Effects of K-channel blockers, calcium, and verapamil suggest different pacemaker mechanisms in cultured neonatal rat and embryonic chick ventricle cells.

abstract：:It has been proposed that medullary washout secondary to increased blood flow will limit maximal urine osmolality and reabsorption of salt and water from the inner medullary collecting duct. We have tested this prediction. The function of the inner medullary collecting duct was examined by microcatheterization. Acetyl...

journal_title：Canadian journal of physiology and pharmacology

authors： Cupples WA,Sonnenberg H

更新日期：1987-12-01 00:00:00

abstract：:Hearts from rats pretreated either with L-triiodothyronine (T3) or with L-thyroxine (T4) exhibited changed function curve characteristics on the working heart apparatus compared with hearts from vehicle-treated rats. There was no supersensitivity of the hyperthyroid myocardium to the inotropic effect of isoproterenol ...

journal_title：Canadian journal of physiology and pharmacology

authors： Marriott ML,McNeill JH

更新日期：1983-11-01 00:00:00

abstract：:Previous studies have demonstrated that the D-enantiomer of isoidide dinitrate (IIDN) is 10-fold more potent than the L-enantiomer for relaxation and cyclic GMP accumulation in isolated rat aorta. To test whether preferential biotransformation of D-IIDN to a species that activates guanylate cyclase is the basis for th...

journal_title：Canadian journal of physiology and pharmacology

authors： Stewart DH,Hayward LD,Bennett BM

更新日期：1989-11-01 00:00:00

abstract：:Measurement of volume, pressure, and length were made on eight segments of human cerebral arteries perfused with chymotrypsin (CT) (EC 3.4.21.1) solution (pH = 7.8) for no more than 19 h, and on nine arterial segments perfused with combined enzyme (CT, trypsin (EC 3.4.21.4), elastase (EC 3.4.21.11)) solutions (pH = 7....

journal_title：Canadian journal of physiology and pharmacology

authors： Damude LC,Cope DA,Roach MR

更新日期：1977-04-01 00:00:00

abstract：:In vivo activation of calorigenesis in rat brown adipose tissue (BAT), whether mediated by noradrenaline (NA) released at sympathetic nerve terminals in BAT during cold exposure or by systemically infused NA, is associated with large increases in blood flow (Q) to satisfy the tissue's O2 requirements. The calorigenic ...

journal_title：Canadian journal of physiology and pharmacology

authors： Foster DO,Depocas F

更新日期：1980-12-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent vasoactive peptide that exerts hypertrophic, migratory, and mitogenic effects in vascular smooth muscle cells. ET-1-induced activation of several signaling events has been shown to mediate the cellular effects of ET-1. In the past several years, transactivation of growth factor receptor...

journal_title：Canadian journal of physiology and pharmacology

authors： Bouallegue A,Vardatsikos G,Srivastava AK

更新日期：2010-05-01 00:00:00

abstract：:Aspirin consumption has been reported to be able to reduce colorectal cancer risk in humans and in animal models of colon carcinogenesis. Although the mechanism involved in such an effect is not yet clear, both prostaglandin-dependent and -independent effects have been proposed. Using HT-29 Glc(-/+)cells, which origin...

journal_title：Canadian journal of physiology and pharmacology

authors： Eklou-Kalonji E,Andriamihaja M,Reinaud P,Mayeur C,Camous S,Robert V,Charpigny G,Blachier F

更新日期：2003-05-01 00:00:00

abstract：:Normal penile erectile function is dependent on arterial adequacy, appropriate venous occlusion, neurohumoral factors, and finally the relaxation of penile cavernous trabecular smooth muscle. The present experiments were designed to test whether compounds related to endothelium-derived relaxing factor have a role in p...

journal_title：Canadian journal of physiology and pharmacology

authors： Heaton JP

更新日期：1989-01-01 00:00:00

abstract：:The validity of a Hodgkin-Huxley type voltage-dependent inactivation of slow inward Ca current (Isi) was tested in frog heart using a computer simulation. The time course of Isi was calculated during the development of a frog atrial action potential (AP). With a time constant of inactivation (tauf) of 55 ms at a membr...

journal_title：Canadian journal of physiology and pharmacology

authors： Fischmeister R,Horackova M

更新日期：1982-09-01 00:00:00

abstract：:This study examined whether the effects of FK506-binding protein dissociation from sarcoplasmic reticulum (SR) Ca(2+) release channels on excitation-contraction (EC) coupling changed when SR Ca(2+) reuptake and (or) the trans-sarcolemmal Ca(2+) extrusion were altered. The steady-state twitch Ca(2+) transient (CaT), ce...

