Sequential analysis and staging of a diethylnitrosamine-induced hepatocellular carcinoma in male Wistar albino rat model.

abstract：:Vascular smooth muscle tone is regulated primarily by the sarcoplasmic free Ca2+ concentration, which determines the level of myosin phosphorylation. Stimulation of the muscle results in an increase in free [Ca2+], whereupon Ca2+ binds to calmodulin, inducing a conformational change enabling calmodulin to interact wit...

journal_title：Canadian journal of physiology and pharmacology

authors： Walsh MP

更新日期：1994-08-01 00:00:00

abstract：:The heat production (HP), heart rate (HR), respiration rate, rumen motility, and body temperature responses to 2.5-h adrenaline (A) and noradrenaline (NA) intrajugular infusions at 0.00, 0.15, 0.30, 0.60, and 0.90 micrograms.kg-1.min-1 were studied in 10 shorn wethers which had been chronically (3-8 weeks) exposed to ...

journal_title：Canadian journal of physiology and pharmacology

authors： Graham AD,Christopherson RJ

更新日期：1981-09-01 00:00:00

abstract：:1. To examine whether different local anesthetics act on different or similar sites in the nerve membrane, the effects of combinations of lipid-soluble anesthetics and tetrodotoxin (TTX) were studied on the compound action potential of the frog sciatic nerve. 2. The nerve-blocking potency of TTX was potentiated 5-fold...

journal_title：Canadian journal of physiology and pharmacology

authors： Staiman AL,Seeman P

更新日期：1975-08-01 00:00:00

abstract：:The effects of Bay K8644, a Ca2+ channel agonist, on the mechanical and electrical properties of frog skeletal muscle fibers were investigated. At relatively low concentrations, such as 10(-6) and 10(-5) M, Bay K8644 significantly potentiated the maximum amplitudes of twitch responses, and this effect was not reversed...

journal_title：Canadian journal of physiology and pharmacology

authors： Oz M,Frank GB

更新日期：1994-10-01 00:00:00

abstract：:Administration of naloxone to morphine-dependent rats results in an elevation of tail skin temperature and a fall in core temperature. Previous studies have demonstrated a role of the adrenal gland in the thermal responses that accompany morphine withdrawal in the rat. In the present study, experiments were designed t...

journal_title：Canadian journal of physiology and pharmacology

authors： Katovich MJ,Pitman D,Schechtman O

更新日期：1992-08-01 00:00:00

abstract：:The activity of the lipolytic system of the obese hyperglycemic mouse was assessed after treatment with physiological doses of thyroxin (T4). The treatment significantly increased fatty acid mobilization in response to adrenaline over the levels observed in the control mice under all conditions studied. The activities...

journal_title：Canadian journal of physiology and pharmacology

authors： Bégin-Heick N,Heick HM

更新日期：1977-12-01 00:00:00

abstract：:We tested the effects of inhibiting the carbonic anhydrase activity of rat soleus and extensor digitorum longus muscles on the isometric contractile properties and the resistance to fatigue. SOL and EDL muscles from female rats were incubated in vitro in the presence of methazolamide, a specific inhibitor of carbonic ...

journal_title：Canadian journal of physiology and pharmacology

authors： Côté C,Tremblay D,Riverin H,Frémont P,Rogers PA

更新日期：1989-06-01 00:00:00

abstract：:The objective of the present study was to assess the cardioprotective effect of dual NEP-ACE inhibition in relation to endogenous cardiac bradykinin (BK), its active metabolite des-Arg9-BK, endogenous brain natriuretic peptides (BNP), and cGMP. Rats were treated with the dual metallopeptidase inhibitor, omapatrilat, o...

journal_title：Canadian journal of physiology and pharmacology

authors： Dumoulin MJ,Adam A,Burnett J,Heublein D,Yamaguchi N,Lamontagne D

更新日期：2005-02-01 00:00:00

abstract：:The intraperitoneal administration of insulin has been recommended because it was found to effectively control the plasma glucose level. Several authors have suggested that intraperitoneal insulin administration may be more "physiological" and therefore preferable because the insulin is absorbed into the portal venous...

journal_title：Canadian journal of physiology and pharmacology

authors： Zingg W,Rappaport AM,Leibel BS

更新日期：1986-03-01 00:00:00

abstract：:The ability of dystrophic hamsters to maintain their body temperature despite abnormal muscle and brown adipose tissue, two organs involved in thermoregulation, was evaluated. Dystrophic hamsters (CHF 146) between the ages of 30 and 160 days kept at 21 degrees C had core (rectal) temperatures (TR) that were 0.5-1.5 de...

