N,N-Diethyl-2-(1-pyridyl)ethylamine, a partial agonist for the histamine receptor in guinea pig ileum.

abstract：:The effects of iontophoretically applied Na+-, K+-dependent adenosinetriphosphatase (Na+,K+-ATPase) (EC 3.6.1.3) inhibitors (ouabain, digitoxin, digitoxigenin, strophanthin K, strophanthidin, thevetin A and B, ethacrynate, and harmaline) on the depression of rat cerebral cortical neurones by noradrenaline, 5-hydroxytr...

journal_title：Canadian journal of physiology and pharmacology

authors： Sastry BS,Phillis JW

更新日期：1977-04-01 00:00:00

abstract：:To determine whether the renal responses to atrial natriuretic factor (ANF) are altered in the diabetic state, the diuretic and natriuretic responses to ANF (0.25 microgram.kg-1.min-1, i.v.) were measured in streptozotocin (STZ) induced diabetic (DIA) rats. Urine flow and sodium excretion were measured before and afte...

journal_title：Canadian journal of physiology and pharmacology

authors： Patel KP,Zhang PL

更新日期：1990-03-01 00:00:00

abstract：:Acute administration of morphine sulfate at 20 mg/kg decreased mouse cerebellar adenosine 3',5'-cyclic phosphate (cAMP) levels while not affecting cAMP phosphodiesterase (EC 3.1.4.17). The cAMP levels and cAMP phosphodiesterase activies were not affected by chronic treatment. However, cAMP levels increased during abru...

journal_title：Canadian journal of physiology and pharmacology

authors： Charalampous KD,Askew WE

更新日期：1977-02-01 00:00:00

abstract：:Apoptotic pathways in breast cancer cells are frequently altered, reducing the efficiency of radiotherapy. Conjugated linoleic acid (CLA), known to trigger apoptosis, was tested as radiosensitizer in breast cancer cells MCF-7 and MDA-MB-231. The CLA-mix, made up of the isomers CLA-9cis 11trans and CLA-10trans 12cis, w...

journal_title：Canadian journal of physiology and pharmacology

authors： Drouin G,Douillette A,Lacasse P,Paquette B

更新日期：2004-02-01 00:00:00

abstract：:The heat production (HP), heart rate (HR), respiration rate, rumen motility, and body temperature responses to 2.5-h adrenaline (A) and noradrenaline (NA) intrajugular infusions at 0.00, 0.15, 0.30, 0.60, and 0.90 micrograms.kg-1.min-1 were studied in 10 shorn wethers which had been chronically (3-8 weeks) exposed to ...

journal_title：Canadian journal of physiology and pharmacology

authors： Graham AD,Christopherson RJ

更新日期：1981-09-01 00:00:00

abstract：:The airway smooth muscle from asthmatic airways produces increased amounts and an altered composition of extracellular matrix proteins. The extracellular matrix can in turn influence the phenotype and function of airway smooth muscle cells, affecting the biochemical, geometric, and mechanical properties of the airway ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tran T,Halayko AJ

更新日期：2007-07-01 00:00:00

abstract：:Natural rodent grooming and other instinctive behavior serves as a natural model of complex movement sequences. Rodent grooming has syntactic (rule-driven) sequences and more random movement patterns. Both incorporate the same movements--only the serial structure differs. Recordings of neural activity in the dorsolate...

journal_title：Canadian journal of physiology and pharmacology

authors： Aldridge JW,Berridge KC,Rosen AR

更新日期：2004-08-01 00:00:00

abstract：:Transmural nerve stimulation following sympathetic (guanethidine 10(-4) mol/L, phenoxybenzamine 2 X 10(-5) mol/L, propanolol 2 X 10(-6) mol/L) and muscarinic blockade (atropine 5 X 10(-5) mol/L) produces a relaxatory response in canine saphenous veins contracted with prostaglandin F2 alpha. This relaxatory response wa...

journal_title：Canadian journal of physiology and pharmacology

authors： Senaratne MP,Kappagoda T

更新日期：1986-10-01 00:00:00

abstract：:The influence of a program of high intensity training and of a combined program of high intensity training and prolonged submaximal training on adaptations to the vastus lateralis muscle was investigated in two groups of elite athletes. The high intensity training (H) consisted of ice hockey practices and games over a...

journal_title：Canadian journal of physiology and pharmacology

authors： Daub WD,Green HJ,Houston ME,Thomson JA,Fraser IG,Ranney DA

更新日期：1982-05-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) and CNTF analogs were reported to have hepatoprotective effect and ameliorate hepatic steatosis in db/db or high-fat-diet-fed mice. Because hepatic steatosis and injury are also commonly induced by hepatotoxin, the aim of the present study is to clarify whether CNTF could alleviate h...

