Chrysin treatment improves diabetes and its complications in liver, brain, and pancreas in streptozotocin-induced diabetic rats.

abstract：:The active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3 or calcitriol), is known to inhibit the proliferation and invasiveness of many types of cancer cells, including breast, colon, pancreatic, prostate, and liver cancer cells. These findings support the use of 1α,25(OH)2D3 for the treatment of these t...

journal_title：Canadian journal of physiology and pharmacology

authors： Matsumoto Y,Kittaka A,Chen TC

更新日期：2015-05-01 00:00:00

abstract：:Torbafylline, a novel xanthine derivative, was given to rats by gavage (2 x 25 mg.kg-1.day-1, morning and evening) to study its effect upon fast muscles (tibialis anterior and extensor digitorum longus) made ischemic by unilateral ligation of the common iliac artery and subjected to two types of activity imposed by ch...

journal_title：Canadian journal of physiology and pharmacology

authors： Hudlicka O,Egginton S,Brown MD,Okyayuz-Baklouti I

更新日期：1994-07-01 00:00:00

abstract：:The experiment examined biological responses produced by combined sequential exposure to low-level tritium contamination, followed by challenging irradiation with fast neutrons. Modifications of endogenous antioxidant potential of different organs in rats were discussed in relation to tissue radiosensitivity. Rats pre...

journal_title：Canadian journal of physiology and pharmacology

authors： Petcu I,Moisol N,Savu D,Constantinescu B

更新日期：2002-07-01 00:00:00

abstract：:The purpose of this study was to investigate the cardiac adrenergic neuronal changes induced by diabetes and hypertension by using an analogue of norepinephrine, meta-iodobenzylguanidine (MIBG), and to compare these changes with the contractile state of ventricular papillary muscle. The tissue concentration of norepin...

journal_title：Canadian journal of physiology and pharmacology

authors： Herman LM,Dai S,Hartman NG,McNeill JH

更新日期：1994-10-01 00:00:00

abstract：:The role of I(K) (delayed rectifier current) and I(f) (hyperpolarization-activated current) in dominant and subsidiary pacemaker ranges was studied in single myocytes isolated from the guinea pig sino-atrial node by means of a perforated patch-clamp technique. In the dominant pacemaker range (approx. -55 to -40 mV), I...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang H,Vassalle M

更新日期：2001-12-01 00:00:00

abstract：:The pHi regulation from intracellular acidosis in the central nervous system appears to be mediated by mechanisms driven by the large inwardly directed Na+ gradient. The involvement of these mechanisms in pHi regulation of neurones and glial cells has been investigated in the leech central nervous system using ion-sel...

journal_title：Canadian journal of physiology and pharmacology

authors： Schlue WR,Dörner R

更新日期：1992-01-01 00:00:00

abstract：:Steady state glucose kinetics were measured in 19 premature and 16 full-term piglets. Bodyweight, plasma glucose concentration, total body glucose turnover rate, and glucose pool size were not significantly different between the two groups. This suggests that the premature piglet is capable of maintaining glucose home...

journal_title：Canadian journal of physiology and pharmacology

authors： Flecknell PA,Wootton R,John M,Royston JP

更新日期：1981-10-01 00:00:00

abstract：:Our previous studies have suggested that GATA-4 increases the differentiation of bone-marrow-derived mesenchymal stem cells (MSCs) into cardiac phenotypes. This study further investigated whether GATA-4 enhances MSC-mediated cardioprotection following hypoxia. MSCs were harvested from rat bone marrow and transduced wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Li HX,Zhou YF,Zhao X,Jiang B,Yang XJ

更新日期：2014-08-01 00:00:00

abstract：:The exchange of Na+ and K+ in rat red cells at 40% hematocrit incubated in a physiological salt solution containing 1 MM ouabain was monitored with ion-specific glass electrodes. Because this system measures a change in the activity of an ion as a logarithmic function of its preexisting level, delta[K+]o is more accur...

journal_title：Canadian journal of physiology and pharmacology

authors： Friedman SM,Nakashima M,McIndoe

更新日期：1977-12-01 00:00:00

abstract：:Changes in metabolic characteristics of the liver and jejunal epithelia as a result of feeding the beta-agonist albuterol to chickens for 3 and 6 weeks were studied. Feeding albuterol resulted in a change in weights of the liver and small intestines. Chickens fed albuterol for 6 weeks had greater levels of plasma none...

journal_title：Canadian journal of physiology and pharmacology

authors： Rompala RE,Darre MJ

更新日期：1989-05-01 00:00:00

abstract：:Total renal blood flow, glomerular filtration rate, and renal excretory function were determined in anesthetized rats treated with intravenous infusion of ethacrynic acid, 0.36 mg.min-1.kg-1, alone or in combination with cysteine. Simultaneously, the corticomedullary electrolyte gradient was evaluated in vivo from mea...

