Use of afterload hemodynamic stress as a practical method for assessing cardiac performance in rats with heart failure.

abstract：:The leaves and bark of Cassia glauca Lam., a glabrous tree in the family Fabaceae, are used in folk medicine for the treatment of diabetes. The aim of this study was to investigate the antidiabetic activity of the aqueous extract of C. glauca bark. The various parameters that were studied in treated or untreated normo...

journal_title：Canadian journal of physiology and pharmacology

authors： Salahuddin M,Jalalpure SS,Gadge NB

更新日期：2010-02-01 00:00:00

abstract：:Many functions of the brain and the sympathetic adrenal system are influenced by those amino acids that exert precursor control over neurotransmitter synthesis. One of the functions affected is regulation of blood pressure. Therefore, the purpose of this review is to describe how food proteins and amino acids affect t...

journal_title：Canadian journal of physiology and pharmacology

authors： Anderson GH

更新日期：1986-06-01 00:00:00

abstract：:The hemodynamic effects of the combination of clonidine and propranolol were studied in conscious rats with portal hypertension owing to secondary biliary cirrhosis. Pressure and blood flow measurements (radioactive microsphere method) were performed in three groups of eight rats before and after drug administration. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Roulot D,Gaudin C,Braillon A,Sekiyama T,Bacq Y,Lebrec D

更新日期：1989-10-01 00:00:00

abstract：:The combined and separate effects of exercise training and bisphosphonate (etidronate) therapy on bone mineral in postmenopausal women were compared. Forty-eight postmenopausal women were randomly assigned (double blind) to groups that took intermittent cyclical etidronate; performed strength training (3 d/week) and r...

journal_title：Canadian journal of physiology and pharmacology

authors： Chilibeck PD,Davison KS,Whiting SJ,Suzuki Y,Janzen CL,Peloso P

更新日期：2002-10-01 00:00:00

abstract：:In previous studies we have been able to demonstrate tighter metabolic control of muscle metabolism during prolonged steady-state exercise 5 to 6 days after the initiation of training and well before changes in oxidative potential. To examine whether the metabolic adaptations are manifested during the non-steady-state...

journal_title：Canadian journal of physiology and pharmacology

authors： Green HJ,Cadefau J,Cussó R,Ball-Burnett M,Jamieson G

更新日期：1995-04-01 00:00:00

abstract：:Cardiac adenosine receptors are coupled to adenylate cyclase inhibition. In the guinea pig heart, the relative agonist potencies observed for adenylate cyclase inhibition were R-N6-phenylisopropyladenosine (R-PIA) = N6-cyclohexyladenosine greater than 5'-N-ethylcarboxamidoadenosine much greater than S-PIA. In both atr...

journal_title：Canadian journal of physiology and pharmacology

authors： Leung E,Woodcock EA

更新日期：1986-12-01 00:00:00

abstract：:Newborn hearts have restricted functional reserve and variable responsiveness to inotropes that could be partly due to differences in myocardial beta-adrenoceptors (beta-AR). To clarify this issue, this study documented ventricle-specific changes in myocardial beta-AR density and affinity during postnatal maturation. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wittnich C,Belanger MP,Bandali K

更新日期：2006-08-01 00:00:00

abstract：:Myopenia or muscle wasting due to ageing, chronic disease, and various medical interventions has been associated with increased mortality, morbidity, and poorer physical function. Attempts through nutrient and exercise interventions have been made to prevent this deterioration. In addition, while a measure of lean bod...

journal_title：Canadian journal of physiology and pharmacology

authors： McDonald C,Bauer J,Capra S

更新日期：2013-06-01 00:00:00

abstract：:In this article we comment on the various in vitro biochemical measurements employed to assess the thermogenic activity and capacity of brown adipose tissue. The meaning and significance of changes in tissue weight, protein content, cell number, and mitochondrial mass are each summarized. In addition, various indices ...

journal_title：Canadian journal of physiology and pharmacology

authors： Trayhurn P,Milner RE

更新日期：1989-08-01 00:00:00

abstract：:When using microelectrodes for intracellular ion activity studies, some uncertainties such as interference from cytosolic components at the microelectrode, cell damage, and cell contamination may arise. A model, which treats kinetic processes of the loss of carriers from the membrane phase of microelectrodes into the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Oesch U,Ammann D,Simon W

更新日期：1987-05-01 00:00:00

abstract：:Chrysin (CH) is a natural flavonoid with pharmacological influences. The purpose of the current study was the assessment of possible protective effects of CH against oxidative damage in the serum, liver, brain, and pancreas of streptozotocin (STZ)- induced diabetic rats. In the present study, the rats were divided int...