journal_title：Canadian journal of physiology and pharmacology

authors： Cui MX,Jiang JF,Min GN,Han W,Wu YJ

更新日期：2017-05-01 00:00:00

abstract：:The mammalian daily (circadian) clock is located in the suprachiasmatic nuclei of the hypothalamus. Clock function can be detected by the measurement of the circadian change in spontaneous firing rate of suprachiasmatic nuclei cells in a brain slice preparation in vitro. We investigated the effects of neuropeptide Y o...

journal_title：Canadian journal of physiology and pharmacology

authors： Harrington ME,Schak KM

更新日期：2000-02-01 00:00:00

abstract：:The effect of the administration route, dose, and sampling time on the total urinary excretion of four major benzo[a]pyrene (BaP) metabolites, 3-hydroxyBaP (3-OHBaP), 9-hydroxyBaP 9-hydroxyBaP (9-OHBaP), trans-4,5-dihydrodiolBaP (4,5-diolBaP), and trans-9,10-dihydrodiolBaP (9,10-diolBaP), was studied in male Sprague-D...

journal_title：Canadian journal of physiology and pharmacology

authors： Bouchard M,Viau C

更新日期：1997-03-01 00:00:00

abstract：:Immediately following exposure to thiocyanate (SCN-)-containing solutions, the cystic fibrosis conductance regulator Cl- channel exhibits high unitary SCN conductance and anomalous mole fraction behaviour, suggesting the presence of multiple anion binding sites within the channel pore. However, under steady-state cond...

journal_title：Canadian journal of physiology and pharmacology

authors： Linsdell P

更新日期：2001-07-01 00:00:00

abstract：:This review presents, from the author's viewpoint, avenues of histamine research likely to produce new information. One potentially useful approach may be to attempt to relate histamine's function to its occurrence in different body tissues such as the pituitary and hypothalamus, the gastrointestinal mucosa, and the b...

journal_title：Canadian journal of physiology and pharmacology

authors： Code CF

更新日期：1985-06-01 00:00:00

abstract：:Effects of 6-hydroxydopamine (6-OHDA) on rat brain and blood adrenaline (A), noradrenaline (NA), ammonia (NH3), gamma-aminobutyric acid (GABA), and amino acid metabolism prior to and after high pressure oxygen (OHP) induced convulsions have been studied. 6-OHDA reduces GABA and glutamate (Glu) rior to OHP exposure in ...

journal_title：Canadian journal of physiology and pharmacology

authors： Singh AK,Banister EW

更新日期：1978-04-01 00:00:00

abstract：:This study examined whether the effects of FK506-binding protein dissociation from sarcoplasmic reticulum (SR) Ca(2+) release channels on excitation-contraction (EC) coupling changed when SR Ca(2+) reuptake and (or) the trans-sarcolemmal Ca(2+) extrusion were altered. The steady-state twitch Ca(2+) transient (CaT), ce...

journal_title：Canadian journal of physiology and pharmacology

authors： Yoshihara S,Satoh H,Saotome M,Katoh H,Terada H,Watanabe H,Hayashi H

更新日期：2005-04-01 00:00:00

abstract：:A major limitation of the use of organic nitrates in cardiovascular medicine is the development of tolerance, which has been attributed, in part, to a decrease in their metabolic activation in the vascular smooth muscle cell. Recently, 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) was shown to potentiate vascu...

journal_title：Canadian journal of physiology and pharmacology

authors： O'Reilly DA,McLaughlin BE,Marks GS,Brien JF,Nakatsu K

更新日期：2001-01-01 00:00:00

abstract：:Our purpose was to determine the effect of eight different combinations of contraction intensity, duration, and rest on the rate of fatigue in vastus lateralis muscle. A single combination consisted of contractions at 30 or 70% maximal voluntary contraction (MVC), held for 3 or 7 s with 3- or 7-s rest intervals. Contr...

journal_title：Canadian journal of physiology and pharmacology

authors： Dolmage T,Cafarelli E

更新日期：1991-10-01 00:00:00

abstract：:The first steps of leucine utilization are reversible deamination to α-ketoisocaproic acid (α-KIC) and irreversible oxidation. Recently, the regulatory role of leucine deamination over oxidation was underlined in rodents. Our aim was to measure leucine deamination and reamination in the whole body, in respect to previ...

journal_title：Canadian journal of physiology and pharmacology

authors： Garibotto G,Verzola D,Vettore M,Tessari P

更新日期：2018-04-01 00:00:00

abstract：:The metabolism of endogenous and exogenous diacylglycerol (DG) was studied in SM-3 cells derived from rabbit aortic smooth muscle to determine the biochemical step(s) responsible for degrading DG second messengers. Incubation of growth-arrested SM-3 cells with [3H]myristate for 2 h resulted in selective labelling of c...

