Immune changes induced by exercise in an adverse environment.

abstract：:Sodium deoxycholate (NaDOC) inhibits the intestinal Ca2+ absorption and ursodeoxycholic acid (UDCA) stimulates it. The aim of this study was to determine whether NaDOC and UDCA produce differential effects on the redox state of duodenal mitochondria altering the Krebs cycle and the electron transport chain (ETC) funct...

journal_title：Canadian journal of physiology and pharmacology

authors： Pérez A,Rivoira MA,Rodríguez V,Marchionatti A,Tolosa de Talamoni N

更新日期：2020-07-20 00:00:00

abstract：:Hyperglycemia in diabetes induces increased endothelin-1 (ET-1) production in the retina, kidney, and heart that may lead to hemodynamic impairment, permeability alteration, and increased extracellular matrix (ECM) protein production. Chronically elevated blood glucose levels may cause oxidative stress in these target...

journal_title：Canadian journal of physiology and pharmacology

authors： Chiu J,Xu BY,Chen S,Feng B,Chakrabarti S

更新日期：2008-06-01 00:00:00

abstract：:The Na+/H+ exchanger isoform 1 is an integral membrane protein that regulates intracellular pH. It extrudes 1 intracellular H+ in exchange for 1 extracellular Na+. It has 2 large domains, an N-terminal membrane domain of 12 transmembrane segments and an intracellular C-terminal regulatory domain. We characterized the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Ding J,Ng RW,Fliegel L

更新日期：2007-03-01 00:00:00

abstract：:The adenylate cyclase activity induced by norepinephrine (10(-8)-10(-9) M) was studied in hypothalamic particulate fractions from female rats. The effect of estradiol on this activity was studied in rats that were ovariectomized in diestrus 1, injected with estradiol benzoate (50 micrograms/kg body weight), and killed...

journal_title：Canadian journal of physiology and pharmacology

authors： Zubin P,Defagot C

更新日期：1994-11-01 00:00:00

abstract：:The role of iron-loaded transferrin in xanthine-xanthine oxidase (X-XO) induced cardiac injury in isolated perfused rat hearts was examined. X (2 mM) - XO (10 U/L) perfusion resulted in contractile failure, a rise in resting tension, an increase in lipid peroxidation, and myocardial cell damage. The addition of transf...

journal_title：Canadian journal of physiology and pharmacology

authors： Tiede R,Sareen S,Singal PK

更新日期：1990-04-01 00:00:00

abstract：:Connexin43 has been recognized as forming gap junctions in Leydig cells. However, previous work has shown that mouse Leydig cells lacking this connexin do not suffer any limitation of their ability to produce testosterone when stimulated with luteinizing hormone. The objective of this study was to identify additional ...

journal_title：Canadian journal of physiology and pharmacology

authors： Li D,Sekhon P,Barr KJ,Márquez-Rosado L,Lampe PD,Kidder GM

更新日期：2013-02-01 00:00:00

abstract：:Biochemical studies using highly condensed Xenopus sperm chromatin and protein extracts prepared from multiple systems have lead to the identification of conserved proteins involved in chromosome decondensation. However, mutations to these proteins are unavailable as the systems used are not amenable to genetic studie...

journal_title：Canadian journal of physiology and pharmacology

authors： Harkness TA

更新日期：2006-03-01 00:00:00

abstract：:Bicuculline methochloride (BMC), applied by microiontophoresis, tends to depolarize spinal motoneurons and lower their input resistance. With approximately equal iontophoretic currents of gamma-aminobutyric acid (GABA) and BMC, there is an almost equal chance of observing no change, a potentiation, or a depression of ...

journal_title：Canadian journal of physiology and pharmacology

authors： Krnjević K,Puil E,Werman R

更新日期：1977-06-01 00:00:00

abstract：:Newborn hearts have restricted functional reserve and variable responsiveness to inotropes that could be partly due to differences in myocardial beta-adrenoceptors (beta-AR). To clarify this issue, this study documented ventricle-specific changes in myocardial beta-AR density and affinity during postnatal maturation. ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wittnich C,Belanger MP,Bandali K

更新日期：2006-08-01 00:00:00

abstract：:The inotropic response induced by beta-adrenergic and H1 histaminergic receptor stimulation was characterized in guinea pig left atria by obtaining dose-response relationships for isoproterenol and histamine under various experimental conditions. Conditions (hypothermia, high frequencies of stimulation, and large extr...

journal_title：Canadian journal of physiology and pharmacology

authors： Tenner TE Jr,McNeill JH

更新日期：1978-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most life-threatening cancers. The present study was designed to chronologically analyze the HCC chemically induced by diethylnitrosamine (DEN) in male Wistar rats during a 27-week period. DEN was given to rats in drinking water (100 mg/L) to induce HCC. In the present stud...