journal_title：Canadian journal of physiology and pharmacology

authors： Kompanowska-Jezierska E,Dobrowolski L,Sadowski J

更新日期：1990-09-01 00:00:00

abstract：:Hedysarum polybotrys polysaccharide (HPS) is the principal active fraction responsible for the antidiabetic properties of this species. The aim of this study was to determine the antidiabetic properties of 4 purified fractions of different molecular weight range HPSs (HPS1, HPS2, HPS3, HPS4). HPS3 was selected for exa...

journal_title：Canadian journal of physiology and pharmacology

authors： Hu F,Li X,Zhao L,Feng S,Wang C

更新日期：2010-01-01 00:00:00

abstract：:Tolerance to ethanol was induced in male Sprague-Dawley rats (225-250 g) by chronic feeding with a liquid diet containing 6.5% ethanol (v/v). Control rats were pair-fed with a liquid diet in which the ethanol was replaced by an equicaloric concentration of sucrose. Immediately following sacrifice of the animals the ne...

journal_title：Canadian journal of physiology and pharmacology

authors： Gianoulakis C,Chan JS,Kalant H,Chrétien M

更新日期：1983-09-01 00:00:00

abstract：:We investigated potential sex differences in bone resorption and the conservation of whole body bone mass in 24-week-old Sprague-Dawley rats maintained on a 1.0% calcium diet and then fed diets containing 0.02, 0.5, 1.0, or 1.75% calcium for 31 days. Lowering dietary calcium from 1.00% to 0.02% doubled whole skeleton ...

journal_title：Canadian journal of physiology and pharmacology

authors： Geng W,Wright GL

更新日期：2001-05-01 00:00:00

abstract：:Administration of naloxone to morphine-dependent rats results in an elevation of tail skin temperature and a fall in core temperature. Previous studies have demonstrated a role of the adrenal gland in the thermal responses that accompany morphine withdrawal in the rat. In the present study, experiments were designed t...

journal_title：Canadian journal of physiology and pharmacology

authors： Katovich MJ,Pitman D,Schechtman O

更新日期：1992-08-01 00:00:00

abstract：:Opioid and N-methyl-d-aspartate (NMDA) receptors mediate different effects of fluoxetine. We investigated whether opioid and NMDA receptors are involved in the protective effect of fluoxetine against the behavioral despair induced by acute physical stress in male mice. We used the forced swimming test (FST), tail susp...

journal_title：Canadian journal of physiology and pharmacology

authors： Haj-Mirzaian A,Kordjazy N,Ostadhadi S,Amiri S,Haj-Mirzaian A,Dehpour A

更新日期：2016-06-01 00:00:00

abstract：:There have been conflicting observations regarding the effects of ketoconazole on hepatic metabolism. The objectives of these studies were to determine whether ketoconazole was an enzyme inducer or inhibitor in the mouse and then to establish the time frame of these ketoconazole-induced enzyme changes. Ketoconazole wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Whitehouse LW,Pakuts AP,Paul CJ,Mueller RW,Thomas BH

更新日期：1990-08-01 00:00:00

abstract：:In this study, we aimed to investigate the protective effects of androgens, using letrozole (LET; an aromatase inhibitor), grape seed extract (GSE; a naturally occurring aromatase inhibitor and antioxidant), and testosterone propionate (Tp), against methotrexate (MTX)-induced testicular toxicity in adult male rats. MT...

journal_title：Canadian journal of physiology and pharmacology

authors： Makary S,Abdo M,Fekry E

更新日期：2018-04-01 00:00:00

abstract：:Salvianolic acid B (Sal B) exerts strong antioxidant activity and eliminates the free radical effect. However, how it affects the antioxidant pathway is not very clear. The objective of this study was to investigate the underlying mechanism of Sal B in CCl4-induced acute liver injury, especially its effect on the Nrf2...

journal_title：Canadian journal of physiology and pharmacology

authors： Jin YM,Tao XM,Shi YN,Lu Y,Mei JY

更新日期：2020-03-01 00:00:00

abstract：:The physiological action of alpha bungarotoxin in the central nervous system of the horseshoe crab Limulus polyphemus was investigated. Two types of effects were produced by the toxin. The predominant effect was an inhibition of spontaneous activity. However, in some instances alpha bungarotoxin caused a stimulation o...