journal_title：Canadian journal of physiology and pharmacology

authors： Samarghandian S,Azimi-Nezhad M,Samini F,Farkhondeh T

更新日期：2016-04-01 00:00:00

abstract：:Inhibition of prostaglandin synthesis together with vagally mediated peristaltic contractions are essential if mucosal injury is to occur in the stomach of indomethacin-treated rats. The neomycin group of antibiotics has been shown to interfere with acetylcholine release. Agents blocking peristalsis have been demonstr...

journal_title：Canadian journal of physiology and pharmacology

authors： Mersereau WA,Hinchey EJ

更新日期：1989-09-01 00:00:00

abstract：:Energy-deprivation contractures were investigated in unloaded rat ventricular myocytes. Application of 2 mM cyanide in the presence of 10 mM 2-deoxyglucose (metabolic blockade) led to a rapid shortening "contracture" (maximum speed 1.5 +/- 0.2% control cell length/s). Cells shortened to a constant length of 69 +/- 1.6...

journal_title：Canadian journal of physiology and pharmacology

authors： Nichols CG,Lederer WJ

更新日期：1990-02-01 00:00:00

abstract：:The effect of ionizing radiation on jejunal blood flow was investigated in rats receiving whole-body exposure to 10 Gy gamma-radiation. Irradiation resulted in increased myeloperoxidase activity, indicative of neutrophil infiltration, and prostaglandin E2 synthesis by 2 h post-irradiation, but had no effect on leukotr...

journal_title：Canadian journal of physiology and pharmacology

authors： MacNaughton WK,Prud'homme-Lalonde L

更新日期：1995-06-01 00:00:00

abstract：:The world-wide increase in cancer incidence imposes a corresponding significant increase in the use of chemotherapeutic agents. Nephrotoxicity is a side effect frequently encountered with cyclophosphamide (CP), which is also well-known to cause acute and chronic lung toxicities. The current study focuses on the evalua...

journal_title：Canadian journal of physiology and pharmacology

authors： Said E,Elkashef WF,Abdelaziz RR

更新日期：2016-04-01 00:00:00

abstract：:Physical activity and training have some potential as tools for examining immune responses to inflammation and trauma. Contributors to the present symposium review various aspects of the inflammatory process, including issues of lymphocyte recirculation and endotoxemia. They examine also the extent and nature of the i...

journal_title：Canadian journal of physiology and pharmacology

authors： Shephard RJ,Shek PN

更新日期：1998-05-01 00:00:00

abstract：:The role of sodium and calcium on strophanthidin inotropy was studied in canine cardiac Purkinje fibers perfused in vitro under conditions that vary cellular sodium and calcium. With high concentrations of strophanthidin (greater than or equal to 10(-7) M), force increases more in the presence of low [Ca]0 or high [Na...

journal_title：Canadian journal of physiology and pharmacology

authors： Li T,Bernabei R,Carbonin P,Vassalle M

更新日期：1986-11-01 00:00:00

abstract：:N,N-Diethyl-2-(1-pyridyl)ethylamine (E-2-P) produced 59 +/- 7% of the maximal response to histamine in guinea pig ileal longitudinal smooth muscle and antagonized the responses of this tissue to histamine. The estimated binding constant of E-2-P for the histamine receptor predicted a binding curve nearly coincident wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Kenakin TP,Cook DA

更新日期：1980-11-01 00:00:00

abstract：:To assess development changes in kinetic properties of the cardiac sodium current, whole-cell voltage-clamp experiments were conducted using 3-, 10-, and 17-day-old embryonic chick ventricular heart cells. Experimental data were quantified according to the Hodgkin-Huxley model. While the Na current density, as examine...

journal_title：Canadian journal of physiology and pharmacology

authors： Sada H,Ban T,Fujita T,Ebina Y,Sperelakis N

更新日期：1995-10-01 00:00:00

abstract：:This study aimed to investigate the anti-depressant effect of hesperidin (Hsp) in streptozotocin (STZ)-induced diabetic rats. Additionally, the effect of Hsp on hyperglycaemia, oxidative stress, inflammation, brain-derived neurotrophic factor (BDNF), and brain monoamines in diabetic rats was also assessed. The Wistar ...

journal_title：Canadian journal of physiology and pharmacology

authors： El-Marasy SA,Abdallah HM,El-Shenawy SM,El-Khatib AS,El-Shabrawy OA,Kenawy SA

