Preservation of ischemic myocardial tissue with an antagonist of vasoconstrictor eicosanoids.

abstract：:N,N-Diethyl-2-(1-pyridyl)ethylamine (E-2-P) produced 59 +/- 7% of the maximal response to histamine in guinea pig ileal longitudinal smooth muscle and antagonized the responses of this tissue to histamine. The estimated binding constant of E-2-P for the histamine receptor predicted a binding curve nearly coincident wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Kenakin TP,Cook DA

更新日期：1980-11-01 00:00:00

abstract：:Carbon monoxide (CO), a vasodilator, has been implicated as an activator of soluble guanylyl cyclase (sGC) to effect smooth muscle relaxation; however, this idea has not received universal support. The purpose of this study was to examine the effects of the sGC inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one...

journal_title：Canadian journal of physiology and pharmacology

authors： Hussain AS,Marks GS,Brien JF,Nakatsu K

更新日期：1997-08-01 00:00:00

abstract：:A major limitation of the use of organic nitrates in cardiovascular medicine is the development of tolerance, which has been attributed, in part, to a decrease in their metabolic activation in the vascular smooth muscle cell. Recently, 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) was shown to potentiate vascu...

journal_title：Canadian journal of physiology and pharmacology

authors： O'Reilly DA,McLaughlin BE,Marks GS,Brien JF,Nakatsu K

更新日期：2001-01-01 00:00:00

abstract：:Volume overload is a common phenomenon in patients with chronic kidney disease that is associated with cardiovascular risk factors. However, its contribution to the development of adverse cardiovascular outcomes in those patients is not fully understood. Thus, the present work investigated the effect of salt-induced v...

journal_title：Canadian journal of physiology and pharmacology

authors： Mahmoud MM,Shamseldeen AM,Rashed LA,Fares AE,Shamaa A,Gharib DM

更新日期：2018-12-01 00:00:00

abstract：:Canadian Aboriginal people encompass diverse cultural groups, whose daily food patterns vary in regard to the kinds and proportions of indigenous foods. Standard dietary methods of assessing food consumption sometimes require modification to be understandable and acceptable to Aboriginal communities. Depending upon th...

journal_title：Canadian journal of physiology and pharmacology

authors： Wein EE

更新日期：1995-06-01 00:00:00

abstract：:The role of sodium and calcium on strophanthidin inotropy was studied in canine cardiac Purkinje fibers perfused in vitro under conditions that vary cellular sodium and calcium. With high concentrations of strophanthidin (greater than or equal to 10(-7) M), force increases more in the presence of low [Ca]0 or high [Na...

journal_title：Canadian journal of physiology and pharmacology

authors： Li T,Bernabei R,Carbonin P,Vassalle M

更新日期：1986-11-01 00:00:00

abstract：:We found when L-type calcium current (ICa-L) was recorded with the perforated patch-clamp method in rat ventricular myocytes that bath application of phenylephrine (with propranolol) evoked a biphasic response characterized by an initial transient suppression followed by a sustained potentiation. The transient suppres...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang S,Lin J,Hirano Y,Hiraoka M

更新日期：2005-11-01 00:00:00

abstract：:Acrolein, a highly reactive alpha,beta-unsaturated aldehyde, is an omnipresent environmental pollutant. Chronic and acute human exposures occur through exogenous and endogenous sources, including food, vapors of overheated cooking oil, house and forest fires, cigarette smoke, and automobile exhaust. Acrolein is a toxi...

journal_title：Canadian journal of physiology and pharmacology

authors： Roy J,Pallepati P,Bettaieb A,Averill-Bates DA

更新日期：2010-03-01 00:00:00

abstract：:The epicardial coronary venous pressure in 16 dogs was compared with coronary arterial pressure as well as aortic, intraventricular, and intramyocardial pressures. Partial aortic occlusion augmented intraventricular (IVP), intramyocardial (IMP), aortic (AP), and coronary arterial pressures. Peripheral coronary venous ...

journal_title：Canadian journal of physiology and pharmacology

authors： Klassen GA,Armour JA

更新日期：1983-03-01 00:00:00

abstract：:Structural analysis of G-protein-coupled receptors has largely been limited to photoaffinity labeling and site-directed mutagenesis. This is primarily due to the difficulty in the production of antibodies against this class of receptors. We were therefore interested in tagging the amino-terminal side of the human angi...

journal_title：Canadian journal of physiology and pharmacology

authors： Roy SF,Laporte SA,Escher E,Leduc R,Guillemette G

更新日期：1997-06-01 00:00:00

abstract：:Pertussis toxin (PTX) is a heterohexameric protein, which is divided into subunits A and B. The A-subunit (protomer) possesses adenine diphosphate (ADP) ribosyltransferase activity, and the B-oligomer confers cell surface binding specificity on the toxin. By virtue of the ADP-ribosylation activity in the A-subunit, PT...

