increasing the extraction of O2 from the blood to maintain O2 delivery to the muscle. This paper examin...

journal_title：Canadian journal of physiology and pharmacology

authors： Hughson RL,Kowalchuk JM

更新日期：1991-02-01 00:00:00

abstract：:The development of cardiac hypertrophy was examined in rats given ethanol in a nutritionally adequate, liquid diet mixture, by intubation, in severely intoxicating doses at 8-h intervals for up to 96 h, alone or in combination with prazosin. Other groups of rats received isocalorically paired quantities of maltose-dex...

journal_title：Canadian journal of physiology and pharmacology

authors： Adams MA,Hirst M

更新日期：1989-03-01 00:00:00

abstract：:Beat-to-beat variability of cardiac action potential duration (short-term variability, SV) is a common feature of various cardiac preparations, including the human heart. Although it is believed to be one of the best arrhythmia predictors, the underlying mechanisms are not fully understood at present. The magnitude of...

journal_title：Canadian journal of physiology and pharmacology

authors： Nánási PP,Magyar J,Varró A,Ördög B

更新日期：2017-10-01 00:00:00

abstract：:The interactions of ligands with their receptors and the modulation of those interactions by other ligands are commonly described in the (verbal and mathematical) language of enzymology. While this analogy is appropriate in that velocity-substrate concentration curves and ligand-receptor binding isotherms often confor...

journal_title：Canadian journal of physiology and pharmacology

authors： Tomlinson G

更新日期：1988-04-01 00:00:00

abstract：:In rats anesthetized with alpha-chloralose, doses of 0.1, 0.5, and 1 g/kg of ethanol produced an upward shift of baroreflex curves constructed by plotting the heart rate response against mean arterial pressure following evoked rises in mean arterial pressures by phenylephrine or angiotensin II. Whereas the upward shif...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdel-Rahman AR,Russ R,Strickland JA,Wooles WR

更新日期：1987-05-01 00:00:00

abstract：:To investigate the contribution of pulmonary surfactant to a low airflow resistance through narrow conducting airways, a system was developed with which it was possible to determine the resistance meeting a steady flow of air at 0.5 mL/min. The airflow, delivered by an infusion pump, entered the extreme periphery of a...

journal_title：Canadian journal of physiology and pharmacology

authors： Enhorning G,Yarussi A,Rao P,Vargas I

更新日期：1996-06-01 00:00:00

abstract：:Radioactively labelled microspheres (15 micron diameter) were used to measure cardiac output (CO) distribution and blood flows in spleen, kidneys, and skeletal muscle before and after normovolemic anemia or polycythemia in anesthetized rats. Hematocrits were changed from 45 to 33% or from 45 to 59% by an exchange tran...

journal_title：Canadian journal of physiology and pharmacology

authors： Ackermann U,Veress AT

更新日期：1980-04-01 00:00:00

abstract：:Endothelin-1 has emerged as an important participant in the pathophysiology of a variety of cardiovascular diseases, where it may act on endocrine, paracrine and autocrine bases. Here we review its regulated biosynthesis, receptor-mediated signaling, and functional consequences in the heart, with particular emphasis o...

journal_title：Canadian journal of physiology and pharmacology

authors： Yang LL,Arab S,Liu P,Stewart DJ,Husain M

更新日期：2005-01-01 00:00:00

abstract：:There is general agreement about potentiation in dose-response studies, characterized by a left shift of the dose-response curve of A by a fixed dose of B when B is causing no effect by itself (simple situation). When B causes an effect similar to A (complex situation) by binding to different molecular sites, we propo...

journal_title：Canadian journal of physiology and pharmacology

authors： Pöch G,Reiffenstein RJ,Köck P,Pancheva SN

更新日期：1995-11-01 00:00:00

abstract：:Autophagy regulates cellular homeostasis and integrates the cellular pro-survival machinery. We investigated the role of autophagy in the natural history of murine abdominal aortic aneurysms (AAA). ApoE(-/-) mice were implanted with saline- or angiotensin II (Ang-II)-filled miniosmotic pumps then treated with either t...