journal_title：Canadian journal of physiology and pharmacology

authors： Yoshihara S,Satoh H,Saotome M,Katoh H,Terada H,Watanabe H,Hayashi H

更新日期：2005-04-01 00:00:00

abstract：:Several laboratories have reported ligand binding studies using radioactive histamine H1 antagonists to label the H1 receptors in mammalian brain. We have extended these studies to a detailed examination of the binding of [3H]mepyramine to monkey brain and have shown that the distribution is similar to that in man, wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Bielkiewicz B,Cook DA

更新日期：1985-06-01 00:00:00

abstract：:The potential of nickel chloride to prevent streptozotocin-induced hyperglycemia was tested in rats in vivo. To induce diabetes, streptozotocin (100 mg/kg body weight) was injected as a single dose. Streptozotocin treatment resulted in a significant decrease in plasma insulin and ceruloplasmin, and pancreatic Cu, prot...

journal_title：Canadian journal of physiology and pharmacology

authors： Novelli EL,Rodrigues NL,Ribas BO

更新日期：1988-05-01 00:00:00

abstract：:Cyclic AMP response element (CRE) binding protein (CREB) is a nuclear transcription factor that regulates the transcription of several genes containing the CRE sites on their promoters. CREB is activated by phosphorylation on a key serine residue, Ser311, in response to a wide variety of extracellular stimuli includin...

journal_title：Canadian journal of physiology and pharmacology

authors： Truong V,Anand-Srivastava MB,Srivastava AK

更新日期：2021-01-01 00:00:00

abstract：:Inorganic vanadium has been shown, both in vivo and in vitro, to have insulin-mimetic properties. A new organic vanadium complex, bis(maltolato)oxovanadium(IV) (BMOV), was developed to increase the absorption of vanadium from the gastrointestinal tract, thereby reducing the dose of vanadium necessary to produce glucos...

journal_title：Canadian journal of physiology and pharmacology

authors： Yuen VG,Orvig C,McNeill JH

更新日期：1993-03-01 00:00:00

abstract：:New methods for chronic instrumentation of the newborn piglet are described, which allow continuous monitoring of not only pressures in the pulmonary artery and aorta but also in the left and right atria, pulmonary vein, as well as main branch pulmonary artery flows. Changes in pulmonary vascular tone to short-acting ...

journal_title：Canadian journal of physiology and pharmacology

authors： Coe JY,Olley PM,Hamilton F,Vanhelder T,Coceani F

更新日期：1987-05-01 00:00:00

abstract：:We investigated the effect of Ginkgo biloba extracts and some of its individual constituents on the oxidative metabolism of valproic acid (VPA) in hepatic microsomes from donors with the CYP2C9*1/*1 genotype. G. biloba extract decreased 4-ene-VPA, 3-OH-VPA, 4-OH-VPA, and 5-OH-VPA formation with mean (+/- SE) IC50 valu...

journal_title：Canadian journal of physiology and pharmacology

authors： Numa AM,Abbott FS,Chang TK

更新日期：2007-09-01 00:00:00

abstract：:In the rat, prolonged enteral or parenteral alimentation with a high-carbohydrate diet results in hyperinsulinemia, which is substantially greater with the parenteral route. Supplementing the parenteral infusate with porcine gastric inhibitory polypeptide (GIP) to approximate plasma immunoreactive GIP levels achieved ...

journal_title：Canadian journal of physiology and pharmacology

authors： Baer AR,Dupré J

更新日期：1989-09-01 00:00:00

abstract：:Glucagon in small intravenous (i.v.) doses markedly increases glomerular filtration rate (GFR) in normal anesthetized dogs. In this study, the effects of glucagon 5 mug/min (i.v.) on renal hemodynamics was tested in four canine models of acute pre-renal failure (hemorrhage, barbiturate overdose; renal arterial clampin...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy M

更新日期：1975-08-01 00:00:00

abstract：:Some current questions regarding muscle afferent receptors are discussed. These include the significance of variable distribution patterns of muscle spindles in different muscles and of differences in intrinsic spindle morphology. The significance of the very large and variable population of small myelinated afferent ...

journal_title：Canadian journal of physiology and pharmacology

authors： Abrahams VC

更新日期：1981-07-01 00:00:00

abstract：:Most cardiac diseases are associated with fibrosis. Calcineurin (CaN) is regulated by Ca(2+)/calmodulin (CaM). The CaN-NFAT (nuclear factor of activated T cell) pathway is involved in the process of cardiac diseases, such as cardiac hypertrophy, but its effect on myocardial fibrosis remains unclear. The present study ...

journal_title：Canadian journal of physiology and pharmacology

authors： Chen QQ,Zhang W,Chen XF,Bao YJ,Wang J,Zhu WZ

更新日期：2012-12-01 00:00:00

abstract：:Cumulative data suggest the significant role of the renin-angiotensin system in the development of the pathological consequences of diabetes mellitus (DM). Newly synthesized AT2 receptor agonists gained importance as a target for creating new antihypertensives. The aim of the present work was to study the effects of p...