journal_title：Canadian journal of physiology and pharmacology

authors： Migas I,Chuang M,Sasaki Y,Severson DL

更新日期：1997-10-01 00:00:00

abstract：:Using the glycogen depletion technique, we have examined utilization of specific fibre types during prolonged submaximal exercise to investigate the recruitment pattern employed by the central nervous system to sustain force generation in the face of a progressive glycogen depletion. Six male subjects (Vo2 max, 52.8 +...

journal_title：Canadian journal of physiology and pharmacology

authors： Green HJ,Smith D,Murphy P,Fraser I

更新日期：1990-10-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver conditions that are characterized by steatosis, inflammation, fibrosis, and liver injury. The global prevalence of NAFLD is rapidly increasing in proportion to the rising incidence of obesity and type 2 diabetes. Because NAFLD is a multifaceted di...

journal_title：Canadian journal of physiology and pharmacology

authors： Sid V,Siow YL,O K

更新日期：2017-10-01 00:00:00

abstract：:The intramuscular injection of aminooxyacetic acid (AOAA) into mice elevated the concentration of gamma-aminobutyric acid (GABA) in the brain, inhibited glutamic acid decarboxylase activity and delayed the onset of isonicotinic acid hydrazide induced seizures. Analyses of these results and of those obtained previously...

journal_title：Canadian journal of physiology and pharmacology

authors： Wood JD,Peesker SJ

更新日期：1976-08-01 00:00:00

abstract：:The endothelin receptors in rabbit isolated rings of saphenous artery and saphenous vein have been characterized using endothelin-1, endothelin-2, endothelin-3, sarafotoxin S6c, and BQ123. Although artery rings were more sensitive than those from vein to the contractile action of phenylephrine, endothelin-1 was about ...

journal_title：Canadian journal of physiology and pharmacology

authors： Auguet M,Delaflotte S,Chabrier PE,Braquet P

更新日期：1993-10-01 00:00:00

abstract：:In anesthetized rats micropuncture and microcatheterization were used to collect tubular fluid from end proximal and distal tubules and from the outer medullary collecting duct. Urine was collected at the papilla tip. Samples were taken from the same sites before and after intravenous injection of atrial tissue extrac...

journal_title：Canadian journal of physiology and pharmacology

authors： Sonnenberg H,Cupples WA,de Bold AJ,Veress AT

更新日期：1982-09-01 00:00:00

abstract：:Metformin (MET) is widely used in the correction of insulin (INS) resistance and metabolic abnormalities in type 2 diabetes. However, its effect on INS resistance and metabolic disorders associated with cancer cachexia is not established. We investigated the MET effects, isolated or associated with INS, on INS resista...

journal_title：Canadian journal of physiology and pharmacology

authors： de Fatima Silva F,Ortiz-Silva M,Galia WBS,Cassolla P,da Silva FG,Graciano MFR,Carpinelli AR,de Souza HM

更新日期：2018-05-01 00:00:00

abstract：:To elucidate the involvement of the brain renin-angiotensin system and the brain atrial natriuretic polypeptide (ANP) system in the regulation of ANP secretion from the heart, the effects of intracerebroventricular administration of angiotensin II and ANP on the plasma ANP level were examined in conscious unrestrained...

journal_title：Canadian journal of physiology and pharmacology

authors： Itoh H,Nakao K,Yamada T,Morii N,Shiono S,Sugawara A,Saito Y,Mukoyama M,Arai H,Imura H

更新日期：1988-03-01 00:00:00

abstract：:The distribution of atrial natriuretic factor (ANF) binding sites in Wistar rat tissues, as well as tissues from other species was studied. Using autoradiography of slide mounted tissue sections incubated with 125I-labelled ANF, high densities of binding sites were found in the renal glomeruli and papilla, aortic smoo...

journal_title：Canadian journal of physiology and pharmacology

authors： von Schroeder HP,Nishimura E,McIntosh CH,Buchan AM,Wilson N,Ledsome JR

更新日期：1985-11-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a key pathogenic factor in sepsis, and its recognition by toll-like receptor 4 (TLR4) can activate two district signaling pathways, leading to activation of transcription factors including NF-κB and interferon regulatory factor 3 (IRF3). Chloroquine (CQ) has been shown to affect LPS-TLR4 co...

journal_title：Canadian journal of physiology and pharmacology

authors： Ding C,Li F,Long Y,Zheng J

更新日期：2017-05-01 00:00:00

abstract：:Carbon monoxide (CO), a vasodilator, has been implicated as an activator of soluble guanylyl cyclase (sGC) to effect smooth muscle relaxation; however, this idea has not received universal support. The purpose of this study was to examine the effects of the sGC inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one...

journal_title：Canadian journal of physiology and pharmacology

authors： Hussain AS,Marks GS,Brien JF,Nakatsu K

更新日期：1997-08-01 00:00:00