Studies on transhepatic insulin absorption.

Abstract:

:The intraperitoneal administration of insulin has been recommended because it was found to effectively control the plasma glucose level. Several authors have suggested that intraperitoneal insulin administration may be more "physiological" and therefore preferable because the insulin is absorbed into the portal venous system without, however, identifying the exact pathways. The possibility that insulin is absorbed through the surface of the liver was investigated in rats. The results show that insulin is absorbed rapidly by this route, but the effect on glucose modulation is similar to that of insulin given by other routes. In contrast, the effect on glucose modulation was delayed following insulin administration into the lower peritoneal cavity with exclusion of the liver.

authors

Zingg W,Rappaport AM,Leibel BS

doi

10.1139/y86-036

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

231-4

issue

3

eissn

0008-4212

issn

1205-7541

journal_volume

64

pub_type

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