journal_title：Canadian journal of physiology and pharmacology

authors： Fathy AH,Bashandy MA,Bashandy SAE,Mansour AM,Elsadek B

更新日期：2017-12-01 00:00:00

abstract：:Although ATP-MgCl2 enhances the recovery of renal function after ischemia and reperfusion, it is not known whether this agent has any beneficial effects on renal microcirculation and function in a nonheparinized model of trauma and severe hemorrhage. To study this, a midline laparotomy was performed (i.e., trauma indu...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang P,Zhou M,Rana MW,Singh G,Ba ZF,Ayala A,Chaudry IH

更新日期：1992-03-01 00:00:00

abstract：:When carbon tetrachloride (CCl4) was administered to rats, a localized region of hepatic edema could be detected within 1 h by in vivo proton magnetic resonance imaging. However, if rats were pretreated with gadolinium chloride (GdCl3), an inhibitor of Kupffer cell function, the CCl4-induced edema was greatly decrease...

journal_title：Canadian journal of physiology and pharmacology

authors： Towner RA,Reinke LA,Janzen EG,Yamashiro S

更新日期：1994-05-01 00:00:00

abstract：:Administration of naloxone to morphine-dependent rats results in an elevation of tail skin temperature and a fall in core temperature. Previous studies have demonstrated a role of the adrenal gland in the thermal responses that accompany morphine withdrawal in the rat. In the present study, experiments were designed t...

journal_title：Canadian journal of physiology and pharmacology

authors： Katovich MJ,Pitman D,Schechtman O

更新日期：1992-08-01 00:00:00

abstract：:Immediately following exposure to thiocyanate (SCN-)-containing solutions, the cystic fibrosis conductance regulator Cl- channel exhibits high unitary SCN conductance and anomalous mole fraction behaviour, suggesting the presence of multiple anion binding sites within the channel pore. However, under steady-state cond...

journal_title：Canadian journal of physiology and pharmacology

authors： Linsdell P

更新日期：2001-07-01 00:00:00

abstract：:Using a time-lapse cinephotomicrographic technique, the locomotory paths taken by lymphocytes have been shown to satisfy the requirements for a continuous-time Markov chain analysis consisting of four directional states defined by the four quadrants of a Cartesian plane and state 0 in which the cells are stationary. T...

journal_title：Canadian journal of physiology and pharmacology

authors： Noble PB,Boyarsky A,Bentley KC

更新日期：1979-01-01 00:00:00

abstract：:We tested the hypothesis that ethanol consumption would aggravate the renal damage induced by cyclophosphamide (CYP). Male C57BL/6J mice from control (n=8) and CYP (n=12) groups had free access to filtered water and standard rodent chow for 12 weeks. Then, 24 h before euthanasia mice received an intraperitoneal inject...

journal_title：Canadian journal of physiology and pharmacology

authors： Sousa AH,Do Vale GT,Silva CB,Awata WM,Pinheiro LC,Tirapelli CR

更新日期：2020-11-11 00:00:00

abstract：:The effect of chlorpromazine on subcellular biosynthesis, hydrolysis, and transfer of lipids and liponucleotides participating in the biosynthesis of polyglycerophosphatides in guinea pig liver was studied. Chlorpromazine showed an apparent stimulation of accumulation of phosphatidic acid and CDP-diglycerides in micro...

journal_title：Canadian journal of physiology and pharmacology

authors： Stuhne-Sekalec L,Chudzik J,Stanacev NZ

更新日期：1987-03-01 00:00:00

abstract：:The effect of one bout of acute exercise on impaired glucose metabolism was studied in obese (480 +/- 20 g), untrained rats, at rest (n = 10) and after 60 min of swimming (n = 5). Using the euglycemic, hyperinsulinemic (10 mU.kg-1 x min-1) clamp, glucose clearance rate increased from 7.6 +/- 0.9 at rest to 9.7 +/- 0.5...

journal_title：Canadian journal of physiology and pharmacology

authors： Burstein R,Zissholtz A,Zick-Bachar Y,Epstein Y,Shapiro Y,Karnieli E

更新日期：1992-11-01 00:00:00

abstract：:To determine the effects of chronic hyperinsulinemia on glucagon release, rats were made hyperinsulinemic for 14 days by supplementation of drinking water with sucrose (10%; sucrose-fed) to increase endogenous release or by implantation of osmotic minipumps (subcutaneous, s.c.; or intraperitoneal, i.p.) to deliver exo...

