Acute effects of ethanol on baroreceptor reflex control of heart rate and on pressor and depressor responsiveness in rats.

abstract：:The present research was to assess the relationship between ABCB1 (G2677T/A, C3435T) polymorphisms and lipid homeostasis as well as risk of liver injury induced by atorvastatin in in-patients from China. The lipid levels (total cholesterol, high-density lipoprotein, triglycerides) as well as metabolic enzymes of hepar...

journal_title：Canadian journal of physiology and pharmacology

authors： Qu KK,Zhang CN,Dong LX,Wang SS,Zhang ZD,Zhang L

更新日期：2020-01-01 00:00:00

abstract：:Inorganic vanadium has been shown, both in vivo and in vitro, to have insulin-mimetic properties. A new organic vanadium complex, bis(maltolato)oxovanadium(IV) (BMOV), was developed to increase the absorption of vanadium from the gastrointestinal tract, thereby reducing the dose of vanadium necessary to produce glucos...

journal_title：Canadian journal of physiology and pharmacology

authors： Yuen VG,Orvig C,McNeill JH

更新日期：1993-03-01 00:00:00

abstract：:Myometrial tissues from guinea pigs were quantitatively examined for gap junctions in electron micrographs. Small numbers of gap junctions were present between smooth muscle cells in myometria of pregnant guinea pigs at days 50 and 65 of gestation. The junctions increased in number and size at parturition on day 69 an...

journal_title：Canadian journal of physiology and pharmacology

authors： Garfield RE,Daniel EE,Dukes M,Fitzgerald JD

更新日期：1982-03-01 00:00:00

abstract：:Over the past few years, a number of cases of tendon injuries associated with statin therapy have been reported. In this study, we assessed whether statins can affect the extracellular matrix (ECM) of the deep digital flexor tendon (DDFT) and patellar tendon (PT). Wistar rats were assigned to groups treated with atorv...

journal_title：Canadian journal of physiology and pharmacology

authors： Oliveira LP,Vieira CP,Marques PP,Pimentel ER

更新日期：2017-04-01 00:00:00

abstract：:Natural rodent grooming and other instinctive behavior serves as a natural model of complex movement sequences. Rodent grooming has syntactic (rule-driven) sequences and more random movement patterns. Both incorporate the same movements--only the serial structure differs. Recordings of neural activity in the dorsolate...

journal_title：Canadian journal of physiology and pharmacology

authors： Aldridge JW,Berridge KC,Rosen AR

更新日期：2004-08-01 00:00:00

abstract：:Ischemic heart disease is the leading cause of morbi-mortality in developed countries. Both ischemia-reperfusion injury and mechanisms of cardioprotection have been studied for more than 50 years. It is known that the physiopathological mechanism of myocardial ischemia involves several factors that are closely related...

journal_title：Canadian journal of physiology and pharmacology

authors： D'Annunzio V,Donato M,Buchholz B,Pérez V,Miksztowicz V,Berg G,Gelpi RJ

更新日期：2012-09-01 00:00:00

abstract：:Energy-deprivation contractures were investigated in unloaded rat ventricular myocytes. Application of 2 mM cyanide in the presence of 10 mM 2-deoxyglucose (metabolic blockade) led to a rapid shortening "contracture" (maximum speed 1.5 +/- 0.2% control cell length/s). Cells shortened to a constant length of 69 +/- 1.6...

journal_title：Canadian journal of physiology and pharmacology

authors： Nichols CG,Lederer WJ

更新日期：1990-02-01 00:00:00

abstract：:The aim of this study was to elucidate the variables of gastroduodenal motility determining gastric emptying. For this purpose the effects of exogenous cholecystokinin, secretin, and gastric inhibitory polypeptide on motility and gastric emptying were studied during a meal. Motility was measured with extraluminal stra...

journal_title：Canadian journal of physiology and pharmacology

authors： Keinke O,Ehrlein HJ,Wulschke S

更新日期：1987-03-01 00:00:00

abstract：:Delta 9-Tetrahydrocannabinol (20 mg/kg i.p.) and propranolol (20 and 50 mg/kg i.p.) produced marked falls in the rectal temperatures of mice kept at an ambient temperature of 22 degrees C. Propranolol (50 mg/kg i.p.) also decreased the thermogenic activity of brown fat, as measured by a decrease in the level of [3H]GD...

journal_title：Canadian journal of physiology and pharmacology

authors： Pertwee RG,Nash K,Trayhurn P

更新日期：1991-06-01 00:00:00

abstract：:The goal of the present study was to investigate the formation of portacaval shunts in a new experimental model of chronic portal hypertension, portal vein stenosis in the cat. The procedure gradually occluded the portal vein by use of an Ameroid constrictor around the portal vein. After 4 weeks, the portal vein was c...