journal_title：Canadian journal of physiology and pharmacology

authors： Wong WS,Rosoff PM

更新日期：1996-05-01 00:00:00

abstract：:Using radioligand binding techniques, the effect of reserpine pretreatment on ventricular adrenergic receptors from guinea pig was studied. [3H]Prazosin and [3H]dihydroalprenolol were used to label alpha 1- and beta-adrenergic receptors, respectively. Administration of 2.5 mg/kg reserpine for 2 days caused a significa...

journal_title：Canadian journal of physiology and pharmacology

authors： Latifpour J,McNeill JH

更新日期：1984-01-01 00:00:00

abstract：:Complexes of vanadyl(IV) with 4 monosaccharides and 5 disaccharides were tested in 2 osteoblast-like cell lines (MC3T3E1 and UMR106). Many complexes caused stimulation of UMR106 proliferation (120% basal) in the range of 2.5 to 25 micromol/L. In the nontransformed osteoblasts, some vanadyl-saccharide complexes stimula...

journal_title：Canadian journal of physiology and pharmacology

authors： Barrio DA,Cattáneo ER,Apezteguía MC,Etcheverry SB

更新日期：2006-07-01 00:00:00

abstract：:The role of nitric oxide (NO) on the vasorelaxant effect of atrial natriuretic peptide (ANP) on the basal tone of rabbit aortic rings conditioned to angiotensin II (Ang II) was studied. ANP aortic relaxation and nitrite release were measured in the presence and absence of endothelium and a NO-synthase inhibitor. Ang I...

journal_title：Canadian journal of physiology and pharmacology

authors： Romano L,Coviello A,Jerez S,Peral de Bruno M

更新日期：2002-10-01 00:00:00

abstract：:The role of sympathetic innervation in the regulation of hindlimb skeletal muscle blood flow (QL) and metabolism was studied prior to and during acute anemia in anesthetized, paralyzed, and ventilated dogs (n = 8). Neural activity in the sciatic nerve was reversibly cold blocked for a 15-min period at control hematocr...

journal_title：Canadian journal of physiology and pharmacology

authors： Kubes P,Cain SM,Chapler CK

更新日期：1988-09-01 00:00:00

abstract：:We used the clearance ratio test to determine whether the presence of albumin enhances the uptake of palmitate by hepatocyte monolayers. If uptake is facilitated, then the ratio of palmitate clearance by hepatocytes in the presence of 600 and 300 microM albumin (i.e., Clt600/Clt300) will exceed the square root of the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Burczynski FJ,Moran JB,Cai ZS

更新日期：1993-12-01 00:00:00

abstract：:Intra- and extra-cellular concentrations of calcium were measured in hippocampal neurons of areas CA1 and CA3 during 8 min ischaemia and short-term (up to 60 min) recovery. During an ischaemic insult, [Ca2+]i increased progressively and [Ca2+]e decreased. There were large interneuronal differences, although, in genera...

journal_title：Canadian journal of physiology and pharmacology

authors： Erecińska M,Silver IA

更新日期：1992-01-01 00:00:00

abstract：:Our previous results showed that addition of agonists, such as vasopressin and angiotensin, added to incubation medium with freshly excised rat atria caused marked release of atrial natriuretic factor (ANF). This release was in the form of prohormone rather than active peptide. Since others had difficulty reproducing ...

journal_title：Canadian journal of physiology and pharmacology

authors： Sonnenberg H,Milojevic S,Yip C,Veress AT

更新日期：1989-10-01 00:00:00

abstract：:The vasculature of the mammalian renal medulla is complex, having neither discrete input nor output. There is also efficient countercurrent exchange between ascending and descending vasa recta in the vascular bundles. These considerations have hampered measurement of medullary blood flow since they impose pronounced c...

journal_title：Canadian journal of physiology and pharmacology

authors： Cupples WA

更新日期：1986-07-01 00:00:00

abstract：:The effects of haloperidol, an antipsychotic butyrophenone, on excitability and action potential production in frog's sartorius muscle fibers were studied. This drug produced a local-anestheticlike effect which developed slowly over 1 to 5 h with lower concentrations (2.7 to 5.3 X 10(-6 M) but was completely reversed ...

journal_title：Canadian journal of physiology and pharmacology

authors： Durham HD,Frank GB,Marwaha J

更新日期：1977-06-01 00:00:00

abstract：:Activators of the slow delayed rectifier K⁺ current (IKs) have been suggested as promising tools for suppressing ventricular arrhythmias due to prolongation of repolarization. Recently, L-364,373 (R-L3) was nominated to activate IKs in myocytes from several species; however, in some studies, it failed to activate IKs....

