Abstract:
:The activity of the lipolytic system of the obese hyperglycemic mouse was assessed after treatment with physiological doses of thyroxin (T4). The treatment significantly increased fatty acid mobilization in response to adrenaline over the levels observed in the control mice under all conditions studied. The activities of the high- and low-Km phosphodiesterases and of adenylate cyclase were also studied. Treatment of the ob/ob mice with T4 had little effect on the activities of the cyclic AMP phosphodiesterases (high and low Km) but it partially restored the activity of adenylate cyclase, which is deficient in these animals. A correlation was found in the T4-treated obese animals between the ability of the epididymal adipose tissue to mobilize fatty acids, its ability to increase the intracellular levels of cyclic AMP, and the activity of adenylate cyclase in response to adrenaline stimulation.
journal_name
Can J Physiol Pharmacoljournal_title
Canadian journal of physiology and pharmacologyauthors
Bégin-Heick N,Heick HMdoi
10.1139/y77-177subject
Has Abstractpub_date
1977-12-01 00:00:00pages
1320-9issue
6eissn
0008-4212issn
1205-7541journal_volume
55pub_type
杂志文章abstract::Luminal nutrition is important for the maintenance of small intestinal structure and function. The equilibrium between crypt cell production and villous cell loss in the mucosal epithelium of the small intestine is altered under certain conditions such as after a small bowel resection. Immediately after resection, the...
journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章,评审
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journal_title:Canadian journal of physiology and pharmacology
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doi:10.1139/cjpp-76-12-1161
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更新日期:2000-01-01 00:00:00
abstract::The world-wide increase in cancer incidence imposes a corresponding significant increase in the use of chemotherapeutic agents. Nephrotoxicity is a side effect frequently encountered with cyclophosphamide (CP), which is also well-known to cause acute and chronic lung toxicities. The current study focuses on the evalua...
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更新日期:2016-04-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:2013-06-01 00:00:00
abstract::A possible implication of endogenously released ATP and (or) ADP in insulin response to glucose stimulation was investigated in the isolated rat pancreas. The first phase of insulin response to the same glucose concentration (8.3 mM) was much higher in pancreas previously perfused in the absence of glucose than in pan...
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更新日期:1993-08-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y75-020
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
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更新日期:1991-06-01 00:00:00
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doi:10.1139/y83-159
更新日期:1983-09-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y83-033
更新日期:1983-03-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 临床试验,杂志文章
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更新日期:2002-08-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章,评审
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更新日期:1992-04-01 00:00:00
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doi:10.1139/cjpp-2017-0252
更新日期:2018-06-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 临床试验,杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/y95-205
更新日期:1995-10-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章,评审
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更新日期:1995-12-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
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journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
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pub_type: 杂志文章
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abstract::The present study was designed to investigate the effects of YC-1, a nitric oxide (NO)-independent soluble guanylate cyclase (sGC) activator, and DEA/NO, a NO donor, on smooth muscle responses in the preeclampsia model with suramin-treated rats and on the levels of cyclic guanosine monophosphate (cGMP) of thoracic aor...
journal_title:Canadian journal of physiology and pharmacology
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更新日期:2013-10-01 00:00:00
abstract::Endothelin 1 (ET-1) is a potent vasoconstrictor implicated in the control of blood pressure and renal function. Its effects can be modulated by nitric oxide (NO), which inhibits ET-1 production and action. Recently, we reported that ET-1 production can also be modulated by angiotensin II (AngII) in vivo. To investigat...
journal_title:Canadian journal of physiology and pharmacology
pub_type: 杂志文章
doi:10.1139/cjpp-77-1-8
更新日期:1999-01-01 00:00:00
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journal_title:Canadian journal of physiology and pharmacology
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