L-364,373 (R-L3) enantiomers have opposite modulating effects on IKs in mammalian ventricular myocytes.

abstract：:We studied the in vitro effect of corticosterone on insulin binding, uptake of 2-deoxy-D-glucose, glycolysis, and glycogenesis in the soleus and extensor digitorum longus (EDL) of Swiss-Webster mice. In each experiment, one muscle (soleus/EDL) was incubated with corticosterone (0.1, 1, 50, and 100 micrograms/mL) and t...

journal_title：Canadian journal of physiology and pharmacology

authors： Tan MH,Bonen A

更新日期：1985-09-01 00:00:00

abstract：:Single-electrode voltage-clamp experiments were made on CA1 neurons in the presence of tetrodotoxin and K channel blockers. Applications of halothane (1-3% v/v) for 3-10 min caused a similar marked and reversible depression of slow inward currents (probably Ca currents) evoked by depolarizing pulses from a holding pot...

journal_title：Canadian journal of physiology and pharmacology

authors： Krnjević K,Puil E

更新日期：1988-12-01 00:00:00

abstract：:The relationship between the postsynaptic alpha 1-adrenoceptor reserve and the sensitivity of vasoconstriction induced by alpha-adrenoceptor agonists to the dihydropyridine Ca2+ entry blocker nifedipine was investigated in isolated muscle strips of dog mesenteric artery (DMA) and saphenous vein (DSV). The amplitudes o...

journal_title：Canadian journal of physiology and pharmacology

authors： Guan YY,Kwan CY,Daniel EE

更新日期：1990-10-01 00:00:00

abstract：:The shear-stress sensor function of vascular glycocalyx heparan sulphate and hyaluronic acid was investigated in vivo by assessing flow-mediated dilation before and after their removal. Heparinase III exposure (100 mU·mL-1 for 20 min;n = 6) did not significantly affect flow-mediated dilation of the iliac, from 0.42 ± ...

journal_title：Canadian journal of physiology and pharmacology

authors： Ruane-O'Hora T,O'Malley D,Buckley MM,Markos F

更新日期：2019-08-01 00:00:00

abstract：:We examined the interaction of smooth muscle myosin with alpha-actin and beta-actin isoforms during the contraction of A7r5 smooth muscle cells and rat aortic smooth muscle. The techniques of confocal microscopy and fluorescence resonance energy transfer (FRET) analysis were utilized in examining A7r5 cells and rat ao...

journal_title：Canadian journal of physiology and pharmacology

authors： Black J,Dykes A,Thatcher S,Brown D,Bryda EC,Wright GL

更新日期：2009-05-01 00:00:00

abstract：:This report reviews the research and mentoring career of Richard B. Stein (1940-). In 1962, he completed a B.S. degree in physics at the Massachusetts Institute of Technology, USA, and thereafter an M.A. (1964), Ph.D. (1966), and postdoctoral training (1966-68) at the University of Oxford, UK. He subsequently assumed ...

journal_title：Canadian journal of physiology and pharmacology

authors： Stuart DG

更新日期：2004-08-01 00:00:00

abstract：:The calyx-type synapse of the embryonic chick ciliary ganglion is reviewed as a model of transmitter release from a vertebrate presynaptic nerve terminal. This nerve terminal is extensive in area, enabling the penetration with microelectrodes and the application of patch-clamp techniques. In other respects the calyx s...

journal_title：Canadian journal of physiology and pharmacology

authors： Stanley EF

更新日期：1992-01-01 00:00:00

abstract：:The present study was undertaken to determine the beta-receptor subtype responsible for the enhanced anaphylactic histamine release from bovine leukocytes produced by isoprenaline. The selective beta 1 antagonist practolol competitively inhibited the enhancement of histamine release produced by isoprenaline. The selec...

journal_title：Canadian journal of physiology and pharmacology

authors： Perron R,Eyre P

更新日期：1982-07-01 00:00:00

abstract：:Inhibition of prostaglandin synthesis together with vagally mediated peristaltic contractions are essential if mucosal injury is to occur in the stomach of indomethacin-treated rats. The neomycin group of antibiotics has been shown to interfere with acetylcholine release. Agents blocking peristalsis have been demonstr...

journal_title：Canadian journal of physiology and pharmacology

authors： Mersereau WA,Hinchey EJ

更新日期：1989-09-01 00:00:00

abstract：:In urethane-anaesthetized rats, ion-selective microelectrodes recorded changes in extracellular K+ and Ca2+ concentrations (delta[K+]omicron and delta[Ca2+]omicron) in pyramidal layers of the hippocampus (mostly in area CA1), which were evoked by fimbrial-commissural stimulation. [K+]omicron increased linearly with fr...