journal_title：Canadian journal of physiology and pharmacology

authors： Inglés AC,Légaré DJ,Lautt WW

更新日期：1993-09-01 00:00:00

abstract：:The effect of high potassium depolarization on the release of exogenously supplied [3H]glutamate and endogenous glutamate from tissue slices of the cestode Hymenolepis diminuta was examined. Increasing concentrations of potassium stimulated the release of radiolabel from tissues preloaded with [3H]glutamate. This rele...

journal_title：Canadian journal of physiology and pharmacology

authors： Webb RA

更新日期：1988-07-01 00:00:00

abstract：:Endometritis is one of the main diseases that harms the dairy cow industry. Tanshinone IIA (TIIA), a fat-soluble alkaloid isolated from Salviae miltiorrhizae, has been reported to have potent anti-inflammatory properties. However, the anti-inflammatory effects of TIIA on a mouse model of lipopolysaccharide (LPS)-induc...

journal_title：Canadian journal of physiology and pharmacology

authors： Lv X,Fu K,Li W,Wang Y,Wang J,Li H,Tian W,Cao R

更新日期：2015-11-01 00:00:00

abstract：:To develop a mathematical model of the distribution and metabolism of rat corticotropin-releasing factor (rCRF), the time course of 125I-labelled rCRF in plasma was measured in male Sprague-Dawley rats (i) following a rapid injection of 24 ng rCRF/100 g body weight (BW), or (ii) following a rapid injection of 424 ng r...

journal_title：Canadian journal of physiology and pharmacology

authors： Candas B,Lalonde J,Normand M

更新日期：1986-06-01 00:00:00

abstract：:Recent evidence suggests that some Ca2+ channels are regulated by a tyrosine kinase pathway. The possibility that Ca2+ entry is regulated by tyrosine kinase was investigated in canine vascular muscles. Functional studies were carried out in the dog mesenteric arteries and saphenous veins. Nicardipine-insensitive refil...

journal_title：Canadian journal of physiology and pharmacology

authors： Low AM

更新日期：1996-03-01 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease resulting in the formation of the atherosclerotic plaque. Plaque formation starts with the inflammation in fatty streaks and progresses through atheroma, atheromatous plaque, and fibroatheroma leading to development of stable plaque. Hypercholesterolemia, dyslipidemia,...

journal_title：Canadian journal of physiology and pharmacology

authors： Rai V,Agrawal DK

更新日期：2017-10-01 00:00:00

abstract：:Steady state glucose kinetics were measured in 19 premature and 16 full-term piglets. Bodyweight, plasma glucose concentration, total body glucose turnover rate, and glucose pool size were not significantly different between the two groups. This suggests that the premature piglet is capable of maintaining glucose home...

journal_title：Canadian journal of physiology and pharmacology

authors： Flecknell PA,Wootton R,John M,Royston JP

更新日期：1981-10-01 00:00:00

abstract：:Chronically elevated plasma norepinephrine has the potential for supporting function of diseased hearts, yet may also initiate harmful biochemical and (or) structural changes in the myocardium. The present study investigated the dosage-related effects of chronic norepinephrine infusion on markers of myocardial damage ...

journal_title：Canadian journal of physiology and pharmacology

authors： Siri FM,Smith RM

更新日期：1986-07-01 00:00:00

abstract：:After the discovery of an inactive, putative renin precursor that could be proteolytically activated, and the proteases involved in vivo, Morris and co-workers directly demonstrated that renin is indeed synthesized as a "pro" form, and from genetic coding sequences they provided the structure of human prorenin. The ge...

journal_title：Canadian journal of physiology and pharmacology

authors： Morris BJ,Smith DL

更新日期：1991-09-01 00:00:00

abstract：:Hormonal replacement therapy (HRT) has failed to provide a cardioprotective action in postmenopausal women, and thus alternative pharmacological approaches are required. The present study examined the therapeutic potential of the partial estrogen receptor agonist tamoxifen and the angiotensin II type-1 receptor antago...

journal_title：Canadian journal of physiology and pharmacology

authors： Pham-Dang ML,Clement R,Mercier I,Calderone A

更新日期：2003-09-01 00:00:00

abstract：:Aortas were removed from six mature lambs and four sheep and pressure fixed at 100 and 120 mmHg pressure (1 mmHg = 133.322 Pa), respectively, in 10% buffered formalin. The numbers of elastin layers were counted from cross sections at different distances down the aorta, from the distal arch to the iliac bifurcation, an...