journal_title：Canadian journal of physiology and pharmacology

authors： Thomas W,Townsel JG

更新日期：1981-02-01 00:00:00

abstract：:The 3,5-pyrazolidinedione (3,5-P) drugs, phenylbutazone and sulfinpyrazone, have been reported to bind to receptors for the chemotactic peptide, f-Met-Leu-Phe, and to behave as functional antagonists of f-Met-Leu-Phe in human and rabbit neutrophils. To explore the structure-activity relationship of this family of drug...

journal_title：Canadian journal of physiology and pharmacology

authors： Levesque L,Gaudreault RC,Marceau F

更新日期：1991-03-01 00:00:00

abstract：:In anesthetized rats micropuncture and microcatheterization were used to collect tubular fluid from end proximal and distal tubules and from the outer medullary collecting duct. Urine was collected at the papilla tip. Samples were taken from the same sites before and after intravenous injection of atrial tissue extrac...

journal_title：Canadian journal of physiology and pharmacology

authors： Sonnenberg H,Cupples WA,de Bold AJ,Veress AT

更新日期：1982-09-01 00:00:00

abstract：:This study aimed to investigate the interrelationship of plasma lipid profile, lipid peroxidation, and erythrocyte antioxidative defense in patients with insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. Plasma levels of total cholesterol, triglycerides, and lipid peroxides and the activiti...

journal_title：Canadian journal of physiology and pharmacology

authors： Cimbaljević B,Vasilijević A,Cimbaljević S,Buzadzić B,Korać A,Petrović V,Janković A,Korać B

更新日期：2007-10-01 00:00:00

abstract：:Phosphofructokinase activity was measured in the sciatic nerve of streptozotocin-induced diabetic and nondiabetic rats. Average steady-state phosphofructokinase activity was obtained from three consecutive segments of the mid-femoral region in the left sciatic nerve in both diabetic (4 and 24 weeks) and nondiabetic, a...

journal_title：Canadian journal of physiology and pharmacology

authors： Kilgour RD,Gardiner K,Gardiner PF

更新日期：1990-10-01 00:00:00

abstract：:Diazinon (DZN) is a common organophosphorus insecticide extensively used for agriculture and veterinary purposes. DZN toxicity is not limited to insects; it also induces harmful effects in mammals and birds. Our experiment evaluated the protective and antioxidant potential of sesame oil (SO) and (or) alpha-lipoic acid...

journal_title：Canadian journal of physiology and pharmacology

authors： Abdel-Daim MM,Taha R,Ghazy EW,El-Sayed YS

更新日期：2016-01-01 00:00:00

abstract：:We studied the effect of pertussis toxin (PT) treatment on the ability of insulin to inhibit lipolysis and to stimulate glucose oxidation in isolated rat adipocytes. In cells maximally modified by PT (100% ADP ribosylation of a 41-kdalton protein in membranes), the ability of insulin to inhibit lipolysis stimulated ei...

journal_title：Canadian journal of physiology and pharmacology

authors： Goren HJ,Northup JK,Hollenberg MD

更新日期：1985-08-01 00:00:00

abstract：:The role of sympathetic innervation in the regulation of hindlimb skeletal muscle blood flow (QL) and metabolism was studied prior to and during acute anemia in anesthetized, paralyzed, and ventilated dogs (n = 8). Neural activity in the sciatic nerve was reversibly cold blocked for a 15-min period at control hematocr...

journal_title：Canadian journal of physiology and pharmacology

authors： Kubes P,Cain SM,Chapler CK

更新日期：1988-09-01 00:00:00

abstract：:In assessing the role that atrial natriuretic peptide (ANP) might have in the homeostasis of fluid volume and blood pressure, it is important to define the physiological and pathophysiological conditions that determine its release into the circulation. There is substantial evidence that ANP is released through atrial ...

journal_title：Canadian journal of physiology and pharmacology

authors： Rankin AJ

更新日期：1987-08-01 00:00:00

abstract：:We found when L-type calcium current (ICa-L) was recorded with the perforated patch-clamp method in rat ventricular myocytes that bath application of phenylephrine (with propranolol) evoked a biphasic response characterized by an initial transient suppression followed by a sustained potentiation. The transient suppres...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang S,Lin J,Hirano Y,Hiraoka M

更新日期：2005-11-01 00:00:00

abstract：:Mepivacaine is an aminoamide local anesthetic with an intermediate duration that intrinsically produces vasoconstriction both in vivo and in vitro. This study investigated the arachidonic acid metabolic pathways involved in mepivacaine-induced contraction, and elucidated the associated cellular mechanism with a partic...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee HM,Ok SH,Sung HJ,Eun SY,Kim HJ,Lee SH,Kang S,Shin IW,Lee HK,Chung YK,Choi MJ,Bae SI,Sohn JT

更新日期：2013-04-01 00:00:00