journal_title：Canadian journal of physiology and pharmacology

authors： Desautels M,Dulos RA,Thornhill JA

更新日期：1985-09-01 00:00:00

abstract：:The present study was designed to examine the possible neuroprotective and antiepileptic effects of metformin (Metf) in a rat model of pentylenetetrazole (PTZ)-induced epilepsy and its possible underlying mechanisms. Forty male albino rats were assigned to 4 groups of equal size: (1) normal control (NC) group, (2) Met...

journal_title：Canadian journal of physiology and pharmacology

authors： Hussein AM,Eldosoky M,El-Shafey M,El-Mesery M,Ali AN,Abbas KM,Abulseoud OA

更新日期：2019-01-01 00:00:00

abstract：:We have measured the responses to endurance exercise training on body composition and glucose regulation, as well as cardiovascular and liver structure and function in rats fed a high carbohydrate and high fat (HCHF) diet as a model of human metabolic syndrome. Male Wistar rats (9-10 weeks old) were randomly allocated...

journal_title：Canadian journal of physiology and pharmacology

authors： Cameron I,Alam MA,Wang J,Brown L

更新日期：2012-11-01 00:00:00

abstract：:Metabolic syndrome (MS) is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. MS is associated with obesity, increased blood pressure, hyperlipidemia, and hyperglycemia. This study was designed to investigate the pharmacological profile of phentolamine, a nonse...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhou K,Kumar U,Yuen VG,McNeill JH

更新日期：2012-08-01 00:00:00

abstract：:Activators of the slow delayed rectifier K⁺ current (IKs) have been suggested as promising tools for suppressing ventricular arrhythmias due to prolongation of repolarization. Recently, L-364,373 (R-L3) was nominated to activate IKs in myocytes from several species; however, in some studies, it failed to activate IKs....

journal_title：Canadian journal of physiology and pharmacology

authors： Corici C,Kohajda Z,Kristóf A,Horváth A,Virág L,Szél T,Nagy N,Szakonyi Z,Fülöp F,Muntean DM,Varró A,Jost N

更新日期：2013-08-01 00:00:00

abstract：:Although ATP-MgCl2 enhances the recovery of renal function after ischemia and reperfusion, it is not known whether this agent has any beneficial effects on renal microcirculation and function in a nonheparinized model of trauma and severe hemorrhage. To study this, a midline laparotomy was performed (i.e., trauma indu...

journal_title：Canadian journal of physiology and pharmacology

authors： Wang P,Zhou M,Rana MW,Singh G,Ba ZF,Ayala A,Chaudry IH

更新日期：1992-03-01 00:00:00

abstract：:Two natriuretic peptides, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), are found principally in the heart. In preliminary experiments with mouse kidney cells or slices, we found mouse BNP1-45 much more potent than ANP1-28 in causing elevations of cGMP (>50-fold). The guanylyl cyclase-A (GC-A)...

journal_title：Canadian journal of physiology and pharmacology

authors： Kishimoto I,Hamra FK,Garbers DL

更新日期：2001-08-01 00:00:00

abstract：:Experiments were carried out in pigs to investigate the relationship between concentration of intestinal calcium-binding protein (CaBP) and the presence of rickets. Pigs made rachitic by a diet deficient in calcium and in vitamin D had concentrations of intestinal CaBP no less than values obtained on control pigs. The...

journal_title：Canadian journal of physiology and pharmacology

authors： Harrison JE,Hitchman AJ,Brown RG

更新日期：1975-02-01 00:00:00

abstract：:To determine if increased endometrial vascular permeability (a response which precedes decidualization) could be obtained in temporally nonsensitized uteri by treatments designed to increase endometrial adenosine 3':5'-cyclic monophosphate (cAMP) concentrations, cholera toxin (an activator of adenylate cyclase) was in...

journal_title：Canadian journal of physiology and pharmacology

authors： Johnston ME,Kennedy TG

更新日期：1985-09-01 00:00:00

abstract：:In vivo assessment of treatment efficacy on postinfarct left ventricular (LV) remodeling is crucial for experimental studies. We examined the technical feasibility of serial magnetic resonance imaging (MRI) for monitoring early postinfarct remodeling in rats. MRI studies were performed with a 7-Tesla unit, 1, 3, 8, 15...

journal_title：Canadian journal of physiology and pharmacology

authors： Prunier F,Marescaux L,Franconi F,Thia A,Legras P,Lejeune JJ,Furber A

更新日期：2005-12-01 00:00:00

abstract：:It was recently shown that a peptide (hypertensive factor, HF) isolated from erythrocyte hemolysates from spontaneously hypertensive rats induced a prolonged elevation of blood pressure in normotensive rats. In addition, the peptide produced a marked stimulation of the in vitro uptake of lanthanum-resistant calcium by...