journal_title：Canadian journal of physiology and pharmacology

authors： Krnjević K,Morris ME,Reiffenstein RJ

更新日期：1982-12-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) has physiological roles in the absence of exposure to exogenous ligands, and mediates adaptive and toxic responses to the environmental pollutant 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD). A readily metabolized AHR agonist, 3-methylcholanthrene, disrupts the expression of mouse he...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee C,Riddick DS

更新日期：2012-10-01 00:00:00

abstract：:Blood pressure fluctuates continuously throughout life and autoregulation is the primary mechanism that isolates the kidney from this fluctuation. Compared with Wistar rats, Brown Norway (B-N) rats display impaired renal myogenic autoregulation when blood pressure fluctuation is increased. They also are very susceptib...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang X,Cupples WA

更新日期：2001-03-01 00:00:00

abstract：:An acidic proteinase was purified from human kidney cortex. The enzyme showed a molecular mass of 31 kDa by SDS-PAGE, 36 kDa by gel filtration, and isoelectric points of 5.2 and 6.1. The optimum pH for hydrolysis of bovine hemoglobin was about 3.5. Reverse-phase HPLC analysis of the incubation mixture of the enzyme wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Gomes RA,Juliano L,Chagas JR,Hial V

更新日期：1997-06-01 00:00:00

abstract：:Fluctuations in the concentrations of cortisol and progesterone in fetal plasma, maternal plasma, and amniotic and allantoic fluids were measured in samples taken at 10-min intervals over a 90-min period from three groups of sheep sampled at different times during late pregnancy. During the last 30 days of gestation t...

journal_title：Canadian journal of physiology and pharmacology

authors： Challis JR,Patrick JE,Cross J,Workewych J,Manchester E,Power S

更新日期：1981-03-01 00:00:00

abstract：:Tissues from the duodenum and vas deferens of Sprague-Dawley rats were examined of the rat vas deferens and gap junctions. Can. J. Physiol. Pharmacol. 54, 412-416. by electron microscopy after glutaraldehyde fixation and postosmication. Gap junctions (nexuses) were readily demonstrated in the duodenum in both control ...

journal_title：Canadian journal of physiology and pharmacology

authors： Paton DM,Buckland-Nicks J,Johns A

更新日期：1976-06-01 00:00:00

abstract：:Immediately following exposure to thiocyanate (SCN-)-containing solutions, the cystic fibrosis conductance regulator Cl- channel exhibits high unitary SCN conductance and anomalous mole fraction behaviour, suggesting the presence of multiple anion binding sites within the channel pore. However, under steady-state cond...

journal_title：Canadian journal of physiology and pharmacology

authors： Linsdell P

更新日期：2001-07-01 00:00:00

abstract：:Methionine sulfoximine (MSO) is a rare amino acid. It occurs in nature or as a by-product of some forms of food processing. A notable example of the latter was a former method for bleaching wheat flour, using nitrogen trichloride, the "agene process," in use for most of the first 50 years of this century. "Agenized" f...

journal_title：Canadian journal of physiology and pharmacology

authors： Shaw CA,Bains JS,Pasqualotto BA,Curry K

更新日期：1999-11-01 00:00:00

abstract：:Both physical activity and exposure to environmental stressors such as cold, heat, and high altitudes modify various components of immune function: T cell counts, natural killer (NK) cell counts, and cytolytic activity, cytokine secretion, lymphocyte proliferation and immunoglobulin levels. Light physical activity or ...

journal_title：Canadian journal of physiology and pharmacology

authors： Shephard RJ

更新日期：1998-05-01 00:00:00

abstract：:The long noncoding RNA (lncRNA) GAS5 has been found to act as a decoy for the glucocorticoid receptor (GR), thus implicating GAS5 as a potential regulator of glucocorticoid sensitivity and resistance. Airway smooth muscle (ASM) cells and airway epithelial cells (AEC) play an important role in the pathogenesis and pers...

journal_title：Canadian journal of physiology and pharmacology

authors： Keenan CR,Schuliga MJ,Stewart AG

更新日期：2015-03-01 00:00:00

abstract：:Phosphocreatine (PCr) and intracellular pH changes were monitored by 31P-NMR spectroscopy in isolated, arterially perfused cat biceps and soleus muscles, while the pH of the CO2-bicarbonate buffered perfusate was decreased from 7.1-7.4 to 6.4-6.7 by increasing the CO2 in the equilibrating gas from 5 to up to 70%. In b...

journal_title：Canadian journal of physiology and pharmacology

authors： Meyer RA,Adams GR,Fisher MJ,Dillon PF,Krisanda JM,Brown TR,Kushmerick MJ