journal_title：Canadian journal of physiology and pharmacology

authors： Ramadan A,Wheatcroft MD,Quan A,Singh KK,Lovren F,Dhingra N,Teoh H,Al-Omran M,Leong-Poi H,Verma S

更新日期：2015-08-01 00:00:00

abstract：:The rate of glucose oxidation of fresh corneas of guinea pigs at different ages has been determined. Full-thickness corneal discs, 4 mm in diameter, were incubated in radioactive glucose solution. The quantity of the released CO2 was expressed in terms of the corneal discs, their dry weights, and DNA and protein conte...

journal_title：Canadian journal of physiology and pharmacology

authors： Liao HM,Lin BJ,Hasany SM,Basu PK

更新日期：1979-10-01 00:00:00

abstract：:The pharmacological characteristics of postjunctional alpha-adrenoceptors in isolated canine internal carotid arteries were investigated by the use of selective agonists and antagonists for alpha 1- and alpha 2-adrenoceptors. Norepinephrine, phenylephrine, and xylazine caused concentration-dependent contractions in th...

journal_title：Canadian journal of physiology and pharmacology

authors： Kawai Y,Kobayashi S,Ohhashi T

更新日期：1988-05-01 00:00:00

abstract：:Male spontaneously hypertensive stroke-prone (SHRsp) rats were fed 4% NaCl diets containing either 0.75% (normal) K or 2.11% (high) K, starting at 6 weeks of age. After 8 months on these diets, 40 out of 58 SHRsp rats on the 0.75% K diet had died (69% mortality) versus 2 dead out of 95 on the 2.11% K diet (2% mortalit...

journal_title：Canadian journal of physiology and pharmacology

authors： Tobian L

更新日期：1986-06-01 00:00:00

abstract：:The major functional alpha1-adrenoceptor in the rat aorta is of the alpha1Dsubtype and that in the caudal artery is of the alpha1A subtype. In the present study, the participation of protein kinase C (PKC) and Rho kinase (RhoK) in contractile responses to stimulation of the alpha1-adrenoceptors in these two arteries w...

journal_title：Canadian journal of physiology and pharmacology

authors： Mueed I,Bains P,Zhang L,Macleod KM

更新日期：2004-10-01 00:00:00

abstract：:Initially the impetus to develop iron (Fe) chelators for clinical use was based upon the need for a drug to treat Fe-overload diseases such as beta-thalassemia. However, it has become clear that Fe chelators may be useful for the treatment of a wide variety of disease states, including cancer, malaria, and free radica...

journal_title：Canadian journal of physiology and pharmacology

authors： Richardson DR

更新日期：1997-10-01 00:00:00

abstract：:Doxorubicin treatment causes delayed development of cardiotoxicity. Whether the doxorubicin-induced impairment of cardiac functions reverses or progresses with time after the cessation of the treatment was examined. The rats were injected with doxorubicin (2.5 mg/kg, i.v., once a week for 3 weeks) and sacrificed at 1 ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chugun A,Temma K,Oyamada T,Suzuki N,Kamiya Y,Hara Y,Sasaki T,Kondo H,Akera T

更新日期：2000-04-01 00:00:00

abstract：:Metabolic syndrome (MS) is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. MS is associated with obesity, increased blood pressure, hyperlipidemia, and hyperglycemia. This study was designed to investigate the pharmacological profile of phentolamine, a nonse...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhou K,Kumar U,Yuen VG,McNeill JH

更新日期：2012-08-01 00:00:00

abstract：:The measurement of the sodium reversal potential (Erev), as that potential where the early current reverses during voltage clamp, was found to exceed the true Erev by 4.1 +/- 2.4 mV (mean +/- SD) in squid giant axon. This error was found in both intact and internally perfused axons and is due to interference from the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wodlinger H,Kunov H,Atwood HL

更新日期：1982-12-01 00:00:00