journal_title：Canadian journal of physiology and pharmacology

authors： Wright GL,Huang BS,Johnson PJ,McCumbee WD

更新日期：1988-10-01 00:00:00

abstract：:Energy balance studies suggest that the overall efficiency of energy utilization does not increase during pregnancy in rodents, other than as a consequence of "hyperphagia". Diet-induced thermogenesis is not stimulated in response to the increased energy intake of the pregnant animal, the extra intake being retained a...

journal_title：Canadian journal of physiology and pharmacology

authors： Trayhurn P

更新日期：1989-04-01 00:00:00

abstract：:Ethanol was administered to rats by oral intubation 3 h after intraperitoneal administration of calcium carbimide. Increased blood acetaldehyde concentration and the presence of acetaldehyde in brain were found for the calcium carbimide--ethanol interaction. There was no detectable brain acetaldehyde for ethanol admin...

journal_title：Canadian journal of physiology and pharmacology

authors： Hoover DJ,Brien JF

更新日期：1981-01-01 00:00:00

abstract：:It is possible to embed the control and computation of a simple single-joint movement at different speeds by a small non-linear network of neuron-like elements. The network "learns" by appropriate adjustment of the strengths of interconnection, or synaptic weights, between the neuron-like elements. The learning of a f...

journal_title：Canadian journal of physiology and pharmacology

authors： Kwan HC,Yeap TH,Jiang BC,Borrett D

更新日期：1990-01-01 00:00:00

abstract：:In anesthetized rats micropuncture and microcatheterization were used to collect tubular fluid from end proximal and distal tubules and from the outer medullary collecting duct. Urine was collected at the papilla tip. Samples were taken from the same sites before and after intravenous injection of atrial tissue extrac...

journal_title：Canadian journal of physiology and pharmacology

authors： Sonnenberg H,Cupples WA,de Bold AJ,Veress AT

更新日期：1982-09-01 00:00:00

abstract：:Hepatotoxicity and nephrotoxicity are important drawbacks of cisplatin. The objective of this study is to evaluate the ability of ambroxol in 2 different doses (35 and 70 mg/kg, i.p.) to protect liver and kidney from damage induced by a single dose of cisplatin (10 mg/kg, i.p.) in comparison with N-acetylcysteine (250...

journal_title：Canadian journal of physiology and pharmacology

authors： Bishr A,Sallam N,Nour El-Din M,Awad AS,Kenawy SA

更新日期：2019-01-01 00:00:00

abstract：:The effects of estrogen and progesterone domination, achieved by administering estrogen (E) and estrogen plus progesterone (E + P), on rat uterine reactivity to Ca2+ and to Ca2+ channel ligands (antagonist and activator) were compared. The inhibitory activities of nifedipine, diltiazem, and D 600 against K+ depolariza...

journal_title：Canadian journal of physiology and pharmacology

authors： Ruzycky AL,Crankshaw DJ,Triggle DJ

更新日期：1987-10-01 00:00:00

abstract：:Salvianolic acid B (Sal B) exerts strong antioxidant activity and eliminates the free radical effect. However, how it affects the antioxidant pathway is not very clear. The objective of this study was to investigate the underlying mechanism of Sal B in CCl4-induced acute liver injury, especially its effect on the Nrf2...

journal_title：Canadian journal of physiology and pharmacology

authors： Jin YM,Tao XM,Shi YN,Lu Y,Mei JY

更新日期：2020-03-01 00:00:00

abstract：:The beneficial hypolipidemic and antioxidant influences of the dietary spice compounds curcumin and capsaicin were evaluated. Curcumin, capsaicin, or their combination were included in the diet of high-(30%)-fat-fed rats for 8 weeks. Dietary high-fat-induced hypertriglyceridemia was countered by dietary curcumin, caps...

journal_title：Canadian journal of physiology and pharmacology

authors： Manjunatha H,Srinivasan K

更新日期：2007-06-01 00:00:00

abstract：:The measurement of the sodium reversal potential (Erev), as that potential where the early current reverses during voltage clamp, was found to exceed the true Erev by 4.1 +/- 2.4 mV (mean +/- SD) in squid giant axon. This error was found in both intact and internally perfused axons and is due to interference from the ...

journal_title：Canadian journal of physiology and pharmacology

authors： Wodlinger H,Kunov H,Atwood HL

更新日期：1982-12-01 00:00:00

abstract：:Theanine and caffeine, 2 naturally occurring components in tea, have repeatedly been shown to deliver unique cognitive benefits when consumed in combination. In this study, we assessed the beneficial synergistic effects of concurrent treatment with theanine and caffeine against cerebral damage in rats. Theanine and ca...

journal_title：Canadian journal of physiology and pharmacology

authors： Sun L,Tian X,Gou L,Ling X,Wang L,Feng Y,Yin X,Liu Y

更新日期：2013-07-01 00:00:00