更新日期：1991-02-01 00:00:00

abstract：:Various researchers have hypothesized that the thickening of the vascular wall plays an important role in the maintenance of hypertension. Such an alteration can increase the vascular resistance by exerting two effects. A thickened vascular wall could occlude the lumen of the blood vessel and (or) cause the artery to ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lee RM,Smeda JS

更新日期：1985-04-01 00:00:00

abstract：:Thymic stromal lymphopoietin (TSLP) was reported to induce mast cell proliferation and aggravate allergic reactions through activation of mouse double minute 2 (MDM2). We aimed to ascertain that β-sitosterol (SI), which is one of the several phytosterols found mostly in foods, would regulate TSLP-induced mast cell pro...

journal_title：Canadian journal of physiology and pharmacology

authors： Han NR,Kim HM,Jeong HJ

更新日期：2015-11-01 00:00:00

abstract：:The kinetics of sodium gradient dependent phosphate uptake by the renal brush border membrane vesicles of the rat have ben studied under various conditions of temperature and pH. From 7 to 30 degrees C the Lineweaver-Burk plots are linear, and the apparent Km progressively increases from 54 to 91 microM. Above 30 degr...

journal_title：Canadian journal of physiology and pharmacology

authors： Brunette MG,Beliveau R,Chan M

更新日期：1984-02-01 00:00:00

abstract：:The effects of isoproterenol and forskolin on tension, cyclic AMP levels, and cyclic AMP dependent protein kinase activity were compared in helical strips of bovine coronary artery. Elevation of cyclic AMP and activation of the protein kinase appeared to be well correlated with relaxation of potassium-contracted arter...

journal_title：Canadian journal of physiology and pharmacology

authors： Vegesna RV,Diamond J

更新日期：1984-09-01 00:00:00

abstract：:The effects of Bay K8644, a Ca2+ channel agonist, on the mechanical and electrical properties of frog skeletal muscle fibers were investigated. At relatively low concentrations, such as 10(-6) and 10(-5) M, Bay K8644 significantly potentiated the maximum amplitudes of twitch responses, and this effect was not reversed...

journal_title：Canadian journal of physiology and pharmacology

authors： Oz M,Frank GB

更新日期：1994-10-01 00:00:00

abstract：:Neuronal factors co-released with neurotransmitters may play an important role in synapse development and function. Calcitonin gene related peptide (CGRP) and adenosine 5'-triphosphate (ATP), two principal neuromodulators present in the motor nerve terminals, were studied for their roles and mechanisms during early de...

journal_title：Canadian journal of physiology and pharmacology

authors： Lu B,Fu WM

更新日期：1995-07-01 00:00:00

abstract：:The effects of gallopamil, D600, a methoxy derivative of verapamil, on the mechanical and electrophysiological parameters of isolated guinea-pig myocardial preparations were compared with those of verapamil. Both gallopamil and verapamil produced concentration-dependent negative chronotropic and negative inotropic eff...

journal_title：Canadian journal of physiology and pharmacology

authors： Noguchi K,Masumiya H,Takahashi K,Kaneko K,Higuchi S,Tanaka H,Shigenobu K

更新日期：1997-12-01 00:00:00

abstract：:Experiments in right atria isolated from adult male rats were designed to determine which of the alpha 1-adrenergic receptor (alpha 1-AR) subtypes are involved in the positive chronotropic effect of phenylephrine, an alpha 1-AR agonist. Chloroethylclonidine (CEC), an irreversible alpha 1b-, alpha 1c-, and alpha 1d-AR ...

journal_title：Canadian journal of physiology and pharmacology

authors： Williamson AP,Seifen E,Lindemann JP,Kennedy RH

更新日期：1994-12-01 00:00:00

abstract：:The effects of fast neutrons (10-100 Gy) on chromatin extracted from normal (liver of Wistar rats) and tumor (Walker carcinosarcoma maintained on Wistar rats) tissues were compared. The spectroscopic assays used were (i) chromatin intrinsic fluorescence, (ii) time-resolved fluorescence of chromatin - proflavine comple...

journal_title：Canadian journal of physiology and pharmacology

authors： Radu L,Constantinescu B,Gazdaru D

更新日期：2002-07-01 00:00:00

abstract：:The risk assessment of mycotoxins is made up of two major components: an exposure assessment and a hazard assessment. There are many uncertainties in both of these components. This paper will briefly discuss the various aspects of the risk assessment process as it applies to mycotoxins and will then focus mainly on so...

journal_title：Canadian journal of physiology and pharmacology

authors： Kuiper-Goodman T

更新日期：1990-07-01 00:00:00