journal_title：Canadian journal of physiology and pharmacology

authors： Pechlivanova D,Petrov K,Grozdanov P,Nenchovska Z,Tchekalarova J,Stoynev A

更新日期：2018-05-01 00:00:00

abstract：:Magnesium concentrations in erythrocyte ghosts and arterial tissue of male, spontaneously hypertensive rats (SHR) were significantly less than in these tissues of male normotensive controls (Wistar-Kyoto; WKY) of the same age, which were also fed rat chow and tap water. The magnesium concentration in SHR erythrocyte g...

journal_title：Canadian journal of physiology and pharmacology

authors： Wells IC,Agrawal DK

更新日期：1992-09-01 00:00:00

abstract：:Fetal and neonatal rats received daily subcutaneous injections of 10 microgram thyrotropin-releasing hormone (TRH) until 7 or 14 days postnatally. At 70 days the pups were challenged with 1 microgram TRH intravenously via an indwelling jugular cannula. Basal serum thyroxine, triiodothyronine, and thyroid-stimulating h...

journal_title：Canadian journal of physiology and pharmacology

authors： Walker P,Dussault JH

更新日期：1979-01-01 00:00:00

abstract：:Serotonin (5-HT) acts as a neuromodulator and plays a critical role in brain development. Changes in 5-HT signaling during the perinatal period can affect neural development and may result in behavioral changes in adulthood. However, further investigations are necessary including both sexes to study possible differenc...

journal_title：Canadian journal of physiology and pharmacology

authors： Campos RMM,Toscano AE,Gouveia HJCB,Lacerda DC,Pereira SDC,Paz IAASG,Dantas-Alves JS,Manhaes-de-Castro R

更新日期：2020-09-17 00:00:00

abstract：:In sepsis, systemic inflammatory response syndrome (SIRS), and multiorgan dysfunction syndrome (MODS), a severe prognostically relevant cardiac autonomic dysfunction exists, as manifested by a strong attenuation of sympathetically and vagally mediated heart rate variability (HRV). The mechanisms underlying this attenu...

journal_title：Canadian journal of physiology and pharmacology

authors： Werdan K,Schmidt H,Ebelt H,Zorn-Pauly K,Koidl B,Hoke RS,Heinroth K,Müller-Werdan U

更新日期：2009-04-01 00:00:00

abstract：:Previous studies have shown that when atrial natriuretic peptide (ANF) is given to anaesthetized dogs with hypovolemic acute pancreatitis, it will produce a diuresis and natriuresis but will not elevate the glomerular filtration rate (GFR). When the same dose of peptide is given to dogs equally hypovolemic (hemorrhage...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy M,Cernacek P

更新日期：1990-06-01 00:00:00

abstract：:Muscle pain and poor sleep commonly occur together. Whether pain induces poor sleep or vice versa is difficult to know. Muscle pain is also observed in the presence of some types of dyskinesia or movement disorders. The interaction between sleep, movement disorders, and some musculoskeletal pain appears to be complex ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lavigne GJ,Velly-Miguel AM,Montplaisir J

更新日期：1991-05-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a multifactorial disease characterized by left ventricular dilation that is associated with systolic dysfunction and increased action potential duration. The Kir2.x K⁺ channels (encoded by KCNJ genes) regulate the inward rectifier current (IK1) contributing to the final repolarization i...

journal_title：Canadian journal of physiology and pharmacology

authors： Szuts V,Ménesi D,Varga-Orvos Z,Zvara Á,Houshmand N,Bitay M,Bogáts G,Virág L,Baczkó I,Szalontai B,Geramipoor A,Cotella D,Wettwer E,Ravens U,Deák F,Puskás LG,Papp JG,Kiss I,Varró A,Jost N

更新日期：2013-08-01 00:00:00

abstract：:Xerostomia is a self-conscious symptom. High-mobility group box 1 (HMGB1) promotes pro-inflammatory effects in many diseases. This study aimed to clarify the role of HMGB1 in Sjögren syndrome (SS)-triggered xerostomia. Nonobese diabetic (NOD)/Ltj mice were used to establish an SS-triggered xerostomia model. The result...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang D,Zhou M,Wang Y,Sun S

更新日期：2020-06-01 00:00:00

abstract：:The our objective was to investigate the adaptations induced by a low-protein, high-carbohydrate (LPHC) diet in growing rats, which by comparison with the rats fed a control (C) diet at displayed lower fasting glycemia and similar fasting insulinemia, despite impairment in insulin signaling in adipose tissues. In the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Pereira MP,Buzelle SL,Batistela E,Doneda DL,França SA,Santos MP,Andrade CM,Garófalo MA,Kettelhut Ido C,Navegantes LC,Chaves VE,Bertolini GL,Kawashita NH

更新日期：2014-06-01 00:00:00