更新日期：2014-11-01 00:00:00

abstract：:MicroRNA-146a (miR-146a) is reportedly implicated in the pathogenesis of ischemia-reperfusion (I/R) injury; however, its role in cerebral I/R injury is unclear and requires further investigation. In this study, cerebral I/R injury was established in mice via middle cerebral artery occlusion, and the expression of miR-...

journal_title：Canadian journal of physiology and pharmacology

authors： Chu B,Zhou Y,Zhai H,Li L,Sun L,Li Y

更新日期：2018-06-01 00:00:00

abstract：:The present study focused on the interactive pain regulation of endokinin A/B (EKA/B, the common C-terminal decapeptide in EKA and EKB) or endokinin C/D (EKC/D, the common C-terminal duodecapeptide in EKC and EKD) on chimeric peptide MCRT (YPFPFRTic-NH2, based on YPFP-NH2 and PFRTic-NH2) at the supraspinal level in mi...

journal_title：Canadian journal of physiology and pharmacology

authors： He C,Gong J,Yang L,Zhang H,Dong S,Zhou L

更新日期：2016-09-01 00:00:00

abstract：:The electrophysiologist's view of brain astrocytes has changed markedly in recent years. In the past astrocytes were viewed as passive, K+ selective cells, but it is now evident that they are capable of expressing voltage- and ligand-activated channels previously thought to be restricted to neurons. The functional imp...

journal_title：Canadian journal of physiology and pharmacology

authors： Sontheimer H

更新日期：1992-01-01 00:00:00

abstract：:The effects of Bay K8644, a Ca2+ channel agonist, on the mechanical and electrical properties of frog skeletal muscle fibers were investigated. At relatively low concentrations, such as 10(-6) and 10(-5) M, Bay K8644 significantly potentiated the maximum amplitudes of twitch responses, and this effect was not reversed...

journal_title：Canadian journal of physiology and pharmacology

authors： Oz M,Frank GB

更新日期：1994-10-01 00:00:00

abstract：:The natural history of the disease of the dilated strain Bio TO-2 of cardiomyopathic hamsters (CMH) is not totally characterized. We investigated its hemodynamic and histomorphometric characteristics at 140, 180, 220, 260, and 300 days of age. Forty CMH and 40 controls were investigated (8 at each stage). Mean arteria...

journal_title：Canadian journal of physiology and pharmacology

authors： Goineau S,Pape D,Guillo P,Ramée MP,Bellissant E

更新日期：2001-04-01 00:00:00

abstract：:Intrinsic regulation of hepatic blood flow is mediated only through the hepatic artery because the liver is not able to directly regulate portal vein blood flow. Hepatic metabolic activity does not affect hepatic artery flow. Although the hepatic artery is affected by sympathetic nerves and blood-borne agents, the int...

journal_title：Canadian journal of physiology and pharmacology

authors： Lautt WW

更新日期：1996-03-01 00:00:00

abstract：:The blood volume of anesthetized rats was expanded acutely by 33% with donor blood while a caval snare was gradually tightened so that right atrial pressure (RAP) was prevented from rising (n = 6). In control experiments (n = 5) an aortic snare was used to hold mean arterial blood pressure near the values found in the...

journal_title：Canadian journal of physiology and pharmacology

authors： Ackermann U,Rudolph JR

更新日期：1984-07-01 00:00:00

abstract：:The effect of calcium ionophore A23187 on the metabolism of pregnenolone to progesterone was examined in rat granulosa cells during a 24-h culture period. Granulosa cells harvested from pregnant mare's serum gonadotropin treated immature rats were incubated in the presence and absence of the divalent cation ionophore ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tsang BK,Mattice DF,Li M,Asem EK

更新日期：1988-07-01 00:00:00

abstract：:Tea is perceived as more relaxing than coffee, even though both contain caffeine. L-theanine in tea may account for the difference. Consumed together, caffeine and theanine exert similar cognitive effects to that of caffeine alone, but exert opposite effects on arousal, in that caffeine accentuates and theanine mitiga...

journal_title：Canadian journal of physiology and pharmacology

authors： Giles GE,Mahoney CR,Brunyé TT,Taylor HA,Kanarek RB

更新日期：2017-01-01 00:00:00

abstract：:Radiolabelled acetylsalicylic acid (ASA) and salicylic acid (SA) were given intravenously to four near-term ewes and their occurrence in both maternal and fetal plasma was ascertained using a specific thin-layer chromatographic analysis procedure. Findings proved that ASA and SA cross the placental barrier and reach d...

journal_title：Canadian journal of physiology and pharmacology

authors： Thiessen JJ,Salama RB,Coceani F,Olley PM

更新日期：1984-04-01 00:00:00