journal_title：Canadian journal of physiology and pharmacology

authors： van Baardwijk C,Roach MR

更新日期：1983-02-01 00:00:00

abstract：:The distribution of atrial natriuretic factor (ANF) binding sites in Wistar rat tissues, as well as tissues from other species was studied. Using autoradiography of slide mounted tissue sections incubated with 125I-labelled ANF, high densities of binding sites were found in the renal glomeruli and papilla, aortic smoo...

journal_title：Canadian journal of physiology and pharmacology

authors： von Schroeder HP,Nishimura E,McIntosh CH,Buchan AM,Wilson N,Ledsome JR

更新日期：1985-11-01 00:00:00

abstract：:Mentoring in academia is often carried out in an informal way depending on individuals and circumstances. I was quite fortunate to make the acquaintance of Professor E.E. Daniel when I was making a transition from my research in entomology to biomedical sciences. Here I recount some of that experience, and describe so...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee RM

更新日期：2005-08-01 00:00:00

abstract：:We compared the determinants of spontaneous activity in explanted neonatal (2-day-old) rat ventricle cells and in reaggregates derived from 15-day-old chick embryos. We studied the beating rate with an optical recording method and the underlying electrical activity with glass microelectrodes using the K current blocke...

journal_title：Canadian journal of physiology and pharmacology

authors： Schanne OF,Boutin L,Derosiers J

更新日期：1989-07-01 00:00:00

abstract：:The knowledge on alpha-adrenoceptors has expanded enormously in the last decade, mostly as a result of in vitro and in vivo animal experiments. In the face of considerable species differences we have tested several of the newly developed concepts on alpha-adrenoceptors in the circulation of the human forearm. In this ...

journal_title：Canadian journal of physiology and pharmacology

authors： van Brummelen P,Jie K,Timmermans PB,van Zwieten PA

更新日期：1987-08-01 00:00:00

abstract：:In our previous study, l-carnitine was shown to have cytoprotective effect against hydrogen peroxide (H2O2)-induced injury in human normal HL7702 hepatocytes. The aim of this study was to investigate whether the protective effect of l-carnitine was associated with the nuclear factor erythroid 2 (NFE2)-related factor 2...

journal_title：Canadian journal of physiology and pharmacology

authors： Li J,Zhang Y,Luan H,Chen X,Han Y,Wang C

更新日期：2016-05-01 00:00:00

abstract：:The issue of bimanual temporal coordination in human subjects is discussed for three selected movement paradigms: (i) simple, symmetric, bimanual finger movements, (ii) bimanual unloading, and (iii) a complex bimanual pull and grasp task. Temporal synchronization was found for all three experiments and was least varia...

journal_title：Canadian journal of physiology and pharmacology

authors： Wiesendanger M,Kaluzny P,Kazennikov O,Palmeri A,Perrig S

更新日期：1994-05-01 00:00:00

abstract：:After myocardial infarction, the hemodynamics under basal conditions might appear to be unaltered, which makes it difficult to identify cardiac dysfunction by the usual approaches. Thus, we tested the response to sudden afterload stress in infarcted rats with apparently normal ejection function. Control (CT) and infar...

journal_title：Canadian journal of physiology and pharmacology

authors： dos Santos L,Antonio EL,Souza AF,Tucci PJ

更新日期：2010-07-01 00:00:00

abstract：:This study investigated the effects of prolonged exercise on muscle sarcoplasmic reticulum (SR) Ca2+ cycling properties and the metabolic responses with and without a session of exercise designed to reduce muscle glycogen reserves while on a normal carbohydrate (CHO) diet. Eight untrained males (VO(2peak) = 3.81 +/- 0...

journal_title：Canadian journal of physiology and pharmacology

authors： Duhamel TA,Green HJ,Perco JG,Ouyang J

更新日期：2005-07-01 00:00:00

abstract：:Luminal nutrition is important for the maintenance of small intestinal structure and function. The equilibrium between crypt cell production and villous cell loss in the mucosal epithelium of the small intestine is altered under certain conditions such as after a small bowel resection. Immediately after resection, the...

journal_title：Canadian journal of physiology and pharmacology

authors： Grey VL,Morin CL

更新日期：1990-05-01 00:00:00

abstract：:The effect of intracerebroventricular (i.c.v.) injection of the alpha 2-adrenoceptor agonists clonidine and B-HT 920 on mean arterial pressure (MAP), heart rate (HR), and plasma concentrations of noradrenaline and adrenaline was examined in conscious unrestrained rats. The injection of 1.0 microgram clonidine signific...

journal_title：Canadian journal of physiology and pharmacology

authors： King KA,Pang CC

更新日期：1988-11-01 00:00:00