journal_title：Canadian journal of physiology and pharmacology

authors： Brubaker PL,Kazumi T,Hirano T,Vranic M,Steiner G

更新日期：1991-03-01 00:00:00

abstract：:Male spontaneously hypertensive stroke-prone (SHRsp) rats were fed 4% NaCl diets containing either 0.75% (normal) K or 2.11% (high) K, starting at 6 weeks of age. After 8 months on these diets, 40 out of 58 SHRsp rats on the 0.75% K diet had died (69% mortality) versus 2 dead out of 95 on the 2.11% K diet (2% mortalit...

journal_title：Canadian journal of physiology and pharmacology

authors： Tobian L

更新日期：1986-06-01 00:00:00

abstract：:Tension responses to ramp shortening of varying speed in whole muscle or single fibres from the plateau of an isometric tetanus, revealed at least two distinct phases. There was a fast initial drop in tension followed by a change of slope and a definite inflexion on the tension record. As the velocity of the imposed l...

journal_title：Canadian journal of physiology and pharmacology

authors： Bressler BH

更新日期：1985-12-01 00:00:00

abstract：:Our previous studies have suggested that GATA-4 increases the differentiation of bone-marrow-derived mesenchymal stem cells (MSCs) into cardiac phenotypes. This study further investigated whether GATA-4 enhances MSC-mediated cardioprotection following hypoxia. MSCs were harvested from rat bone marrow and transduced wi...

journal_title：Canadian journal of physiology and pharmacology

authors： Li HX,Zhou YF,Zhao X,Jiang B,Yang XJ

更新日期：2014-08-01 00:00:00

abstract：:The leaves and bark of Cassia glauca Lam., a glabrous tree in the family Fabaceae, are used in folk medicine for the treatment of diabetes. The aim of this study was to investigate the antidiabetic activity of the aqueous extract of C. glauca bark. The various parameters that were studied in treated or untreated normo...

journal_title：Canadian journal of physiology and pharmacology

authors： Salahuddin M,Jalalpure SS,Gadge NB

更新日期：2010-02-01 00:00:00

abstract：:The objective of this study was to investigate the protective effects of pomegranate (Punica granatum) juice (PGJ) on oxidative damages in liver tissue and erythrocytes of rats intoxicated by sodium fluoride (NaF). Rats were randomly divided into two groups: group I received standard diet and group II received orally ...

journal_title：Canadian journal of physiology and pharmacology

authors： Bouasla A,Bouasla I,Boumendjel A,Abdennour C,El Feki A,Messarah M

更新日期：2016-07-01 00:00:00

abstract：:A variety of neural factors can influence reproductive hormone secretion by neuromodulatory actions within the hypothalamus or neuroendocrine actions within the anterior pituitary gland. Passive immunoneutralization and antagonist administration protocols have suggested physiological roles for a number of these factor...

journal_title：Canadian journal of physiology and pharmacology

authors： Samson WK,Alexander BD,Skala KD,Huang FL,Fulton RJ

更新日期：1992-05-01 00:00:00

abstract：:Cold ischemia--warm reperfusion (CI/WR) injury of liver transplantation involves hepatocyte cell death, the nature and underlying mechanisms of which remain unclear. Isolated hepatocytes and isolated perfused livers were used to determine the prevalence of necrosis and apoptosis as well as mitochondrial dysfunction. I...

journal_title：Canadian journal of physiology and pharmacology

authors： Duval M,Plin C,Elimadi A,Vallerand D,Tillement JP,Morin D,Haddad PS

更新日期：2006-05-01 00:00:00

abstract：:Changes in electrical potential difference and sodium-potassium ATPase activity of rectal mucosa in dogs were examined before and after jejunal-ileal bypass surgery. The potential difference in the postoperative period was significantly higher (P less than 0.05) than the preoperative value. The potential difference in...

journal_title：Canadian journal of physiology and pharmacology

authors： Grahame GR,Shoenut JP,Takeo S,Sharma GP

更新日期：1983-05-01 00:00:00

abstract：:Liver diseases are associated with a decrease in hepatic drug elimination, but there is evidence that cirrhosis does not result in uniform changes of cytochrome P450 (CYP) isoenzymes. The objective of this study was to determine the content and activity of four CYP isoenzymes in the bile duct ligation and carbon tetra...

journal_title：Canadian journal of physiology and pharmacology

authors： Bastien MC,Leblond F,Pichette V,Villeneuve JP

更新日期：2000-11-01 00:00:00

abstract：:Double-barrelled ion-sensitive microelectrodes were used to measure changes in the intracellular activities of K+, Na+, and Cl- (aKi, aNai, aCli) in neurones of rat sympathetic ganglia and in glial cells of slices from guinea-pig olfactory cortex. In sympathetic neurones, carbachol and gamma-aminobutyric acid (GABA) p...

journal_title：Canadian journal of physiology and pharmacology

authors： Grafe P,Ballanyi K

更新日期：1987-05-01 00:00:00