The effects of an ASA-like hydroperoxide compound on adenosine diphosphate induced platelet aggregation.

Abstract:

:A hydroperoxide compound structurally related to acetylsalicylic acid, 3-hydroperoxy-3-methylphthalide, inhibits both the first and second phases of adenosine diphosphate induced, biphasic, human platelet aggregation. This occurs over the same concentration range (0.05-0.5 mM) that acetylsalicylic acid inhibits second phase aggregation and the release reaction only. The complete inhibition of adenosine diphosphate induced aggregation is a unique pharmacological property for an acetylsalicylic-acid-like compound.

authors

Killackey JJ,Killackey BA,Cerskus I,Philp RB

doi

10.1139/y84-053

subject

Has Abstract

pub_date

1984-03-01 00:00:00

pages

338-40

issue

3

eissn

0008-4212

issn

1205-7541

journal_volume

62

pub_type

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