journal_title：Canadian journal of physiology and pharmacology

authors： Corici C,Kohajda Z,Kristóf A,Horváth A,Virág L,Szél T,Nagy N,Szakonyi Z,Fülöp F,Muntean DM,Varró A,Jost N

更新日期：2013-08-01 00:00:00

abstract：:The effects of clofibrate administration (200 mg/kg, po) on somatic growth, plasma levels of lipids, tryptophan, growth hormone (GH), and prolactin (PRL), as well as on brain concentrations of tryptophan and 5-hydroxytryptamine (5-HT) were studied in prepubertal male rats. The drug did not significantly alter ponderal...

journal_title：Canadian journal of physiology and pharmacology

authors： Tache Y,Letarte J,Collu R

更新日期：1978-04-01 00:00:00

abstract：:The effects of L-641,953 (R-8-fluoro-dibenzo[b, f]thiepin-3-carboxylic acid-5-oxide) have been studied on pulmonary and other smooth muscle preparations in vitro and in vivo. When studied in vitro on guinea-pig tracheal chains, L-641,933 produced significant shifts in the dose-response curves to the prostaglandin endo...

journal_title：Canadian journal of physiology and pharmacology

authors： Hall RA,Rokach JR,Bélanger P,Bianchi L,Ethier D,Ford-Hutchinson AW,Girard Y,Hamel P,Hamel R,Lord A

更新日期：1987-04-01 00:00:00

abstract：:Cyclic AMP formation from ATP was stimulated by unpurified and partially purified soluble hepatic guanylate cyclase in the presence of nitric oxide (NO) or compounds containing a nitroso moiety such as nitroprusside, N-methyl-N-nitro-N-nitrosoguanidine (MNNG), nitrosyl ferroheme, and S-nitrosothiols. Cyclic AMP format...

journal_title：Canadian journal of physiology and pharmacology

authors： McNamara DB,Kadowitz PJ,Hyman AL,Ignarro LJ

更新日期：1980-12-01 00:00:00

abstract：:Cardiac dysfunction due to ischemia-reperfusion (I/R) is associated with marked changes in membrane function and subsequent Ca2+-handling abnormalities in cardiomyocytes. The membrane abnormalities in hearts subjected to I/R arise primarily from oxidative stress as a consequence of increased formation of reactive oxyg...

journal_title：Canadian journal of physiology and pharmacology

authors： Tappia PS,Asemu G,Rodriguez-Leyva D

更新日期：2010-03-01 00:00:00

abstract：:The intestinal uptake of 0.5 and 40 mM glucose, galactose, and 3-O-methyl glucose (3-O-MG) was examined in vitro in rabbits fed a high (HS) or a low (LS) sucrose diet. In animals with an intact intestinal tract, the jejunal uptake of 0.5 mM 3-O-MG was unaffected by the dietary content of sucrose, whereas the uptake of...

journal_title：Canadian journal of physiology and pharmacology

authors： Thomson AB

更新日期：1987-11-01 00:00:00

abstract：:The combined and separate effects of exercise training and bisphosphonate (etidronate) therapy on bone mineral in postmenopausal women were compared. Forty-eight postmenopausal women were randomly assigned (double blind) to groups that took intermittent cyclical etidronate; performed strength training (3 d/week) and r...

journal_title：Canadian journal of physiology and pharmacology

authors： Chilibeck PD,Davison KS,Whiting SJ,Suzuki Y,Janzen CL,Peloso P

更新日期：2002-10-01 00:00:00

abstract：:A number of parallels can be drawn between the reported endocrine status of thiouracil-fed young rodents and that of aged animals, particularly with regard to the hypothalamus-pituitary-adrenal axis. Since the activity of the adrenal steroidogenic enzyme 3beta-hydroxy-delta5-steroid dehydrogenase (3beta-HSD) has been ...

journal_title：Canadian journal of physiology and pharmacology

authors： Meserve LA,Ting SM

更新日期：1982-01-01 00:00:00

abstract：:A semisynthetic chemical compound, demethyldiisoeugenol, concentration dependently inhibited platelet aggregation and ATP release stimulated by thrombin (0.1 U/mL), platelet-activating factor (2 ng/mL), arachidonic acid (100 microM), collagen (10 micrograms/mL), and U46619 (1 microM) in rabbit washed platelets. The IC...

journal_title：Canadian journal of physiology and pharmacology

authors： Liao CH,Ko FN,Kuo YH,Teng CM

更新日期：1996-10-01 00:00:00

abstract：:It has been reported that the intraportal infusion of glutamine in Munich-Wistar rats will cause depression of renal perfusion and the urinary excretion of salt and water. We have attempted to reproduce these findings in anaesthetized dogs. L-Glutamine was infused at doses between 120 and 150 mumol/min into the portal...

journal_title：Canadian journal of physiology and pharmacology

authors： Levy M

更新日期：1992-10-01 00:00:00